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Exploring cell-based tolerance strategies for hand and face transplantation

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References

  • Khalifian S, Brazio PS, Mohan R, et al. Facial transplantation: The first 9 years. Lancet 2014;384(9960):2153
  • Shores JT, Brandacher G, Lee WP. Hand and upper extremity transplantation: An update of outcomes in the worldwide experience. Plast Reconstr Surg 2015;135(2):351e
  • Leonard DA, Kurtz JM, Cetrulo CJr. Vascularized composite allotransplantation: Towards tolerance and the importance of skin-specific immunobiology. Curr Opin Organ Transplantation 2013;18(6):645
  • Leventhal J, Miller J, Abecassis M, et al. Evolving approaches of hematopoietic stem cell-based therapies to induce tolerance to organ transplants: The long road to tolerance. Clin Pharmacol Ther 2013;93(1):36
  • Plock JA, Schnider JT, Solari MG, et al. Perspectives on the use of mesenchymal stem cells in vascularized composite allotransplantation. Frontiers Immunol 2013;4:1
  • Pilat N, Hock K, Wekerle T. Mixed chimerism through donor bone marrow transplantation: A tolerogenic cell therapy for application in organ transplantation. Curr Opin Organ Transplant 2012;17(1):63
  • Yamada Y, Ochiai T, Boskovic S, et al. Use of CTLA4Ig for induction of mixed chimerism and renal allograft tolerance in nonhuman primates. Am J Transplant 2014;14(12):2704
  • Im KI, Park MJ, Kim N, et al. Induction of mixed chimerism using combinatory cell-based immune modulation with mesenchymal stem cells and regulatory T cells for solid-organ transplant tolerance. Stem Cells Dev 2014;23(19):2364
  • Siemionow M, Klimczak A. Chimerism-based experimental models for tolerance induction in vascularized composite allografts: Cleveland clinic research experience. Clin Dev Immunol 2013;2013:831410
  • Sykes M. Hematopoietic cell transplantation for tolerance induction: Animal models to clinical trials. Transplantation 2009;87(3):309
  • Baskiewicz-Masiuk M, Grymula K, Pius E, et al. An optimization of protocol for mixed chimerism induction in mice model. Folia Histochem Cytobiol 2009;47(3):395
  • Siemionow M, Zielinski M, Ozmen S, Izycki D. Intraosseus transplantation of donor-derived hematopoietic stem and progenitor cells induces donor-specific chimerism and extends composite tissue allograft survival. Transplant Proc 2005;37(5):2303
  • Pree I, Wekerle T. Inducing mixed chimerism and transplantation tolerance through allogeneic bone marrow transplantation with costimulation blockade. Methods Mol Biol 2007;380:391
  • Murakami T, Cosimi AB, Kawai T. Mixed chimerism to induce tolerance: Lessons learned from nonhuman primates. Transplant Rev (Orlando) 2009;23(1):19
  • Fuchs EJ. Transplantation tolerance: From theory to clinic. Immunol Rev 2014;258(1):64
  • Al-Adra D, Anderson CC. Mixed chimerism and split tolerance. Chimerism 2011;2(4):89
  • Xing Y, Hogquist KA. T-cell tolerance: Central and peripheral. Cold Spring Harb Perspect Biol 2012;4:6
  • Ramirez AE, Cheng HY, Lao WW, et al. A novel rat full-thickness hemi-abdominal wall/hindlimb osteomyocutaneous combined flap: Influence of allograft mass and vascularized bone marrow content on vascularized composite allograft survival. Transplant Int 2014;27(9):977
  • Sachs DH, Kawai T, Sykes M. Induction of tolerance through mixed chimerism. Cold Spring Harbor Perspectives In Medicine 2014;4(1):a015529
  • Yolcu ES, Leventhal JR, Ildstad ST. Facilitating cells in tolerance induction for kidney transplantation. Curr Opin Organ Transplant 2015;20(1):57
  • Kawai T, Sachs DH, Sprangers B, et al. Long-term results in recipients of combined HLA-mismatched kidney and bone marrow transplantation without maintenance immunosuppression. Am J Transplant 2014;14(7):1599
  • Kim N, Lee H, Shin J, et al. Immune reconstitution kinetics following intentionally induced mixed chimerism by nonmyeloablative transplantation. PLoS One 2015;10(5):e0126318
  • Madariaga ML, Shanmugarajah K, Michel SG, et al. Immunomodulatory strategies directed toward tolerance of vascularized composite allografts. Transplantation 2015. [Epub ahead of print]
