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Review

Comparisons of actin filament disruptors and Rho kinase inhibitors as potential antiglaucoma medications

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Pages 177-187 | Published online: 09 Jan 2014

References

  • Quigley HA, Broman AT. The number of people with glaucoma worldwide in 2010 and 2020. Br. J. Ophthalmol.90(3), 262–267 (2006).
  • Tumminia SJ, Mitton KP, Arora J, Zelenka P, Epstein DL, Russell P. Mechanical stretch alters the actin cytoskeletal network and signal transduction in human trabecular meshwork cells. Invest. Ophthalmol. Vis. Sci.39(8), 1361–1371 (1998).
  • Read AT, Chan DW, Ethier CR. Actin structure in the outflow tract of normal and glaucomatous eyes. Exp. Eye Res.84(1), 214–226 (2007).
  • Tian B, Gabelt BT, Geiger B, Kaufman PL. The role of the actomyosin system in regulating trabecular fluid outflow. Exp. Eye Res.88(4), 713–717 (2009).
  • Mandell KJ, Kudelka MR, Wirostko B. Rho kinase inhibitors for treatment of glaucoma. Expert Rev. Ophthalmol.6(6), 611–622 (2011).
  • Geiger B, Yehuda-Levenberg S, Bershadsky AD. Molecular interactions in the submembrane plaque of cell–cell and cell–matrix adhesions. Acta Anat. (Basel)154(1), 46–62 (1995).
  • Hirata H, Tatsumi H, Sokabe M. Dynamics of actin filaments during tension-dependent formation of actin bundles. Biochim. Biophys. Acta1770(8), 1115–1127 (2007).
  • Millán J, Cain RJ, Reglero-Real N et al. Adherens junctions connect stress fibres between adjacent endothelial cells. BMC Biol.8, 11 (2010).
  • Falk MM. Adherens junctions remain dynamic. BMC Biol.8, 34 (2010).
  • Scherlach K, Boettger D, Remme N, Hertweck C. The chemistry and biology of cytochalasans. Nat. Prod. Rep.27(6), 869–886 (2010).
  • Spector I, Shochet NR, Blasberger D, Kashman Y. Latrunculins – novel marine macrolides that disrupt microfilament organization and affect cell growth: I. Comparison with cytochalasin D. Cell Motil. Cytoskeleton13(3), 127–144 (1989).
  • Sanka K, Maddala R, Epstein DL, Rao PV. Influence of actin cytoskeletal integrity on matrix metalloproteinase-2 activation in cultured human trabecular meshwork cells. Invest. Ophthalmol. Vis. Sci.48(5), 2105–2114 (2007).
  • Cai S, Liu X, Glasser A et al. Effect of latrunculin-A on morphology and actin-associated adhesions of cultured human trabecular meshwork cells. Mol. Vis.6, 132–143 (2000).
  • McKee CT, Wood JA, Shah NM et al. The effect of biophysical attributes of the ocular trabecular meshwork associated with glaucoma on the cell response to therapeutic agents. Biomaterials32(9), 2417–2423 (2011).
  • Bubb MR, Spector I, Bershadsky AD, Korn ED. Swinholide A is a microfilament disrupting marine toxin that stabilizes actin dimers and severs actin filaments. J. Biol. Chem.270(8), 3463–3466 (1995).
  • Lyubimova A, Bershadsky AD, Ben-Ze’ev A. Autoregulation of actin synthesis responds to monomeric actin levels. J. Cell. Biochem.65(4), 469–478 (1997).
  • Mehta D, Gunst SJ. Actin polymerization stimulated by contractile activation regulates force development in canine tracheal smooth muscle. J. Physiol.519(Pt 3), 829–840 (1999).
  • Wiederholt M, Dörschner N, Groth J. Effect of diuretics, channel modulators and signal interceptors on contractility of the trabecular meshwork. Ophthalmologica211(3), 153–160 (1997).
