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Review

Therapeutic potential of melatonin agonists

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Pages 269-279 | Published online: 10 Jan 2014

References

  • Pandi-Perumal SR, Srinivasan V, Maestroni GJM et al. Melatonin: nature’s most versatile biological signal? FEBS J.273(13), 2813–2838 (2006).
  • Srinivasan V, Smits M, Spence W et al. Melatonin in mood disorders. World J. Biol. Psychiatry7(3), 138–151 (2006).
  • Carrillo-Vico A, Reiter RJ, Lardone PJ et al. The modulatory role of melatonin on immune responsiveness. Curr. Opin. Investig. Drugs7(5), 423–431 (2006).
  • Dopfel RP, Schulmeister K, Schernhammer ES. Nutritional and lifestyle correlates of the cancer-protective hormone melatonin. Cancer Detect. Prev.31(2), 140–148 (2007).
  • Tan DX, Manchester LC, Terron MP, Flores LJ, Reiter RJ. One molecule, many derivatives: a never-ending interaction of melatonin with reactive oxygen and nitrogen species? J. Pineal Res.42(1), 28–42 (2007).
  • Cardinali DP, Pevet P. Basic aspects of melatonin action. Sleep Med. Rev.2(3), 175–190 (1998).
  • Reiter RJ, Tan DX. What constitutes a physiological concentration of melatonin? J. Pineal. Res.34(1), 79–80 (2003).
  • Brzezinski A. Melatonin and human reproduction: why the effect is so elusive? In: Pandi-Perumal SR, Cardinali DP (Eds). Nova Biomedical Books, NY, USA Melatonin: from Molecules to Therapy.219–225 (2007).
  • Dubocovich ML, Markowska M. Functional MT1 and MT2 melatonin receptors in mammals. Endocrine27(2), 101–110 (2005).
  • Reppert SM, Weaver DR, Godson C. Melatonin receptors step into the light: cloning and classification of subtypes. Trends Pharmacol. Sci.17(3), 100–102 (1996).
  • von Gall C, Stehle JH, Weaver DR. Mammalian melatonin receptors: molecular biology and signal transduction. Cell. Tissue Res.309(1), 151–162 (2002).
  • Zhdanova IV. Melatonin as a hypnotic: pro. Sleep Med. Rev.9(1), 51–65 (2005).
  • Buscemi N, Vandermeer B, Hooton N et al. Efficacy and safety of exogenous melatonin for secondary sleep disorders and sleep disorders accompanying sleep restriction: meta-analysis. Br. Med. J.332(7538), 385–393 (2006).
  • Brzezinski A, Vangel MG, Wurtman RJ et al. Effects of exogenous melatonin on sleep: a meta-analysis. Sleep Med. Rev.9(1), 41–50 (2005).
  • Turek FW, Gillette MU. Melatonin, sleep, and circadian rhythms: rationale for development of specific melatonin agonists. Sleep Med.5(6), 523–532 (2004).
  • Lewy AJ, Emens J, Jackman A, Yuhas K. Circadian uses of melatonin in humans. Chronobiol. Int.23(1–2), 403–412 (2006).
  • Srinivasan V, Smits G, Kayumov L et al. Melatonin in circadian rhythm sleep disorders. In: Cardinali DP, Pandi-Perumal SR (Eds). Springer, NY, USA Neuroendocrine Correlates of Sleep/Wakefulness.269– 294(2006).
  • Garfinkel D, Laudon M, Nof D, Zisapel N. Improvement of sleep quality in elderly people by controlled-release melatonin. Lancet346(8974), 541–544 (1995).
  • Lemoine P, Nir T, Laudon M, Zisapel N. Prolonged-release melatonin improves sleep quality and morning alertness in insomnia patients aged 55 years and older and has no withdrawal effects. J. Sleep Res.16(4), 372–380 (2007).
  • Wade AG, Ford I, Crawford G et al. Efficacy of prolonged release melatonin in insomnia patients aged 55–80 years: quality of sleep and next-day alertness outcomes. Curr. Med. Res. Opin.23(10), 2597–2605 (2007).
  • Dolberg OT, Hirschmann S, Grunhaus L. Melatonin for the treatment of sleep disturbances in major depressive disorder. Am. J. Psychiatry155(8), 1119–1121 (1998).
