Cognitive correlates of hypothalamic–pituitary–adrenal axis in major depression

References

• Joels M, Karst H, DeRijk R, de Kloet ER. The coming out of the brain mineralocorticoid receptor. Trends Neurosci.31(1), 1–7 (2007).
   PubMed Web of Science ®Google Scholar
• Roozendaal B, Hernandez A, Cabrera SM et al. Membrane-associated glucocorticoid activity is necessary for modulation of long-term memory via chromatin modification. J. Neurosci.30(14), 5037–5046 (2010).
   PubMed Web of Science ®Google Scholar
• Patel PD, Lopez JF, Lyons DM, Burke S, Wallace M, Schatzberg AF. Glucocorticoid and mineralocorticoid receptor mRNA expression in squirrel monkey brain. J. Psychiatr. Res.34, 383–392 (2000).
   PubMed Web of Science ®Google Scholar
• de Kloet ER, Joels M, Holsboer F. Stress and the brain: from adaptation to disease. Nat. Rev. Neurosci.6(6), 463–475 (2005).
   PubMed Web of Science ®Google Scholar
• Barden N. Implication of the hypothalamic–pituitary–adrenal axis in the physiopathology of depression. J. Psychiatry Neurosci.29(3), 185–193 (2004).
   PubMed Web of Science ®Google Scholar
• Burke HM, Davis MC, Otte C, Mohr DC. Depression and cortisol responses to psychological stress: a meta-analysis. Psychoneuroendocrinology30, 846–865 (2005).
   PubMed Web of Science ®Google Scholar
• Gold PW, Goodwin FK, Chrousos GP. Clinical and biochemical manifestations of depression. Relation to the neurobiology of stress (2). N. Engl. J. Med.319(7), 413–420 (1988).
   PubMed Web of Science ®Google Scholar
• Pariante CM, Lightman SL. The HPA axis in major depression: classical theories and new developments. Trends Neurosci.31, 464–468 (2008).
   PubMed Web of Science ®Google Scholar
• Bhagwagar Z, Hafizi S, Cowen PJ. Increased salivary cortisol after waking in depression. Psychopharmacology (Berl.)183(1), 54–57 (2005).
   PubMedGoogle Scholar
• Vreeburg SA, Hoogendijk WJG, van Pelt J et al. Major depressive disorder and hypothalamic–pituitary–adrenal axis activity – results from a large cohort study. Arch. Gen. Psychiatry66(6), 617–626 (2009).
   PubMed Web of Science ®Google Scholar
• Holsboer F. The corticosteroid receptor hypothesis of depression. NeuroPsychopharmacology23(5), 477–501 (2000).
   PubMed Web of Science ®Google Scholar
• Strickland PL, Deakin JF, Percival C, Dixon J, Gater RA, Goldberg DP. Bio-social origins of depression in the community – interactions between social adversity, cortisol and serotonin neurotransmission. Br. J. Psychiatry180, 168–173 (2002).
   PubMed Web of Science ®Google Scholar
• Wong ML, Kling MA, Munson, PJ et al. Pronounced and sustained central hypernoradrenergic function in major depression with melancholic features: Relation to hypercortisolism and corticotropin-releasing hormone. Proc. Natl Acad. Sci. USA97(1), 325–330 (2000).
   PubMed Web of Science ®Google Scholar
• Gold PW, Chrousos GP. Organization of the stress system and its dysregulation in melancholic and atypical depression: high vs low CRH/NE states. Mol. Psychiatry7, 254–275 (2002).
   PubMed Web of Science ®Google Scholar
• Gold PW, Calabrese JR, Kling MA et al.Abnormal ACTH and cortisol responses to ovine corticotropin releasing factor in patients with primary affective disorder. Prog. Neuropsychopharmacol. Biol. Psychiatry10(1), 57–65 (1986).
   PubMedGoogle Scholar
• Holsboer F, Gerken A, von Bardeleben U et al. Human corticotropin-releasing hormone in depression – correlation with thyrotropin secretion following thyrotropin-releasing hormone. Biol. Psychiatry21(7), 601–611 (1986).
   PubMed Web of Science ®Google Scholar
• Carroll BJ. Dexamethasone suppression test for depression. In: Frontiers in Biochemical and Pharmacological Research in Depression (Volume 39). Usdin E. (Ed.). Raven Press, NY, USA, 179–188 (1984).
   Google Scholar
• Appelhof BC, Huyser J, Verweij M et al. Glucocorticoids and relapse of major depression (dexamethasone/corticotropin-releasing hormone test in relation to relapse of major depression). Biol. Psychiatry59, 696–701 (2006).
   PubMed Web of Science ®Google Scholar
• Nemeroff CB, Evans DL. Correlation between the dexamethasone suppression test in depressed patients and clinical response. Am. J. Psychiatry141(2), 247–249 (1984).
