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Review

Amyloid and the GI tract

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Pages 615-630 | Published online: 10 Jan 2014

References

  • Merlini G, Bellotti V. Molecular mechanisms of amyloidosis. N. Engl. J. Med.349(6), 583–596 (2003).
  • Pepys MB. Amyloidosis. Annu. Rev. Med.57, 223–241 (2006).
  • Pepys MB. Pathogenesis, diagnosis and treatment of systemic amyloidosis. Philos. Trans. R. Soc. Lond. B.356(1406), 203–210 (2001).
  • Ihse E, Ybo A, Suhr O, Lindqvist P, Backman C, Westermark P. Amyloid fibril composition is related to the phenotype of hereditary transthyretin V30M amyloidosis. J. Pathol.216(2), 253–261 (2008).
  • Kyle RA, Gertz MA. Primary systemic amyloidosis: clinical and laboratory features in 474 cases. Semin. Hematol.32(1), 45–59 (1995).
  • Kyle RA, Linos A, Beard CM et al. Incidence and natural history of primary systemic amyloidosis in Olmsted County, Minnesota, 1950 through 1989. Blood79(7), 1817–1822 (1992).
  • Kyle RA, Therneau TM, Rajkumar SV et al. A long-term study of prognosis in monoclonal gammopathy of undetermined significance. N. Engl. J. Med.346(8), 565–569 (2002).
  • Dubrey SW, Cha K, Anderson J et al. The clinical features of immunoglobulin light-chain (AL) amyloidosis with heart involvement. QJM91(2), 141–157 (1998).
  • Lovat LB, Pepys MB, Hawkins PN. Amyloid and the gut. Dig. Dis.15(3), 155–171 (1997).
  • Park MA, Mueller PS, Kyle RA, Larson DR, Plevak MF, Gertz MA. Primary (AL) hepatic amyloidosis: clinical features and natural history in 98 patients. Medicine (Baltimore)82(5), 291–298 (2003).
  • Hawkins PN. Systemic amyloidosis. In: Clinical Gastroenterology and Hepatology (1st Edition). Weinstein WM, Hawkey CJ, Bosch J (Eds). Elsevier Health Sciences, PA, USA, 853–858 (2005).
  • Lachmann HJ, Goodman HJ, Gilbertson JA et al. Natural history and outcome in systemic AA amyloidosis. N. Engl. J. Med.356(23), 2361–2371 (2007).
  • Urieli-Shoval S, Linke RP, Matzner Y. Expression and function of serum amyloid A, a major acute-phase protein, in normal and disease states. Curr. Opin. Hematol.7(1), 64–69 (2000).
  • Gillmore JD, Lovat LB, Persey MR, Pepys MB, Hawkins PN. Amyloid load and clinical outcome in AA amyloidosis in relation to circulating concentration of serum amyloid A protein. Lancet358(9275), 24–29 (2001).
  • Lovat LB, Persey MR, Madhoo S, Pepys MB, Hawkins PN. The liver in systemic amyloidosis: insights from 123I serum amyloid P component scintigraphy in 484 patients. Gut42(5), 727–734 (1998).
  • Suhr O, Danielsson A, Holmgren G, Steen L. Malnutrition and gastrointestinal dysfunction as prognostic factors for survival in familial amyloidotic polyneuropathy. J. Intern. Med.235(5), 479–485 (1994).
  • Benson MD. Ostertag revisited: the inherited systemic amyloidoses without neuropathy. Amyloid12(2), 75–87 (2005).
  • Westermark P, Sletten K, Johansson B, Cornwell GG 3rd. Fibril in senile systemic amyloidosis is derived from normal transthyretin. Proc. Natl Acad. Sci. USA87(7), 2843–2845 (1990).
  • Matsutani H, Hoshii Y, Setoguchi M et al. Vascular amyloid of unknown origin and senile transthyretin amyloid in the lung and gastrointestinal tract of old age: histological and immunohistochemical studies. Pathol. Int.51(5), 326–332 (2001).
  • Laeng RH, Altermatt HJ, Scheithauer BW, Zimmermann DR. Amyloidomas of the nervous system: a monoclonal B-cell disorder with monotypic amyloid light chain λ amyloid production. Cancer82(2), 362–374 (1998).