  • Lam RW. Sleep disturbances and depression: a challenge for antidepressants. Int. Clin Psychopharmacol.21(Suppl. 1), S25–S29 (2006).
  • Pandi-Perumal SR, Trakht I, Srinivasan V et al. The effect of melatonergic and non-melatonergic antidepressants on sleep: weighing the alternatives. World J. Biol. Psychiatry (2008) (In Press).
  • Dubocovich ML. Agomelatine targets a range of major depressive disorder symptoms. Curr. Opin. Investig. Drugs7(7), 670–680 (2006).
  • Pandi-Perumal SR, Srinivasan V, Cardinali DP, Monti JM. Could agomelatine be the ideal antidepressant? Expert Rev. Neurother.6(11), 1595–1608 (2006).
  • Wurtman R. Ramelteon: a novel treatment for the treatment of insomnia. Expert. Rev. Neurother.6(7), 957–964 (2006).
  • Pandi-Perumal SR, Srinivasan V, Poeggeler B, Hardeland R, Cardinali DP. Drug insight: the use of melatonergic agonists for the treatment of insomnia – focus on ramelteon. Nat. Clin. Pract. Neurol.3(4), 221–228 (2007).
  • Kato K, Hirai K, Nishiyama K et al. Neurochemical properties of ramelteon (TAK-375), a selective MT1/MT2 receptor agonist. Neuropharmacology48(2), 301–310 (2005).
  • Browning C, Beresford I, Fraser N, Giles H. Pharmacological characterization of human recombinant melatonin MT1 and MT2 receptors. Br. J. Pharmacol.129(5), 877–886 (2000).
  • Reiter RJ. Pineal melatonin: cell biology of its synthesis and of its physiological interactions. Endocr. Rev.12(2), 151–180 (1991).
  • Claustrat B, Brun J, Chazot G. The basic physiology and pathophysiology of melatonin. Sleep Med. Rev.9(1), 11–24 (2005).
  • Wurtman RJ, Axelrod J. The formation, metabolism and physiologic effects of melatonin. Adv. Pharmacol.6(Pt A), 141–151 (1968).
  • Cardinali DP. Melatonin. A mammalian pineal hormone. Endocr. Rev.2(3), 327–346 (1981).
  • Klein DC. Serotonin N-acetyltransferase. A personal historical perspective. Adv. Exp. Med. Biol.460, 5–16 (1999).
  • Fukuhara C, Dirden JC, Tosini G. Photic regulation of melatonin in rat retina and the role of proteasomal proteolysis. Neuroreport12(17), 3833–3837 (2001).
  • Karolczak M, Korf HW, Stehle JH. The rhythm and blues of gene expression in the rodent pineal gland. Endocrine27(2), 89–100 (2005).
  • Gauer F, Craft CM. Circadian regulation of hydroxyindole-O-methyltransferase mRNA levels in rat pineal and retina. Brain Res.737(1–2), 99–109 (1996).
  • Cardinali DP, Lynch HJ, Wurtman RJ. Binding of melatonin to human and rat plasma proteins. Endocrinology91(5), 1213–1218 (1972).
  • Waldhauser F, Waldhauser M, Lieberman HR et al. Bioavailability of oral melatonin in humans. Neuroendocrinology39(4), 307–313 (1984).
  • Dawson D, Armstrong SM. Chronobiotics – drugs that shift rhythms. Pharmacol. Ther.69(1), 15–36 (1996).
  • Hughes RJ, Badia P. Sleep-promoting and hypothermic effects of daytime melatonin administration in humans. Sleep20(2), 124–131 (1997).
  • Monti JM, Cardinali DP. A critical assessment of the melatonin effect on sleep in humans. Biol. Signals Recept.9(6), 328–339 (2000).
  • Karsch FJ, Malpaux B, Wayne NL, Robinson JE. Characteristics of the melatonin signal that provide the photoperiodic code for timing seasonal reproduction in the ewe. Reprod. Nutr. Dev.28(2B), 459–472 (1988).
  • Malpaux B, Tricoire H, Mailliet F et al. Melatonin and seasonal reproduction: understanding the neuroendocrine mechanisms using the sheep as a model. Reprod. Suppl.59, 167–179 (2002).