   PubMedGoogle Scholar
• Zobel AW, Nickel T, Sonntag A, Uhr M, Holsboer F, Ising M. Cortisol response in the combined dexamethasone/CRH test as predictor of relapse in patients with remitted depression: a prospective study. J. Psychiatr. Res.35, 83–94 (2001).
   PubMed Web of Science ®Google Scholar
• Ising M, Horstmann S, Kloiber S et al. Combinded dexamethasone/corticotrophin releasing hormone test predicts treatment response in major depression – a potential biomarker? Biol. Psychiatry62, 47–54 (2007).
   PubMed Web of Science ®Google Scholar
• Young EA, Lopez JF, Murphy-Weinberg V, Watson SJ, Akil H. Mineralocorticoid receptor function in major depression. Arch. Gen. Psychiatry.60, 24–28 (2003).
   PubMed Web of Science ®Google Scholar
• Pariante CM, Papadopoulos AS, Poon L et al. A novel prednisolone suppression test for the hypothalamic–pituitary–adrenal axis. Biol. Psychiatry51, 922–930 (2002).
   PubMedGoogle Scholar
• Juruena MF, Cleare AJ, Papadopoulos AS, Poon L, Lightman S, Pariante CM. Different responses to dexamethasone and prednisolone in the same depressed patients. Psychopharmacology (Berl.)189, 225–235 (2006).
   PubMed Web of Science ®Google Scholar
• Juruena MF, Pariante CM, Papadopoulos A, Cleare AJ. The development and application of the prednisolone suppression test in psychiatry: a novel tool for assessing glucocorticoid and mineralocorticoid receptor function. Mind & Brain, J. Psych.1(1), 115–122 (2010).
   Google Scholar
• Nemeroff CB, Widerlov E, Bisette G et al. Elevated concentrations of CSF corticotropin-releasing factor-like immunoreactivity in depressed patients. Science226, 1342–1343 (1984).
   PubMed Web of Science ®Google Scholar
• Calfa G, Kademian S, Ceschin D, Vega G, Rabinovich GA, Volosin M. Characterization and functional significance of glucocorticoid receptors in patients with major depression: modulation by antidepressant treatment. Psychoneuroendocrinology28, 687–701 (2003).
   PubMed Web of Science ®Google Scholar
• Webster MJ, Knable MB, O’ Grady J, Orthmann J, Weickert CS. Regional specifity of brain glucocorticoid receptor mRNA alterations in subjects with schizophrenia and mood disorders. Mol. Psychiatry7, 985–994 (2002).
   PubMed Web of Science ®Google Scholar
• Ranga K, Krishnan R, Doraiswamy PM et al. Pituitary size in depression. J. Clin. Endocrinol. Metab.72, 256–259 (1991).
   PubMedGoogle Scholar
• Nemeroff CB, Krishnan KRR, Reed D, Leder R, Beam C, Dunnick R. Adrenal gland enlargement in major depression. Arch. Gen. Psychiatry.49, 384–387 (1992).
   PubMed Web of Science ®Google Scholar
• De Kloet ER, Vreugdenhil E, Oitzl MS, Joels M. Brain corticosteroid receptor balance in health and disease. Endocr. Rev.19(3), 269–301 (1988).
   Google Scholar
• De Kloet ER, DeRijk RH, Meijer OC. Therapy insight: is there an imbalanced response of mineralocorticoid and glucocorticoid receptors in depression? Nat. Clin. Pract. Endocrinol. Metab.3(2), 168–179 (2007).
   PubMedGoogle Scholar
• Van Rossum EFC, Binder EB, Majer M et al. Polymorphisms of the glucocorticoid receptor gene and major depression. Biol. Psychiatry59, 681–688 (2006).
   PubMed Web of Science ®Google Scholar
• Otte C, Wüst S, Zhao S, Pawlikowska L, Kwok PY, Whooley MA. Glucocorticoid receptor gene and depression in patients with coronary heart disease: the heart and soul study – 2009 Curt Richter Award Winner. Psychoneuroendocrinology34(10), 1574–1581 (2009).
   PubMedGoogle Scholar
• Kuningas M, de Rijk RH, Westendorp RG, Jolles J, Slagboom PE, van Heemst D. Mental performance in old age dependent on cortisol and genetic variance in the mineralocorticoid and glucocorticoid receptors. NeuroPsychopharmacology32, 1295–1301 (2007).
   PubMedGoogle Scholar
• American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders (DSM-IV). 4th edition. American Psychiatric Publishing, Washington, DC, USA (1994).
   Google Scholar
• Beblo T, Lautenbacher S. [Neuropsychology of depression]. Hogrefe, Göttingen, Germany (2006).