  • Kyle RA, Gertz MA, Lacy MQ, Dispenzieri A. Localized AL amyloidosis of the colon: an unrecognized entity. Amyloid10(1), 36–41 (2003).
  • Bartels H, Dikkers FG, van der Wal JE, Lokhorst HM, Hazenberg BP. Laryngeal amyloidosis: localized versus systemic disease and update on diagnosis and therapy. Ann. Otol. Rhinol. Laryngol.113(9), 741–748 (2004).
  • Prokaeva T, Spencer B, Kaut M et al. Soft tissue, joint and bone manifestations of AL amyloidosis: clinical presentation, molecular features, and survival. Arthritis Rheum.56(11), 3858–3868 (2007).
  • Tabbarah K, Maddden J, Bedlack RS. Dysarthria and dysphagia from light chain amyloidosis. Neurology65(10), 1671 (2005).
  • Kiuru S, Nieminen T, Partinen M. Obstructive sleep apnoea syndrome in hereditary gelsolin-related amyloidosis. J. Sleep Res.8(2), 143–149 (1999).
  • Stoopler ET, Alawi F, Laudenbach JM, Sollecito TP. Bullous amyloidosis of the oral cavity: a rare clinical presentation and review. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod.101(6), 734–740 (2006).
  • Koloktronis A, Chatzigiannis I, Paloukidou N. Oral involvement in a case of AA amyloidosis. Oral Dis.9(5), 269–272 (2003).
  • Gogel HK, Searles RP, Volpicelli NA, Cornwell GG 3rd. Primary amyloidosis presenting as Sjögren’s syndrome. Arch. Intern. Med.143(12), 2325–2326 (1983).
  • Rubrinow A, Burakoff R, Cohen AS, Harris LD. Esophageal manometry in systemic amyloidosis. A study of 30 patients. Am. J. Med.75(6), 951–956 (1983).
  • Burakoff R, Rubinow A, Cohen AS. Esophageal manometry in familial amyloid polyneuropathy. Am. J. Med.79(1), 85–89 (1985).
  • Bjerle P, Ek B, Linderholm H, Steen L. Oesophageal dysfunction in familial amyloidosis with polyneuropathy. Clin. Physiol.13(1), 57–69 (1993).
  • Battle WM, Rubin MR, Cohen S, Snape WJ Jr. Gastrointestinal-motility dysfunction in amyloidosis. N. Engl. J. Med.301(1), 24–25 (1979).
  • Suris X, Moyà F, Panés J, del Olmo JA, Solé M, Munoz-Gómez J. Achalasia of the esophagus in secondary amyloidosis Am. J. Gastroenterol.88(11), 1959–1960 (1993).
  • Melkebeke P, Vandepitte J, Hannon R, Fevery J. Huge hepatomegaly, jaundice and portal hypertension due to amyloidosis of the liver. Digestion20(5), 351–357 (1980).
  • Menke DM, Kyle RA, Fleming CR, Wolfe JT 3rd, Kurtin PJ, Oldenburg WA. Symptomatic gastric amyloidosis in patients with primary systemic amyloidosis. Mayo Clin. Proc.68(8), 763–767 (1993).
  • Youssef N, Carbonell N, Bonte H, Serfaty L, Poupon R, Fléjou JF. Fatal Dieulafoy’s type ulcer in a case of gastric AL-amyloidosis. Ann. Pathol.24(3), 256–258 (2004).
  • Iijima-Dohi N, Shinji A, Shimizu T et al. Recurrent gastric hemorrhaging with large submucosal hematomas in a patient with primary AL systemic amyloidosis: endoscopic and histopathological findings. Intern. Med.43(6), 468–472 (2004).
  • Hizawa K, Ohta Y, Satou H, Aoyagi K, Eguchi K, Fujishima M. Endoscopic hydrostatic balloon dilation of ulcer - induced pyloric stenosis in rheumatoid arthritis and secondary amyloidosis. Surg. Endosc.11(6), 673–675 (1997).
  • Losanoff JE, Antaki F, Salwen WA et al. Amyloid tumor of the stomach simulating an obstructing gastric carcinoma: case report and review of the literature. Endoscopy41(Suppl. 2), E45–E46 (2009).
