Type 2 diabetes in children and adolescents

References

• Nadeau K, Dabelea D. Epidemiology of Type 2 diabetes in children and adolescents. Endocr. Res.33(1–2), 35–58 (2008).
   Web of Science ®Google Scholar
• Dabelea D, Hanson RL, Bennett PH, Roumain J, Knowler WC, Pettitt DJ. Increasing prevalence of Type II diabetes in American Indian children. Diabetologia41(8), 904–910 (1998).
   PubMed Web of Science ®Google Scholar
• Dean HJ, Young TK, Flett B, Wood-Steiman P. Screening for Type-2 diabetes in aboriginal children in northern Canada. Lancet352(9139), 1523–1524 (1998).
   PubMed Web of Science ®Google Scholar
• Fagot-Campagna A, Saaddine JB, Flegal KM, Beckles GL. Diabetes impaired fasting glucose, and elevated HbA1c in U.S. adolescents: the Third National Health and Nutrition Examination survey. Diabetes Care24(5), 834–837 (2001).
   PubMed Web of Science ®Google Scholar
• Duncan GE. Prevalence of diabetes and impaired fasting glucose levels among US adolescents: National Health and Nutrition Examination survey, 1999–2002. Arch. Pediatr. Adolesc. Med.160(5), 523–528 (2006).
   PubMed Web of Science ®Google Scholar
• Liese AD, D’Agostino RB Jr, Hamman RF et al. The burden of diabetes mellitus among US youth: prevalence estimates from the SEARCH for Diabetes in Youth Study. Pediatrics118(4), 1510–1518 (2006).
   PubMed Web of Science ®Google Scholar
• Wei JN, Sung FC, Lin CC, Lin RS, Chiang CC, Chuang LM. National surveillance for Type 2 diabetes mellitus in Taiwanese children. JAMA290(10), 1345–1350 (2003).
   PubMed Web of Science ®Google Scholar
• Dolan LM, Bean J, D’Alessio D et al. Frequency of abnormal carbohydrate metabolism and diabetes in a population-based screening of adolescents. J. Pediatr.146(6), 751–758 (2005).
   Web of Science ®Google Scholar
• Baranowski T, Cooper DM, Harrell J et al. Presence of diabetes risk factors in a large U.S. eighth-grade cohort. Diabetes Care29(2), 212–217 (2006).
   PubMed Web of Science ®Google Scholar
• Bar Dayan Y, Elishkevits K, Grotto I et al. The prevalence of obesity and associated morbidity among 17-year-old Israeli conscripts. Public Health119(5), 385–389 (2005).
   Google Scholar
• Lipton R, Keenan H, Onyemere KU, Freels S. Incidence and onset features of diabetes in African–American and Latino children in Chicago, 1985–1994. Diabetes Metab. Res. Rev.18(2), 135–142 (2002).
   Google Scholar
• Pinhas-Hamiel O, Dolan LM, Daniels SR, Standiford D, Khoury PR, Zeitler P. Increased incidence of non-insulin-dependent diabetes mellitus among adolescents. J. Pediatr.128(5 Pt 1), 608–615 (1996).
   PubMed Web of Science ®Google Scholar
• Zdravkovic V, Daneman D, Hamilton J. Presentation and course of Type 2 diabetes in youth in a large multi-ethnic city. Diabet. Med.21(10), 1144–1148 (2004).
   PubMed Web of Science ®Google Scholar
• Macaluso CJ, Bauer UE, Deeb LC et al. Type 2 diabetes mellitus among Florida children and adolescents, 1994 through 1998. Public Health Rep.117(4), 373–379 (2002).
   PubMed Web of Science ®Google Scholar
• Kitagawa T, Mano T, Fujita H. The epidemiology of childhood diabetes mellitus in Tokyo metropolitan area. Tohoku J. Exp. Med.141(Suppl.), 171–179 (1983).
   Google Scholar
• Urakami T, Kubota S, Nitadori Y, Harada K, Owada M, Kitagawa T. Annual incidence and clinical characteristics of Type 2 diabetes in children as detected by urine glucose screening in the Tokyo metropolitan area. Diabetes Care28(8), 1876–1881 (2005).