  • Cetrulo CJr, Torabi R, Scalea JR, et al. Vascularized composite allograft transplant survival in miniature swine: Is MHC tolerance sufficient for acceptance of epidermis? Transplantation 2013;96(11):966
  • Kawai T, Sachs DH. Tolerance induction: Hematopoietic chimerism. Curr Opin Organ Transplant 2013;18(4):402
  • Lin CH, Zhang W, Ng TW, et al. Vascularized osteomyocutaneous allografts are permissive to tolerance by induction-based immunomodulatory therapy. Am J Transplant 2013;13(8):2161
  • Mathes DW, Chang J, Hwang B, et al. Simultaneous transplantation of hematopoietic stem cells and a vascularized composite allograft leads to tolerance. Transplantation 2014;98(2):131
  • Barth RN, Rodriguez ED, Mundinger GS, et al. Vascularized bone marrow-based immunosuppression inhibits rejection of vascularized composite allografts in nonhuman primates. Am J Transplant 2011;11(7):1407
  • Leonard DA, Kurtz JM, Mallard C, et al. Vascularized composite allograft tolerance across MHC barriers in a large animal model. Am J Transplant 2014;14(2):343
  • Nassimizadeh M, Nassimizadeh AK, Power D. Hand transplant surgery. Ann R Coll Surg Engl 2014;96(8):571
  • Diaz-Siso JR, Fischer S, Sisk GC, et al. Initial experience of dual maintenance immunosuppression with steroid withdrawal in vascular composite tissue allotransplantation. Am J Transplant 2015;15(5):1421-31
  • Traitanon O, Gallon L. Chimerism and tolerance induction in kidney transplantation. Nephron 2015;129(1):34
  • Kawai T, Cosimi AB, Spitzer TR, et al. HLA-mismatched renal transplantation without maintenance immunosuppression. N Engl J Med 2008;358(4):353
  • Scandling JD, Busque S, Dejbakhsh-Jones S, et al. Tolerance and withdrawal of immunosuppressive drugs in patients given kidney and hematopoietic cell transplants. Am J Transplant 2012;12(5):1133
  • Scandling JD, Busque S, Shizuru JA, et al. Chimerism, graft survival, and withdrawal of immunosuppressive drugs in HLA matched and mismatched patients after living donor kidney and hematopoietic cell transplantation. Am J Transplant 2015;15(3):695
  • Leventhal J, Abecassis M, Miller J, et al. Chimerism and tolerance without GVHD or engraftment syndrome in HLA-mismatched combined kidney and hematopoietic stem cell transplantation. Sci Transl Med 2012;4(124):124ra28
  • Dubernard J, Owen E, Herzberg G, et al. Human hand allograft: Report on first 6 months. Lancet 1999;353(9161):1315
  • Thaunat O, Badet L, El-Jaafari A, et al. Composite tissue allograft extends a helping hand to transplant immunologists. Am J Transplant 2006;6(10):2238
  • Dubernard J, Lengelé B, Morelon E, et al. Outcomes 18 months after the first human partial face transplantation. N Engl J Med 2007;357(24):2451
  • Devauchelle B, Badet L, Lengele B, et al. First human face allograft: Early report. Lancet 2006;368(9531):203
  • Petruzzo P, Kanitakis J, Testelin S, et al. Clinicopathological findings of chronic rejection in a face grafted patient. Transplantation 2015; Epub ahead of print
  • Morelon E, Dubois V, Testelin S, et al. Face transplantation with combined hematopoietic stem cell infusion and vascularized bone marrow transplantation is not associated with mixed chimerism in humans. Am J Transplant 2013;13(S5):202
  • Schneeberger S, Gorantla VS, Brandacher G, et al. Upper-extremity transplantation using a cell-based protocol to minimize immunosuppression. Ann Surg 2013;257(2):345
  • Monaco AP. Reflections on the unique tolerogenicity of bone marrow, the enigma of chimerism and clinical tolerance. Clin Transpl 2013;157-66
  • Liberal R, Grant CR, Longhi MS, et al. Regulatory T cells: Mechanisms of suppression and impairment in autoimmune liver disease. IUBMB Life 2015;67(2):88-97
  • Ferrer IR, Hester J, Bushell A, Wood KJ. Induction of transplantation tolerance through regulatory cells: From mice to men. Immunol Rev 2014;258(1):102
  • Bluestone JA, Tang Q. Immunotherapy: Making the case for precision medicine. Sci Transl Med 2015;7(280):280ed3
  • McDonald-Hyman C, Turka LA, Blazar BR. Advances and challenges in immunotherapy for solid organ and hematopoietic stem cell transplantation. Sci Transl Med 2015;7(280):280rv2
  • McMurchy AN, Bushell A, Levings MK, Wood KJ. Moving to tolerance: Clinical application of T regulatory cells. Semin Immunol 2011;23(4):304
