References
- Papers of special note have been highlighted as:
- • of interest
- •• of considerable interest
- Jones PW, Quirk FH, Baveystock CM, et al. A self-complete measure of health status for chronic airflow limitation. The St. George’s Respiratory Questionnaire. Am Rev Respir Dis. 1992;145:1321–1327.
- Burge PS, Calverley PM, Jones PW, et al. Randomised, double blind, placebo controlled study of fluticasone propionate in patients with moderate to severe chronic obstructive pulmonary disease: the ISOLDE trial. BMJ. 2000;320:1297–1303.
- Cazzola M, MacNee W, Martinez FJ, et al. Outcomes for COPD pharmacological trials: from lung function to biomarkers. Eur Respir J. 2008;31:416–469.
- Jones PW. St. George’s Respiratory Questionnaire: MCID. COPD. 2005;2:75–79.
- De Backer JW, Vos WG, Vinchurkar SC, et al. Validation of computational fluid dynamics in CT-based airway models with SPECT/CT. Radiology. 2010;257:854–862.
•• On the basis of these findings, it becomes feasible to use functional imaging for analysis and optimization of drug delivery and respiratory devices.
- Tung MK, Cameron JD, Casan JM, et al. Radiation dose in 320-slice multidetector cardiac CT: a single center experience of evolving dose minimization. J Cardiovasc Comput Tomogr. 2013;7:157–166.
- De Backer JW, Vos WG, Devolder A, et al. Computational fluid dynamics can detect changes in airway resistance in asthmatics after acute bronchodilation. J Biomech. 2008;41:106–113.
- Vos W, De Backer J, Poli G, et al. Novel functional imaging of changes in small airways of patients treated with extrafine beclomethasone/formoterol. Respiration. 2013;86:393–401.
- De Backer LA, Vos WG, Salgado R, et al. Functional imaging using computer methods to compare the effect of salbutamol and ipratropium bromide in patient-specific airway models of COPD. Int J Chron Obstruct Pulmon Dis. 2011;6:637–646.
- De Backer J, Vos W, Vinchurkar S, et al. The effects of extrafine beclometasone/formoterol (BDP/F) on lung function, dyspnea, hyperinflation, and airway geometry in COPD patients: novel insight using functional respiratory imaging. J Aerosol Med Pulm Drug Deliv. 2015;28:88–99.
•• This study showed that functional respiratory imaging (FRI) seems to be a sensitive biomarker to detect clinically relevant changes that are not detected by spirometry and that FRI is useful in detecting regional deposition of particles.
- De Backer LA, Vos W, De Backer J, et al. The acute effect of budesonide/formoterol in COPD: a multi-slice computed tomography and lung function study. Eur Respir J. 2012;40:298–305.
- De Backer J, Vos W, Van Holsbeke C, et al. Effect of high-dose N-acetylcysteine on airway geometry, inflammation, and oxidative stress in COPD patients. Int J Chron Obstruct Pulmon Dis. 2013;8:569–579.
- De Backer W, Vos W, Van Holsbeke C, et al. The effect of roflumilast in addition to LABA/LAMA/ICS treatment in COPD patients. Eur Respir J. 2014;44:527–529.
• The current study confirmed the potential of PDE4 inhibitors to improve lung function in chronic obstructive pulmonary disease (COPD) patients even when administered in addition to triple (long-acting beta agonist/LAMA/ICS) therapy, which has never been previously studied. At the same time, the FRI outcome parameters were able to provide a hypothesis for the mode of action of roflumilast leading to the improvements observed in the lung function.
- De Backer L, Vos W, Dieriks B, et al. The effects of long-term noninvasive ventilation in hypercapnic COPD patients: a randomized controlled pilot study. Int J Chron Obstruct Pulmon Dis. 2011;6:615–624.
- Ides K, Vissers D, De Backer L, et al. Airway clearance in COPD: need for a breath of fresh air? A systematic review. COPD. 2011;8:196–205.
- Ides K, Vos W, De Backer L, et al. Acute effects of intrapulmonary percussive ventilation in COPD patients assessed by using conventional outcome parameters and a novel computational fluid dynamics technique. Int J Chron Obstruct Pulmon Dis. 2012;7:667–671.
- Janssens A, Vos W, Van Holsbeke C, et al. Estimation of post-operative forced expiratory volume by functional respiratory imaging. Eur Respir J. 2015;45:544–546.
- Van Holsbeke CS, Leemans G, Vos WG, et al. Functional respiratory imaging as a tool to personalize respiratory treatment in subjects with unilateral diaphragmatic paralysis. Respir Care. 2014;59:e127–e131. doi:10.4187/respcare.02756.
- Decramer M, Rutten-van Molken M, Dekhuijzen PN, et al. Effects of N-acetylcysteine on outcomes in chronic obstructive pulmonary disease (Bronchitis Randomized on NAC Cost-Utility Study, BRONCUS): a randomised placebo-controlled trial. Lancet. 2005;365:1552–1560.
- Koegelenberg CF, Bolliger CT. Assessing regional lung function. Thorac Surg Clin. 2008;18:19–29, v-vi.
- Akira M, Toyokawa K, Inoue Y, et al. Quantitative CT in chronic obstructive pulmonary disease: inspiratory and expiratory assessment. AJR Am J Roentgenol. 2009;192:267–272.
- Nishino M, Roberts DH, Sitek A, et al. Loss of anteroposterior intralobar attenuation gradient of the lung: correlation with pulmonary function. Acad Radiol. 2006;13:589–597.
