97
Views
20
CrossRef citations to date
0
Altmetric
Review

Impact of vitamin E on immune function and its clinical implications

&
Pages 561-567 | Published online: 10 Jan 2014

References

  • Beisel WR. History of nutritional immmunology: introduction and overview. J. Nutr.122, 591–596 (1992).
  • Traber MG. Vitamin E. In: Modern Nutrition in Health and Disease. Shils ME, Olson JA, Shike M, Ross AC (Eds), Williams & Wilkins, MD, USA, 347–362 (1999).
  • Wu D, Meydani M, Beharka AA, Serafini M, Martin KR, Meydani SN. In vitro supplementation with different tocopherol homologues can affect the function of immune cells in old mice. Free Radic. Biol. Med.28, 643–651 (2000).
  • Jiang Q, Ames BN. γ-tocopherol, but not α-tocopherol, decreases proinflammatory eicosanoids and inflammation damage in rats. Proc. Natl Acad. Sci. USA17, 816–822 (2003).
  • Jiang Q, Wong J, Fyrst H, Saba JD, Ames BN. γ-tocopherol or combinations of vitamin E forms induce cell death in human prostate cancer cells by interrupting sphingolipid synthesis. Proc. Natl Acad. Sci. USA101, 17825–17830 (2004).
  • Murphy SP, Subar AF, Block G. Vitamin E intake and sources in the United States. Am. J. Clin. Nutr.52, 361–367 (1990).
  • Food and Nutrition BoardDietary Reference Intakes for Vitamin C, Vitamin E, Selenium, Carotenoids. National Academy Press, DC, USA (2000).
  • White E, Kristal AR, Shikany JM et al. Correlates of serum α- and γ-tocopherol in the women’s health initiative. Ann. Epidemiol.11, 136–144 (2001).
  • Lewis J, Buss DH. Minerals and vitamins in the British household food supply. Br. J. Nutr.60, 413–424 (1988).
  • Millen AE, Dodd KW, Subar AF. Use of vitamin, mineral, nonvitamin, and nonmineral supplements in the United States: the 1987, 1992, and 2000 National Health Interview Survey results. J. Am. Diet Assoc.104, 942–950 (2004).
  • Radimer K, Bindewald B, Hughes J, Ervin B, Swanson C, Picciano MF. Dietary supplement use by US adults: data from the National Health and Nutrition Examination Survey, 1999–2000. Am. J. Epidemiol.160, 339–349 (2004).
  • Wiygul JB, Evans BR, Peterson BL et al. Supplement use among men with prostate cancer. Urology66, 161–166 (2005).
  • Ford ES, Ajani UA, Mokdad AH. Brief communication: the prevalence of high intake of vitamin E from the use of supplements among U.S. adults. Ann. Intern. Med.143, 116–120 (2005).
  • Tengerdy R, Heinzerling R, Brown G, Mathias M. Enhancement of the humoral response by vitamin E. Intern. Arch. Allergy44, 221–232 (1973).
  • Gebremichael A, Levy EM, Corwin LM. Adherent cell requirement for the effect of vitamin E on in vitro antibody synthesis. J. Nutr.114, 1297–1305 (1984).
  • Eskew ML, Scheuchenzuber WJ, Scholz RW, Reddy CC, Zarkower A. The effects of ozone inhalation on the immunological response of selenium- and vitamin E-deprived rats. Environ. Res.40, 274–284 (1986).
  • Harris RE, Boxer LA, Baehner RL. Consequences of vitamin-E deficiency on the phagocytic and oxidative functions of the rat polymorphonuclear leukocyte. Blood55, 338–343 (1980).
  • Munoz SJ, Heubi JE, Balistreri WF, Maddrey WC. Vitamin E deficiency in primary biliary cirrhosis: gastrointestinal malabsorption, frequency and relationship to other lipid-soluble vitamins. Hepatology9, 525–531 (1989).
  • Sokol RJ, Guggenheim M, Iannaccone ST et al. Improved neurological function after long-term correction of vitamin E deficiency in children with chronic cholestasis. N. Engl. J. Med.313, 1580–1586 (1985).
  • Sitrin MD, Lieberman F, Jensen WE, Noronha A, Milburn C, Addington W. Vitamin E deficiency and neurologic disease in adults with cystic fibrosis. Ann. Intern. Med.107, 51–54 (1987).
  • Kowdley KV, Mason JB, Meydani SN, Cornwall S, Grand RJ. Vitamin E deficiency and impaired cellular immunity related to intestinal fat malabsorption. Gastroenterology102, 2139–2142 (1992).
  • Adachi N, Migita M, Ohta T, Higashi A, Matsuda I. Depressed natural killer cell activity due to decreased natural killer cell population in a vitamin E-deficient patient with Shwachman syndrom: reversible natural killer cell abnormality by α-tocopherol supplementation. Eur. J. Pediatr.156, 444–448 (1997).