  • Hoeppli RE, Wu D, Cook L, Levings MK. The environment of regulatory T cell biology: Cytokines, metabolites, and the microbiome. Frontiers in Immunology 2015;6:1
  • Chen W, Konkel JE. Development of thymic Foxp3(+) regulatory T cells: TGF-ß matters. Eur J Immunol 2015;45(4):958
  • Goldstein JD, Pérol L, Zaragoza B, et al. Role of cytokines in thymus- versus peripherally derived-regulatory T cell differentiation and function. Frontiers in Immunology 2013;4:1
  • Oliveira VG, Caridade M, Paiva RS, et al. CD4+ T-cell activation triggers autonomous TGF-ß-dependent conversion to Foxp3+ regulatory T cells. Eur J Immunol 2011;41(5):1249
  • Horwitz DA, Zheng SG, Gray JD, Natural and TGF-beta-induced Foxp3(+)CD4(+) CD25(+) regulatory T cells are not mirror images of each other. Trends Immunol 2008;29(9):429
  • Tang Q, Bluestone JA. Regulatory T-cell therapy in transplantation: Moving to the clinic. Cold Spring Harb Perspect Med 2013;3:11
  • Tang Q, Lee K. Regulatory T-cell therapy for transplantation: How many cells do we need? Curr Opin Organ Transplant 2012;17(4):349
  • Moore C, Tejon G, Fuentes C, et al. Alloreactive regulatory T cells generated with retinoic acid prevent skin allograft rejection. Eur J Immunol 2015;45(2):452
  • Camirand G, Wang Y, Lu Y, et al. CD45 ligation expands tregs by promoting interactions with DCs. J Clin Invest 2014;124(10):4603
  • Klatzmann D, Abbas AK. The promise of low-dose interleukin-2 therapy for autoimmune and inflammatory diseases. Nat Rev Immunol 2015;15(5):283-94
  • Li Z, Li D, Tsun A, Li B. FOXP3(+) regulatory T cells and their functional regulation. Cell Mol Immunol 2015; Epub ahead of print
  • Verhagen J, Wegner A, Wraith DC. Extra-thymically induced T regulatory cell subsets; the optimal target for antigen-specific immunotherapy. Immunol 2015;145(2):171-81
  • Chapman NM, Chi H. mTOR signaling, tregs and immune modulation. Immunotherapy 2014;6(12):1295
  • Yamaguchi T, Wing JB, Sakaguchi S. Two modes of immune suppression by Foxp3(+) regulatory T cells under inflammatory or non-inflammatory conditions. Semin Immunol 2011;23(6):424
  • Tang Q, Bluestone JA. The Foxp3+ regulatory T cell: A jack of all trades, master of regulation. Nat Immunol 2008;9(3):239
  • Loubaki L, Chabot D, Bazin R. Involvement of the TNF-a/TGF-ß/IDO axis in IVIg-induced immune tolerance. Cytokine 2015;71(2):181
  • Liang B, Workman C, Lee J, et al. Regulatory T cells inhibit dendritic cells by lymphocyte activation gene-3 engagement of MHC class II. J Immunol 2008;180(9):5916
  • Ring S, Pushkarevskaya A, Schild H, et al. Regulatory T cell-derived adenosine induces dendritic cell migration through the epac-Rap1 pathway. J Immunol 2015(8):194-3735
  • Sarris M, Andersen KG, Randow F, et al. Neuropilin-1 expression on regulatory T cells enhances their interactions with dendritic cells during antigen recognition. Immunity 2008;28(3):402
  • Yakushina VD, Vasil’eva OA, Novitskii VV, et al. Effect of galectin-1 on apoptosis of CD4(+) lymphocytes differentiated in vitro towards regulatory T cells. Bull Exp Biol Med 2014;156(5):669
  • Cedeno-Laurent F, Dimitroff CJ. Galectin-1 research in T cell immunity: Past, present and future. Clin Immunol 2012;142(2):107
  • Pandiyan P, Zheng L, Ishihara S, et al. CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation–mediated apoptosis of effector CD4+ T cells. Nat Immunol 2007;8(12):1353-62
  • Rubtsov YP, Rasmussen JP, Chi EY, et al. Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces. Immunity 2008;28(4):546
  • Andersson J, Tran DQ, Pesu M, et al. CD4+ FoxP3+ regulatory T cells confer infectious tolerance in a TGF-beta-dependent manner. J Exp Med 2008;205(9):1975
  • Groux H, Bigler M, de Vries JE, Roncarolo MG. Interleukin-10 induces a long-term antigen-specific anergic state in human CD4+ T cells. J Exp Med 1996;184(1):19
  • Chandrasekharan D, Issa F, Wood KJ. Achieving operational tolerance in transplantation: How can lessons from the clinic inform research directions? Transplant Int 2013;26(6):576
  • Cobbold SP, Adams E, Farquhar CA, et al. Infectious tolerance via the consumption of essential amino acids and mTOR signaling. Proc Natl Acad Sci USA 2009;106(29):12055
  • Guo H, Zhang H, Lu L, et al. Generation, cryopreservation, function and in vivo persistence of ex vivo expanded cynomolgus monkey regulatory T cells. Cell Immunol 2015;295(1):19-28