   Google Scholar
• Chamberlain SR, Sahakian BJ. The neuropsychology of mood disorders. Curr. Psychiatry Rep.8, 458–463 (2006).
   PubMedGoogle Scholar
• Porter RJ, Bourke C, Gallagher P. Neuropsychological impairment in major depression: its nature, origin and clinical significance. Aust. NZ J. Psychiatry41, 115–128 (2007).
   PubMed Web of Science ®Google Scholar
• Christensen H, Griffiths K, Mackinnon A, Jacomb P. A quantitative review of cognitive deficits in depression and Alzheimer-type dementia. J. Int. Neuropsychol. Soc.3(6), 631–651 (1997).
   PubMedGoogle Scholar
• Leppanen JM. Emotional information processing in mood disorders: a review of behavioral and neuroimaging findings. Curr. Opin Psychiatry19(1), 34–39 (2006).
   PubMed Web of Science ®Google Scholar
• Henry J, Crawford JR. A meta-analytic review of verbal fluency deficits in depression. J. Clin. Exp. Neuropsychol.27(1), 78–101 (2005).
   PubMed Web of Science ®Google Scholar
• Gorwood P, Corruble E, Falissard B, Goodwin GM. Toxic effects of depression on brain function: impairment of delayed recall and the cumulative length of depressive disorder in a large sample of depressed outpatients. Am. J. Psychiatry165(6), 731–739 (2008).
   PubMed Web of Science ®Google Scholar
• Williams JMG, Barnhofer T, Crane C et al. Autobiographical memory specifity and emotional disorder. Psychol. Bull.133(1), 122–148 (2007).
   PubMed Web of Science ®Google Scholar
• Gualtieri CT, Johnson LG. Age-related cognitive decline in patients with mood disorders. Prog. Neuropsychopharmacol. Biol. Psychiatry32(4), 962–967 (2008).
   PubMed Web of Science ®Google Scholar
• Douglas KM, Porter R J. Longitudinal assessment of neuropsychological function in major depression. Aust. NZ J. Psychiatry43(12), 1105–1117 (2009).
   PubMed Web of Science ®Google Scholar
• Drevets WC, Price JL, Furey ML. Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression. Brain Struct. Funct.213(1–2), 93–118 (2008).
   PubMed Web of Science ®Google Scholar
• Lorenzetti V, Allen NB, Fornito A, Yucel M. Structural brain abnormalities in major depressive disorder: a selective review of recent MRI studies. J. Affect. Disord.117(1–2), 1–17 (2009).
   PubMed Web of Science ®Google Scholar
• de Kloet ER, Oitzl MS, Joels M. Stress and cognition: are corticosteroids good or bad guys? Trends Neurosci.22(10), 422–426 (1999).
   PubMed Web of Science ®Google Scholar
• Belanoff JK, Gross K, Yager A, Schatzberg AF. Corticosteroids and cognition. J. Psychatr. Res.35, 127–145 (2001).
   PubMed Web of Science ®Google Scholar
• de Quervain JF, Aerni A, Schelling G, Roozendaal B. Glucocorticoids and the regulation of memory in health and disease. Front. Neuroendocrinol.30, 358–370 (2008).
   Google Scholar
• Het S, Ramlow G, Wolf OT. A meta-analytic review of the effects of acute cortisol administration on human memory. Psychoneuroendocrinology30, 771–784 (2005).
   PubMed Web of Science ®Google Scholar
• Lupien SJ, Maheu F, Tu M, Fiocco A, Schramek TE. The effects of stress and stress hormones on human cognition: implications for the field of brain and cognition. Brain Cogn.65, 209–237 (2007).
   PubMed Web of Science ®Google Scholar
• Sandi C, Pinelo-Nava MT. Stress and memory: behavioural effects and neurobiological mechanisms. Neural Plast.1–20 (2007).
   Google Scholar
• Joels M, Pu Z, Wiegert O, Oitzl MS, Krugers HJ. Learning under stress: how does it work? Trends Cogn. Sci.10, 152–158 (2006).
   PubMed Web of Science ®Google Scholar
• Roozendaal B. Stress and memory: opposing effects of glucocorticoids on memory consolidation and memory retrieval. Neurobiol. Learn. Mem.78, 578–595 (2002).
   PubMed Web of Science ®Google Scholar
• Wolf OT. Stress and memory in humans: twelve years of progress? Brain Res.1293, 142–154 (2009).
   PubMed Web of Science ®Google Scholar
• Wolf OT. The influence of stress hormones on emotional memory: relevance for psychopathology. Acta Psychol. (Amst.)127(3), 513–531 (2008).
   PubMed Web of Science ®Google Scholar
• Tulving E. Organization of memory: quo vadis? In: The Cognitive Neurosciences. Gazzangia MS (Ed.). MIT Press, Cambridge, UK, 839–847 (1995).