  • Brown SJ, Shackleton M, Salem H, Schmidt G. Gastro-colic fistula complicating primary (AI) amyloidosis. J. Gastroenterol. Hepatol.17(1), 110–111 (2002).
  • Suhr OB, Anan I, Ahlström KR, Rydh A. Gastric emptying before and after liver transplantation for familial amyloidotic polyneuropathy, Portugese type (Val30Met). Amyloid10(2), 121–126 (2003).
  • Saglam F, Celik A, Cavdar C et al. A renal transplant recipient with delayed gastric emptying in amyloidosis due to familial mediterranean fever improved with erythromycin: a case report. Transplant Proc.40(1), 308–309 (2008).
  • Feurle GE. Pathophysiology of diarrhea in patients with familial amyloid neuropathy. Digestion36(1), 13–17 (1987).
  • Gilat T, Spiro HM. Amyloidosis and the gut. Am. J. Dig. Dis.13(7), 619–633 (1968).
  • Yoshimatsu S, Ando Y, Terazaki H et al. Endoscopic and pathological manifestations of the gastrointestinal tract in familial amyloidotic polyneuropathy type I (Met30). J. Intern. Med.243(1), 65–72 (1998).
  • Ikeda S, Yanagisawa N, Hongo M, Ito N. Vagus nerve and celiac ganglion lesions in generalized amyloidosis. A correlative study of familial amyloid polyneuropathy and AL-amyloidosis. J. Neurol. Sci.79(1–2), 129–139 (1987).
  • Strich SJ, Wade G. Primary amyloidosis presenting with peripheral neuritis and intractable heart failure. Lancet265(6776), 70–71 (1953).
  • El-Salhy M, Suhr O, Stenling R, Wilander E, Grimelius L. Impact of familial amyloid associated polyneuropathy on duodenal endocrine cells. Gut35(10), 1413–1418 (1994).
  • Okuda Y, Takasugi K, Oyama T, Oyama H, Nanba S, Miyamoto T. Intractable diarrhoea associated with secondary amyloidosis in rheumatoid arthritis. Ann. Rheum. Dis.56(9), 535–541 (1997).
  • Chang HS, Myung SJ, Yang SK et al. Massive small bowel bleeding in a patient with amyloidosis. Gastrointest. Endosc.59(1), 126–129 (2004).
  • Andrews CN, Amar JN, Hayes MM, Enns RA. Systemic amyloidosis: a rare presentation of mesenteric angina. Can. J. Gastroenterol.16(10), 683–685 (2002).
  • Choi HS, Heller D, Picken MM, Sidhu GS, Khan T. Infarction of intestine with massive amyloid deposition in two patients on long-term hemodialysis. Gastroenterology96(1), 230–234 (1989).
  • Rajagopalan AE, Pickleman J. Free perforation of the small intestine. Ann. Surg.196(5), 576–579 (1982).
  • Saindane AM, Losada M, Macari M. Focal amyloidoma of the small bowel mimicking adenocarcinoma on CT. AJR Am. J. Roentgenol.185(5), 1187–1189 (2005).
  • Tada S, Iida M, Yao T, Kitamoto T, Yao T, Fujishima M. Intestinal pseudo-obstruction in patients with amyloidosis: clinicopathologic differences between chemical types of amyloid protein. Gut34(10), 1412–1417 (1993).
  • Matsumoto T, Iida M, Hirakawa M et al. Breath hydrogen test using water-diluted lactulose in patients with gastrointestinal amyloidosis. Dig. Dis. Sci.36(12), 1756–1760 (1991).
  • Riordan SM, McIver CJ, Walker BM, Duncombe VM, Bolin TD, Thomas MC. The lactulose breath hydrogen test and small intestinal bacterial overgrowth. Am. J. Gastroenterol.91(9), 1795–1803 (1996).
  • Suhr O, Danielsson A, Steen L. Bile acid malabsorption caused by gastrointestinal motility dysfunction? An investigation of gastrointestinal disturbances in familial amyloidosis with polyneuropathy. Scand. J. Gastroenterol.27(3), 201–207 (1992).