  • Vacas MI, Cardinali DP. Diurnal changes in melatonin binding sites of hamster and rat brains. Correlations with neuroendocrine responsiveness to melatonin. Neurosci. Lett.15(2–3), 259–263 (1979).
  • Pevet P. Melatonin: from seasonal to circadian signal. J. Neuroendocrinol.15(4), 422–426 (2003).
  • Lewy AJ, Bauer VK, Ahmed S et al. The human phase response curve (PRC) to melatonin is about 12 hours out of phase with the PRC to light. Chronobiol. Int.15(1), 71–83 (1998).
  • Kennaway DJ, Wright H. Melatonin and circadian rhythms. Curr. Top. Med. Chem.2(2), 199–209 (2002).
  • Lavie P. Sleep–wake as a biological rhythm. Annu. Rev. Psychol.52, 277–303 (2001).
  • Zhdanova IV, Wurtman RJ, Regan MM et al. Melatonin treatment for age-related insomnia. J. Clin. Endocrinol. Metab.86(10), 4727–4730 (2001).
  • Skene DJ, Lockley SW, Arendt J. Melatonin in circadian sleep disorders in the blind. Biol. Signals Recept.8(1–2), 90–95 (1999).
  • Cardinali DP. A double blind-placebo controlled study on melatonin efficacy to reduce anxiolytic benzodiazepine use in the elderly. Neuroendocrinol. Lett.23, 55–60 (2002).
  • Cardinali DP, Brusco LI, Liberczuk C, Furio AM. The use of melatonin in Alzheimer’s disease. Neuroendocrinol. Lett.23(Suppl. 1), 20–23 (2002).
  • Srinivasan V, Spence DW, Pandi-Perumal SR, Trakht I, Cardinali DP. Jet lag: therapeutic use of melatonin and possible application of melatonin analogues. Travel Med. Infect. Dis. (2008) (In Press).
  • Zisapel N. Sleep and sleep disturbances: biological basis and clinical implications. Cell. Mol. Life Sci.64(10), 1174–1186 (2007).
  • Cajochen C. TAK-375 Takeda. Curr. Opin. Investig. Drugs6(1), 114–121 (2005).
  • Bellon A. Searching for new options for treating insomnia: are melatonin and ramelteon beneficial? J. Psychiatr. Pract.12(4), 229–243 (2006).
  • Stevenson S, Bryson S, Amayke D, Hibberd M. Study to investigate the absolute bioavailability of a single oral dose of ramelteon (TAK-375) in healthy male subjects.Clin. Pharmacol. Ther.75, P22 (2006).
  • Greenblatt DJ, Harmatz JS, Karim A. Age and gender effects on the pharmacokinetics and pharmacodynamics of ramelteon, a hypnotic agent acting via melatonin receptors MT1 and MT2. J. Clin. Pharmacol.47(4), 485–496 (2007).
  • Pandi-Perumal SR, Zisapel N, Srinivasan V, Cardinali DP. Melatonin and sleep in aging population. Exp. Gerontol.40(12), 911–925 (2005).
  • Cajochen C, Munch M, Knoblauch V, Blatter K, Wirz-Justice A. Age-related changes in the circadian and homeostatic regulation of human sleep. Chronobiol. Int.23(1–2), 461–474 (2006).
  • Lavie P. Melatonin: role in gating nocturnal rise in sleep propensity. J. Biol. Rhythms12(6), 657–665 (1997).
  • Roth T, Seiden D, Sainati S et al. Effects of ramelteon on patient-reported sleep latency in older adults with chronic insomnia. Sleep Med.7(4), 312–318 (2006).
  • Erman M, Seiden D, Zammit G, Sainati S, Zhang J. An efficacy, safety, and dose–response study of Ramelteon in patients with chronic primary insomnia. Sleep Med.7(1), 17–24 (2006).
  • Kryger M, Wang-Weigand S, Roth T. Safety of ramelteon in individuals with mild to moderate obstructive sleep apnea. Sleep Breath.11(3), 159–164 (2007).