   Google Scholar
• Baddeley A. Working memory. Science255, 556–559 (1992).
   PubMed Web of Science ®Google Scholar
• Newcomer JW, Sella H, Melson AK. Decreased memory performance in healthy humans induced by stress-level cortisol treatment. Arch. Gen. Psychiatry56, 527–533 (1999).
   PubMed Web of Science ®Google Scholar
• Newcomer JW, Craft S, Hershey T, Askins K, Bardgett ME. Glucocorticoid-induced impairment in declarative memory performance in adult humans. J. Neurosci.14(4), 2047–2053 (1994).
   PubMed Web of Science ®Google Scholar
• Kirschbaum C, Wolf OT, May M, Wippich W, Hellhammer DH. Stress- and treatment-induced elevations of cortisol levels associated with impaired declarative memory in healthy adults. Life Sciences58(17), 1475–1483 (1996).
   PubMed Web of Science ®Google Scholar
• Wolf OT, Convit A, McHugh PF et al. Cortisol differentially affects memory in young and elderly men. Behav. Neurosci.115(5), 1002–1011 (2001).
   PubMed Web of Science ®Google Scholar
• Buchanan TW, Lovallo WR. Enhanced memory for emotional material following stress-level cortisol treatment in humans. Psychoneuroendocrinology26, 307–317 (2001).
   PubMed Web of Science ®Google Scholar
• Cahill L, Gorski L, Le K. Enhanced human memory consolidation with post-learning stress: interaction with the degree of arousal at encoding. Learn. Mem.10, 270–274 (2003).
   PubMed Web of Science ®Google Scholar
• Kuhlmann S, Wolf OT. Arousal and cortisol interact in modulating memory consolidation in healthy young men. Behav. Neurosci.120, 217–223 (2006).
   PubMed Web of Science ®Google Scholar
• Abercrombie HC, Kalin NH, Thurow ME, Rosenkranz MA, Davidson RJ. Cortisol variation in humans affects memory for emotionally laden and neutral information. Behav. Neurosci.117, 505–516 (2003).
   PubMed Web of Science ®Google Scholar
• Rimmele U, Domes G, Mathiak K, Hautzinger M. Cortisol has different effects on human memory for emotional and neutral stimuli. Neuroreport14, 2485–2488 (2003).
   PubMed Web of Science ®Google Scholar
• Lupien S, Gillin CJ, Hauger RL. Working memory is more sensitive than declarative memory to the acute effects of corticosteroids: a dose–response study in humans. Behav. Neurosci.113(3), 420–430 (1999).
   PubMed Web of Science ®Google Scholar
• Young AH, Sahakian BJ, Robbins TW. The effects of chronic administration of hydrocortisone on cognitive function in normal volunteers. Psychopharmacology145, 260–266 (1999).
   PubMed Web of Science ®Google Scholar
• Schoofs D, Preuss D, Wolf OT. Psychosocial stress induces working memory impairments in an n-back paradigm. Psychoneuroendocrinology33, 643–653 (2008).
   PubMed Web of Science ®Google Scholar
• Kuhlmann S, Kirschbaum C, Wolf OT. Effects of oral cortisol treatment in healthy young women on memory retrieval of negative and neutral words. Neurobiol. Learn. Mem.83, 158–162 (2005).
   PubMed Web of Science ®Google Scholar
• Kuhlmann S, Piel M, Wolf OT. Impaired memory retrieval after psychosocial stress in healthy young men. J. Neurosci.25(11), 2977–2982 (2005).
   PubMed Web of Science ®Google Scholar
• Buss C, Wolf OT, Witt J, Hellhammer DH. Autobiographic memory impairment following acute cortisol administration. Psychoneuroendocrinology29, 1093–1096 (2004).
   PubMed Web of Science ®Google Scholar
• Roozendaal B, Okuda S, de Quervain DJ, McGaugh JL. Glucocorticoids interact with emotion-induced noradrenergic activation in influencing different memory functions. Neuroscience138, 901–910 (2006).
   PubMed Web of Science ®Google Scholar
• Pavlides C, Watanabe Y, McEwen BS. Effects of glucocorticoids on hippocampal long-term potentiation. Hippocampus3, 183–192 (1993).
   PubMed Web of Science ®Google Scholar
• de Quervain DJ, Henke K, Aerni A et al. Glucocorticoid-induced impairment of declarative memory retrieval is associated with reduced blood flow in the medial temporal lobe. Eur. J. Neurosci.17, 1296–1302 (2003).
   PubMed Web of Science ®Google Scholar
• Oei NYL, Elzinga BM, Wolf OT et al. Glucocorticoids decrease hippocampal and prefrontal activation during declarative memory retrieval in young men. Brain Imaging Behav.1, 31–41 (2007).
