521
Views
24
CrossRef citations to date
0
Altmetric
Review

Chronic inflammation and cancer: emerging roles of triggering receptors expressed on myeloid cells

, &

References

  • Allcock RJN, Barrow AD, Forbes S, et al. The human TREM gene cluster at 6p21.1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44. Eur J Immunol 2003;33:567-77
  • Arts RJW, Joosten L a B, van der Meer JWM, et al. TREM-1: intracellular signaling pathways and interaction with pattern recognition receptors. J Leukoc Biol 2013;93:209-15
  • Sharif O, Knapp S. From expression to signaling: roles of TREM-1 and TREM-2 in innate immunity and bacterial infection. Immunobiology 2008;213:701-13
  • Bouchon A, Dietrich J, Colonna M. Cutting Edge: Inflammatory Responses Can Be Triggered by TREM-1, a Novel Receptor Expressed on Neutrophils and Monocytes. J Immunol 2000;164:4991-5
  • Bouchon A, Hernández-munain C, Cella M, et al. A DAP12-mediated Pathway Regulates Expression of CC Chemokine Receptor 7 and Maturation of Human Dendritic Cells. J Exp Med 2001;194:1111-22
  • Lanier LL. DAP10- and DAP12-associated receptors in innate immunity. Immunol Rev 2009;227:150-60
  • Colonna M. TREMs in the immune system and beyond. Nat Rev Immunol 2003;3:445-53
  • Colonna M, Facchetti F. TREM-1 (Triggering Receptor Expressed on Myeloid Cells) : A New Player in Acute Inflammatory Responses. J Infect Dis 2003;1:397-401
  • Bleharski JR, Kiessler V, Buonsanti C, et al. A Role for Triggering Receptor Expressed on Myeloid Cells-1 in Host Defense During the Early-Induced and Adaptive Phases of the Immune Response. J Immunol 2003;170:3812-18
  • Pelham C, Agrawal D. Emerging roles for triggering receptor expressed on myeloid cells receptor family signaling in inflammatory diseases. Expert Rev Clin Immunol 2014;10:243-56
  • Pelham CJ, Pandya AN, Agrawal DK. Triggering receptor expressed on myeloid cells receptor family modulators: a patent review. Expert Opin Ther Pat 2014;24:1383-95
  • Haselmayer P. TREM-1 ligand expression on platelets enhances neutrophil activation. Blood 2007;110:1029-36
  • Wong-Baeza I, González-Roldán N, Ferat-Osorio E, et al. Triggering receptor expressed on myeloid cells (TREM-1) is regulated post-transcriptionally and its ligand is present in the sera of some septic patients. Clin Exp Immunol 2006;145:448-55
  • Wu J, Li J, Salcedo R, et al. The proinflammatory myeloid cell receptor TREM-1 controls Kupffer cell activation and development of hepatocellular carcinoma. Cancer Res 2012;72:3977-86
  • Read CB, Kuijper JL, Hjorth SA, et al. Cutting Edge: Identification of Neutrophil PGLYRP1 as a Ligand for TREM-1. J Immunol 2015;194:1417-21
  • Daws MR, Sullam PM, Niemi EC, et al. Pattern Recognition by TREM-2: Binding of Anionic Ligands. J Immunol 2014;171:594-9
  • N’Diaye E-N, Branda CS, Branda SS, et al. TREM-2 (triggering receptor expressed on myeloid cells 2) is a phagocytic receptor for bacteria. J Cell Biol 2009;184:215-23
  • Turnbull IR, Gilfillan S, Cella M, et al. Cutting Edge: TREM-2 Attenuates Macrophage Activation. J Immunol 2006;177:3520-4
  • Nurden AT. Platelets, inflammation and tissue regeneration. Thromb Haemost 2011;105(Suppl):S13-33
  • Washington AV, Schubert RL, Quigley L, et al. A TREM family member, TLT-1, is found exclusively in the a-granules of megakaryocytes and platelets. Blood 2004;104:1042-8
  • Washington AV, Gibot S, Acevedo I, et al. TREM-like transcript-1 protects against inflammation-associated hemorrhage by facilitating platelet aggregation in mice and humans. J Clin Invest 2009;119:1489-501
  • Derive M, Bouazza Y, Sennoun N, et al. Soluble TREM-like transcript-1 regulates leukocyte activation and controls microbial sepsis. J Immunol 2012;188:5585-92
  • Ford JW, McVicar DW. TREM and TREM-like receptors in inflammation and disease. Curr Opin Immunol 2009;21:38-46
  • Colotta F, Allavena P, Sica A, et al. Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability. Carcinogenesis 2009;30:1073-81
