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Drug Profiles

An evaluation of entecavir for the treatment of chronic hepatitis B infection in adults

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Pages 177-186 | Received 20 Sep 2015, Accepted 25 Nov 2015, Published online: 08 Jan 2016

References

  • Papers of special note have been highlighted as:
  • ● of interest
  • ●● of considerable interest
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●● This is the most recent study to summarize the treatment algorithm for chronic hepatitis B (CHB) patients.

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●● This is the most recent real-world data to summarize the effectiveness and safety of entecavir in treatment-naive CHB patients.

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  • Ono A, Suzuki F, Kawamura Y, et al. Long-term continuous entecavir therapy in nucleos(t)ide-naive chronic hepatitis B patients. J Hepatol. 2012;57:508–514.
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  • Colonno RJ, Rose R, Baldick CJ, et al. Entecavir resistance is rare in nucleoside naive patients with hepatitis B. Hepatology. 2006;44:1656–1665.
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● This is the well-designed study to investigate the effect of entecavir on hepatocellular carcinoma development.

  • Kim MN, Kim SU, Park JY, et al. Risk assessment of liver-related events using transient elastography in patients with chronic hepatitis B receiving entecavir. J Clin Gastroenterol. 2014;48:272–278.
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  • Rivkin A. A review of entecavir in the treatment of chronic hepatitis B infection. Curr Med Res Opin. 2005;21:1845–1856.

● This is the baseline review article including the effectiveness and safety of entecavir.

  • Seto WK, Hui AJ, Wong VW, et al. Treatment cessation of entecavir in Asian patients with hepatitis B e antigen negative chronic hepatitis B: a multicentre prospective study. Gut. 2015;64:667–672.
  • Chen CH, Hung CH, Hu TH, et al. Association between level of hepatitis B surface antigen and relapse after entecavir therapy for chronic hepatitis B virus infection. Clin Gastroenterol Hepatol. 2015;13:1984–1992.e1981.

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