Carriage of Neisseria meningitidis in Europe: a review of studies undertaken in the region

References

• Yazdankhah SP, Caugant DA. Neisseria meningitidis, an overview of the carriage state. J. Med. Microbiol.53, 821–832 (2004).
   PubMed Web of Science ®Google Scholar
• Rosenstein NE, Perkins BA, Stephens DS, Popovic T, Hughes JM. Meningococcal disease. N. Engl. J. Med.344, 1378–1388 (2001).
   PubMed Web of Science ®Google Scholar
• Harrison LH, Trotter CL, Ramsay ME. Global epidemiology of meningococcal disease. Vaccine27(Suppl. 2), B51–B63 (2009).
   PubMed Web of Science ®Google Scholar
• Trotter CL, Chandra M, Cano R et al. A surveillance network for meningococcal disease in Europe. FEMS Microbiol. Rev.31(1), 27–36 (2007).
   PubMed Web of Science ®Google Scholar
• Aguilera JF, Perrocheau A, Meffre C, Hahné S. W135 Working Group. Outbreak of serogroup W135 meningococcal disease after the Hajj pilgrimage, Europe, 2000. Emerg. Infect. Dis.8, 761–767 (2002).
   PubMed Web of Science ®Google Scholar
• Koroleva IS, Platonov AE, van Der Ende A, Kuijper E, Dankert J. Characteristics of pathogenic Neisseria meningitidis in Moscow, prevalence of ‘non-European’ strains. Clin. Microbiol. Infect.4, 123–128 (1998).
   PubMedGoogle Scholar
• Tsolia MN, Theodoridou M, Tzanakaki G et al. Invasive meningococcal disease in children in Greece: comparison of serogroup A disease with disease caused by other serogroups. Eur. J. Clin. Microbiol. Infect. Dis.25, 449–456 (2006).
   PubMed Web of Science ®Google Scholar
• Edwards EA, Devine LF, Sengbusch GH, Ward HW. Immunological investigations of meningococcal disease. III. Brevity of group C acquisition prior to disease occurrence. Scand. J. Infect. Dis.9, 105–110 (1997).
   Google Scholar
• Kellerman SE, McCombs K, Ray M et al. Genotype-specific carriage of Neisseria meningitidis in Georgia counties with hyper- and hyposporadic rates of meningococcal disease. J. Infect. Dis.186, 40–48 (2002).
   PubMed Web of Science ®Google Scholar
• Andersen J, Berthelsen L, Jensen BB, Lind I. Surveillance of cases of meningococcal disease associated with military recruits studied for meningococcal carriage. Scand. J. Infect. Dis.32, 527–531 (2000).
   PubMedGoogle Scholar
• Chamot-Rooke J, Mikaty G, Malosse C et al. Posttranslational modification of pili upon cell contact triggers N. meningitidis dissemination. Science331, 778–782 (2011).
   PubMed Web of Science ®Google Scholar
• Neal KR, Nguyen-van-Tam JS, Slack RC, Kaczmarski EB, White A, Ala’Aldeen DA. Seven-week interval between acquisition of a meningococcus and the onset of invasive disease. A case report. Epidemiol. Infect.123, 507–509 (1999).
   PubMed Web of Science ®Google Scholar
• Maiden MC, Ibarz-Pavón AB, Urwin R et al. Impact of meningococcal serogroup C conjugate vaccines on carriage and herd immunity. J. Infect. Dis.13 (2008).
   Web of Science ®Google Scholar
• Ramsay ME, Andrews NJ, Trotter CL, Kaczmarski EB, Miller E. Herd immunity from meningococcal serogroup C conjugate vaccination in England: database analysis. BMJ326, 365–366 (2003).
   PubMed Web of Science ®Google Scholar
• Roberts J, Greenwood B, Stuart J. Sampling methods to detect carriage of Neisseria meningitidis, literature review. J. Infect.58, 103–107 (2009).
   PubMed Web of Science ®Google Scholar
• Sadler F, Borrow R, Dawson MM, Kaczmarski EB, Cartwright K, Fox AJ. Improved methods of detection of meningococcal DNA from oropharyngeal swabs from cases and contacts of meningococcal disease. Epidemiol. Infect.125, 277–283 (2000).
   PubMed Web of Science ®Google Scholar
• Diggle MA, Clarke SC. Molecular methods for the detection and characterization of Neisseria meningitidis. Expert Rev. Mol. Diagn.6, 79–87 (2006).