   PubMed Web of Science ®Google Scholar
• Dantzer R, O’Connor JC, Freund GG, Johnson RW, Kelley KW. From inflammation to sickness and depression: when the immune system subjugates the brain. Nat. Rev. Neurosci.9, 46–56 (2008).
   PubMed Web of Science ®Google Scholar
• Herbert J, Goodyer IM, Grossman AB et al. Do corticosteroids damage the brain? J. Neuroendocrinol.18, 393–411 (2006).
   PubMed Web of Science ®Google Scholar
• Vythilingam M, Heim C, Newport J et al. Childhood trauma associated with smaller hippocampal volume in women with major depression. Am. J. Psychiatry159(12), 2072–2080 (2002).
   PubMed Web of Science ®Google Scholar
• Sheline YI, Sanghavi M, Mintun MA, Gado MH. Depression duration but not age predicts hippocampal volume loss in medically healthy women with major depression. J. Neurosci.19, 5034–5043 (1999).
   PubMed Web of Science ®Google Scholar
• Sheline YI, Wang PW, Gado MH, Csernansky JG, Vannier MW. Hippocampal atrophy in recurrent major depression. Proc. Natl Acad. Sci. USA93(9), 3908–3913 (1996).
   PubMed Web of Science ®Google Scholar
• Paizanis E, Hamon M, Lanfumey L. Hippocampal neurogenesis, depressive disorders, and antidepressant therapy. Neural Plast.737–754 (2007).
   Google Scholar
• Becker S, Macqueen G, Wojtowicz JM. Computational modeling and empirical studies of hippocampal neurogenesis-dependent memory: effects of interference, stress and depression. Brain Res.1299, 45–54 (2009).
   PubMed Web of Science ®Google Scholar
• Kelly WF, Checkley SA, Bender DA, Mashiter K. Cushing’s syndrome and depression – a prospective study of 26 patients. Br. J. Psychiatry142, 16–19 (1983).
   PubMed Web of Science ®Google Scholar
• Starkman MN, Giordani B, Berent S, Schork MA, Schteingart DE. Elevated cortisol levels in Cushing’s disease are associated with cognitive decrements. Psychosom. Med.63, 985–993 (2001).
   PubMed Web of Science ®Google Scholar
• Bremner JD, Vythilingam M, Vermetten E, Anderson G, Newcomer JW, Charney DS. Effects of glucocorticoids on declarative memory function in major depression. Biol. Psychiatry55, 811–815 (2004).
   PubMed Web of Science ®Google Scholar
• Schlosser N, Wolf OT, Carvalho Fernando S et al. Effects of acute cortisol administration on autobiographical memory in patients with major depression and healthy controls. Psychoneuroendocrinology35, 316–320 (2010).
   PubMed Web of Science ®Google Scholar
• Rubinow DR, Post RM, Savard R, Gold PW. Cortisol hypersecretion and cognitive impairment in depression. Arch. Gen. Psychiatry41, 279–283 (1984).
   PubMed Web of Science ®Google Scholar
• Wauthy J, Ansseau M, von Frenckell R, Mormont C, Legros JJ. Memory disturbances and dexamethasone suppression test in major depression. Biol. Psychiatry30, 736–738 (1991).
   PubMed Web of Science ®Google Scholar
• Sikes CR, Stokes PE, Lasley BJ. Cognitive sequelae of hypothalamic–pituitary–adrenal (HPA) dysregulation in depression. Biol. Psychiatry25, 148A–152A (1989).
   Google Scholar
• Egeland J, Lund A, Landro NI et al. Cortisol level predicts executive and memory function in depression, symptom level predicts psychomotor speed. Acta Psychiatr. Scand.112, 434–441 (2005).
   PubMed Web of Science ®Google Scholar
• Gomez R, Fleming SH, Keller J et al. The neuropsychological profile of psychotic major depression and its relation to cortisol. Biol. Psychiatry60, 472–478 (2006).
   PubMed Web of Science ®Google Scholar
• van Londen L, Goekoop JG, Zwindermann AH, Lanser JBK, Wiegant VM, de Wied D. Neuropsychological performance and plasma cortisol, arginine vasopressin and oxytocin in patients with major depression. Psychol. Med.28, 275–284 (1998).
   PubMedGoogle Scholar
• Michopoulos I, Zervas IM, Pantelis C et al. Neuropsychological and hypothalamic–pituitary-axis function in female patients with melancholic and non-melancholic depression. Eur. Arch. Psychiatry Clin. Neurosci.258, 217–225 (2008).
   PubMed Web of Science ®Google Scholar
• Belanoff JK, Kalehzan M, Sund B, Fleming Ficek SK, Schatzberg, AF. Cortisol activity and cognitive changes in psychotic major depression. Am. J. Psychiatry158, 1612–1616 (2001).