  • Peterson JA, Tian B, Geiger B, Kaufman PL. Latrunculin-A causes mydriasis and cycloplegia in the cynomolgus monkey. Invest. Ophthalmol. Vis. Sci.40(3), 631–638 (1999).
  • Shaw L, Ahmed S, Austin C, Taggart MJ. Inhibitors of actin filament polymerisation attenuate force but not global intracellular calcium in isolated pressurised resistance arteries. J. Vasc. Res.40(1), 1–10 (2003).
  • Iizuka K, Yoshii A, Samizo K et al. A major role for the Rho- associated coiled coil forming pretein kinase in G-protein-mediated Ca2+ sensitization through inhibition of myosin phosphatase in rabbit trachea. Br. J. Pharmacol.128(4), 925–933 (1999).
  • Harnett KM, Biancani P. Calcium-dependent and calcium-independent contractions in smooth muscles. Am. J. Med.115(Suppl. 3A), 24S–30S (2003).
  • Volberg T, Geiger B, Citi S, Bershadsky AD. Effect of protein kinase inhibitor H-7 on the contractility, integrity, and membrane anchorage of the microfilament system. Cell Motil. Cytoskeleton29(4), 321–338 (1994).
  • Tian B, Kaufman PL, Volberg T, Gabelt BT, Geiger B. H-7 disrupts the actin cytoskeleton and increases outflow facility. Arch. Ophthalmol.116(5), 633–643 (1998).
  • Liu X, Cai S, Glasser A et al. Effect of H-7 on cultured human trabecular meshwork cells. Mol. Vis.7, 145–153 (2001).
  • Uehata M, Ishizaki T, Satoh H et al. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature389(6654), 990–994 (1997).
  • Katoh K, Kano Y, Amano M, Onishi H, Kaibuchi K, Fujiwara K. Rho-kinase-mediated contraction of isolated stress fibers. J. Cell Biol.153(3), 569–584 (2001).
  • Nakajima E, Nakajima T, Minagawa Y, Shearer TR, Azuma M. Contribution of ROCK in contraction of trabecular meshwork: proposed mechanism for regulating aqueous outflow in monkey and human eyes. J. Pharm. Sci.94(4), 701–708 (2005).
  • Rosenthal R, Choritz L, Schlott S et al. Effects of ML-7 and Y-27632 on carbachol- and endothelin-1-induced contraction of bovine trabecular meshwork. Exp. Eye Res.80(6), 837–845 (2005).
  • Honjo M, Tanihara H, Inatani M et al. Effects of Rho-associated protein kinase inhibitor Y-27632 on intraocular pressure and outflow facility. Invest. Ophthalmol. Vis. Sci.42(1), 137–144 (2001).
  • Rao PV, Deng PF, Kumar J, Epstein DL. Modulation of aqueous humor outflow facility by the Rho kinase-specific inhibitor Y-27632. Invest. Ophthalmol. Vis. Sci.42(5), 1029–1037 (2001).
  • Rao PV, Deng P, Sasaki Y, Epstein DL. Regulation of myosin light chain phosphorylation in the trabecular meshwork: role in aqueous humour outflow facility. Exp. Eye Res.80(2), 197–206 (2005).
  • Epstein DL, Rowlette LL, Roberts BC. Acto-myosin drug effects and aqueous outflow function. Invest. Ophthalmol. Vis. Sci.40(1), 74–81 (1999).
  • Peterson JA, Tian B, Bershadsky AD et al. Latrunculin-A increases outflow facility in the monkey. Invest. Ophthalmol. Vis. Sci.40(5), 931–941 (1999).
  • Luykenaar KD, El-Rahman RA, Walsh MP, Welsh DG. Rho-kinase-mediated suppression of KDR current in cerebral arteries requires an intact actin cytoskeleton. Am. J. Physiol. Heart Circ. Physiol.296(4), H917–H926 (2009).
  • Zhang M, Maddala R, Rao PV. Novel molecular insights into RhoA GTPase-induced resistance to aqueous humor outflow through the trabecular meshwork. Am. J. Physiol. Cell Physiol.295(5), C1057–C1070 (2008).