   PubMed Web of Science ®Google Scholar
• Christensen H, May M, Bowen L, Hickman M, Trotter CL. Meningococcal carriage by age, a systematic review and meta-analysis. Lancet Infect. Dis.10, 853–861 (2010).
   PubMed Web of Science ®Google Scholar
• De Wals P, Gilquin C, De Maeyer S, Bouckaert A, Noel A, Lechat MF. Lafontaine longitudinal study of asymptomatic meningococcal carriage in two Belgian populations of schoolchildren. J. Infect.6, 147–156 (1983).
   PubMed Web of Science ®Google Scholar
• De Wals P, Gilquin C, De Maeyer S. Methods for analyzing the frequency, prevalence and the duration of asymptomatic carriage of Neisseria meningitidis. Longitudinal study of a school population in Belgium. Med. Trop. (Mars.)42, 537–543 (1982).
   PubMedGoogle Scholar
• Claus H, Maiden MC, Wilson DJ et al. Genetic analysis of meningococci carried by children and young adults. J. Infect. Dis.191, 1263–1271 (2005).
   PubMed Web of Science ®Google Scholar
• Oppermann H, Thriene B, Irmscher HM et al. Meningococcal carriers in high school students and possible risk factors. Gesundheitswesen68, 633–637 (2006).
   PubMed Web of Science ®Google Scholar
• Conyn-van Spaendonck MA, Reintjes R, van Kregten E, Kraaijeveld AG, Jacobs PH. Meningococcal carriage in relation to an outbreak of invasive disease due to Neisseria meningitidis serogroup C in The Netherlands. J. Infect.39, 42–48 (1999).
   PubMed Web of Science ®Google Scholar
• Bogaert D, Hermans PW, Boelens H et al. Epidemiology of nasopharyngeal carriage of Neisseria meningitidis in healthy Dutch children. Clin. Infect. Dis.40, 899–902 (2005).
   PubMed Web of Science ®Google Scholar
• Fraser PK, Bailey GK, Abbott JD, Gill JB, Walker DJ. The meningococcal carrier-rate. Lancet1, 1235–1237 (1973).
   PubMed Web of Science ®Google Scholar
• Gilmore A, Jones G, Barker M, Soltanpoor N, Stuart JM. Meningococcal disease at the University of Southampton: outbreak investigation. Epidemiol. Infect.123, 185–192 (1999).
   PubMed Web of Science ®Google Scholar
• Riordan T. A college outbreak of group C meningococcal infection, how widely should investigation and prophylaxis extend? Commun. Dis. Rep. CDR Rev.7, R5–R9 (1997).
   PubMedGoogle Scholar
• Fitzpatrick PE, Salmon RL, Hunter PR, Roberts RJ, Palmer SR. Risk factors for carriage of Neisseria meningitidis during an outbreak in Wales. Emerg. Infect. Dis.6, 65–69 (2000).
   PubMed Web of Science ®Google Scholar
• Robinson K, Neal KR, Howard C et al. Characterization of humoral and cellular immune responses elicited by meningococcal carriage. Infect. Immun.70, 1301–1309 (2002).
   PubMed Web of Science ®Google Scholar
• Cann KJ, Rogers TR, Jones DM, Noah ND, Burns C. Neisseria meningitidis in a primary school. Arch. Dis. Child.62, 1113–1117 (1987).
   PubMed Web of Science ®Google Scholar
• Neal KR, Irwin DJ, Davies S, Kaczmarski EB, Wale MC. Sustained reduction in the carriage of Neisseria meningitidis as a result of a community meningococcal disease control programme. Epidemiol. Infect.121, 487–493 (1998).
   PubMed Web of Science ®Google Scholar
• Ala’Aldeen DA, Neal KR, Ait-Tahar K et al. Dynamics of meningococcal long-term carriage among university students and their implications for mass vaccination. J. Clin. Microbiol.38, 2311–2316 (2000).
   PubMed Web of Science ®Google Scholar
• Jordens JZ, Williams JN, Jones GR, Christodoulides M, Heckels JE. Development of immunity to serogroup B meningococci during carriage of Neisseria meningitidis in a cohort of university students. Infect. Immun.72, 6503–6510 (2004).
   PubMed Web of Science ®Google Scholar
• Greiner O, Berger C, Day PJ, Meier G, Tang CM, Nadal D. Rates of detection of Neisseria meningitidis in tonsils differ in relation to local incidence of invasive disease. J. Clin. Microbiol.40, 3917–3921 (2002).