  • Steen L, Stenling R. Relationship between morphological findings and function of the small intestine in familial amyloidosis with polyneuropathy. Scand. J. Gastroenterol.18(7), 961–968 (1983).
  • Guirl MJ, Högenauer C, Santa Ana CA et al. Rapid intestinal transit as a primary cause of severe chronic diarrhea in patients with amyloidosis. Am. J. Gastroenterol.98(10), 2219–2225 (2003).
  • Kyle RA, Greipp PR. Amyloidosis (AL). Clinical and laboratory features in 229 cases. Mayo Clin. Proc.58(10), 665–683 (1983).
  • Hayman SR, Lacy MQ, Kyle RA, Gertz MA. Primary systemic amyloidosis: a cause of malabsorption syndrome. Am. J. Med.111(7), 535–540 (2001).
  • Steen L, Ek B. Familial amyloidosis with polyneuropathy. A long-term follow-up of 21 patients with special reference to gastrointestinal symptoms. Acta Med. Scand.214(5), 387–397 (1983).
  • Fushimi T, Takahashi Y, Kashima Y et al. Severe protein losing enteropathy with intractable diarrhea due to systemic AA amyloidosis, successfully treated with corticosteroid and octreotide. Amyloid12(1), 48–53 (2005).
  • Suzuki C, Higaki S, Nishiaki M et al. 99m Tc-HSA-D scintigraphy in the diagnosis of protein-losing gastroenteropathy due to secondary amyloidosis. J. Gastroenterol.32(1), 78–82 (1997).
  • Florent C, L’Hirondel C, DEsmazures C, Aymes C, Bernier JJ. Intestinal clearance of α1-antitrypsin. A sensitive method for the detection of protein-losing enteropathy. Gastroenterology81(4), 777–780 (1981).
  • Peny MO, Debongnie JC, Haot J, Van Gossum A. Localized amyloid tumor in small bowel. Dig. Dis. Sci.45(9), 1850–1853 (2000).
  • Mallory A, Struthers JE Jr., Kern F Jr. Persistent hypotension and intestinal infarction in a patient with primary amyloidosis. Gastroenterology68(6), 1587–1592 (1975).
  • Rapoport M, Yona R, Kaufman S, Segal M, Kornberg A. Unusual bleeding manifestations of amyloidosis in patients with multiple myeloma. Clin. Lab. Haematol.16(4), 349–353 (1994).
  • Kaiserling E, Kröber S. Massive intestinal hemorrhage associated with intestinal amyloidosis. An investigation of underlying pathologic processes. Gen. Diagn. Pathol.141(2), 147–154 (1995).
  • Mumford AD, O’Donnell J, Gillmore JD, Manning RA, Hawkins PN, Laffan M. Bleeding symptoms and coagulation abnormalities in 337 patients with AL-amyloidosis. Br. J. Haematol.110(2), 454–460 (2000).
  • Yood RA, Skinner M, Rubinow A, Talarico L, Cohen AS. Bleeding manifestations in 100 patients with amyloidosis. JAMA249(10), 1322–1324 (1983).
  • Caccialanza R, Palladini G, Klersy C et al. Nutritional status of outpatients with systemic immunoglobulin light-chain amyloidosis. Am. J. Clin. Nutr.83(2), 350–354 (2006).
  • Chen JH, Lai SJ, Tsai PP, Chen YF. Localized amyloidosis mimicking carcinoma of the colon. AJR Am. J. Roentgenol.179(2), 536–537 (2002).
  • García-Gonzáles R, Fernández FA, Garijo MF, Val-Bernal FJ. Amyloidosis of the rectum mimicking collagenous colitis. Pathol. Res. Pract.194(10), 731–735 (1998).
  • Casad DE, Bocian JJ. Primary systemic amyloidosis simulating acute idiopathic ulcerative colitis. Dig. Dis.10(1), 63–74 (1965).
  • Yoshida T, Kanbe H, Haraguchi Y et al. Submucosal hematoma producing mechanical obstruction in the sigmoid colon, complicated by systemic amyloidosis. Endoscopy15(4), 277–280 (1983).
  • Thaler W, Schatzer G, Eder P, Fichtel G. Amyloidosis – an unusual case of recurrent intestinal bleeding and sigmoid perforation: case report with review of the literature. Int. J. Colorectal Dis.14(6), 297–299 (1999).