  • Zammit G, Erman M, Wang-Weigand S et al. Evaluation of the efficacy and safety of ramelteon in subjects with chronic insomnia. J. Clin. Sleep Med.3(5), 495–504 (2007).
  • Lack LC, Wright HR. Chronobiology of sleep in humans. Cell. Mol. Life Sci.64(10), 1205–1215 (2007).
  • Barion A, Zee PC. A clinical approach to circadian rhythm sleep disorders. Sleep Med.8(6), 566–577 (2007).
  • van denTop M, Buijs RM, Ruijter JM et al. Melatonin generates an outward potassium current in rat suprachiasmatic nucleus neurones in vitro independent of their circadian rhythm. Neuroscience107(1), 99–108 (2001).
  • Saper CB, Lu J, Chou TC, Gooley J. The hypothalamic integrator for circadian rhythms. Trends Neurosci.28(3), 152–157 (2005).
  • Fuller PM, Gooley JJ, Saper CB. Neurobiology of the sleep–wake cycle: sleep architecture, circadian regulation, and regulatory feedback. J. Biol. Rhythms21(6), 482–493 (2006).
  • Edgar DM, Dement WC, Fuller CA. Effect of SCN lesions on sleep in squirrel monkeys: evidence for opponent processes in sleep-wake regulation. J. Neurosci.13(3), 1065–1079 (1993).
  • Yukuhiro N, Kimura H, Nishikawa H et al. Effects of ramelteon (TAK-375) on nocturnal sleep in freely moving monkeys. Brain Res.1027(1–2), 59–66 (2004).
  • Yous S, Andrieux J, Howell HE et al. Novel naphthalenic ligands with high affinity for the melatonin receptor. J. Med. Chem.35(8), 1484–1486 (1992).
  • Millan MJ, Gobert A, Lejeune F et al. The novel melatonin agonist agomelatine (S20098) is an antagonist at 5-hydroxytryptamine2C receptors, blockade of which enhances the activity of frontocortical dopaminergic and adrenergic pathways. J. Pharmacol. Exp. Ther.306(3), 954–964 (2003).
  • Conway S, Drew JE, Mowat ES et al. Chimeric melatonin MT1 and melatonin-related receptors. Identification of domains and residues participating in ligand binding and receptor activation of the melatonin mt1 receptor. J. Biol. Chem.275(27), 20602–20609 (2000).
  • Bogaards JJ, Hissink EM, Briggs M et al. Prediction of interindividual variation in drug plasma levels in vivo from individual enzyme kinetic data and physiologically based pharmacokinetic modeling. Eur. J. Pharm. Sci12(2), 117–124 (2000).
  • Reynolds CF, Kupler D. Sleep in depression. In: Williams RZ, Karacan I, Moore CA (Eds). John Wiley, NY, USA Sleep Disorders, Diagnosis and Treatment.147–164 (1988).
  • Armitage R. Sleep and circadian rhythms in mood disorders. Acta Psychiatr. Scand. (Suppl.433), 104–115 (2007).
  • Cajochen C, Brunner DP, Krauchi K, Graw P, Wirz-Justice A. EEG and subjective sleepiness during extended wakefulness in seasonal affective disorder: circadian and homeostatic influences. Biol. Psychiatry47(7), 610–617 (2000).
  • Kupfer DJ. Depression and associated sleep disturbances: patient benefits with agomelatine. Eur. Neuropsychopharmacol.16(Suppl. 5), S639–S643 (2006).
  • Loo H, Hale A, D’haenen H. Determination of the dose of agomelatine, a melatoninergic agonist and selective 5-HT2C antagonist, in the treatment of major depressive disorder: a placebo-controlled dose range study. Int. Clin. Psychopharmacol.17(5), 239–247 (2002).
  • Kennedy SH, Emsley R. Placebo-controlled trial of agomelatine in the treatment of major depressive disorder. Eur. Neuropsychopharmacol.16(2), 93–100 (2006).
  • Pjrek E, Winkler D, Konstantinidis A et al. Agomelatine in the treatment of seasonal affective disorder. Psychopharmacology (Berl.)190(4), 575–579 (2007).
  • Calabrese JR, Guelfi JD, Perdrizet-Chevallier C. Agomelatine adjunctive therapy for acute bipolar depression: preliminary open data. Bipolar Disord.9(6), 628–635 (2007).