  • Zhang H, Guo H, Lu L, et al. Sequential monitoring and stability of ex vivo-expanded autologous and nonautologous regulatory T cells following infusion in nonhuman primates. Am J Transplant 2015;15(5):1253-66
  • Lu X, Yang X, Zhou Q, et al. Cardiac allograft tolerance induced by isogeneic CD4+CD25+ regulatory T cells. Exp Clin Transplant 2014;12(2):133
  • Tang Q, Kang SM. Interpretation of transplant biopsies and immune responses following treg cell therapy. Curr Opin Organ Transplant 2014;19(6):616
  • Grant CR, Liberal R, Mieli-Vergani G, et al. Regulatory T-cells in autoimmune diseases: Challenges, controversies and—yet—unanswered questions. Autoimmun Rev 2015;14(2):105
  • Vercoulen Y, Bellutti Enders F, Meerding J, et al. Increased presence of FOXP3+ regulatory T cells in inflamed muscle of patients with active juvenile dermatomyositis compared to peripheral blood. PLoS One 2014;9(8):1
  • Anderson KM, Olson KE, Estes KA, et al. Dual destructive and protective roles of adaptive immunity in neurodegenerative disorders. Transl Neurodegener 2014;3(1):25
  • Nie H, Zheng Y, Li R, et al. Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-α in rheumatoid arthritis. Nat Med 2013;19(3):322-8
  • Sanchez Rodriguez R, Pauli ML, Neuhaus IM, et al. Memory regulatory T cells reside in human skin. J Clin Invest 2014;124(3):1027
  • Afeltra A, Gigante A, Margiotta DP, et al. The involvement of T regulatory lymphocytes in a cohort of lupus nephritis patients: A pilot study. Inter Emerg Med 2015; Epub ahead of print
  • Brunstein CG, Fuchs EJ, Carter SL, et al. Alternative donor transplantation after reduced intensity conditioning: Results of parallel phase 2 trials using partially HLA-mismatched related bone marrow or unrelated double umbilical cord blood. Blood 2011;118(2):282
  • Trzonkowski P, Bieniaszewska M, Juscinska J, et al. First-in-man clinical results of the treatment of patients with graft versus host disease with human ex vivo expanded CD4+CD25+CD127- T regulatory cells. Clin Immunol 2009;133(1):22
  • Cabello-Kindelan C, Mackey S, Bayer AL. Adoptive T regulatory cell therapy for tolerance induction. Curr Transplant Rep 2015;2(2):191
  • Marek-Trzonkowska N, Mysliwiec M, Dobyszuk A, et al. Administration of CD4+CD25highCD127- regulatory T cells preserves ß-cell function in type 1 diabetes in children. Diabetes Care 2012;35(9):1817
  • Dijke IE, Velthuis JH, Caliskan K, et al. Intragraft FOXP3 mRNA expression reflects antidonor immune reactivity in cardiac allograft patients. Transplantation 2007;83(11):1477
  • Cirocco RE, Carreño MR, Mathew JM, et al. FoxP3 mRNA transcripts and regulatory cells in renal transplant recipients 10 years after donor marrow infusion. Transplantation 2007;83(12):1611
  • Eljaafari A, Badet L, Kanitakis J, et al. Isolation of regulatory T cells in the skin of a human hand-allograft, up to six years posttransplantation. Transplantation 2006;82(12):1764
  • Jindal R, Unadkat J, Zhang W, et al. Spontaneous resolution of acute rejection and tolerance induction with IL-2 fusion protein in vascularized composite allotransplantation. Am J Transplant 2015;15(5):1231-40
  • Neujahr DC. Intragraft regulatory T cells and lung transplant outcomes - we are still at square one. Clin Transplant 2015;29(3):177
  • Kmieciak M, Gowda M, Graham L, et al. Human T cells express CD25 and Foxp3 upon activation and exhibit effector/memory phenotypes without any regulatory/suppressor function. J Transl Med 2009;7:89-9
  • US National Institutes of Health. Available from: ClinicalTrials.gov https://clinicaltrials.gov/.Updated2015 [Last accessed 20 May 2015]
  • Weisheit CK, Engel DR, Kurts C. Dendritic cells and macrophages: Sentinels in the kidney. Clin J Am Soc Nephrol 2015. [Epub ahead of print]
  • Zhuang Q, Lakkis FG. Dendritic cells and innate immunity in kidney transplantation. Kidney Int 2015;87(4):712
  • Rescigno M. Dendritic cell functions: Learning from microbial evasion strategies. Semin Immunol 2015;27(2):119-24
  • Hilkens CMU, Isaacs JD, Thomson AW. Development of dendritic cell-based immunotherapy for autoimmunity. Int Rev Immunol 2010;29(2):156