   PubMed Web of Science ®Google Scholar
• Kriz P, Kriz B, Svandova E, Musilek M. Antimeningococcal herd immunity in the Czech Republic – influence of an emerging clone, Neisseria meningitidis ET-15/37. Epidemiol. Infect.123, 193–200 (1999).
   PubMed Web of Science ®Google Scholar
• Jolley KA, Kalmusova J, Feil EJ et al. Carried meningococci in the Czech Republic, a diverse recombining population. J. Clin. Microbiol.38(12), 4492–4498 (2000).
   PubMed Web of Science ®Google Scholar
• Jolley KA, Kalmusova J, Feil EJ et al. Authors correction. Carried meningococci in the Czech Republic, a diverse recombining population. J. Clin. Microbiol.40(9), 3549–3550 (2002).
   Web of Science ®Google Scholar
• Kremastinou J, Tzanakaki G, Velonakis E et al. Carriage of Neisseria meningitidis and Neisseria lactamica among ethnic Greek school children from Russian immigrant families in Athens. FEMS Immunol. Med. Microbiol.23, 13–20 (1999).
   PubMed Web of Science ®Google Scholar
• Kremastinou J, Tzanakaki G, Levidiotou S et al. Carriage of Neisseria meningitidis and Neisseria lactamica in northern Greece. FEMS Immunol. Med. Microbiol.39, 23–29 (2003).
   PubMedGoogle Scholar
• Pavlopoulou ID, Daikos GL, Alexandrou H et al. Carriage of Neisseria meningitidis by Greek children: risk factors and strain characteristics. Clin. Microbiol. Infect.10, 137–142 (2004).
   PubMed Web of Science ®Google Scholar
• Verdú ME, Coll P, Vázquez JA et al. Association between asymptomatic carriage and sporadic (endemic) meningococcal disease in an open community. Epidemiol. Infect.127, 245–259 (2001).
   PubMed Web of Science ®Google Scholar
• Domínguez A, Cardeñosa N, Izquierdo C et al. Prevalence of Neisseria meningitidis carriers in the school population of Catalonia, Spain. Epidemiol. Infect.127, 425–433 (2001).
   PubMed Web of Science ®Google Scholar
• Fernández S, Arreaza L, Santiago I et al. Impact of meningococcal vaccination with combined serogroups A and C polysaccharide vaccine on carriage of Neisseria meningitidis C. J. Med. Microbiol.52, 75–77 (2003).
   PubMed Web of Science ®Google Scholar
• Saez-Nieto JA, Dominguez JR, Monton JL et al. Carriage of Neisseria meningitidis and Neisseria lactamica in a school population during an epidemic period in Spain. J. Hyg. (Lond.)94, 279–288 (1985).
   PubMedGoogle Scholar
• Calle PEM, Morano FL, Leralta M, Del RCJ. Estimation of Neisseria meningitidis carriers among healthy subjects in contact with patients with meningococcal sepsis in the Madrid area. An. Esp. Pediatr.39, 102–104 (1993).
   Google Scholar
• Caugant DA, Høiby EA, Magnus P et al. Asymptomatic carriage of Neisseria meningitidis in a randomly sampled population. J. Clin. Microbiol.32, 323–330 (1994).
   PubMed Web of Science ®Google Scholar
• Kristiansen BE, Lind KW, Mevold K et al. Meningococcal phenotypic and genotypic characteristics and human antibody levels. J. Clin. Microbiol.26, 1988–1992 (1988).
   PubMed Web of Science ®Google Scholar
• Holten E, Bratlid D, Bøvre K. Carriage of Neisseria meningitidis in a semi-isolated arctic community. Scand. J. Infect. Dis.10, 36–40 (1978).
   PubMed Web of Science ®Google Scholar
• Chapalain JC, Guibourdenche M, Perrier-Gros-Claude JD, Bartoli M, Riou JY. The chemoprophylaxis of cerebrospinal meningitis using rifampin in a military population. Pathol. Biol. (Paris)40, 230–233 (1992).
   PubMedGoogle Scholar
• Glitza IC, Ehrhard I, Müller-Pebody B et al. Longitudinal study of meningococcal carrier rates in teenagers. Int. J. Hyg. Environ. Health211(3–4), 263–272 (2008).