- Laurent F, Tunon de Lara M. Assessment of imaging techniques for evaluating small-airway disease in asthma. Rev Mal Respir. 2011;28:e7–10.
- Grydeland TB, Thorsen E, Dirksen A, et al. Quantitative CT measures of emphysema and airway wall thickness are related to D(L)CO. Respir Med. 2011;105:343–351.
- Rutten EP, Grydeland TB, Pillai SG, et al. Quantitative CT: associations between emphysema, airway wall thickness and body composition in COPD. Pulm Med. 2011;2011:419328.
- Xie X, de Jong PA, Oudkerk M, et al. Morphological measurements in computed tomography correlate with airflow obstruction in chronic obstructive pulmonary disease: systematic review and meta-analysis. Eur Radiol. 2012;22:2085–2093.
• Computed tomography (CT) measurements of emphysema or peripheral airways are significantly related to airflow obstruction in COPD patients. CT provides a morphological method to investigate airway obstruction in COPD.
- Sorensen L, Loog M, Lo P, et al. Image dissimilarity-based quantification of lung disease from CT. Med Image Comput Comput Assist Interv. 2010;13:37–44.
- Sorensen L, Shaker SB, de Bruijne M. Quantitative analysis of pulmonary emphysema using local binary patterns. IEEE Trans Med Imaging. 2010;29:559–569.
- Sorensen L, Nielsen M, Lo P, et al. Texture-based analysis of COPD: a data-driven approach. IEEE Trans Med Imaging. 2012;31:70–78.
- Nishio M, Matsumoto S, Ohno Y, et al. Emphysema quantification by low-dose CT: potential impact of adaptive iterative dose reduction using 3D processing. AJR Am J Roentgenol. 2012;199:595–601.
- Murphy K, Pluim JP, van Rikxoort EM, et al. Toward automatic regional analysis of pulmonary function using inspiration and expiration thoracic CT. Med Phys. 2012;39:1650–1662.
- Mets OM, van Hulst RA, Jacobs C, et al. Normal range of emphysema and air trapping on CT in young men. AJR Am J Roentgenol. 2012;199:336–340.
- Mets OM, de Jong PA, van Ginneken B, et al. Quantitative computed tomography in COPD: possibilities and limitations. Lung. 2012;190:133–145.
- Mets OM, Willemink MJ, de Kort FP, et al. The effect of iterative reconstruction on computed tomography assessment of emphysema, air trapping and airway dimensions. Eur Radiol. 2012;22:2103–2109.
- Mets OM, Murphy K, Zanen P, et al. The relationship between lung function impairment and quantitative computed tomography in chronic obstructive pulmonary disease. Eur Radiol. 2012;22:120–128.
• The combination of quantitative CT air trapping and emphysema measurements is strongly associated with lung function impairment in current and former heavy smokers with a wide range of airflow limitation.
- Martinez CH, Chen YH, Westgate PM, et al. Relationship between quantitative CT metrics and health status and BODE in chronic obstructive pulmonary disease. Thorax. 2012;67:399–406.
- Li JS, Zhang HL, Bai YP, et al. Diagnostic value of computed tomography in chronic obstructive pulmonary disease: a systematic review and meta-analysis. COPD. 2012;9:563–570.
- Lee CW, Seo JB, Lee Y, et al. A pilot trial on pulmonary emphysema quantification and perfusion mapping in a single-step using contrast-enhanced dual-energy computed tomography. Invest Radiol. 2012;47:92–97.
- Koyama H, Ohno Y, Nishio M, et al. Three-dimensional airway lumen volumetry: comparison with bronchial wall area and parenchymal densitometry in assessment of airway obstruction in pulmonary emphysema. Br J Radiol. 2012;85:1525–1532.
- Besir FH, Mahmutyazicioglu K, Aydin L, et al. The benefit of expiratory-phase quantitative CT densitometry in the early diagnosis of chronic obstructive pulmonary disease. Diagn Interv Radiol. 2012;18:248–254.
- Hersh CP, Washko GR, Estepar RS, et al. Paired inspiratory-expiratory chest CT scans to assess for small airways disease in COPD. Respir Res. 2013;14:42.
- Lynch DA, Al-Qaisi MA. Quantitative computed tomography in chronic obstructive pulmonary disease. J Thorac Imaging. 2013;28:284–290.
- Kundu S, Gu S, Leader JK, et al. Assessment of lung volume collapsibility in chronic obstructive lung disease patients using CT. Eur Radiol. 2013 Jun;23(6):1564–1572.
- Kitano M, Iwano S, Hashimoto N, et al. Lobar analysis of collapsibility indices to assess functional lung volumes in COPD patients. Int J Chron Obstruct Pulmon Dis. 2014;9:1347–1356.
- Matsuoka S, Yamashiro T, Washko GR, et al. Quantitative CT assessment of chronic obstructive pulmonary disease. Radiographics. 2010;30:55–66.
- Holanda MA, Fortaleza SC, Alves-de-Almeida M, et al. Continuous positive airway pressure effects on regional lung aeration in patients with COPD: a high-resolution CT scan study. Chest. 2010;138:305–314.
- Dettmer S, Peters L, de Wall C, et al. Bronchial wall measurements in patients after lung transplantation: evaluation of the diagnostic value for the diagnosis of bronchiolitis obliterans syndrome. PLoS One. 2014;9:e93783.