  • Satpathy AT, Wu X, Albring JC, Murphy KM. Re(de)fining the dendritic cell lineage. Nat Immunol 2012;13(12):1145
  • Moreau A, Varey E, Bouchet-Delbos L, Cuturi MC. Cell therapy using tolerogenic dendritic cells in transplantation. Transplantation Research 2012;1(1):13
  • Morelli AE, Thomson AW. Tolerogenic dendritic cells and the quest for transplant tolerance. Nature Reviews Immunology 2007;7(8):610
  • Pêche H, Trinité B, Martinet B, Cuturi MC. Prolongation of heart allograft survival by immature dendritic cells generated from recipient type bone marrow progenitors. Am J Transplant 2005;5(2):255
  • Moreau A, Chiffoleau E, Beriou G, et al. Superiority of bone marrow-derived dendritic cells over monocyte-derived ones for the expansion of regulatory T cells in the macaque. Transplantation 2008;85(9):1351
  • Beriou G, Moreau A, Cuturi MC. Tolerogenic dendritic cells: Applications for solid organ transplantation. Curr Opin Organ Transplant 2012;17(1):42
  • Turnquist HR, Raimondi G, Zahorchak AF, et al. Rapamycin-conditioned dendritic cells are poor stimulators of allogeneic CD4+ T cells, but enrich for antigen-specific Foxp3+ T regulatory cells and promote organ transplant tolerance. J Immunol 2007;178(11):7018
  • Raïch-Regué D, Glancy M, Thomson AW. Regulatory dendritic cell therapy: From rodents to clinical application. Immunol Lett 2014;161(2):216
  • Gregori S, Tomasoni D, Pacciani V, et al. Differentiation of type 1 T regulatory cells (Tr1) by tolerogenic DC-10 requires the IL-10-dependent ILT4/HLA-G pathway. Blood 2010;116(6):935
  • Naranjo-Gómez M, Raïch-Regué D, Oñate C, et al. Comparative study of clinical grade human tolerogenic dendritic cells. J Transl Med 2011;9:89
  • Valdor R, Macian F. Induction and stability of the anergic phenotype in T cells. Semin Immunol 2013;25(4):313
  • Janardhan SV, Praveen K, Marks R, Gajewski TF. Evidence implicating the ras pathway in multiple CD28 costimulatory functions in CD4+ T cells. PLoS One 2011;6(9):1
  • Ocadlíková D, Trabanelli S, Salvestrini V, et al. CD103 marks a subset of human CD34(+)-derived langerin(+) dendritic cells that induce T-regulatory cells via indoleamine 2,3-dioxygenase-1. Exp Hematol 2015;43(4):268-76
  • Levings MK, Gregori S, Tresoldi E, et al. Differentiation of Tr1 cells by immature dendritic cells requires IL-10 but not CD25+CD4+ tr cells. Blood 2005;105(3):1162
  • Allione A, Bernabei P, Bosticardo M, et al. Nitric oxide suppresses human T lymphocyte proliferation through IFN-gamma-dependent and IFN-gamma-independent induction of apoptosis. J Immunol 1999;163(8):4182
  • Cousin C, Aubatin A, Le Gouvello S, et al. The immunosuppressive enzyme IL4I1 promotes FoxP3(+) regulatory T lymphocyte differentiation. Eur J Immunol 2015; Epub ahead of print
  • O’Sullivan D, Pearce EL. Targeting T cell metabolism for therapy. Trends Immunol 2015;36(2):71
  • Moreau A, Hill M, Thébault P, et al. Tolerogenic dendritic cells actively inhibit T cells through heme oxygenase-1 in rodents and in nonhuman primates. FASEB J 2009;23(9):3070
  • Campos-Acuña J, Pérez F, Narváez E, et al. Rapamycin-conditioned dendritic cells activated with monophosphoryl lipid-A promote allograft acceptance in vivo. Immunotherapy 2015;7(2):101
  • Segovia M, Louvet C, Charnet P, et al. Autologous dendritic cells prolong allograft survival through Tmem176b-dependent antigen cross-presentation. Am J Transplant 2014;14(5):1021
  • Baas MC, Kuhn C, Valette F, et al. Combining autologous dendritic cell therapy with CD3 antibodies promotes regulatory T cells and permanent islet allograft acceptance. J Immunol 2014;193(9):4696
  • Dhodapkar MV, Steinman RM, Krasovsky J, et al. Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells. J Exp Med 2001;193(2):233
  • Dhodapkar MV, Steinman RM. Antigen-bearing immature dendritic cells induce peptide-specific CD8(+) regulatory T cells in vivo in humans. Blood 2002;100(1):174
  • Giannoukakis N, Phillips B, Finegold D, et al. Phase I (safety) study of autologous tolerogenic dendritic cells in type 1 diabetic patients. Diabetes Care 2011;34(9):2026
  • Moreau A, Varey E, Bériou G, et al. Tolerogenic dendritic cells and negative vaccination in transplantation: From rodents to clinical trials. Frontiers in Immunology 2012;3:1