   PubMed Web of Science ®Google Scholar
• Linde H, Glück T, Metz M, Reng C, Erlmeier S, Lehn N. Six different strains of Neisseria meningitidis in a case with meningococcal sepsis and five contact persons in a boys’ home. Infection28, 157–160 (2000).
   PubMed Web of Science ®Google Scholar
• Cartwright KA, Stuart JM, Jones DM, Noah ND. The Stonehouse survey: nasopharyngeal carriage of meningococci and Neisseria lactamica. Epidemiol. Infect.99, 591–601 (1987).
   PubMed Web of Science ®Google Scholar
• Blackwell CC, Weir DM, James VS, Cartwright KA, Stuart JM, Jones DM. The Stonehouse study: secretor status and carriage of Neisseria species. Epidemiol. Infect.102, 1–10 (1989).
   PubMed Web of Science ®Google Scholar
• Blackwell CC, Weir DM, James VS et al. Secretor status, smoking and carriage of Neisseria meningitidis. Epidemiol. Infect.104, 203–209 (1990).
   PubMed Web of Science ®Google Scholar
• Cartwright KA, Stuart JM, Noah ND. An outbreak of meningococcal disease in Gloucestershire. Lancet2, 558–561 (1986).
   PubMed Web of Science ®Google Scholar
• Neal KR, Nguyen-Van-Tam JS, Jeffrey N et al. Changing carriage rate of Neisseria meningitidis among university students during the first week of term: cross sectional study. BMJ320, 846–849 (2000).
   PubMed Web of Science ®Google Scholar
• Round A, Evans MR, Salmon RL et al. Public health management of an outbreak of group C meningococcal disease in university campus residents. Eur. J. Pub. Health11, 431–436 (2001).
   PubMed Web of Science ®Google Scholar
• Jones GR, Williams JN, Christodoulides M, Jolley K, Heckels JE. Lack of immunity in university students before an outbreak of serogroup C meningococcal infection. J. Infect. Dis.181, 1172–1175 (2000).
   PubMed Web of Science ®Google Scholar
• Jordens JZ, Williams JN, Jones GR, Heckels JE. Detection of meningococcal carriage by culture and PCR of throat swabs and mouth gargles. J. Clin. Microbiol.40, 75–79 (2002).
   PubMed Web of Science ®Google Scholar
• Orr HJ, Gray SJ, Macdonald M, Stuart JM. Saliva and meningococcal transmission. Emerg. Infect. Dis.9, 1314–1315 (2003).
   PubMed Web of Science ®Google Scholar
• Bidmos FA, Neal KR, Oldfield NJ, Turner DP, Ala’Aldeen DA, Bayliss CD. Rapid clonal expansion, persistence and clonal replacement of meningococcal carriage isolates in a 2008 university student cohort. J. Clin. Microbiol.49, 506–512 (2010).
   PubMed Web of Science ®Google Scholar
• Wall R, Wilson J, MacArdle B, Vellani Z. Meningococcal infection: evidence for school transmission. J. Infect.23, 155–159 (1991).
   PubMed Web of Science ®Google Scholar
• Farries JS, Dickson W, Greenwood E, Malhotra TR, Abbott JD, Jones DM. Meningococcal infections in Bolton, 1971–1974. Lancet2, 118–120 (1975).
   PubMed Web of Science ®Google Scholar
• Davies AL, O’Flanagan D, Salmon RL, Coleman TJ. Risk factors for Neisseria meningitidis carriage in a school during a community outbreak of meningococcal infection. Epidemiol. Infect.117, 259–266 (1996).
   PubMed Web of Science ®Google Scholar
• Cartwright KA, Stuart JM, Robinson PM. Meningococcal carriage in close contacts of cases. Epidemiol. Infect.106, 133–141 (1991).
   PubMed Web of Science ®Google Scholar
• Irwin DJ, Crawshaw JG, Readman RA, Teare L, Kaczmarski EB. Carriage of Neisseria meningitidis in residents and staff at a residential home for elderly people following a case of invasive disease. Commun. Dis. Pub. Health3, 172–174 (2000).
   PubMedGoogle Scholar
• Masterton RG, Youngs ER, Wardle JC, Croft KF, Jones DM. Control of an outbreak of group C meningococcal meningitis with a polysaccharide vaccine. J. Infect.17, 177–182 (1998).
   Google Scholar
• Pether JV, Lightfoot NF, Scott RJ, Morgan J, Steele-Perkins AP, Sheard SC. Carriage of Neisseria meningitidis, investigations in a military establishment. Epidemiol. Infect.101, 21–42 (1988).
