2
Views
0
CrossRef citations to date
0
Altmetric
Drug Profile

Parathyroid hormone (1–84): new clinical perspectives for treating patients at high-risk of fractures

Pages 577-585 | Published online: 10 Jan 2014

References

  • Poole KE, Compston JE. Osteoporosis and its management. Br. Med. J.333, 1251–1256 (2006).
  • Compston JE. Recombinant parathyroid hormone in the management of osteoporosis. Calcif. Tissue Int.77, 65–71 (2005).
  • Neer RM, Arnaud CD, Zanchetta JR et al. Effect of parathyroid hormone (1–34) on fractures and bone mineral density in postmenopausal women with osteoporosis. N. Engl. J. Med.344, 1434–1441 (2001).
  • Potts JT. Parathyroid hormone: past and present. J. Endocrinol.187, 311–325 (2005).
  • Brown EM, Jüppner H. Parathyroid hormone: synthesis, secretion and action. In: Primer on the Metabolic Bone Diseases and Disorders of Bone Metabolism, Sixth edition. Favus MJ (Ed.). American Society for Bone and Mineral Research, Washington, DC, USA 90–106 (2006).
  • Onyia JE, Helvering LM, Gelbert L et al. Molecular profile of catabolic versus anabolic treatment regimens of parathyroid hormone (PTH) in rat bone: an analysis by DNA microarray. J. Cell Biochem.95, 403–418 (2005).
  • Locklin RM, Khosla S, Turner RT, Riggs BL 2003 Mediators of the biphasic responses of bone to intermittent and continuously administered parathyroid hormone. J. Cell Biochem.89, 180–190 (2003).
  • Ma YL, Zeng Q, Donley DW et al. Teriparatide increases bone formation in modeling and remodeling osteons and enhances IGF-II immunoreactivity in postmenopausal women with osteoporosis. J. Bone Miner. Res.21, 855–864 (2006).
  • Huang JC, Sakata T, Pfleger LL et al. PTH differentially regulates expression of RANKL and OPG. J. Bone Miner. Res.19, 235–244 (2004).
  • von Stechow D, Zurakowski D, Pettit AR et al. Differential transcriptional effects of PTH and estrogen during anabolic bone formation. J. Cell Biochem.93, 476–490 (2004).
  • Kulkarni NH, Halladay DL, Miles RR et al. Effects of parathyroid hormone on Wnt signaling pathway in bone. J. Cell Biochem.95, 1178–1190 (2005).
  • Tobimatsu T, Kaji H, Sowa H et al. Parathyroid hormone increases β-catenin levels through Smad3 in mouse osteoblastic cells. Endocrinology147, 2583–2590 (2006).
  • Keller H, Kneissel M. SOST is a target gene for PTH in bone. Bone37, 148–158 (2005).
  • Bellido T, Ali AA, Plotkin LI et al. Proteasomal degradation of Runx2 shortens parathyroid hormone-induced anti-apoptotic signaling in osteoblasts. J. Biol. Chem.278, 50259–50272 (2003).
  • Schwietert HR, Groen EWJ, Sollie FAE, Jonkman JH. Single-dose subcutaneous administration of recombinant parathyroid hormone (rPTH [1–84] in healthy postmenopausal volunteers. Clin. Pharmacol. Ther.61, 360–376 (1997).
  • Hodsman AB, Hanley DA, Ettinger MP et al. Efficacy and safety of human parathyroid hormone-(1–84) in increasing bone mineral density in postmenopausal osteoporosis. J. Clin. Endocrinol. Metab.88, 5212–5220 (2003).
  • Kimmel DB, Bozzato RP, Kronis KA et al. The effect of recombinant human (1–84) or synthetic human (1–34) parathyroid hormone on the skeleton of adult osteopenic ovariectomised rates. Endocrinology132, 1577–1584 (1993).
  • Whitfield JF, Morley P, Willick GE et al. Comparison of the ability of recombinant human parathyroid hormone, rhPTH-(1–84), and hPTH-(1–31)NH2 to stimulate femoral trabecular bone growth in ovariectomised rats. Calcif. Tissue Int.60, 26–29 (1997).
  • Ejersted C, Andreassen TT, Oxlund H et al. Human parathyroid hormone (1–34) and (1–84) increase the mechanical strength and thickness of cortical bone in rats. J. Bone Miner. Res.8, 1097–1010 (1993).
  • Samnegard E, Iwaniec UT, Cullen DM, Kimmel DB, Recker RR. Maintenance of cortical bone in human parathyroid hormone (1–84)-treated ovariectomised rats. Bone28, 251–260 (2001).
  • Moreau IA, Smith SY, Guldberg RE, Turner CH, Newman MK, Fox J. Treatment of osteopenic rhesus monkeys with parathyroid hormone 1–84 for 16 months improves vertebral trabecular bone quantity and quality. J. Bone Miner. Res.20(Suppl. 1), S412 (2005).
  • Dempster DW, Cosman F, Kurland ES et al. Effects of daily treatment with parathyroid hormone on bone microarchitecture and turnover in patients with osteoporosis: a paired biopsy study. J. Bone Miner. Res.16, 1846–1853 (2001).
  • Lindsay R, Cosman F, Zhou H et al. A novel tetracycline labeling schedule for longitudinal evaluation of the short-term effects of anabolic therapy with a single iliac crest biopsy: early actions of teriparatide. J. Bone Miner. Res.21, 366–373 (2006).
  • Compston JE. Skeletal actions of intermittent parathyroid hormone: effects on bone remodelling and structure. Bone40(6), 1447-52 (2007).