   PubMed Web of Science ®Google Scholar
• Urakami T, Morimoto S, Nitadori Y, Harada K, Owada M, Kitagawa T. Urine glucose screening program at schools in Japan to detect children with diabetes and its outcome-incidence and clinical characteristics of childhood Type 2 diabetes in Japan. Pediatr. Res.61(2), 141–145 (2007).
   Google Scholar
• Craig ME, Femia G, Broyda V, Lloyd M, Howard NJ. Type 2 diabetes in indigenous and non-indigenous children and adolescents in New South Wales. Med. J. Aust.186(10), 497–499 (2007).
   Google Scholar
• Schober E, Waldhoer T, Rami B, Hofer S. Incidence and time trend of Type 1 and Type 2 diabetes in Austrian children 1999–2007. J. Pediatr.155(2), 190–193 e191 (2009).
   Google Scholar
• Haines L, Wan KC, Lynn R, Barrett TG, Shield JP. Rising incidence of Type 2 diabetes in children in the U.K. Diabetes Care30(5), 1097–1101 (2007).
   PubMedGoogle Scholar
• Amed S, Dean HJ, Panagiotopoulos D et al. Type 2 diabetes, medication-induced diabetes, and monogenic diabetes in canadian children: a prospective national surveillance study. Diabetes Care (2010) (Epub ahead of print).
   Google Scholar
• Dabelea D, Bell RA, D’Agostino RB Jr et al. Incidence of diabetes in youth in the United States. JAMA297(24), 2716–2724 (2007).
   PubMed Web of Science ®Google Scholar
• Dabelea D, DeGroat J, Sorrelman C et al. Diabetes in Navajo youth: prevalence, incidence, and clinical characteristics: the SEARCH for Diabetes in Youth Study. Diabetes Care32(Suppl. 2), S141–S147 (2009).
   PubMed Web of Science ®Google Scholar
• Gungor N, Bacha F, Saad R, Janosky J, Arslanian S. Youth Type 2 diabetes: insulin resistance, β-cell failure, or both? Diabetes Care28(3), 638–644 (2005).
   PubMed Web of Science ®Google Scholar
• Druet C, Tubiana-Rufi N, Chevenne D, Rigal O, Polak M, Levy-Marchal C. Characterization of insulin secretion and resistance in Type 2 diabetes of adolescents. J. Clin. Endocrinol. Metab.91(2), 401–404 (2006).
   Google Scholar
• Elder DA, Prigeon RL, Wadwa RP, Dolan LM, D’Alessio DA. β-cell function, insulin sensitivity, and glucose tolerance in obese diabetic and nondiabetic adolescents and young adults. J. Clin. Endocrinol. Metab.91(1), 185–191 (2006).
   PubMed Web of Science ®Google Scholar
• Weiss R. Impaired glucose tolerance and risk factors for progression to Type 2 diabetes in youth. Pediatr. Diabetes8(Suppl. 9), 70–75 (2007).
   PubMed Web of Science ®Google Scholar
• Trout KK, Homko C, Tkacs NC. Methods of measuring insulin sensitivity. Biol. Res. Nurs.8(4), 305–318 (2007).
   Google Scholar
• Goran MI, Gower BA. Longitudinal study on pubertal insulin resistance. Diabetes50(11), 2444–2450 (2001).
   PubMed Web of Science ®Google Scholar
• Moran A, Jacobs DR Jr, Steinberger J et al. Insulin resistance during puberty: results from clamp studies in 357 children. Diabetes48(10), 2039–2044 (1999).
   PubMed Web of Science ®Google Scholar
• Caprio S, Cline G, Boulware S et al. Effects of puberty and diabetes on metabolism of insulin-sensitive fuels. Am. J. Physiol.266(6 Pt 1), E885–E891 (1994).
   PubMed Web of Science ®Google Scholar
• Moran A, Jacobs DR Jr, Steinberger J et al. Association between the insulin resistance of puberty and the insulin-like growth factor-I/growth hormone axis. J. Clin. Endocrinol. Metab.87(10), 4817–4820 (2002).