   PubMed Web of Science ®Google Scholar
• Tayal SC, Rashid S, Muttu KM, Hildreth AJ. Meningococcal carriage: prevalence and sex-related risk factors. J. Infect.34, 101–105 (1997).
   PubMed Web of Science ®Google Scholar
• Tayal SC, Rashid S, Muttu KM. An audit of pharyngeal infection in patients attending GUM clinic in Sunderland. Int. J. STD AIDS6, 60–61 (1995).
   PubMed Web of Science ®Google Scholar
• Young H, Bain SS. Neisserial colonisation of the pharynx. Br. J. Vener. Dis.59, 228–231 (1983).
   PubMedGoogle Scholar
• Young H, Harris AB, Robertson DH. Individual susceptibility to neisserial infection? Br. J. Vener. Dis.55, 188–190 (1979).
   PubMedGoogle Scholar
• Bennett JS, Griffiths DT, McCarthy ND et al. Genetic diversity and carriage dynamics of Neisseria lactamica in infants. Infect. Immun.73, 2424–2432 (2005).
   PubMed Web of Science ®Google Scholar
• Sim RJ, Harrison MM, Moxon ER, Tang CM. Underestimation of meningococci in tonsillar tissue by nasopharyngeal swabbing. Lancet356, 1653–1654 (2000).
   PubMed Web of Science ®Google Scholar
• Caugant DA, Tzanakaki G, Kriz P. Lessons from meningococcal carriage studies. FEMS Microbiol. Rev.31, 52–63 (2007).
   PubMed Web of Science ®Google Scholar
• Tyski S, Grzybowska W, Dulny G, Berthelsen L, Lind I. Phenotypical and genotypical characterization of Neisseria meningitidis carrier strains isolated from Polish recruits in 1998. Eur. J. Clin. Microbiol. Infect. Dis.20, 350–353 (2001).
   PubMed Web of Science ®Google Scholar
• Grzybowska W, Tyski S. Characterization of Neisseria meningitidis strains isolated from carriers. Med. Dosw. Mikrobiol.52, 257–266 (2000).
   PubMedGoogle Scholar
• Grzybowska W, Dulny G, Czerska A, Tyski S. The study of carrier of Neisseria meningitidis performed in Zielonec and characteristics of meningogocci isolated from patients at the Wołomin hospital, Warsaw district. Przegl. Epidemiol.52, 237–244 (1998).
   PubMedGoogle Scholar
• Tyski S, Grzybowska W, Dulny G. Tests for Neisseria meningitidis in adolescents and adults (recruits). Med. Dosw. Mikrobiol.52, 247–255 (2000).
   PubMedGoogle Scholar
• Kremastinou J, Blackwell C, Tzanakaki G, Kallergi C, Elton R, Weir D. Parental smoking and carriage of Neisseria meningitidis among Greek schoolchildren. Scand. J. Infect. Dis.26, 719–723 (1994).
   PubMed Web of Science ®Google Scholar
• Blackwell CC, Tzanakaki G, Kremastinou J et al. Factors affecting carriage of Neisseria meningitidis among Greek military recruits. Epidemiol. Infect.108, 441–448 (1992).
   PubMed Web of Science ®Google Scholar
• Kalapothaki V, Vassiliadis P, Trichopoulos D, Kaklamani E, Sérié C. Sero-epidemiological characteristics of the meningococcal carrier state in Greece. Ann. Microbiol. (Paris)130B, 43–54 (1979).
   PubMed Web of Science ®Google Scholar
• Fernández S, Arreaza L, Santiago I et al. Carriage of a new epidemic strain of Neisseria meningitidis and its relationship with the incidence of meningococcal disease in Galicia, Spain. Epidemiol. Infect.123, 349–357 (1999).
   PubMed Web of Science ®Google Scholar
• Uberos J, Molina-Carballo A, Galdo-Muñoz G, Muñoz-Hoyos A. Total antioxidant capacity of plasma in asymptomatic carrier state of Neisseria meningitidis. Epidemiol. Infect.135, 857–860 (2007).
   PubMed Web of Science ®Google Scholar
• Fontanals D, Van Esso D, Pons I et al. Prevalence of Neisseria meningitidis carriers among the population of Cerdanyola (Barcelona). Enferm. Infecc. Microbiol. Clin.13, 398–405 (1995).
