Immunosenescence and its potential modulation: lessons from mouse models

References

• Goldmann O, Lehne S, Medina E. Age-related susceptibility to Streptococcus pyogenes infection in mice: underlying immune dysfunction and strategy to enhance immunity. J. Pathol.220(5), 521–529 (2009).
   Google Scholar
• Jaggi P, Shulman ST. Group A streptococcal infections. Pediatr. Rev.27, 99–105 (2006).
   PubMedGoogle Scholar
• Medina E, Goldmann O, Rohde M Lengeling A, Chhatwal GS. Genetic control of susceptibility to group A streptococcal infection in mice. J. Infect. Dis.184, 846–852 (2001).
   PubMedGoogle Scholar
• Goldmann O, Chhatwal GS, Medina E. Immune mechanisms underlying host susceptibility to infection with group A streptococci. J. Infect. Dis.187, 854–861 (2003).
   PubMedGoogle Scholar
• Goldmann O, Rohde M, Chhatwal GS, Medina E. Role of macrophages in host resistance to group A streptococci. Infect. Immun.72, 2956–2963 (2004).
   PubMedGoogle Scholar
• Goldmann O, Chhatwal GS, Medina E. Contribution of natural killer cells to the pathogenesis of septic shock induced by Streptococcus pyogenes in mice. J. Infect. Dis.191, 1280–1286 (2005).
   PubMedGoogle Scholar
• Loof TG, Rohde M, Chhatwal GS, Jung S, Medina E. The contribution of dendritic cells to host defenses against Streptococcus pyogenes. J. Infect. Dis.196, 1794–1803 (2007).
   PubMed Web of Science ®Google Scholar
• Ginaldi L, De Martinis M, D’Ostilio A, Marni L, Loreto MI, Quaglino D. The immune system in the elderly: III. Innate immunity. Immunol. Res.20, 117–126 (1999).
   PubMedGoogle Scholar
• Hakim FT, Gress RE. Immunosenescence: deficits in adaptive immunity in the elderly. Tissue Antigens70, 179–189 (2007).
   PubMedGoogle Scholar
• Kovacs EJ, Palmer JL, Fortin CF, Fülöp T Jr, Goldstein DR, Linton PJ. Aging and innate immunity in the mouse: impact of intrinsic and extrinsic factors. Trends Immunol.30, 319–324 (2009).
   PubMedGoogle Scholar
• Weiskopf D, Weinberger B, Grubeck-Loebenstein B. The aging of the immune system. Transpl. Int.22, 1041–1050 (2009).
   PubMed Web of Science ®Google Scholar
• Goronzy JJ, Lee WW, Weyand CM. Aging and T-cell diversity. Exp. Gerontol.42, 400–406 (2007).
   PubMed Web of Science ®Google Scholar
• Naylor K, Li G, Vallejo AN et al. The influence of age on T cell generation and TCR diversity. J. Immunol.174, 7446–7452 (2005).
   PubMed Web of Science ®Google Scholar
• Aspinall R, Andrew D. Thymic involution in aging. J. Clin. Immunol.20, 250–256 (2000).
   PubMed Web of Science ®Google Scholar
• Andrews NP, Fujii H, Goronzy JJ, Weyand CM. Telomeres and immunological diseases of aging. Gerontology (Epub ahead of print) (2009).
   PubMedGoogle Scholar
• Linton PJ, Li SP, Zhang Y, Bautista B, Huynh Q, Trinh T. Intrinsic versus environmental influences on T-cell responses in aging. Immunol. Rev.205, 207–219 (2005).
   PubMed Web of Science ®Google Scholar
• Tarjanyi O, Boldizsar F, Nemeth P, Mikecz K, Glant TT. Age-related changes in arthritis susceptibility and severity in a murine model of rheumatoid arthritis. Immun. Ageing6, 8 (2009).
   PubMedGoogle Scholar
• Glant TT, Mikecz K, Arzoumanian A, Poole AR. Proteoglycan-induced arthritis in BALB/c mice. Clinical features and histopathology. Arthritis Rheum.30, 201–212 (1987).
   PubMed Web of Science ®Google Scholar
• Mikecz K, Glant TT, Poole AR. Immunity to cartilage proteoglycans in BALB/c mice with progressive polyarthritis and ankylosing spondylitis induced by injection of human cartilage proteoglycan. Arthritis Rheum.30, 306–318 (1987).
   PubMed Web of Science ®Google Scholar
• Stuart JM, Townes AS, Kang AH. Nature and specificity of the immune response to collagen in type II collagen-induced arthritis in mice. J. Clin. Invest.69, 673–683 (1982).
   PubMed Web of Science ®Google Scholar
• Bell DA, Clark C, Blomgren SE, Vaughan JH. Anti DNA antibody production by lymphoid cells of NZB-W mice and human systemic lupus erythematosus (SLE). Clin. Immunol. Immunopathol.1, 293–303 (1973).