   PubMed Web of Science ®Google Scholar
• Barnhofer T, Kuehn EM, de Jong-Meyer R. Specifity of autobiographical memories and basal cortisol levels in patients with major depression. Psychoneuroendocrinology30, 403–411 (2005).
   PubMed Web of Science ®Google Scholar
• den Hartog M, Nicolson NA, Derix MMA, van Bemmel AL, Kremer B, Jolles J. Salivary cortisol patterns and cognitive speed in major depression: a comparison with allergic rhinitis and healthy control subjects. Biol. Psychol.63, 1–14 (2003).
   PubMed Web of Science ®Google Scholar
• Gomez RG, Posener JA, Keller J, DeBattista C, Solvason B, Schatzberg AF. Effects of major depression diagnosis and cortisol levels on indices of neurocognitive function. Psychoneuroendocrinology34, 1012–1018 (2009).
   PubMed Web of Science ®Google Scholar
• Hinkelmann K, Moritz S, Botzenhardt J et al. Cognitive impairment in major depression: association with salivary cortisol. Biol. Psychiatry66, 879–885 (2009).
   PubMed Web of Science ®Google Scholar
• Mannie ZN, Barnes J, Bristow GC, Harmer CJ, Cowen PJ. Memory impairment in young women at increased risk of depression: influence of cortisol and 5-HTT genotype. Psychol. Med.39, 757–762 (2009).
   PubMed Web of Science ®Google Scholar
• Holsboer F, Lauer CJ, Schreiber W, Krieg JC. Altered hypothalamic–pituitary–adrenocortical regulation in healthy subjects at high familial risk for affective disorders. Neuroendocrinology62, 340–347 (1995).
   PubMed Web of Science ®Google Scholar
• Modell S, Lauer CJ, Schreiber W, Huber J, Krieg JC, Holsboer F. Hormonal response pattern in the combined DEX-CRH test is stable over time in subjects at high familial risk for affective disorders. Neuropsychopharmacology18, 253–262 (1998).
   PubMed Web of Science ®Google Scholar
• Vythilingam M, Vermetten E, Anderson GM et al. Hippocampal volume, memory, and cortisol status in major depressive disorder: effects of treatment. Biol. Psychiatry56, 101–112 (2004).
   PubMed Web of Science ®Google Scholar
• Brown WA, Qualls CB. Pituitary–adrenal disinhibition in depression: marker of a subtype with characteristic clinical features and response to treatment? Psychiatr. Res.4, 115–128 (1981).
   PubMedGoogle Scholar
• Winokur G, Black DW, Nasrallah A. DST nonsuppressor status: relationship to specific aspects of the depressive syndrome. Biol. Psychiatry22, 360–368 (1987).
   PubMedGoogle Scholar
• Caine ED, Yerevanian BI, Bamford KA. Cognitive function and the dexamethasone suppression test in depression. Am. J. Psychiatry141, 116–118 (1984).
   PubMedGoogle Scholar
• Wolkowitz OM, Reus VI, Weingartner H et al. Cognitive effects of corticosteroids. Am. J. Psychiatry147, 1297–1303 (1990).
   PubMed Web of Science ®Google Scholar
• Zobel AW, Schulze-Rauschenbach S, von Widdern OC et al. Improvement of working but not declarative memory is correlated with HPA normalization during antidepressant treatment. J. Psychiatr. Res.38, 377–383 (2004).
   PubMed Web of Science ®Google Scholar
• Reppermund S, Zihl J, Lucae S. Persistent cognitive impairment in depression: the role of psychopathology and altered hypothalamic–pituitary–adrenocortical (HPA) system regulation. Biol. Psychiatry62, 400–406 (2007).
   PubMed Web of Science ®Google Scholar
• Juruena MF, Pariante CM, Papadopoulos AS, Poon L, Lightman S, Cleare AJ. Prednisolone suppression test in depression: prospective study of the role of HPA axis dysfunction in treatment resistance. Br. J. Psychiatry194(4), 342–349 (2009).
   PubMed Web of Science ®Google Scholar
• Kaufmann J, Charney D. Effects of early stress on brain structure and function: implications for understanding the relationship between child maltreatment and depression. Dev. Psychopathol.13, 451–471 (2001).
   PubMedGoogle Scholar
• Hammen CL. Stress and depression. In: Annual Review of Clinical Psychiatry (Volume 1). Annual Reviews, Palo Alto, CA, USA, 293–319 (2005).
   Google Scholar
• Monroe SM, Hadjiyannakis KL. The social environment and depression: focusing on severe life stress. In: Handbook of Depression. Gotlib IH, Hammen CL (Eds). Guilford Press, NY, USA, 314–340 (2002).