  • Meydani SN, Barklund MP, Liu S et al. Vitamin E supplementation enhances cell-mediated immunity in healthy elderly subjects. Am. J. Clin. Nutr.52, 557–563 (1990).
  • Meydani SN, Meydani M, Blumberg JB et al. Vitamin E supplementation and in vivo immune response in healthy subjects. JAMA277, 1380–1386 (1997).
  • Lee C-YJ, Wan JM-F. Vitamin E supplementation improves cell-mediated immunity and oxidative stress of asian men and women. J. Nutr.130, 2932–2937 (2000).
  • Pallast EG, Schouten EG, de Waart FG et al. Effect of 50- and 100-mg vitamin E supplements on cellular immune function in noninstitutionalized elderly persons. Am. J. Clin. Nutr.69, 1273–1281 (1999).
  • Adolfsson O, Huber BT, Meydani SN. Vitamin E-enhanced IL-2 production in old mice: naive but not memory T cells show increased cell division cycling and IL-2-producing capacity. J. Immunol.167, 3809–3817 (2001).
  • Lohmiller JJ, Roellich KM, Toledano A, Rabinovitch PS, Wolf NS, Grossmann A. Aged murine T-lymphocytes are more resistant to oxidative damage due to the predominance of the cells possessing the memory phenotype. J. Gerontol.51, B132–B140 (1996).
  • Beharka AA, Wu D, Han SN, Meydani SN. Macrophage prostaglandin production contributes to the age-associated decrease in T cell function which is reversed by the dietary antioxidant vitamin E. Mech. Ageing Dev.93, 59–77 (1997).
  • Wu D, Mura C, Beharka AA et al. Age-associated increase in PGE2 synthesis and COX activity in murine macrophages is reversed by vitamin E. Am. J. Physiol.275, C661–C668 (1998).
  • Traber MG, Packer l. Vitamin E: beyond antioxidant function. Am. J. Clin. Nutr.62, 1501S–1509S (1995).
  • Azzi A, Ricciarelli R, Zingg J-M. Non-antioxidant molecular functions of α-tocopherol (vitamin E). FEBS Lett.519, 8–10 (2002).
  • Ahmed T, Marko M, Wu D, Chung H, Huber B, Meydani SN. Vitamin E supplementation reverses the age-associated decrease in effective immune synapse formation in CD4+ T cells. Ann. NY Acad. Sci.1031, 412–414 (2004).
  • Han SN, Adolfsson O, Lee CK, Prolla TA, Ordovas J, Meydani SN. Vitamin E and gene expression in immune cells. Ann. NY Acad. Sci.1031, 96–101 (2004).
  • Han SN, Wu D, Ha WK et al. Vitamin E supplementation increases T helper 1 cytokine production of old mice infected with influenza virus. Immunology100, 487–493 (2000).
  • Smith KL, Harrison JH, Hancock DD, Todhunter DA, Conrad HR. Effect of vitamin E and selenium supplementation on incidence of clinical mastitis and duration of clinical symptoms. J. Dairy Sci.67, 1293–1300 (1984).
  • Tengerdy RP, Nockels CF. Vitamin E or vitamin A protects chickens against E. coli infection.Poult. Sci.54, 1292–1296 (1975).
  • Meydani SN, Leka LS, Fine BC et al. Vitamin E and respiratory tract infections in elderly nursing home residents: a randomized controlled trial. JAMA292, 828–836 (2004).
  • Chavance M, Herbeth B, Fournier C, Janot C, Vernhes G. Vitamin status, immunity and infections in an elderly population. Eur. J. Clin. Nutr.43, 827–835 (1989).
  • Hemila H, Kaprio J, Albanes D, Heinonen OP, Virtamo J. Vitamin C, vitamin E, and β-carotene in relation to common cold incidence in male smokers. Epidemiology13, 32–37 (2002).
  • Graat JM, Schouten EG, Kok FJ. Effect of daily vitamin E and multivitamin-mineral supplementation on acute respiratory tract infections in elderly persons. JAMA288, 715–721 (2002).
  • Merchant AT, Curhan G, Bendich A, Singh VN, Willett WC, Fawzi WW. Vitamin intake is not associated with community-acquired pneumonia in U.S. men. J. Nutr.134, 439–444 (2004).
  • Andreone P, Fiorino S, Cursaro C et al. Vitamin E as treatment for chronic hepatitis B: results of a randomized controlled pilot trial. Antiviral Res.49, 75–81 (2001).
  • Miller ER III, Pastor-Barriuso R, Dalal D, Riemersma RA, Appel LJ, Guallar E. Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality. Ann. Intern. Med.142, 37–46 (2005).
  • Hathcock JN, Azzi A, Blumberg J et al. Vitamins E and C are safe across a broad range of intakes. Am. J. Clin. Nutr.81, 736–745 (2005).
  • Meydani SN, Han SN. Nutrient regulation of the immune response: the case of vitamin E. In: Present Knowledge in Nutrition, 8th Ed. Bowman B, Russell R (Eds), ILSI Press, DC, USA (2001).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.