  • Pattabiraman PP, Rao PV. Mechanistic basis of Rho GTPase-induced extracellular matrix synthesis in trabecular meshwork cells. Am. J. Physiol. Cell Physiol.298(3), C749–C763 (2010).
  • Overby DR, Stamer WD, Johnson M. The changing paradigm of outflow resistance generation: towards synergistic models of the JCT and inner wall endothelium. Exp. Eye Res.88(4), 656–670 (2009).
  • Tamm ER. The trabecular meshwork outflow pathways: structural and functional aspects. Exp. Eye Res.88(4), 648–655 (2009).
  • Kaufman PL, Erickson KA. Cytochalasin B and D dose-outflow facility response relationships in the cynomolgus monkey. Invest. Ophthalmol. Vis. Sci.23(5), 646–650 (1982).
  • Peterson JA, Tian B, Geiger B, Kaufman PL. Effect of latrunculin-B on outflow facility in monkeys. Exp. Eye Res.70(3), 307–313 (2000).
  • Peterson JA, Tian B, McLaren JW, Hubbard WC, Geiger B, Kaufman PL. Latrunculins’ effects on intraocular pressure, aqueous humor flow, and corneal endothelium. Invest. Ophthalmol. Vis. Sci.41(7), 1749–1758 (2000).
  • Okka M, Tian B, Kaufman PL. Effect of low-dose latrunculin B on anterior segment physiologic features in the monkey eye. Arch. Ophthalmol.122(10), 1482–1488 (2004).
  • Ethier CR, Read AT, Chan DW. Effects of latrunculin-B on outflow facility and trabecular meshwork structure in human eyes. Invest. Ophthalmol. Vis. Sci.47(5), 1991–1998 (2006).
  • Chen J, Runyan SA, Robinson MR. Novel ocular antihypertensive compounds in clinical trials. Clin. Ophthalmol.5, 667–677 (2011).
  • Tian B, Wang RF, Podos SM, Kaufman PL. Effects of topical H-7 on outflow facility, intraocular pressure, and corneal thickness in monkeys. Arch. Ophthalmol.122(8), 1171–1177 (2004).
  • Tian B, Gabelt BT, Peterson JA, Kiland JA, Kaufman PL. H-7 increases trabecular facility and facility after ciliary muscle disinsertion in monkeys. Invest. Ophthalmol. Vis. Sci.40(1), 239–242 (1999).
  • Bahler CK, Hann CR, Fautsch MP, Johnson DH. Pharmacologic disruption of Schlemm’s canal cells and outflow facility in anterior segments of human eyes. Invest. Ophthalmol. Vis. Sci.45(7), 2246–2254 (2004).
  • Hu Y, Gabelt BT, Kaufman PL. Monkey organ-cultured anterior segments: technique and response to H-7. Exp. Eye Res.82(6), 1100–1108 (2006).
  • Honjo M, Inatani M, Kido N et al. Effects of protein kinase inhibitor, HA1077, on intraocular pressure and outflow facility in rabbit eyes. Arch. Ophthalmol.119(8), 1171–1178 (2001).
  • Tokushige H, Inatani M, Nemoto S et al. Effects of topical administration of y-39983, a selective Rho-associated protein kinase inhibitor, on ocular tissues in rabbits and monkeys. Invest. Ophthalmol. Vis. Sci.48(7), 3216–3222 (2007).
  • Tian B, Kaufman PL. Effects of the Rho kinase inhibitor Y-27632 and the phosphatase inhibitor calyculin A on outflow facility in monkeys. Exp. Eye Res.80(2), 215–225 (2005).
  • Peterson WM, Lampe J, Navratil T et al. Topical administration of a novel and potent Rho kinase (ROK) inhibitor INS117548 alters the actin cytoskeleton, effectively lowers IOP, and is well tolerated on the ocular surface. Invest. Ophthalmol. Vis. Sci.49, E-abstract 3816 (2008).