   PubMedGoogle Scholar
• Glant TT, Finnegan A, Mikecz K. Proteoglycan-induced arthritis: immune regulation, cellular mechanisms and genetics. Crit. Rev. Immunol.23, 199–250 (2003).
   PubMed Web of Science ®Google Scholar
• Adarichev VA, Vegvari A, Szabo Z, Kis-Toth K, Mikecz K, Glant TT. Congenic strains displaying similar clinical phenotype of arthritis represent different immunologic models of inflammation. Genes Immun.9, 591–601 (2008).
   PubMedGoogle Scholar
• Glant TT, Szanto S, Vegvari A et al. Two loci on chromosome 15 control experimentally induced arthritis through the differential regulation of IL-6 and lymphocyte proliferation. J. Immunol.181, 1307–1314 (2008).
   PubMedGoogle Scholar
• Boldizsar F, Tarjanyi O, Nemeth P, Mikecz K, Glant TT. Th1/Th17 polarization and acquisition of an arthritogenic phenotype in arthritis-susceptible BALB/c, but not in MHC-matched, arthritis-resistant DBA/2 mice. Int. Immunol.21, 511–522 (2009).
   PubMed Web of Science ®Google Scholar
• Goldmann O, Lengeling A, Bose J et al. The role of the MHC on resistance to group a streptococci in mice. J. Immunol.175, 3862–3872 (2005).
   PubMedGoogle Scholar
• Nooh MM, El Gengehi N, Kansal R, David CS, Kotb M. HLA transgenic mice provide evidence for a direct and dominant role of HLA class II variation in modulating the severity of streptococcal sepsis. J. Immunol.178, 3076–3083 (2007).
   PubMedGoogle Scholar
• Grubeck-Loebenstein B, Della BS, Iorio AM, Michel JP, Pawelec G, Solana R. Immunosenescence and vaccine failure in the elderly. Aging Clin. Exp. Res.21, 201–209 (2009).
   PubMed Web of Science ®Google Scholar
• Capri M, Monti D, Salvioli S et al. Complexity of anti-immunosenescence strategies in humans. Artif. Organs30, 730–742 (2006).
   PubMed Web of Science ®Google Scholar
• Hume DA, Pavli P, Donahue RE, Fidler IJ. The effect of human recombinant macrophage colony-stimulating factor (CSF-1) on the murine mononuclear phagocyte system in vivo. J. Immunol.141, 3405–3409 (1988).
   PubMed Web of Science ®Google Scholar
• Pahlavani MA. Caloric restriction and immunosenescence: a current perspective. Front. Biosci.5, D580–D587 (2000).
   Google Scholar
• ThyagaRajan S, Felten DL. Modulation of neuroendocrine–immune signaling by L-deprenyl and L-desmethyldeprenyl in aging and mammary cancer. Mech. Ageing Dev.123, 1065–1079 (2002).
   PubMedGoogle Scholar
• Ku LT, Gercel-Taylor C, Nakajima ST, Taylor DD. Alterations of T cell activation signalling and cytokine production by postmenopausal estrogen levels. Immun. Ageing6, 1 (2009).
   PubMedGoogle Scholar
• Rai S, Haldar C, Singh R. Modulation of immunity in young-adult and aged squirrel, Funambulus pennanti by melatonin and p-chlorophenylalanine. Immun. Ageing6, 5 (2009).
   PubMedGoogle Scholar
• Kanoni S, Dedoussis GV, Herbein G et al. Assessment of gene-nutrient interactions on inflammatory status of the elderly with the use of a zinc diet score – ZINCAGE study. J. Nutr. Biochem. (2009) (Epub ahead of print).
   Google Scholar
• Varin A, Larbi A, Dedoussis GV et al.In vitro and in vivo effects of zinc on cytokine signalling in human T cells. Exp. Gerontol.43, 472–482 (2008).
   PubMedGoogle Scholar
• De Martinis M, Franceschi C, Monti D, Ginaldi L. Apoptosis remodeling in immunosenescence: implications for strategies to delay ageing. Curr. Med. Chem.14, 1389–1397 (2007).
   PubMedGoogle Scholar
• Virts EL, Phillips JA, Thoman ML. A novel approach to thymic rejuvenation in the aged. Rejuvenation Res.9, 134–142 (2006).
   PubMed Web of Science ®Google Scholar
• Yung RL, Julius A. Epigenetics, aging, and autoimmunity. Autoimmunity41, 329–335 (2008).
   PubMed Web of Science ®Google Scholar
• Wang J, Zhang S, Wang Y, Chen L, Zhang XS. Disease-aging network reveals significant roles of aging genes in connecting genetic diseases. PLoS. Comput. Biol.5(9), e1000521 (2009).
   PubMedGoogle Scholar
• de Magalhaes JP, Finch CE, Janssens G. Next-generation sequencing in aging research: emerging applications, problems, pitfalls and possible solutions. Ageing Res. Rev. DOI:10.1016/j.arr.2009.10.006 (2009) (Epub ahead of print).
   PubMedGoogle Scholar