   Google Scholar
• Starkman MN, Schteingart DE, Schork MA. Cushing’s syndrome after treatment: changes in cortisol and ACTH levels, and amelioration of the depressive syndrome. Psychiatry Res.19, 177–188 (1986).
   PubMed Web of Science ®Google Scholar
• Berton O, Nestler EJ. New approaches to antidepressant drug discovery: beyond monoamines. Nat. Neurosci.7, 137–151 (2006).
   Web of Science ®Google Scholar
• Kling MA, Coleman VH, Schulkin J. Glucocorticoid inhibition in the treatment of depression: can we think outside the endocrine hypothalamus? Depress. Anxiety26, 641–649 (2009).
   PubMed Web of Science ®Google Scholar
• Porter RJ, Gallagher P. Abnormalities of the HPA axis in affective disorders: clinical subtypes and potential treatments. Acta Neuropsychiatrica18, 193–209 (2006).
   PubMed Web of Science ®Google Scholar
• Schüle C, Baghai TC, Eser D, Rupprecht R. Hypothalamic–pituitary–adrenocortical system dysregulation and new treatment strategies in depression. Expert Rev. Neurother.9(7), 1005–1019 (2009).
   PubMed Web of Science ®Google Scholar
• Thomson F, Craighead M. Innovative approaches for the treatment of depression: targeting the HPA axis. Neurochem. Res.33, 691–707 (2008).
   PubMed Web of Science ®Google Scholar
• Gallagher P, Malik N, Newham J, Young AH, Ferrier IN, Mackin P. Antiglucocorticoid treatments for mood disorders. Cochrane Database Syst. Rev.1, CD005168 (2008).
   Google Scholar
• Young AH, Gallagher P, Watson S, Del-Estal D, Owen BM, Ferrier IN. Improvements in neurocognitive function and mood following adjunctive treatment with mifepristone (RU-486) in bipolar disorder. Neuropsychopharmacology29, 1538–1545 (2004).
   PubMed Web of Science ®Google Scholar
• Mason BL, Pariante CM. The effects of antidepressants on the hypothalamic–pituitary–adrenal axis. Drug News Perspect.19(10), 603–608 (2006).
   PubMedGoogle Scholar
• Schüle C. Neuroendocrinological mechanisms of actions of antidepressant drugs. J. Neuroendocrinol.19, 213–226 (2006).
   Google Scholar
• Brady LS, Whitfield HJ Jr, Fox RJ, Gold PW, Herkenham M. Long-term antidepressant administration alters corticotropin-releasing hormone, tyrosine hydroxylase, and mineralocorticoid receptor gene expression in rat brain. Therapeutic implications. J. Clin. Invest.87, 831–837 (1991).
   PubMed Web of Science ®Google Scholar
• Seckl JR, Fink G. Antidepressants increase glucocorticoid and mineralocorticoid receptor mRNA expression in rat hippocampus in vivo.Neuroendocrinology55, 621–626 (1992).
   PubMed Web of Science ®Google Scholar
• Reul JM, Stee I, Soder M, Holsboer F. Chronic treatment of rats with the antidepressant amitriptyline attenuates the activity of the hypothalamic–pituitary–adrenocortical system. Endocrinology133, 312–320 (1993).
   PubMed Web of Science ®Google Scholar
• Reul JM, Labeur MS, Grigoriadis DE, De Souza EB, Holsboer F. Hypothalamic–pituitary–adrenocortical axis changes in the rat after long-term treatment with the reversible monoamine oxidase-A inhibitor moclobemide. Neuroendocrinology60, 509–519 (1994).
   PubMed Web of Science ®Google Scholar
• Yau JL, Olsson T, Morris RG, Meaney MJ, Seckl JR. Glucocorticoids, hippocampal corticoid receptor gene expression and antidepressant treatment: relationship with spatial learning in young and aged rats. Neuroscience66, 571–581 (1995).
   PubMed Web of Science ®Google Scholar
• Carvalho LA, Pariante CM. In vitromodulation of the glucocorticoid receptor by antidepressants. Stress11(6), 411–424 (2008).
   PubMed Web of Science ®Google Scholar
• Otte C, Hinkelmann K, Moritz S. Modulation of the mineralocorticoid receptor as add-on treatment in depression: a randomized, double blind, placebo-controlled proof-of-concept study. J. Psychiatr. Res.44(6), 339–346 (2010).
   PubMed Web of Science ®Google Scholar
• Juruena MF, Gama CS, Berk M, Belmonte-de-Abreu PS. Improved stress response in bipolar affective disorder with adjunctive spironolactone (mineralocorticoid receptor antagonist): case series. J. Psychopharmacol.23, 985–987 (2009).