  • Tanihara H, Inatani M, Honjo M, Tokushige H, Azuma J, Araie M. Intraocular pressure-lowering effects and safety of topical administration of a selective ROCK inhibitor, SNJ-1656, in healthy volunteers. Arch. Ophthalmol.126(3), 309–315 (2008).
  • Williams RD, Novack GD, van Haarlem T, Kopczynski C. AR-12286 Phase 2a Study Group. Ocular hypertensive effect of the Rho kinase inhibitor AR-12286 in patients with glaucoma and ocular hypertension. Am. J. Ophthalmol.152(5), 834–841 (2011).
  • Sabanay I, Tian B, Gabelt BT, Geiger B, Kaufman PL. Latrunculin B effects on trabecular meshwork and corneal endothelial morphology in monkeys. Exp. Eye Res.82(2), 236–246 (2006).
  • Sabanay I, Gabelt BT, Tian B, Kaufman PL, Geiger B. H-7 effects on the structure and fluid conductance of monkey trabecular meshwork. Arch. Ophthalmol.118(7), 955–962 (2000).
  • Sabanay I, Tian B, Gabelt BT, Geiger B, Kaufman PL. Functional and structural reversibility of H-7 effects on the conventional aqueous outflow pathway in monkeys. Exp. Eye Res.78(1), 137–150 (2004).
  • Lu Z, Overby DR, Scott PA, Freddo TF, Gong H. The mechanism of increasing outflow facility by Rho-kinase inhibition with Y-27632 in bovine eyes. Exp. Eye Res.86(2), 271–281 (2008).
  • Lu Z, Zhang Y, Freddo TF, Gong H. Similar hydrodynamic and morphological changes in the aqueous humor outflow pathway after washout and Y27632 treatment in monkey eyes. Exp. Eye Res.93(4), 397–404 (2011).
  • Johnson M, Shapiro A, Ethier CR, Kamm RD. Modulation of outflow resistance by the pores of the inner wall endothelium. Invest. Ophthalmol. Vis. Sci.33(5), 1670–1675 (1992).
  • Lutjen-Drecoll E, Wiendl H, Kaufman PL. Acute and chronic structural effects of pilocarpine on monkey outflow tissues. Trans. Am. Ophthalmol. Soc.96, 171–191 (1998).
  • Keller KE, Aga M, Bradley JM, Kelley MJ, Acott TS. Extracellular matrix turnover and outflow resistance. Exp. Eye Res.88(4), 676–682 (2009).
  • Svedbergh B, Lütjen-Drecoll E, Ober M, Kaufman PL. Cytochalasin B-induced structural changes in the anterior ocular segment of the cynomolgus monkey. Invest. Ophthalmol. Vis. Sci.17(8), 718–734 (1978).
  • Kaye GI, Fenoglio CM, Hoefle FB, Fischbarg J. Studies on the cornea. IX. Physiologic and morphologic effects of cytochalasin B on endothelium of rabbit corneas perfused in vitro. J. Cell Biol.61(2), 537–543 (1974).
  • Kiland JA, Miller CL, Kim CB et al. Effect of H-7 and Lat-B on retinal physiology. Curr. Eye Res.31(5), 441–455 (2006).
  • Tian B, Sabanay I, Peterson JA, Hubbard WC, Geiger B, Kaufman PL. Acute effects of H-7 on ciliary epithelium and corneal endothelium in monkey eyes. Curr. Eye Res.22(2), 109–120 (2001).
  • Okumura N, Ueno M, Koizumi N et al. Enhancement on primate corneal endothelial cell survival in vitro by a ROCK inhibitor. Invest. Ophthalmol. Vis. Sci.50(8), 3680–3687 (2009).
  • Olson MF. Applications for ROCK kinase inhibition. Curr. Opin. Cell Biol.20(2), 242–248 (2008).
  • Coleman ML, Marshall CJ, Olson MF. Ras and Rho GTPases in G1-phase cell-cycle regulation. Nat. Rev. Mol. Cell Biol.5(5), 355–366 (2004).