   PubMedGoogle Scholar
• Cardeñosa N, Domínguez A, Orcau A et al. Carriers of Neisseria meningitidis in household contacts of meningococcal disease cases in Catalonia (Spain). Eur. J. Epidemiol.17, 877–884 (2001).
   PubMed Web of Science ®Google Scholar
• Rodriguez-Contreras Pelayo R, Rodriguez MR, Fernandez-Crehuet M, Fernandez-Crehuet J, Vargas RG. Evaluation of Neisseria meningitidis carriage in families where a case of cerebrospinal meningitis has occurred. Med. Trop. (Mars.)41(4), 443–448 (1981).
   PubMedGoogle Scholar
• Di Martino M, Calì G, Astorre P, Usai GC, Ferrari R, Stroffolini T. Meningococcal carriage and vaccination in army recruits in Italy. Boll. Ist. Sieroter. Milan69, 357–359 (1990).
   PubMedGoogle Scholar
• Stroffolini T, Angelini L, Galanti I, Occhionero M, Congiu ME, Mastrantonio P. The effect of meningococcal group A and C polysaccharide vaccine on nasopharyngeal carrier state. Microbiologica13, 225–229 (1990).
   PubMed Web of Science ®Google Scholar
• Germinario C, Tafuri S, Napoli C et al. Young-adult carriers of Neisseria meningitidis in Puglia (Italy). Will the pattern of circulating meningococci change following the introduction of meningococcal serogroup C conjugate vaccines? Hum. Vaccin.6(12), 1025–1027 (2010).
   PubMed Web of Science ®Google Scholar
• Rønne T, Berthelsen L, Buhl LH, Lind I. Comparative studies on pharyngeal carriage of Neisseria meningitidis during a localized outbreak of serogroup C meningococcal disease. Scand. J. Infect. Dis.25, 331–339 (1993).
   PubMed Web of Science ®Google Scholar
• Olsen SF, Djurhuus B, Rasmussen K et al. Pharyngeal carriage of Neisseria meningitidis and Neisseria lactamica in households with infants within areas with high and low incidences of meningococcal disease. Epidemiol. Infect.106, 445–457 (1991).
   PubMed Web of Science ®Google Scholar
• Weis N, Lind I. Pharyngeal carriage of Neisseria meningitidis before and after treatment of meningococcal disease. J. Med. Microbiol.41, 339–342 (1994).
   PubMed Web of Science ®Google Scholar
• Andersen J, Berthelsen L, Bech Jensen B, Lind I. Dynamics of the meningococcal carrier state and characteristics of the carrier strains: a longitudinal study within three cohorts of military recruits. Epidemiol. Infect.121, 85–94 (1998).
   PubMed Web of Science ®Google Scholar
• Renkonen OV, Sivonen A, Visakorpi R. Effect of ciprofloxacin on carrier rate of Neisseria meningitidis in army recruits in Finland. Antimicrob. Agents Chemother.31, 962–963 (1987).
   PubMed Web of Science ®Google Scholar
• Mäkelä PH, Käyhty H, Weckström P, Sivonen A, Renkonen OV. Effect of group-A meningococcal vaccine in army recruits in Finland. Lancet2, 883–886 (1975).
   PubMed Web of Science ®Google Scholar
• Sivonen A, Renkonen OV, Weckström P, Koskenvuo K, Raunio V, Mäkelä PH. The effect of chemoprophylactic use of rifampin and minocycline on rates of carriage of Neisseria meningitidis in army recruits in Finland. J. Infect. Dis.137, 238–244 (1978).
   PubMed Web of Science ®Google Scholar
• Jounio U, Juvonen R, Bloigu A et al. Pneumococcal carriage is more common in asthmatic than in non-asthmatic young men. Clin. Respir. J.4, 222–229 (2010).
   PubMed Web of Science ®Google Scholar
• Caugant DA, Kristiansen BE, Frøholm LO, Bøvre K, Selander RK. Clonal diversity of Neisseria meningitidis from a population of asymptomatic carriers. Infect. Immun.56, 2060–2068 (1988).
   PubMed Web of Science ®Google Scholar
• Kristiansen BE, Elverland H. Increased meningococcal carrier rate after tonsillectomy. Br. Med. J. (Clin. Res. Ed.)288, 974 (1984).