  • Vassalli G. Dendritic cell-based approaches for therapeutic immune regulation in solid-organ transplantation. J Transplant 2013;1
  • Kaplan DH, Jenison MC, Saeland S, et al. Epidermal langerhans cell-deficient mice develop enhanced contact hypersensitivity. Immunity 2005;23(6):611
  • Chadha R, Leonard DA, Kurtz JM, Cetrulo CJr. The unique immunobiology of the skin: Implications for tolerance of vascularized composite allografts. Curr Opin Organ Transplant 2014;19(6):566
  • van der Aar AMG, Picavet DI, Muller FJ, et al. Langerhans cells favor skin flora tolerance through limited presentation of bacterial antigens and induction of regulatory T cells. J Invest Dermatol 2013;133(5):1240-9
  • Hutchinson JA, Riquelme P, Sawitzki B, et al. Cutting edge: Immunological consequences and trafficking of human regulatory macrophages administered to renal transplant recipients. J Immunol 2011;187(5):2072
  • Hutchinson JA, Riquelme P, Geissler EK. Human regulatory macrophages as a cell-based medicinal product. Curr Opin Organ Transplant 2012;17(1):48
  • Fleming BD, Mosser DM. Regulatory macrophages: Setting the threshold for therapy. Eur J Immunol 2011;41(9):2498
  • Radu CA, Horn D, Kiefer J, et al. Donor-derived transplant acceptance-inducing cells in composite tissue allotransplantation. J Plastic Reconstr Aesthet Surg 2012;65(12):1684
  • Hutchinson JA, Riquelme P, Brem-Exner BG, et al. Transplant acceptance-inducing cells as an immune-conditioning therapy in renal transplantation. Transplant Int 2008;21(8):728
  • Broichhausen C, Riquelme P, Geissler EK, Hutchinson JA. Regulatory macrophages as therapeutic targets and therapeutic agents in solid organ transplantation. Curr Opin Organ Transplant 2012;17(4):332
  • ONE Study Team. The ONE study. Available from: www.onestudy.org/ [Last accessed 20 May 2015]
  • Rincón-Arévalo H, Sanchez-Parra C, Castaño D, et al. Regulatory B cells and mechanisms. Int Rev Immunol 2015. [Epub ahead of print]
  • Ding Q, Yeung M, Camirand G, et al. Regulatory B cells are identified by expression of TIM-1 and can be induced through TIM-1 ligation to promote tolerance in mice. J Clin Invest 2011;121(9):3645
  • Stolp J, Turka LA, Wood KJ. B cells with immune-regulating function in transplantation. Nat Rev Nephrol 2014;10(7):389
  • Miyagaki T, Fujimoto M, Sato S. Regulatory B cells in human inflammatory and autoimmune diseases: From mouse models to clinical research. Int Immunol 2015. [Epub ahead of print]
  • Yeung MY, Ding Q, Brooks CR, et al. TIM-1 signaling is required for maintenance and induction of regulatory B cells. Am J Transplant 2015;15(4):942-53
  • Baba Y, Matsumoto M, Kurosaki T. Signals controlling the development and activity of regulatory B-lineage cells. Int Immunol 2015. [Epub ahead of print]
  • Fillatreau S. Regulatory plasma cells. Curr Opin Pharmacol 2015;23:1
  • Rosser EC, Mauri C. Regulatory B cells: Origin, phenotype, and function. Immunity 2015;42(4):607
  • Nouël A, Pochard P, Simon Q, et al. B-cells induce regulatory T cells through TGF-ß/IDO production in A CTLA-4 dependent manner. J Autoimmun 2015. [Epub ahead of print]
  • Matsumoto M, Baba A, Yokota T, et al. Interleukin-10-producing plasmablasts exert regulatory function in autoimmune inflammation. Immunity 2014;41(6):1040
  • Banham GD, Clatworthy MR. B-cell biomarkers in transplantation - from genes to therapy. Tissue Antigens 2015;85(2):82
  • Wei Y, Zheng D, Li X, et al. Infusion of dendritic cells carrying donor lymphocytes treated with 8-methoxypsoralen and ultraviolet A light induces CD19+IL-10+ regulatory B cells and promotes skin allograft survival. Transplant Proc 2014;46(10):3641
  • de Masson A, Bouaziz JD, Le Buanec H, et al. CD24hiCD27+ and plasmablast-like regulatory B cells in human chronic graft-versus-host disease. Blood 2015;125(11):1830
  • Peng Y, Chen X, Liu Q, et al. Mesenchymal stromal cells infusions improve refractory chronic graft versus host disease through an increase of CD5+ regulatory B cells producing interleukin 10. Leukemia (08876924) 2015;29(3):636
  • Chesneau M, Michel L, Degauque N, Brouard S. Regulatory B cells and tolerance in transplantation: From animal models to human. Front Immunol 2013;4:1