  • Mantovani A, Allavena P, Sica A, et al. Cancer-related inflammation. Nature 2008;454:436-44
  • Liao R, Sun T-W, Yi Y, et al. Expression of TREM-1 in hepatic stellate cells and prognostic value in hepatitis B-related hepatocellular carcinoma. Cancer Sci 2012;103:984-92
  • Ho C-C, Liao W-Y, Wang C-Y, et al. TREM-1 expression in tumor-associated macrophages and clinical outcome in lung cancer. Am J Respir Crit Care Med 2008;177:763-70
  • Zhu W, Fang C, Gramatikoff K, et al. Proteins and an inflammatory network expresed in colon tumors. J Proteome Res 2012;10:2129-39
  • Rubin DC, Shaker A, Levin MS. Chronic intestinal inflammation: inflammatory bowel disease and colitis-associated colon cancer. Front Immunol 2012;3:107
  • Xavier RJ, Podolsky DK. Unravelling the pathogenesis of inflammatory bowel disease. Nature 2007;448:427-34
  • Schenk M, Bouchon A, Birrer S, et al. Macrophages Expressing Triggering Receptor Expressed on Myeloid Cells-1 Are Underrepresented in the Human Intestine. J Immunol 2004;174:517-24
  • Schenk M, Bouchon A, Seibold F, et al. TREM-1 – expressing intestinal macrophages crucially amplify chronic inflammation in experimental colitis and inflammatory bowel diseases. J Clin Invest 2007;117:3097-106
  • Billioud V, Gibot S, Massin F, et al. Plasma soluble triggering receptor expressed on myeloid cells-1 in Crohn’s disease. Dig Liver Dis 2012;44:466-70
  • Park JJ, Cheon JH, Kim BY, et al. Correlation of serum-soluble triggering receptor expressed on myeloid cells-1 with clinical disease activity in inflammatory bowel disease. Dig Dis Sci 2009;54:1525-31
  • Saurer L, Rihs S, Birrer M, et al. Elevated levels of serum-soluble triggering receptor expressed on myeloid cells-1 in patients with IBD do not correlate with intestinal TREM-1 mRNA expression and endoscopic disease activity. J Crohns Colitis 2012;6:913-23
  • Tzivras M, Koussoulas V, Giamarellos-Bourboulis E, et al. Role of soluble triggering receptor expressed on myeloid cells in inflammatory bowel disease. World J Gastroenterol 2006;12:3416-19
  • Jung YS, Park JJ, Kim SW, et al. Correlation between soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) expression and endoscopic activity in inflammatory bowel diseases. Dig Liver Dis 2012;44:897-903
  • Correale C, Genua M, Vetrano S, et al. Bacterial sensor triggering receptor expressed on myeloid cells-2 regulates the mucosal inflammatory response. Gastroenterology 2013;144:346-56; e3
  • Zhou J, Chai F, Lu G, et al. TREM-1 inhibition attenuates inflammation and tumor within the colon. Int Immunopharmacol 2013;17:155-61
  • Rigo I, McMahon L, Dhawan P, et al. Induction of triggering receptor expressed on myeloid cells (TREM-1) in airway epithelial cells by 1,25(OH)2 vitamin D3. Innate Immunol 2012;18:250-7
  • Hecht SS. Lung carcinogenesis by tobacco smoke. Int J Cancer 2012;131:2724-32
  • DeMarini DM. Genotoxicity of tobacco smoke and tobacco smoke condensate: a review. Mutat Res 2004;567:447-74
  • Woodruff PG, Ellwanger A, Solon M, et al. Alveolar macrophage recruitment and activation by chronic second hand smoke exposure in mice. COPD 2009;6:86-94
  • Gan WQ. Association between chronic obstructive pulmonary disease and systemic inflammation: a systematic review and a meta-analysis. Thorax 2004;59:574-80
  • Radsak MP, Taube C, Haselmayer P, et al. Soluble triggering receptor expressed on myeloid cells 1 is released in patients with stable chronic obstructive pulmonary disease. Clin Dev Immunol 2007:2007:52040
  • Nichols D, Chmiel J, Berger M. Chronic inflammation in the cystic fibrosis lung: alterations in inter- and intracellular signaling. Clin Rev Allergy Immunol 2008;34:146-62
  • Maisonneuve P, Marshall BC, Knapp EA, et al. Cancer risk in cystic fibrosis: a 20-year nationwide study from the United States. J Natl Cancer Inst 2013;105:122-9
  • Del Fresno C, García-Rio F, Gómez-Piña V, et al. Potent phagocytic activity with impaired antigen presentation identifying lipopolysaccharide-tolerant human monocytes: demonstration in isolated monocytes from cystic fibrosis patients. J Immunol 2009;182:6494-507