  • Quera-Salva MA, Vanier B, Chapotot F. Effect of agomelatine on the sleep EEG in patients with major depressive disorders (MDD). Eur. Neuropsychopharmacol.15(Suppl. 3), S435 (2007).
  • Salva MA, Vanier B, Laredo J et al. Major depressive disorder, sleep EEG and agomelatine: an open-label study. Int. J Neuropsychopharmacol.10(5), 691–696 (2007).
  • Guilleminault C. Efficacy of agomelatine versus venlafaxine on subjective sleep of patients with major depressive disorder. Eur. Neuropsychopharmacol.15(Suppl. 3), S419 (2005).
  • Lopes MC, Quera-Salva MA, Guilleminault C. Non-REM sleep instability in patients with major depressive disorder: Subjective improvement and improvement of non-REM sleep instability with treatment (Agomelatine). Sleep Med.9(1), 33–41 (2007).
  • Lemoine P, Guilleminault C, Alvarez E. Improvement in subjective sleep in major depressive disorder with a novel antidepressant, agomelatine: randomized, double-blind comparison with venlafaxine. J. Clin. Psychiatry68(11), 1723–1732 (2007).
  • Boivin DB. Influence of sleep–wake and circadian rhythm disturbances in psychiatric disorders. J. Psychiatry Neurosci.25(5), 446–458 (2000).
  • Jindal RD, Thase ME. Treatment of insomnia associated with clinical depression. Sleep Med. Rev.8(1), 19–30 (2004).
  • Racagni G, Riva MA, Popoli M. The interaction between the internal clock and antidepressant efficacy. Int. Clin. Psychopharmacol.22(Suppl. 2), S9–S14 (2007).
  • Fuchs E, Simon M, Schmelting B. Pharmacology of a new antidepressant: benefit of the implication of the melatonergic system. Int. Clin. Psychopharmacol.21(Suppl. 1), S17–S20 (2006).
  • Bertaina-Anglade V, la Rochelle CD, Boyer PA, Mocaer E. Antidepressant-like effects of agomelatine (S 20098) in the learned helplessness model. Behav. Pharmacol.17(8), 703–713 (2006).
  • Strauss WH, Klieser E. Psychotropic effects of ritanserin, a selective S2 antagonist: an open study. Eur. Neuropsychopharmacol.1(2), 101–105 (1991).
  • Niswender CM, Herrick-Davis K, Dilley GE et al. RNA editing of the human serotonin 5-HT2C receptor. alterations in suicide and implications for serotonergic pharmacotherapy. Neuropsychopharmacology24(5), 478–491 (2001).
  • Gurevich I, Tamir H, Arango V et al. Altered editing of serotonin 2C receptor pre-mRNA in the prefrontal cortex of depressed suicide victims. Neuron34(3), 349–356 (2002).
  • Iwamoto K, Kato T. RNA editing of serotonin 2C receptor in human postmortem brains of major mental disorders. Neurosci. Lett.346(3), 169–172 (2003).
  • Rouillon F. Efficacy and tolerance profile of agomelatine and practical use in depressed patients. Int. Clin. Psychopharmacol.21(Suppl. 1), S31–S35 (2006).
  • Clayton AH. Female sexual dysfunction related to depression and antidepressant medications. Curr. Womens Health Rep.2(3), 182–187 (2002).
  • Rothschild AJ. Sexual side effects of antidepressants. J. Clin. Psychiatry61(Suppl. 11), 28–36 (2000).
  • Montejo AL, Llorca G, Izquierdo JA, Rico-Villademoros F. Incidence of sexual dysfunction associated with antidepressant agents: a prospective multicenter study of 1022 outpatients. Spanish Working Group for the Study of Psychotropic-Related Sexual Dysfunction. J. Clin. Psychiatry62(Suppl. 3), 10–21 (2001).
  • Montgomery SA, Kennedy SH, Burrows GD, Lejoyeux M, Hindmarch I. Absence of discontinuation symptoms with agomelatine and occurrence of discontinuation symptoms with paroxetine: a randomized, double-blind, placebo-controlled discontinuation study. Int. Clin. Psychopharmacol.19(5), 271–280 (2004).

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