   PubMedGoogle Scholar
• Libman IM, Arslanian SA. Prevention and treatment of Type 2 diabetes in youth. Horm. Res.67(1), 22–34 (2007).
   Google Scholar
• Bjorntorp P, Rosmond R. Visceral obesity and diabetes. Drugs58(Suppl. 1), 13–18; discussion 75–82 (1999).
   PubMedGoogle Scholar
• Kadowaki T, Yamauchi T, Kubota N, Hara K, Ueki K, Tobe K. Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J. Clin. Invest.116(7), 1784–1792 (2006).
   PubMed Web of Science ®Google Scholar
• Hajer GR, van Haeften TW, Visseren FL. Adipose tissue dysfunction in obesity, diabetes, and vascular diseases. Eur. Heart J.29(24), 2959–2971 (2008).
   PubMed Web of Science ®Google Scholar
• Li S, Shin HJ, Ding EL, van Dam RM. Adiponectin levels and risk of Type 2 diabetes: a systematic review and meta-analysis. JAMA302(2), 179–188 (2009).
   PubMed Web of Science ®Google Scholar
• Weiss R, Taksali SE, Dufour S et al. The ‘obese insulin-sensitive’ adolescent: importance of adiponectin and lipid partitioning. J. Clin. Endocrinol. Metab.90(6), 3731–3737 (2005).
   Google Scholar
• Bottner A, Kratzsch J, Muller G et al. Gender differences of adiponectin levels develop during the progression of puberty and are related to serum androgen levels. J. Clin. Endocrinol. Metab.89(8), 4053–4061 (2004).
   PubMed Web of Science ®Google Scholar
• Bacha F, Gungor N, Arslanian SA. Measures of β-cell function during the oral glucose tolerance test, liquid mixed-meal test, and hyperglycemic clamp test. J. Pediatr.152(5), 618–621 (2008).
   Google Scholar
• Weiss R, Caprio S, Trombetta M, Taksali SE, Tamborlane WV, Bonadonna R. β-cell function across the spectrum of glucose tolerance in obese youth. Diabetes54(6), 1735–1743 (2005).
   PubMed Web of Science ®Google Scholar
• Rosenbaum M, Nonas C, Horlick M et al. β-cell function and insulin sensitivity in early adolescence: association with body fatness and family history of Type 2 diabetes mellitus. J. Clin. Endocrinol. Metab.89(11), 5469–5476 (2004).
   PubMedGoogle Scholar
• Tfayli H, Bacha F, Gungor N, Arslanian S. Phenotypic Type 2 diabetes in obese youth: insulin sensitivity and secretion in islet cell antibody-negative versus -positive patients. Diabetes58(3), 738–744 (2009).
   Google Scholar
• Goran MI, Lane C, Toledo-Corral C, Weigensberg MJ. Persistence of pre-diabetes in overweight and obese Hispanic children: association with progressive insulin resistance, poor β-cell function, and increasing visceral fat. Diabetes57(11), 3007–3012 (2008).
   PubMed Web of Science ®Google Scholar
• Weiss R, Taksali SE, Tamborlane WV, Burgert TS, Savoye M, Caprio S. Predictors of changes in glucose tolerance status in obese youth. Diabetes Care28(4), 902–909 (2005).
   PubMed Web of Science ®Google Scholar
• Edelstein SL, Knowler WC, Bain RP et al. Predictors of progression from impaired glucose tolerance to NIDDM: an analysis of six prospective studies. Diabetes46(4), 701–710 (1997).
   PubMed Web of Science ®Google Scholar
• Matthews DR, Cull CA, Stratton IM, Holman RR, Turner RC; UK Prospective Diabetes Study (UKPDS) group. UKPDS 26: sulphonylurea failure in non-insulin-dependent diabetic patients over six years. Diabet. Med.15(4), 297–303 (1998).
   PubMed Web of Science ®Google Scholar
• Saad R, Gungor N, Arslanian S. Progression from normal glucose tolerance to Type 2 diabetes in a young girl: longitudinal changes in insulin sensitivity and secretion assessed by the clamp technique and surrogate estimates. Pediatr. Diabetes6(2), 95–99 (2005).
