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Expert Review of Respiratory Medicine Volume 9, 2015 - Issue 6
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Allergic airway inflammation: unravelling the relationship between IL-37, IL-18Rα and Tir8/SIGIRR

Lars LundingDivision of Asthma Mouse Models, Priority Area Asthma & Allergy, Research Center Borstel, Airway Research Center North, Member of the German Center for Lung Research, Borstel, Germany
,
Alexandra SchröderDivision of Asthma Mouse Models, Priority Area Asthma & Allergy, Research Center Borstel, Airway Research Center North, Member of the German Center for Lung Research, Borstel, Germany
&
Michael WegmannDivision of Asthma Mouse Models, Priority Area Asthma & Allergy, Research Center Borstel, Airway Research Center North, Member of the German Center for Lung Research, Borstel, GermanyCorrespondence[email protected]
Pages 739-750 | Published online: 11 Nov 2015

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* This paper focuses on the inhibiting influence of IL-37 on the proinflammatory inflammasome in mice.

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** This paper described the anti-inflammatory potential of IL-37 in a mouse model of allergic inflammation. Furthermore, this paper showed for the first time that this mode of action requires IL18Rα and SIGIRR.

  • Nold-Petry CA, Lo CY, Rudloff I, et al. IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction. Nat Immunol. 2015;16(4):354–365.

**This excellent paper clarifies the intracellular effects of IL-37 binding to the IL18Rα/SIGIRR receptor complex.

  • Ye L, Ji L, Wen Z, et al. IL-37 inhibits the production of inflammatory cytokines in peripheral blood mononuclear cells of patients with systemic lupus erythematosus: its correlation with disease activity. J Transl Med. 2014;12:69.
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