  • Heidt S, Vergunst M, Anholts JD, et al. B cell markers of operational tolerance can discriminate acute kidney allograft rejection from stable graft function. Transplantation 2014. [Epub ahead of print]
  • Shabir S, Girdlestone J, Briggs D, et al. Transitional B lymphocytes are associated with protection from kidney allograft rejection: A prospective study. Am J Transplant 2015;15(5):1384
  • Tena A, Sachs DH. Stem cells: Immunology and immunomodulation. Dev Ophthalmol 2014;53:122
  • Hanley PJ. Therapeutic mesenchymal stromal cells: Where we are headed. Methods Mol Biol 2015;1283:1
  • Yur-Ren Kuo, Chien-Chang Chen, Goto S, et al. Mesenchymal StemCells as immunomodulators in a vascularized composite allotransplantation. Clin Develop Immunol 2012;1:8
  • Leto Barone AA, Khalifian S, Lee WP, Brandacher G. Immunomodulatory effects of adipose-derived stem cells: Fact or fiction? Biomed Research International 2013;2013:383685
  • Galipeau J. The mesenchymal stromal cells dilemma–does a negative phase III trial of random donor mesenchymal stromal cells in steroid-resistant graft-versus-host disease represent a death knell or a bump in. Cytotherapy 2013;15(1):2
  • De Ugarte DA, Morizono K, Elbarbary A, et al. Comparison of multi-lineage cells from human adipose tissue and bone marrow. Cells Tissues Organs (Print) 2003;174(3):101
  • Day RB, Bhattacharya D, Nagasawa T, Link DC. Granulocyte colony-stimulating factor reprograms bone marrow stromal cells to actively suppress B lymphopoiesis in mice. Blood 2015. [Epub ahead of print]
  • Bacskai I, Mázló A, Kis-Tóth K, et al. Mesenchymal stromal cell-like cells set the balance of stimulatory and inhibitory signals in monocyte-derived dendritic cells. Stem Cells And Development 2015. [Epub ahead of print]
  • Liu X, Ren S, Ge C, et al. Sca-1+Lin-CD117- mesenchymal stem/stromal cells induce the generation of novel IRF8-controlled regulatory dendritic cells through notch-RBP-J signaling. J Immunol 2015;194(9):4298
  • Del Fattore A, Luciano R, Pascucci L, et al. Immunoregulatory effects of mesenchymal stem cell-derived extracellular vesicles on T lymphocytes. Cell Transplant 2015. [Epub ahead of print]
  • Yur-Ren Kuo, Chien-Chang C, Goto S, et al. Immunomodulatory effects of bone marrow-derived mesenchymal stem cells in a swine hemi-facial allotransplantation model. PLoS One 2012;7(4):1
  • Ben Nasr M, Vergani A, Avruch J, et al. Co-transplantation of autologous MSCs delays islet allograft rejection and generates a local immunoprivileged site. Acta Diabetol 2015. [Epub ahead of print]
  • Kuo YR, Chen CC, Shih HS, et al. Prolongation of composite tissue allotransplant survival by treatment with bone marrow mesenchymal stem cells is correlated with T-cell regulation in a swine hind-limb model. Plast Reconstr Surg 2011;127(2):569
  • Kuo YR, Goto S, Shih HS, et al. Mesenchymal stem cells prolong composite tissue allotransplant survival in a swine model. Transplantation 2009;87(12):1769
  • Luk F, de Witte SF, Bramer WM, et al. Efficacy of immunotherapy with mesenchymal stem cells in man: A systematic review. Expert Rev Clin Immunol 2015;11(5):617
  • Resnick IB, Barkats C, Shapira MY, et al. Treatment of severe steroid resistant acute GVHD with mesenchymal stromal cells (MSC). Am J Blood Res 2013;3(3):225
  • Vega A, Martín-Ferrero MA, Del Canto F, et al. Treatment of knee osteoarthritis with allogeneic bone marrow mesenchymal stem cells: A randomized controlled trial. Transplantation 2015. [Epub ahead of print]
  • Weiss DJ, Casaburi R, Flannery R, et al. A placebo-controlled, randomized trial of mesenchymal stem cells in COPD. Chest 2013;143(6):1590
  • Le Blanc K, Frassoni F, Ball L, et al. Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: A phase II study. Lancet 2008;371(9624):1579
  • Mudrabettu C, Kumar V, Rakha A, et al. Safety and efficacy of autologous mesenchymal stromal cells transplantation in patients undergoing living donor kidney transplantation: A pilot study. Nephrology 2015;20(1):25
  • Khalifian S, Sarhane KA, Tammia M, et al. Stem cell-based approaches to improve nerve regeneration: Potential implications for reconstructive transplantation? Arch Immunol Ther Exp (Warsz) 2015;63(1):15