   Google Scholar
• Weiss R, Dufour S, Taksali SE et al. Prediabetes in obese youth: a syndrome of impaired glucose tolerance, severe insulin resistance, and altered myocellular and abdominal fat partitioning. Lancet362(9388), 951–957 (2003).
   PubMed Web of Science ®Google Scholar
• Cali AM, Caprio S. Obesity in children and adolescents. J. Clin. Endocrinol. Metab.93(11 Suppl. 1), S31–S36 (2008).
   PubMed Web of Science ®Google Scholar
• Canadian Diabetes Association 2008. Clinical Practice Guidelines for the Prevention and Management of Diabetes in Canada. Can. J. Diabetes32(Suppl. 1), S162–S167 (2008).
   Google Scholar
• Rosenbloom AL, Silverstein JH, Amemiya S, Zeitler P, Klingensmith GJ. ISPAD Clinical Practice Consensus Guideline 2006–2007. Type 2 diabetes mellitus in the child and adolescent. Pediatr. Diabetes9(5), 512–526 (2008).
   PubMed Web of Science ®Google Scholar
• Wang Y, Lobstein T. Worldwide trends in childhood overweight and obesity. Int. J. Pediatr. Obes.1(1), 11–25 (2006).
   PubMed Web of Science ®Google Scholar
• Haslam DW, James WP. Obesity. Lancet366(9492), 1197–1209 (2005).
   PubMed Web of Science ®Google Scholar
• Clarke WR, Lauer RM. Does childhood obesity track into adulthood? Crit. Rev. Food Sci. Nutr.33(4–5), 423–430 (1993).
   PubMed Web of Science ®Google Scholar
• Lee JM, Okumura MJ, Davis MM, Herman WH, Gurney JG. Prevalence and determinants of insulin resistance among U.S. adolescents: a population-based study. Diabetes Care29(11), 2427–2432 (2006).
   PubMed Web of Science ®Google Scholar
• Weiss R, Dziura J, Burgert TS et al. Obesity and the metabolic syndrome in children and adolescents. N. Engl. J. Med.350(23), 2362–2374 (2004).
   PubMed Web of Science ®Google Scholar
• Berenson GS, Srinivasan SR, Bao W, Newman WP 3rd, Tracy RE, Wattigney WA. Association between multiple cardiovascular risk factors and atherosclerosis in children and young adults. The Bogalusa Heart study. N. Engl. J. Med.338(23), 1650–1656 (1998).
   PubMed Web of Science ®Google Scholar
• Silverstein JH, Rosenbloom AL. Type 2 diabetes in children. Curr. Diab. Rep.1(1), 19–27 (2001).
   Google Scholar
• Magge SN, Stettler N, Jawad AF, Levitt Katz LE. Increased prevalence of abnormal glucose tolerance among obese siblings of children with Type 2 diabetes. J. Pediatr.154(4), 562–566 e561 (2009).
   Google Scholar
• Arslanian SA, Bacha F, Saad R, Gungor N. Family history of Type 2 diabetes is associated with decreased insulin sensitivity and an impaired balance between insulin sensitivity and insulin secretion in white youth. Diabetes Care28(1), 115–119 (2005).
   PubMed Web of Science ®Google Scholar
• Groop LC, Tuomi T. Non-insulin-dependent diabetes mellitus – a collision between thrifty genes and an affluent society. Ann. Med.29(1), 37–53 (1997).
   PubMed Web of Science ®Google Scholar
• Stolerman ES, Florez JC. Genomics of Type 2 diabetes mellitus: implications for the clinician. Nat. Rev. Endocrinol.5(8), 429–436 (2009).
   PubMed Web of Science ®Google Scholar
• Olefsky JM. Treatment of insulin resistance with peroxisome proliferator-activated receptor γ agonists. J. Clin. Invest.106(4), 467–472 (2000).