  • Williamson RC. Primary amyloidosis of the rectum. Proc. R. Soc. Med.65(1), 74 (1972).
  • Rives S, Pera M, Rosinol L et al. Primary systemic amyloidosis presenting as a colonic stricture: successful treatment with left hemicolectomy followed by autologous hematopoietic stem-cell transplantation: report of a case. Dis. Colon Rectum45(9), 1263–1266 (2002).
  • Legge DA, Wollaeger EE, Carlson HC. Intestinal pseudo-obstruction in systemic amyloidosis. Gut11(9), 764–767 (1970).
  • Anan I, El-Salhy M, Ando Y, Terazaki H, Suhr OB. Comparison of amyloid deposits and infiltration of enteric nervous system in the upper with those in the lower gastrointestinal tract in patients with familial amyloidotic polyneuropathy. Acta Neuropathol.102(3), 227–232 (2001).
  • El-Salhy M, Suhr O. Endocrine cells in rectal biopsy specimens from patients with familial amyloidotic polyneuropathy. Scand. J. Gastroenterol.31(1), 68–73 (1996).
  • Anan I, El-Salhy M, Ando Y et al. Colonic endocrine cells in patients with familial amyloidotic polyneuropathy. J. Intern. Med.245(5), 469–473 (1999).
  • Obayashi K, Olsson M, Anan I et al. Impact of serotonin transporter and catechol-O-methyl transferase genes polymorphism on gastrointestinal dysfunction in Swedish and Japanese familial amyloidotic polyneuropathy patients. Clin. Chim. Acta.398(1–2), 10–14 (2008).
  • Ito T, Sakakibara R, Ito S et al. Mechanism of constipation in familial amyloid polyneuropathy: a case report. Intern. Med.45(20), 1173–1175 (2006).
  • Greenstein AJ, Sachar DB, Panday AK et al. Amyloidosis and inflammatory bowel disease. A 50-year experience with 25 patients. Medicine (Baltimore)71(5), 261–270 (1992).
  • Sattianayagam P, Gibbs SD, Wechalekar A et al. Systemic AA amyloidosis in Crohn’s disease (CD): Serum Amyloid P Component (SAP) Scintigraphy Study. Presented at: Digestive Disease Week. Chicago, IL, USA, 29 May–4 June 2009.
  • Wester AL, Vatn MH, Fausa O. Secondary amyloidosis in inflammatory bowel disease: a study of 18 patients admitted to Rikshospitalet University Hospital, Oslo, from 1962 to 1998. Inflamm. Bowel Dis.7(4), 295–300 (2001).
  • Puchtler H, Sweat F, Levine M. On the binding of Congo red by amyloid. J. Histochem. Cytochem.10, 355–364 (1962).
  • Röcken C, Schwotzer EB, Linke RP, Saeger W. The classification of amyloid deposits in clinicopathological practice. Histopathology29(4), 325–335 (1996).
  • Lachmann HJ, Booth DR, Booth SE et al. Misdiagnosis of hereditary amyloidosis as AL (primary) amyloidosis. N. Engl. J. Med.346(23), 1786–1791 (2002).
  • Hawkins PN, Lavender JP, Pepys MB. Evaluation of systemic amyloidosis with 123I-labeled serum amyloid P component. N. Engl. J. Med.323(8), 508–513 (1990).
  • Hawkins PN. Studies with radiolabelled serum amyloid P component provide evidence for turnover and regression of amyloid deposits in vivo. Clin. Sci. (Lond.)87(3), 289–295 (1994).
  • Hazenberg BP, van Rijswijk MH, Piers DA et al. Diagnostic performance of 123I-labeled serum amyloid P component scintigraphy in patients with amyloidosis. Am. J. Med.119(4), 355; e15–e24 (2006).
  • Han S, Chong V, Murray T et al. Preliminary experience of 99m Tc-Aprotinin scintigraphy in amyloidosis. Eur. J. Haematol.79(6), 494–500 (2007).
  • Selvanayagam JB, Hawkins PN, Paul B, Myerson SG, Neubauer S. Evaluation and management of the cardiac amyloidosis. J. Am. Coll. Cardiol.50(22), 2101–2110 (2007).