  • Gomez-Pina V. Soares-Schanoski a., Rodriguez-Rojas a., et al. Metalloproteinases Shed TREM-1 Ectodomain from Lipopolysaccharide-Stimulated Human Monocytes. J Immunol 2007;179:4065-73
  • Li C, Li H, Jiang K, et al. TLR4 signaling pathway in mouse Lewis lung cancer cells promotes the expression of TGF-β1 and IL-10 and tumor cells migration. Biomed Mater Eng 2014;24:869-75
  • Yuan Z, Mehta HJ, Mohammed K, et al. TREM-1 is induced in tumor associated macrophages by cyclo-oxygenase pathway in human non-small cell lung cancer. PLoS One 2014;9:e94241
  • Karapanagiotou EM, Pelekanou E, Charpidou A, et al. Soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) detection in cancer patients: a prognostic marker for lung metastases from solid malignancies. Anticancer Res 2008;28:1411-15
  • Sigalov AB. A novel ligand-independent peptide inhibitor of TREM-1 suppresses tumor growth in human lung cancer xenografts and prolongs survival of mice with lipopolysaccharide-induced septic shock. Int Immunopharmacol 2014;21:208-19
  • Nochi H, Aoki N, Oikawa K, et al. Modulation of hepatic granulomatous responses by transgene expression of DAP12 or TREM-1-Ig molecules. Am J Pathol 2003;162:1191-201
  • Pikarsky E, Porat RM, Stein I, et al. NF-κB functions as a tumour promoter in inflammation-associated cancer. Lett to Nat 2004;431:461-6
  • Maeda S, Kamata H, Luo J-L, et al. IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis. Cell 2005;121:977-90
  • Sakurai T, Maeda S, Chang L, et al. Loss of hepatic NF-kappa B activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation. Proc Natl Acad Sci U S A 2006;103:10544-51
  • Schulz A, Toedt G, Zenz T, et al. Inflammatory cytokines and signaling pathways are associated with survival of primary chronic lymphocytic leukemia cells in vitro: a dominant role of CCL2. Haematologica 2011;96:408-16
  • Li W, Yi X, Huang S, et al. Differential expression of TREM-1 In myelogenous leukemia cells. Li Li HJ, ed Blood 2013;122:4951
  • Klein G, Vellenga E, Fraaije MW, et al. The possible role of matrix metalloproteinase (MMP)-2 and MMP-9 in cancer, e.g. acute leukemia. Crit Rev Oncol Hematol 2004;50:87-100
  • Sims GP, Rowe DC, Rietdijk ST, et al. HMGB1 and RAGE in inflammation and cancer. Annu Rev Immunol 2010;28:367-88
  • Klesney-tait J, Keck K, Li X, et al. Transepithelial migration of neutrophils into the lung requires TREM-1. J Clin Invest 2013;123:138-49
  • Seno H, Miyoshi H, Brown SL, et al. Efficient colonic mucosal wound repair requires Trem2 signaling. Proc Natl Acad Sci 2008;106:256-61
  • Nguyen AH, Berim IG, Agrawal DK. Cellular and molecular immunology of lung cancer: therapeutic implications. Expert Rev Clin Immunol 2014;10:1711-30
  • Allavena P, Mantovani A. Immunology in the clinic review series; focus on cancer: tumour-associated macrophages: undisputed stars of the inflammatory tumour microenvironment. Clin Exp Immunol 2012;167:195-205
  • Ye W, Hu Y, Zhang R, et al. Diagnostic value of the soluble triggering receptor expressed on myeloid cells-1 in lower respiratory tract infections: a meta-analysis. Respirology 2014;19:501-7
  • Summah H, Tao L-L, Zhu Y-G, et al. Pleural fluid soluble triggering receptor expressed on myeloid cells-1 as a marker of bacterial infection: a meta-analysis. BMC Infect Dis 2011;11:280
  • Zhang J, She D, Feng D, et al. Dynamic changes of serum soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) reflect sepsis severity and can predict prognosis: a prospective study. BMC Infect Dis 2011;11:53
  • Su L, Han B, Liu C, et al. Value of soluble TREM-1, procalcitonin, and C-reactive protein serum levels as biomarkers for detecting bacteremia among sepsis patients with new fever in intensive care units: a prospective cohort study. BMC Infect Dis 2012;12:157

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.