   PubMed Web of Science ®Google Scholar
• Altshuler D, Hirschhorn JN, Klannemark M et al. The common PPARγ Pro12Ala polymorphism is associated with decreased risk of Type 2 diabetes. Nat. Genet.26(1), 76–80 (2000).
   PubMed Web of Science ®Google Scholar
• Gloyn AL, Weedon MN, Owen KR et al. Large-scale association studies of variants in genes encoding the pancreatic β-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with Type 2 diabetes. Diabetes52(2), 568–572 (2003).
   PubMed Web of Science ®Google Scholar
• Grant SF, Thorleifsson G, Reynisdottir I et al. Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of Type 2 diabetes. Nat. Genet.38(3), 320–323 (2006).
   PubMed Web of Science ®Google Scholar
• Zeggini E, McCarthy MI. TCF7L2: the biggest story in diabetes genetics since HLA? Diabetologia50(1), 1–4 (2007).
   PubMed Web of Science ®Google Scholar
• Groves CJ, Zeggini E, Minton J et al. Association analysis of 6,736 U.K. subjects provides replication and confirms TCF7L2 as a Type 2 diabetes susceptibility gene with a substantial effect on individual risk. Diabetes55(9), 2640–2644 (2006).
   PubMed Web of Science ®Google Scholar
• Korner A, Berndt J, Stumvoll M, Kiess W, Kovacs P. TCF7L2 gene polymorphisms confer an increased risk for early impairment of glucose metabolism and increased height in obese children. J. Clin. Endocrinol. Metab.92(5), 1956–1960 (2007).
   PubMed Web of Science ®Google Scholar
• Sellers EA, Triggs-Raine B, Rockman-Greenberg C, Dean HJ. The prevalence of the HNF-1α G319S mutation in Canadian aboriginal youth with Type 2 diabetes. Diabetes Care25(12), 2202–2206 (2002).
   Web of Science ®Google Scholar
• Arslanian SA. Metabolic differences between Caucasian and African–American children and the relationship to Type 2 diabetes mellitus. J. Pediatr. Endocrinol. Metab.15(Suppl. 1), 509–517 (2002).
   PubMed Web of Science ®Google Scholar
• Weiss R, Dziura JD, Burgert TS, Taksali SE, Tamborlane WV, Caprio S. Ethnic differences in β cell adaptation to insulin resistance in obese children and adolescents. Diabetologia49(3), 571–579 (2006).
   Google Scholar
• Weiss R, Kaufman FR. Metabolic complications of childhood obesity: identifying and mitigating the risk. Diabetes Care31(Suppl. 2), S310–S316 (2008).
   PubMed Web of Science ®Google Scholar
• Saad RJ, Danadian K, Lewy V, Arslanian SA. Insulin resistance of puberty in African–American children: lack of a compensatory increase in insulin secretion. Pediatr. Diabetes3(1), 4–9 (2002).
   Google Scholar
• Steinberger J, Daniels SR, Eckel RH et al. Progress and challenges in metabolic syndrome in children and adolescents: a scientific statement from the American Heart Association Atherosclerosis, Hypertension, and Obesity in the Young Committee of the Council on Cardiovascular Disease in the Young; Council on Cardiovascular Nursing; and Council on Nutrition, Physical Activity, and Metabolism. Circulation119(4), 628–647 (2009).
   PubMed Web of Science ®Google Scholar
• Bao W, Srinivasan SR, Berenson GS; the Bogalusa Heart study. Persistent elevation of plasma insulin levels is associated with increased cardiovascular risk in children and young adults. Circulation93(1), 54–59 (1996).
   PubMed Web of Science ®Google Scholar
• Sinaiko AR, Steinberger J, Moran A et al. Relation of body mass index and insulin resistance to cardiovascular risk factors, inflammatory factors, and oxidative stress during adolescence. Circulation111(15), 1985–1991 (2005).
   PubMed Web of Science ®Google Scholar
• Simeoni U, Barker DJ. Offspring of diabetic pregnancy: long-term outcomes. Semin. Fetal Neonatal Med.14(2), 119–124 (2009).