  • Tada S, Iida M, Iwashita A et al. Endoscopic and biopsy findings of the upper digestive tract in patients with amyloidosis. Gastrointest. Endosc.36(1), 10–14 (1990).
  • Yamada M, Hatakeyama S, Tsukagoshi H. Gastrointestinal amyloid deposition in AL (primary or myeloma-associated) and AA (secondary) amyloidosis: diagnostic value of gastric biopsy. Hum. Pathol.16(12), 1206–1211 (1985).
  • Ebert EC, Nagar M. Gastrointestinal manifestations of amyloidosis. Am. J. Gastroenterol.103(3), 776–787 (2008).
  • Kobayashi H, Tada S, Fuchigami T et al. Secondary amyloidosis in patients with rheumatoid arthritis: diagnostic and prognostic value of gastroduodenal biopsy. Br. J. Rheum.35(1), 44–49 (1996).
  • Tada S, Iida M, Yao T et al. Endoscopic features in amyloidosis of the small intestine: clinical and morphologic differences between chemical types of amyloid protein. Gastrointest. Endosc.40(1), 45–50 (1994).
  • Michael H, Brandt LJ, Tanaka KE, Berkowitz D, Cardillo M, Weidenheim K. Congo-red negative colonic amyloid with scalloping of the valvulae conniventes. Gastrointest. Endosc.53(6), 653–655 (2001).
  • Fry LC, Bellutti M, Neumann H, Malfertheiner P, Monkemuller K. Utility of double-balloon enteroscopy for the evaluation of malabsorption. Dig. Dis.26(2), 134–139 (2008).
  • Mandelli G, Radaelli F, Amato A et al. The spectrum of small-bowel lesions of AL-type amyloidosis at capsule endoscopy. Endoscopy41(Suppl. 2), E51–E52 (2009).
  • Dray X, Treton X, JolyF et al. Hemorrhagic bullous colitis as a primary manifestation of AL amyloidosis. Endoscopy38(Suppl. 2), E15–E16 (2006).
  • Schmidt H, Frühmorgen P, Riemann JF, Becker V. Mucosal suggillation in the colon in secondary amyloidosis. Endoscopy13(4), 181–183 (1981).
  • Ko CW, Chow WK, Chang CS, Chen GH, Jan YJ. Endoscopic appearance of amyloidosis with gastrointestinal tract involvement after biopsy. Gastrointest. Endosc.46(3), 284–286 (1997).
  • Hui YT, Lam TW, Yee Lam PW, Yan Wu WH, Lam WM. Narrow-band imaging system with magnifying endoscopy for rectal amyloidosis. Gastrointest. Endosc.68(2), 400–401 (2008).
  • Tada A, Iida M, Yao T et al. Gastrointestinal amyloidosis: radiologic features by chemical types. Radiology190(1), 37–42 (1994).
  • Tada S, Iida M, Matsui T et al. Amyloidosis of the small intestine: findings on double-contrast radiographs. AJR Am. J. Roentgenol.165(4), 741–744 (1991).
  • Kala Z, Válek V, Kysela P. Amyloidosis of the small intestine. Eur. J. Radiol.63(1), 105–109 (2007).
  • Goulding C, O’Hanlon DM, Clark E, Kennedy M, Lennon J. Primary amyloidosis of the stomach: EUS appearances. Gastrointest. Endosc.56(2), 305–306 (2002).
  • Trinh TD, Jones B, Fishman EK. Amyloidosis of the colon presenting as ischemic colitis: a case report and review of the literature. Gastrointest. Radiol.16(2), 133–136 (1991).
  • Araoz PA, Batts KP, MacCarty RL. Amyloidosis of the alimentary canal: radiologic-pathologic correlation of CT findings. Abdom. Imaging25(1), 38–44 (2000).
  • Gandolfi L, Colecchia A, Leo P et al. Endoscopic ultrasonography in the diagnosis of gastrointestinal amyloid deposits: clinical case report. Endoscopy27(1), 132–134 (1995).
  • Lachmann HJ, Gallimore R, Gillmore JD et al. Outcome in systemic AL amyloidosis in relation to changes in concentration of circulating free immunoglobulin light chains following chemotherapy. Br. J. Haematol.122(1), 78–84 (2003).