  • Preotact®, product information. Full-length parathyroid hormone, Nycomed UK, Ltd, EU (Online) (2006).
  • Vahle JL, Sato M, Long GG et al. Skeletal changes in rats given daily subcutaneous injections of recombinant human parathyroid hormone (1–34) for 2 years and relevance to human safety. Toxicol. Pathol.30, 312–321 (2002).
  • Jolette J, Wilker CE, Smith SY et al. Defining a non-carcinogenic dose of recombinant human parathyroid hormone 1–84 in a 2-yr study in Fischer 344 rats. Toxicol. Pathol.34, 929–940 (2006).
  • Preotact. Summary of Product Characteristics (2006).
  • Greenspan SL, Bone HG, Ettinger MP et al. Effect of recombinant human parathyroid hormone (1–84) on vertebral fracture and bone mineral density in postmenopausal women with osteoporosis. Ann. Intern. Med.146, 326–339 (2007).
  • Bogado C, Zanchetta JR, Gordon CL et al. Treatment of postmenopausal osteoporotic women with parathyroid hormone (1–84) for 18 months decreases BMD but does not affect indices of bone strength at the distal radius. J. Bone Miner. Res.21(Suppl. 1), S112 (2006).
  • Bogado C, Zanchetta JR, Mango A, Mathisen AL, Fox J, Newman MK. Effects of parathyroid hormone 1–84 on cortical and trabecular bone at the hip as assessed by QCT: results at 18 months from the TOP Study. J. Bone Miner. Res.20(Suppl. 1), S22 (2005).
  • Greenspan SL, Hanley DA, Morris SA, Marriott TB. Bone turnover markers and BMD remain elevated in postmenopausal osteoporotic women through a full 24 months of treatment with human parathyroid hormone 1–84 (PTH). J. Bone Miner. Res.21(Suppl. 1), S114 (2006).
  • Black DM, Greenspan SL, Ensrud KE et al. The effects of parathyroid hormone and alendronate alone or in combination in postmenopausal osteoporosis. N. Engl. J. Med.349, 1207–1215 (2003).
  • Black DM, Bilezekian JP, Ensrud KE et al. One year of alendronate after one year of parathyroid hormone (1–84) for osteoporosis. New Engl. J. Med.353, 555–565 (2005).
  • Fogelman I, Christiansen C, Spector T, Fraser WD, Fordham J. Safety and efficacy of PTH(1–84) at 18 and 24 months in women with postmenopausal osteoporosis receiving hormone therapy: results from the POWER study. J. Bone Miner. Res.20(Suppl. 1), S21–S22 (2005).
  • Black D, Thompson D, Quandt SA, Palermo L, Ensrud K, Johnell O. Alendronate reduces risk of vertebral fracture in women with BMD T-scores above -2.5: results from the fracture intervention trial (FIT). Osteoporos. Int.13(Suppl. 1), S27 (2002).
  • Harris ST, Watts NB, Genant HK et al. Effects of risedronate treatment on vertebral and nonvertebral fractures in women with postmenopausal osteoporosis. A randomized controlled trial. JAMA282, 1344–1352 (1999).
  • Reginster J-Y, Minne HW, Sorensen OH et al. Randomized trial of the effects of risedronate on vertebral fractures in women with established postmenopausal osteoporosis. Osteoporos. Int.11, 83–91 (2000).
  • Chesnut CH, Skag A, Christiansen C et al. Effects of oral ibandronate administered daily or intermittently on fracture risk in postmenopausal osteoporosis. J. Bone Miner. Res.19, 1241–1249 (2004).
  • Ettinger B, Black DM, Mitlak BH et al. Reduction of vertebral fracture risk in postmenopausal women with osteoporosis treated with raloxifene: results from a 3-year randomized clinical trial. JAMA282, 637–645 (1999).
  • Meunier PJ, Roux C, Seeman E et al. The effect of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis. N. Engl. J. Med.350, 459–468 (2004).
  • Black DM, Delmas PD, Eastell R et al. Once-yearly zoledronic acid for treatment of postmenopausal osteoporosis. N. Engl. J. Med.356, 1809–1822 (2007).
  • McClung MR, Geusens P, Miller PD et al. Effect of risedronate on the risk of hip fracture in elderly women. N. Engl. J. Med.344, 333–340 (2001)
  • Reginster J-Y, Seeman E, De Vernejoul MC et al. Strontium ranelate reduces the risk of nonvertebral fractures in postmenopausal women with osteoporosis: Treatment of Peripheral Osteoporosis (TROPOS) study. J. Clin. Endocrinol. Metab.90, 2816–2822 (2005).
  • Kanis JA, Borgstrom F, Zethraeus N, Johnell O, Oden A, Jonsson B. Intervention thresholds for osteoporosis in the UK. Bone36, 22–32 (2005).
  • Compston JE, Seeman E. Compliance with osteoporosis therapy is the weakest link. Lancet368, 973–974 (2006).
  • Seeman E, Compston J, Adachi J et al. Non-compliance: the Achilles’ heel; of anti-fracture efficacy. Osteoporos. Int.18, 711–719 (2007).
  • Compston J. Treatments for osteoporosis - looking beyond the HORIZON. N. Engl. J. Med.356, 1878–1880 (2007).
  • McClung MR, Lewiecki EM, Cohen SB et al. Denosumab in postmenopausal women with low bone mineral density. N. Engl. J. Med.354, 821–831 (2006).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.