  • Whikehart DR. The inhibition of sodium, potassium-stimulated ATPase and corneal swelling: the role played by polyols. J. Am. Optom. Assoc.66(6), 331–333 (1995).
  • Hatou S, Yamada M, Akune Y et al. Role of insulin in regulation of Na+-/K+-dependent ATPase activity and pump function in corneal endothelial cells. Invest. Ophthalmol. Vis. Sci.51(8), 3935–3942 (2010).
  • Tian B, Gabelt BT, Kaufman PL. Effect of staurosporine on outflow facility in monkeys. Invest. Ophthalmol. Vis. Sci.40(5), 1009–1011 (1999).
  • Turner MS, Fen-Fen-Lin, Trauger JW, Stephens J, LoGrasso P. Characterization and purification of truncated human Rho-kinase II expressed in Sf-21 cells. Arch. Biochem. Biophys.405(1), 13–20 (2002).
  • Tamaoki T, Nomoto H, Takahashi I, Kato Y, Morimoto M, Tomita F. Staurosporine, a potent inhibitor of phospholipid/Ca++dependent protein kinase. Biochem. Biophys. Res. Commun.135(2), 397–402 (1986).
  • Weiner AL, Gilger BC. Advancements in ocular drug delivery. Vet. Ophthalmol.13(6), 395–406 (2010).
  • Calvo P, Sanchez A, Martinez J et al. Polyester nanocapsules as new topical ocular delivery systems for cyclosporin A. Pharm. Res.13(2), 311–315 (1996).
  • Kaufman PL. Pharmacologic trabeculocanalotomy. Facilitating aqueous outflow by assaulting the meshwork cytoskeleton, junctional complexes, and extracellular matrix. Arch. Ophthalmol.110(1), 34–36 (1992).
  • Borrás T, Xue W, Choi VW et al. Mechanisms of AAV transduction in glaucoma-associated human trabecular meshwork cells. J. Gene Med.8(5), 589–602 (2006).
  • Khare PD, Loewen N, Teo W et al. Durable, safe, multi-gene lentiviral vector expression in feline trabecular meshwork. Mol. Ther.16(1), 97–106 (2008).
  • Barraza RA, Rasmussen CA, Loewen N et al. Prolonged transgene expression with lentiviral vectors in the aqueous humor outflow pathway of nonhuman primates. Hum. Gene Ther.20(3), 191–200 (2009).
  • Buie LK, Rasmussen CA, Porterfield EC et al. Self-complementary AAV virus (scAAV) safe and long-term gene transfer in the trabecular meshwork of living rats and monkeys. Invest. Ophthalmol. Vis. Sci.51(1), 236–248 (2010).
  • Gabelt BT, Hu Y, Vittitow JL et al. Caldesmon transgene expression disrupts focal adhesions in HTM cells and increases outflow facility in organ-cultured human and monkey anterior segments. Exp. Eye Res.82(6), 935–944 (2006).
  • Grosheva I, Vittitow JL, Goichberg P et al. Caldesmon effects on the actin cytoskeleton and cell adhesion in cultured HTM cells. Exp. Eye Res.82(6), 945–958 (2006).
  • Liu X, Hu Y, Filla MS et al. The effect of C3 transgene expression on actin and cellular adhesions in cultured human trabecular meshwork cells and on outflow facility in organ cultured monkey eyes. Mol. Vis.11, 1112–1121 (2005).
  • Rao PV, Deng P, Maddala R, Epstein DL, Li CY, Shimokawa H. Expression of dominant negative Rho-binding domain of Rho-kinase in organ cultured human eye anterior segments increases aqueous humor outflow. Mol. Vis.11, 288–297 (2005).
  • Gabelt BT, Kaufman PL. Production and flow of aqueous humor. In: Adler’s Physiology of the Eye (11th Edition). Levin LA, Nilsson SFE, Ver Hoeve J, Wu SM (Eds). Elsevier Inc., Edinburgh, UK, 274–307 (2011).

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