  • Wechalekar AD, Hawkins PN, Gillmore JD. Perspectives in treatment of AL amyloidosis. Br. J. Haematol.140(4), 365–377 (2008).
  • Jaccard A, Moreau P, Leblond V et al. High-dose melpahalan versus melphalan plus dexamethasone for AL amyloidosis. N. Engl. J. Med.357(11), 1083–1093 (2008).
  • Lachmann HJ, Gilbertson JA, Gillmore JD, Hawkins PN, Pepys MB. Unicentric Castleman’s disease complicated by systemic AA amyloidosis: a curable disease. QJM95(4), 211–218 (2002).
  • Holmgren G, Ericzon BG, Groth CG et al. Clinical improvement and amyloid regression after liver transplantation in hereditary transthyretin amyloidosis. Lancet341(8853), 1113–1116 (1993).
  • Gillmore JD, Booth DR, Rela M et al. Curative hepatorenal transplantation in systemic amyloidosis caused by the Glu526Val fibrinogen α-chain variant in an English family. QJM93(5), 269–275 (2000).
  • Gillmore JD, Stangou AJ, Tennent GA et al. Clinical and biochemical outcome of hepatorenal transplantation for hereditary systemic amyloidosis associated with apolipoprotein AI Gly26Arg. Transplantation71(7), 986–992 (2001).
  • Tan SY, Irish A, Winearls CG et al. Long term effect of renal transplantation on dialysis-related amyloid deposits and symptomatology. Kidney Int.50(1), 282–289 (1996).
  • Cherian D, Baraun K, Flomenberg N, Palazzo J, Kastenberg D. Complete resolution of gastric amyloidosis after autologous stem cell transplantation. Endoscopy40(Suppl. 2), E167–E168 (2008).
  • Amemori S, Iwakiri R, Endo H et al. Oral dimethyl sulfoxide for systemic amyloid A amyloidosis complication in chronic inflammatory disease: a retrospective patient chart review. J. Gastroenterol.41(5), 444–449 (2006).
  • Shimoyama M, Ohtahara A, Fukui H et al. Acute secondary gastrointestinal amyloidosis in a patient with rheumatoid arthritis. Am. J. Med. Sci.326(3), 145–147 (2003).
  • Okuda Y, Takasugi K. Successful use of humanized anti-interleukin-6 receptor antibody, tocilizumab, to treat amyloid A amyloidosis complicating juvenile idiopathic arthritis. Arthritis Rheum.54(9), 2997–3000 (2006).
  • Kuroda T, Otaki Y, Sato H et al. A case of AA amyloidosis associated with rheumatoid arthritis effectively treated with infliximab. Rheumatol. Int.28(11), 1155–1159 (2008).
  • Kuo WT, Lee DE, Saad WE, Patel N, Sahler LG, Waldman DL. Superselective microcoil embolization for the treatment of lower gastrointestinal hemorrhage. J. Vasc. Interv. Radiol.14(12), 1503–1509 (2003).
  • Kim SH, Kang EJ, Park JW et al. Gastrointestinal amyloidosis presenting with multiple episodes of gastrointestinal bleeding. Cardiovasc. Intervent. Radiol.32(3), 577–580 (2009).
  • Costigan DJ, Clouse RE. Achalasia-like esophagus from amyloidosis. Successful treatment with pneumatic bag dilatation. Dig. Dis. Sci.28(8), 763–765 (1983).
  • Fraser AG, Arthur JF, Hamilton I. Intestinal pseudoobstruction secondary to amyloidosis responsive to cisapride. Dig. Dis. Sci.36(4), 532–535 (1991).
  • Reddy AB, Wright RA, Wheeler GE, Nazer H. Nonobstructive gastroparesis in amyloid improved with metoclopramide. Arch. Intern. Med.143(2), 247–248 (1983).
  • Carvalho M, Alves M, Luis ML. Octreotide – a new treatment for diarrhoea in familial amyloidotic polyneuropathy. J. Neurol. Neurosurg. Psychiatry55(9), 860–861 (1992).
  • Ek BO, Holmlund DE, Sjödin JG, Steen LE. Enterostomy in patients with primary neuropathic amyloidosis. Am. J. Gastroenterol.70(4), 365–370 (1978).