   PubMed Web of Science ®Google Scholar
• Plagemann A. A matter of insulin: developmental programming of body weight regulation. J. Matern. Fetal Neonatal Med.21(3), 143–148 (2008).
   PubMed Web of Science ®Google Scholar
• Silverman BL, Rizzo T, Green OC et al. Long-term prospective evaluation of offspring of diabetic mothers. Diabetes40(Suppl. 2), 121–125 (1991).
   PubMed Web of Science ®Google Scholar
• Pettitt DJ, Bennett PH, Saad MF et al. Abnormal glucose tolerance during pregnancy in Pima Indian women. Long-term effects on offspring. Diabetes40(Suppl. 2), 126–130 (1991).
   PubMed Web of Science ®Google Scholar
• Dabelea D, Mayer-Davis EJ, Lamichhane AP et al. Association of intrauterine exposure to maternal diabetes and obesity with Type 2 diabetes in youth: the SEARCH Case–Control study. Diabetes Care31(7), 1422–1426 (2008).
   PubMed Web of Science ®Google Scholar
• Dabelea D, Pettitt DJ. Intrauterine diabetic environment confers risks for Type 2 diabetes mellitus and obesity in the offspring, in addition to genetic susceptibility. J. Pediatr. Endocrinol. Metab.14(8), 1085–1091 (2001).
   PubMed Web of Science ®Google Scholar
• Bhargava SK, Sachdev HS, Fall CH et al. Relation of serial changes in childhood body-mass index to impaired glucose tolerance in young adulthood. N. Engl. J. Med.350(9), 865–875 (2004).
   PubMed Web of Science ®Google Scholar
• Eriksson JG, Forsen T, Tuomilehto J, Osmond C, Barker DJ. Early adiposity rebound in childhood and risk of Type 2 diabetes in adult life. Diabetologia46(2), 190–194 (2003).
   PubMed Web of Science ®Google Scholar
• Leunissen RW, Kerkhof GF, Stijnen T, Hokken-Koelega A. Timing and tempo of first-year rapid growth in relation to cardiovascular and metabolic risk profile in early adulthood. JAMA301(21), 2234–2242 (2009).
   PubMed Web of Science ®Google Scholar
• Pinhas-Hamiel O, Zeitler P. Clinical presentation and treatment of Type 2 diabetes in children. Pediatr. Diabetes8(Suppl. 9), 16–27 (2007).
   PubMed Web of Science ®Google Scholar
• Pinhas-Hamiel O, Standiford D, Hamiel D, Dolan LM, Cohen R, Zeitler PS. The Type 2 family: a setting for development and treatment of adolescent Type 2 diabetes mellitus. Arch. Pediatr. Adolesc. Med.153(10), 1063–1067 (1999).
   PubMedGoogle Scholar
• No authors listed. Type 2 diabetes in children and adolescents. American Diabetes Association. Pediatrics105(3 Pt 1), 671–680 (2000).
   PubMed Web of Science ®Google Scholar
• Libman IM, Barinas-Mitchell E, Bartucci A, Robertson R, Arslanian S. Reproducibility of the oral glucose tolerance test in overweight children. J. Clin. Endocrinol. Metab.93(11), 4231–4237 (2008).
   PubMed Web of Science ®Google Scholar
• Nader NS, Kumar S. Type 2 diabetes mellitus in children and adolescents: where do we stand with drug treatment and behavioral management? Curr. Diab. Rep.8(5), 383–388 (2008).
   Google Scholar
• Willi SM, Martin K, Datko FM, Brant BP. Treatment of Type 2 diabetes in childhood using a very-low-calorie diet. Diabetes Care27(2), 348–353 (2004).
   Google Scholar
• Sondike SB, Copperman N, Jacobson MS. Effects of a low-carbohydrate diet on weight loss and cardiovascular risk factor in overweight adolescents. J. Pediatr.142(3), 253–258 (2003).
   PubMed Web of Science ®Google Scholar
• Ebbeling CB, Leidig MM, Sinclair KB, Hangen JP, Ludwig DS. A reduced-glycemic load diet in the treatment of adolescent obesity. Arch. Pediatr. Adolesc. Med.157(8), 773–779 (2003).