  • Cartarozzi LP, Spejo AB, Ferreira RSJ, et al. Mesenchymal stem cells engrafted in a fibrin scaffold stimulate Schwann cell reactivity and axonal regeneration following sciatic nerve tubulization. Brain Res Bull 2015;112:14
  • Casañas J, de la Torre J, Soler F, et al. Peripheral nerve regeneration after experimental section in ovine radial and tibial nerves using synthetic nerve grafts, including expanded bone marrow mesenchymal cells: Morphological and. Injury 2014;45:Suppl 4:S2
  • Oliveira JT, Bittencourt-Navarrete RE, de Almeida FM, et al. Enhancement of median nerve regeneration by mesenchymal stem cells engraftment in an absorbable conduit: Improvement of peripheral nerve morphology with enlargement of somatosensory cortical. Front Neuroanatomy 2014;8:111
  • Walsh S, Midha R. Use of stem cells to augment nerve injury repair. Neurosurgery 2009;65(4):A80
  • Lopatina T, Kalinina N, Karagyaur M, et al. Adipose-derived stem cells stimulate regeneration of peripheral nerves: BDNF secreted by these cells promotes nerve healing and axon growth de novo. PLoS One 2011;6(3):1
  • June CH, Riddell SR, Schumacher TN. Adoptive cellular therapy: A race to the finish line. Sci Transl Med 2015;7(280):280ps7
  • Mathes DW, Solari MG, Gazelle GS, et al. Stable mixed hematopoietic chimerism permits tolerance of vascularized composite allografts across a full major histocompatibility mismatch in swine. Transplant Int 2014;27(10):1086
  • Li H, Shi B. Tolerogenic dendritic cells and their applications in transplantation. Cell Mol Immunol 2015;12(1):24
  • Hutchinson JA, Geissler EK. Now or never? the case for cell-based immunosuppression in kidney transplantation. Kidney Int 2015; Epub ahead of print
  • Issa F, Wood KJ. Translating tolerogenic therapies to the clinic - where do we stand? Front Immunol 2012;3:1
  • Hutchinson JA, Ahrens N, Riquelme P, et al. Clinical management of patients receiving cell-based immunoregulatory therapy. Transfusion 2014;54(9):2336
  • Waldmann H, Hilbrands R, Howie D, Cobbold S. Harnessing FOXP3+ regulatory T cells for transplantation tolerance. J Clin Invest 2014;124(4):1439
  • Bortolotti F, Ukovich L, Razban V, et al. In vivo therapeutic potential of mesenchymal stromal cells depends on the source and the isolation procedure. Stem Cell Reports 2015;4(3):332
  • Berger TG, Schulze-Koops H, Schäfer M, et al. Immature and maturation-resistant human dendritic cells generated from bone marrow require two stimulations to induce T cell anergy in vitro. PLoS One 2009;4(8):1
  • Issa F, Wood KJ. The potential role for regulatory T-cell therapy in vascularized composite allograft transplantation. Curr Opin Organ Transplant 2014;19(6):558
  • Smyth LA, Ratnasothy K, Moreau A, et al. Tolerogenic donor-derived dendritic cells risk sensitization in vivo owing to processing and presentation by recipient APCs. J Immunol 2013;190(9):4848
  • Brandacher G, Lee WP, Schneeberger S. Minimizing immunosuppression in hand transplantation. Expert Rev Clin Immunol 2012;8(7):673
  • Cheng HY, Ghetu N, Huang WC, et al. Syngeneic adipose-derived stem cells with short-term immunosuppression induce vascularized composite allotransplantation tolerance in rats. Cytotherapy 2014;16(3):369
  • Kuo YR, Chen CC, Goto S, et al. Proteomic analysis in serum of rat hind-limb allograft tolerance induced by immunosuppressive therapy with adipose-derived stem cells. Plast Reconstr Surg 2014;134(6):1213
  • Tonsho M, Lee S, Aoyama A, et al. Tolerance of lung allografts achieved in nonhuman primates via mixed hematopoietic chimerism. Am J Transplant 2015; Epub ahead of print
  • Xiao F, Ma L, Zhao M, et al. Ex vivo expanded human regulatory T cells delay islet allograft rejection via inhibiting islet-derived monocyte chemoattractant protein-1 production in CD34+ stem cells-reconstituted NOD-scid IL2rγnull mice. PLoS One 2014;9:3):1-12
  • Takasato F, Morita R, Schichita T, et al. Prevention of allogeneic cardiac graft rejection by transfer of ex vivo expanded antigen-specific regulatory T-cells. PLoS One 2014;9(2):1
  • Warnecke G, Hutchinson JA, Riquelme P, et al. Postoperative intravenous infusion of donor-derived transplant acceptance-inducing cells as an adjunct immunosuppressive therapy in a porcine pulmonary allograft model. Transplant Int 2009;22(3):332

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