  • Suhr OB, Wiklund U, Eleborg L et al. Impact of autonomic neuropathy on circulatory instability during liver transplantation for familial amyloidotic polyneuropathy. Transplantation63(5), 675–679 (1997).
  • Mardinger O, Rotenberg L, Chaushu G, Taicher S. Surgical management of macroglossia due to primary amyloidosis. Int. J. Oral Maxillofac. Surg.28(2), 129–131 (1999).
  • Usui M, Matsuda S, Suzuki H, Hirata K, Ogura Y, Shiraishi T. Gastric amyloidosis with massive bleeding requiring emergency surgery. J. Gastroenterol.35(12), 924–928 (2000).
  • Johnson DH, Guthrie TH, Tedesco FJ, Griffin JW, Anthony HF Jr. Amyloidosis masquerading as inflammatory bowel disease with a mass lesion simulating a malignancy. Am. J. Gastroenterol.77(3), 141–145 (1982).
  • Herlenius G, Wilczek HE, Larsson M, Ericzon BG. Ten years of international experience with liver transplantation for familial amyloidotic polyneuropathy: results from the Familial Amyloidotic Polyneuropathy World Transplant Registry. Transplantation77(1), 64–71 (2004).
  • Suhr O, Danielsson A, Rydh A, Nyhlin N, Hietala SO, Steen L. Impact of gastrointestinal dysfunction on survival after liver transplantation for familial amyloidotic polyneuropathy. Dig. Dis. Sci.41(10), 1909–1914 (1996).
  • Lång K, Wikström L, Danielsson A, Tashima K, Suhr OB. Outcome of gastrointestinal complications after liver transplantation for familial amyloidotic polyneuropathy. Scand. J. Gastroenterol.35(9), 985–989 (2000).
  • Sachettini JC, Kelly JW. Therapeutic strategies for human amyloid diseases. Nat. Rev. Drug Discov.1(4), 265–275 (2002).
  • Mairal T, Nieto J, Pinto M et al. Iodine atoms: a new molecular feature for the design of potent transthyretin fibrillogenesis inhibitors. PLoS One4(1), E4124 (2009).
  • Sekijima Y, Kelly JW, Ikeda S. Pathogenesis of and therapeutic strategies to ameliorate the transthyretin amyloidoses. Curr. Pharm. Des.14(30), 3219–3230 (2008).
  • Cardoso I, Saraiva MJ. Doxycycline disrupts transthyretin amyloid: evidence from studies in FAP transgenic mice model. FASEB J.20(2), 234–239 (2006).
  • Kisilevsky R, Ancsin JB, Szarek WA, Petanceska S. Heparan sulfate as a therapeutic target in amyloidogenesis: prospects and possible complications. Amyloid14(1), 21–32 (2007).
  • Li JP, Galvis ML, Gong F et al.In vivo fragmentation of heparan sulfate by heparanase overexpression renders mice resistant to amyloid protein A amyloidosis. Proc. Natl Acad. Sci. USA102(18), 6473–6477 (2005).
  • Dember LM, Hawkins PN, Hazenberg BP et al. Eprodisate for the treatment of renal disease in AA amyloidosis. N. Engl. J. Med.356(23), 2349–2360 (2007).
  • O’Nuallain B, Wetzel R. Conformational Abs recognizing a generic amyloid fibril epitope. Proc. Natl Acad. Sci. USA99(3), 1485–1490 (2002).
  • Solomon A, Weiss DT, Wall JS. Therapeutic potential of chimeric amyloid-reactive monoclonal antibody 11–1F4. Clin. Cancer Res.9(10 Pt 2), S3831–S3838 (2003).
  • Botto M, Hawkins PN, Bickerstaff MC et al. Amyloid deposition is delayed in mice with targeted deletion of the serum amyloid P component gene. Nat. Med.3(8), 855–859 (1997).
  • Pepys MB, Herbert J, Hutchinson WL et al. Targeted pharmacological depletion of serum amyloid P component for treatment of human amyloidosis. Nature417(6886), 254–259 (2002).
  • Pepys MB. Science and serendipity. Clin. Med.7(6), 562–578 (2007).

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