   PubMed Web of Science ®Google Scholar
• Giannini C, de Giorgis T, Mohn A, Chiarelli F. Role of physical exercise in children and adolescents with diabetes mellitus. J. Pediatr. Endocrinol. Metab.20(2), 173–184 (2007).
   PubMed Web of Science ®Google Scholar
• Bell LM, Watts K, Siafarikas A et al. Exercise alone reduces insulin resistance in obese children independently of changes in body composition. J. Clin. Endocrinol. Metab.92(11), 4230–4235 (2007).
   PubMed Web of Science ®Google Scholar
• Kaufman FR. Type 2 diabetes mellitus in children and youth: a new epidemic. J. Pediatr. Endocrinol. Metab.15(Suppl. 2), 737–744 (2002).
   PubMed Web of Science ®Google Scholar
• Sellers EA, Dean HJ. Short-term insulin therapy in adolescents with Type 2 diabetes mellitus. J. Pediatr. Endocrinol. Metab.17(11), 1561–1564 (2004).
   Google Scholar
• Glaser B, Cerasi E. Early intensive insulin treatment for induction of long-term glycaemic control in Type 2 diabetes. Diabetes Obes. Metab.1(2), 67–74 (1999).
   PubMed Web of Science ®Google Scholar
• Jones KL, Arslanian S, Peterokova VA, Park JS, Tomlinson MJ. Effect of metformin in pediatric patients with Type 2 diabetes: a randomized controlled trial. Diabetes Care25(1), 89–94 (2002).
   PubMed Web of Science ®Google Scholar
• Dabiri G, JK, Krebs J et al. Benefits of rosiglitazone in children with T2DM. Diabetes (1904-P) (2005) (Abstract).
   Google Scholar
• Schauer PR, Burguera B, Ikramuddin S et al. Effect of laparoscopic Roux-en Y gastric bypass on Type 2 diabetes mellitus. Ann. Surg.238(4), 467–484; discussion 484–465 (2003).
   PubMed Web of Science ®Google Scholar
• Inge TH, Miyano G, Bean J et al. Reversal of Type 2 diabetes mellitus and improvements in cardiovascular risk factors after surgical weight loss in adolescents. Pediatrics123(1), 214–222 (2009).
   PubMed Web of Science ®Google Scholar
• White NH PL, Tamborlane WV, Geffner ME, Guandalini C. Clinical characteristics and co-morbidities in a large cohort of youth with Type 2 diabetes mellitus (T2DM) screened for the Treatment Options for Type 2 diabetes in Adolescents and Youth (TODAY) study. Diabetes (265-OR) (2009) (Abstract).
   Google Scholar
• Kavey RE, Allada V, Daniels SR et al. Cardiovascular risk reduction in high-risk pediatric patients: a scientific statement from the American Heart Association Expert Panel on Population and Prevention Science; the Councils on Cardiovascular Disease in the Young, Epidemiology and Prevention, Nutrition, Physical Activity and Metabolism, High Blood Pressure Research, Cardiovascular Nursing, and the Kidney in Heart Disease; and the Interdisciplinary Working Group on Quality of Care and Outcomes Research: endorsed by the American Academy of Pediatrics. Circulation114(24), 2710–2738 (2006).
   PubMed Web of Science ®Google Scholar
• Tuomilehto J, Lindstrom J, Eriksson JG et al. Prevention of Type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N. Engl. J. Med.344(18), 1343–1350 (2001).
   PubMed Web of Science ®Google Scholar
• Ettinger LM, Freeman K, DiMartino-Nardi JR, Flynn JT. Microalbuminuria and abnormal ambulatory blood pressure in adolescents with Type 2 diabetes mellitus. J. Pediatr.147(1), 67–73 (2005).
   PubMed Web of Science ®Google Scholar
• Fagot-Campagna A, Knowler WC, Pettitt D. Type 2 diabetes in Pima Indian children: cardiovascular risk factors at diagnosis and 10 years later. Diabetes47(Suppl. 1), A155 (1998).