   PubMed Web of Science ®Google Scholar
• Smith I, Lehmann AK, Lie L et al. Outbreak of meningococcal disease in western Norway due to a new serogroup C variant of the ET-5 clone: effect of vaccination and selective carriage eradication. Epidemiol. Infect.123, 373–382 (1999).
   PubMed Web of Science ®Google Scholar
• Bevanger L, Bergh K, Gisnås G, Caugant DA, Frøholm LO. Identification of nasopharyngeal carriage of an outbreak strain of Neisseria meningitidis by pulsed-field gel electrophoresis versus phenotypic methods. J. Med. Microbiol.47, 993–998 (1998).
   PubMed Web of Science ®Google Scholar
• Kristiansen BE, Tveten Y, Ask E et al. Preventing secondary cases of meningococcal disease by identifying and eradicating disease-causing strains in close contacts of patients. Scand. J. Infect. Dis.24, 165–173 (1992).
   PubMed Web of Science ®Google Scholar
• Kristiansen BE, Tveten Y, Jenkins A. Which contacts of patients with meningococcal disease carry the pathogenic strain of Neisseria meningitidis? A population based study. BMJ317, 621–325 (1998).
   PubMed Web of Science ®Google Scholar
• Caugant DA, Høiby EA, Rosenqvist E, Frøholm LO, Selander RK. Transmission of Neisseria meningitidis among asymptomatic military recruits and antibody analysis. Epidemiol. Infect.109, 241–253 (1992).
   PubMed Web of Science ®Google Scholar
• Frøholm LO, Berdal BP, Bøvre K et al. Meningococcal group B vaccine trial in Norway 1981–1982. Preliminary report of results available November 1982. NIPH Ann.6, 133–138 (1983).
   PubMedGoogle Scholar
• Olcén P, Kjellander J, Danielsson D, Lindquist BL. Culture diagnosis of meningococcal carriers: yield from different sites and influence of storage in transport medium. J. Clin. Pathol.32, 1222–1225 (1979).
   PubMed Web of Science ®Google Scholar
• Olcén P, Kjellander J, Danielsson D, Lindquist BL. Epidemiology of Neisseria meningitidis, prevalence and symptoms from the upper respiratory tract in family members to patients with meningococcal disease. Scand. J. Infect. Dis.13, 105–109 (1981).
   PubMedGoogle Scholar
• MacLennan J, Kafatos G, Neal K et al. Social behavior and meningococcal carriage in British teenagers. Emerg. Infect. Dis.12, 950–957 (2006).
   PubMed Web of Science ®Google Scholar
• Maiden MC, Stuart JM. UK meningococcal carriage group. Carriage of serogroup C meningococci 1 year after meningococcal C conjugate polysaccharide vaccination. Lancet359, 1829–1831 (2002).
   PubMed Web of Science ®Google Scholar
• Stuart JM, Cartwright KA, Robinson PM, Noah ND. Effect of smoking on meningococcal carriage. Lancet2, 723–725 (1989).
   PubMed Web of Science ®Google Scholar
• Reintjes R, Kajueter H, Ehrhard I, van Treeck U, Ammons A. Applying a case–crossover study design to examine transient exposures in the transmission of N. meningitidis. Eur. J. Epidemiol.20, 629–633 (2005).
   PubMed Web of Science ®Google Scholar
• Trotter CL, Maiden MC. Meningococcal vaccines and herd immunity: lessons learned from serogroup C conjugate vaccination programs. Expert Rev. Vaccines8, 851–861 (2009).
   PubMed Web of Science ®Google Scholar
• Yazdankhah SP, Kriz P, Tzanakaki G et al. Distribution of serogroups and genotypes among disease-associated and carried isolates of Neisseria meningitidis from the Czech Republic, Greece, and Norway. J. Clin. Microbiol.42(11), 5146–5153 (2004).
   PubMed Web of Science ®Google Scholar
• Harrison OB, Brueggemann AB, Caugant DA et al. Molecular typing methods for outbreak detection and surveillance of invasive disease caused by Neisseria meningitidis, Haemophilus influenzae and Streptococcus pneumoniae, a review. Microbiology157(Pt 8), 2181–2195 (2011).
   PubMed Web of Science ®Google Scholar
• Kristiansen PA, Diomandé F, Wei SC et al. Baseline meningococcal carriage in Burkina Faso before the introduction of a meningococcal serogroup A conjugate vaccine. Clin. Vaccine Immunol.18, 435–443 (2011).
   PubMed Web of Science ®Google Scholar