   PubMedGoogle Scholar
• López JF, Chalmers DT, Little KY, Watson SJ. Regulation of serotonin 1A, glucocorticoid, and mineralocorticoid receptor in rat and human hippocampus: implications for the neurobiology of depression. Biol. Psychiatry43, 547–573 (1998).
   PubMed Web of Science ®Google Scholar
• McKay MS, Zakzanis KK. The impact of treatment on HPA axis activity in unipolar major depression. J. Psychiatr. Res.44, 183–192 (2010).
   PubMed Web of Science ®Google Scholar
• Young EA, Abelson JL, Cameron OG. Effect of comorbid anxiety disorders on the hypothalamic–pituitary–adrenal axis response to a social stressor in major depression. Biol. Psychiatry56, 113–120 (2004).
   PubMed Web of Science ®Google Scholar
• Watson S, Gallagher P, Del-Estal D, Hearn A, Ferrier IN, Young AH. Hypothalamic–pituitary–adrenal axis function in patients with chronic depression. Psychol. Med.32, 1021–1028 (2002).
   PubMed Web of Science ®Google Scholar
• Nemeroff CB, Heim CM, Thase ME et al. Differential responses to psychotherapy versus pharmacotherapy in patients with chronic forms of major depression and childhood trauma. PNAS100(24), 14293–14296 (2003).
   PubMed Web of Science ®Google Scholar
• Heim C, Plotsky PM, Nemeroff CB. Importance of studying the contributions of adverse early experience to neurobiological findings in depression. Neuropsychopharmacology29, 641–648 (2004).
   PubMed Web of Science ®Google Scholar
• Heim C, Mletzko T, Purselle D, Musselman DL, Nemeroff CB. The dexamethasone/corticotrophin-releasing factor test in men with major depression: role of childhood trauma. Biol. Psychiatry63(4), 398–405 (2008).
   PubMed Web of Science ®Google Scholar
• Adam EK, Hawkley LC, Kudielka BM, Cacioppo JT. Day-to-day dynamics of experience cortisol associations in a population-based sample of older adults. Proc. Natl Acad. Sci. USA103, 17058–17063 (2006).
   PubMed Web of Science ®Google Scholar
• Adam EK, Sutton JM, Doane LD, Mineka S. Incorporating hypothalamic–pituitary–adrenal axis measures into preventive interventions for adolescent depression: are we there yet? Dev. Psychopathol.20, 975–1001 (2008).
   PubMed Web of Science ®Google Scholar
• Hawley LL, Ho MHR, Zuroff DC, Blatt SJ. Stress reactivity following brief treatment for depression: differential effects of psychotherapy and medication. J. Consult. Clin. Psychol.75(2), 244–256 (2007).
   PubMed Web of Science ®Google Scholar
• Thase ME, Dubé S, Bowler K et al. Hypothalamic–pituitary–adrenocortical acitivity and response to cognitive behaviour therapy in unmedicated, hospitalized depressed patients. Am. J. Psychiatry153(7), 886–891 (1996).
   PubMedGoogle Scholar
• Schwabe L, Wolf OT. Stress prompts habit behavior in humans. J. Neurosci.29(22), 7191–7198 (2009).
   PubMed Web of Science ®Google Scholar
• Yang TT, Hsiao FH, Wang KC et al. The effect of psychotherapy added to pharmacotherapy on cortisol responses in outpatients with major depressive disorder. J. Nerv. Ment. Dis.197(6), 401–406 (2009).
   PubMedGoogle Scholar
• Heinrichs M, Baumgartner T, Kirschbaum C, Ehlert U. Social support and oxytocin interact to suppress cortisol and subjective responses to psychosocial stress. Biol. Psychiatry54, 1389–1398 (2003).
   PubMed Web of Science ®Google Scholar
• Kirschbaum C, Klauer T, Filipp SH, Hellhammer DH. Sex-specific effects of social support on cortisol and subjective responses to acute psychosocial stress. Psychosom. Med.57, 23–31 (1995).
   PubMed Web of Science ®Google Scholar
• Gaab J, Blattler N, Menzi T, Pabst B, Stoyer S, Ehlert U. Randomized controlled evaluation of the effects of cognitive-behavioral stress management on cortisol responses to acute stress in healthy subjects. Psychoneuroendocrinology28, 767–779 (2003).
   PubMed Web of Science ®Google Scholar
• Hammerfald K, Eberle C, Grau M, Kinsperger A, Zimmermann A, Ehlert U. Persistent effects of cognitive-behavioral stress management on cortisol responses to acute stress in healthy subjects – a randomized controlled trial. Psychoneuroendocrinology31, 333–339 (2006).
   PubMed Web of Science ®Google Scholar
• Ursin H, Erikson HR. The cognitive activation theory of stress. Psychoneuroendocrinology29, 567–592 (2004).
   PubMed Web of Science ®Google Scholar