   PubMed Web of Science ®Google Scholar
• Pavkov ME, Bennett PH, Knowler WC, Krakoff J, Sievers ML, Nelson RG. Effect of youth-onset Type 2 diabetes mellitus on incidence of end-stage renal disease and mortality in young and middle-aged Pima Indians. JAMA296(4), 421–426 (2006).
   PubMed Web of Science ®Google Scholar
• Yokoyama H, Okudaira M, Otani T et al. Higher incidence of diabetic nephropathy in Type 2 than in Type 1 diabetes in early-onset diabetes in Japan. Kidney Int.58(1), 302–311 (2000).
   PubMed Web of Science ®Google Scholar
• Yokoyama H, Okudaira M, Otani T et al. High incidence of diabetic nephropathy in early-onset Japanese NIDDM patients. Risk analysis. Diabetes Care21(7), 1080–1085 (1998).
   Google Scholar
• Bronson-Castain KW, Bearse MA Jr, Neuville J et al. Adolescents with Type 2 diabetes: early indications of focal retinal neuropathy, retinal thinning, and venular dilation. Retina29(5), 618–626 (2009).
   Web of Science ®Google Scholar
• Pavkov ME, Sievers ML, Knowler WC, Bennett PH, Nelson RG. An explanation for the increase in heart disease mortality rates in diabetic Pima Indians: effect of renal replacement therapy. Diabetes Care27(5), 1132–1136 (2004).
   Google Scholar
• Gungor N, Thompson T, Sutton-Tyrrell K, Janosky J, Arslanian S. Early signs of cardiovascular disease in youth with obesity and Type 2 diabetes. Diabetes Care28(5), 1219–1221 (2005).
   PubMed Web of Science ®Google Scholar
• Pinhas-Hamiel O, Zeitler P. Acute and chronic complications of Type 2 diabetes mellitus in children and adolescents. Lancet369(9575), 1823–1831 (2007).
   PubMed Web of Science ®Google Scholar
• Nadeau KJ, Klingensmith G, Zeitler P. Type 2 diabetes in children is frequently associated with elevated alanine aminotransferase. J. Pediatr. Gastroenterol. Nutr.41(1), 94–98 (2005).
   PubMed Web of Science ®Google Scholar
• Papandreou D, Rousso I, Mavromichalis I. Update on non-alcoholic fatty liver disease in children. Clin. Nutr.26(4), 409–415 (2007).
   PubMedGoogle Scholar
• Angulo P, Keach JC, Batts KP, Lindor KD. Independent predictors of liver fibrosis in patients with nonalcoholic steatohepatitis. Hepatology30(6), 1356–1362 (1999).
   PubMed Web of Science ®Google Scholar
• Birmingham CL, Muller JL, Palepu A, Spinelli JJ, Anis AH. The cost of obesity in Canada. CMAJ160(4), 483–488 (1999).
   PubMed Web of Science ®Google Scholar
• Johnson JA, Pohar SL, Majumdar SR. Health care use and costs in the decade after identification of Type 1 and Type 2 diabetes: a population-based study. Diabetes Care29(11), 2403–2408 (2006).
   Google Scholar
• Schubert CM, Sun SS, Burns TL, Morrison JA, Huang TT. Predictive ability of childhood metabolic components for adult metabolic syndrome and Type 2 diabetes. J. Pediatr.155(3), S6 e1–e7 (2009).
   Google Scholar
• Shah S, Kublaoui BM, Oden JD, White PC. Screening for Type 2 diabetes in obese youth. Pediatrics124(2), 573–579 (2009).
   Google Scholar
• Zeitler P, Epstein L, Grey M et al. Treatment options for Type 2 diabetes in adolescents and youth: a study of the comparative efficacy of metformin alone or in combination with rosiglitazone or lifestyle intervention in adolescents with Type 2 diabetes. Pediatr. Diabetes8(2), 74–87 (2007).
   PubMed Web of Science ®Google Scholar
• Drucker DJ, Nauck MA. The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in Type 2 diabetes. Lancet368(9548), 1696–1705 (2006).
   PubMed Web of Science ®Google Scholar