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Review

Treatment of neuro-Behçet’s disease: an update

Pages 565-574 | Published online: 09 Jan 2014

References

  • Borhani Haghighi A, Pourmand R, Nikseresht AR. Neuro-Behçet’s disease: a review. Neurologist11, 80–89 (2005).
  • Akman-Demir G, Serdaroglu P, Tasci B; the Neuro-Behçet Study Group. Clinical patterns of neurological involvement in Behçet’s disease: evaluation of 200 patients. Brain122, 2171–2182 (1999).
  • Davatchi F. Behçet’s disease: global perspective. Indian J. Rheumatol.2, 65–71 (2007).
  • Scolding NJ, Joseph FG. Neuro-Behçet’s disease in Caucasians: a study of 22 patients. Eur. J. Neurol.14(2), 174–180 (2007).
  • Suda A, Takeno M, Ideguchi H et al. Neurological manifestations in Japanese patients with Behçet’s disease: a retrospective analysis in Japan (I 8). Presented at: 13th International Congress on Behçet’s Disease. Pörtschach/Klagenfurt, Austria, 24–27 May 2008.
  • Kurtuncu M, Tuzen E, Mutlu M, Pehlivan M, Serdaroglu P, Akman Demir G. Clinical patterns and course of neuro-Behçet’s disease. Analysis of 354 patients comparing cases presented before and after 1990 (I 7). Presented at: 13th International Congress on Behçet’s Disease. Pörtschach/Klagenfurt, Austria, 24–27 May 2008.
  • Borhani Haghighi A, Samangooie S, Ashjazadeh N et al. Neurological manifestations of Behçet’s disease. Saudi Med. J.27(10), 1542–1546 (2006).
  • Al-Araji A, Sharquie K, Al-Rawi Z. Prevalence and patterns of neurological involvement in Behçet’s disease: a prospective study from Iraq. J. Neurol. Neurosurg. Psychiatry74(5), 608–613 (2003)
  • Serdaroglu P. Behçet’s disease and the nervous system. J. Neurol.245(4), 197–205 (1998).
  • Aykutlu E, Baykan B, Serdaroglu P, Gökyigit A, Akman-Demir G. Epileptic seizures in Behçet disease. Epilepsia43(8), 832–835 (2002)
  • Bogdanova D, Milanov I, Georgiev D. Parkinsonian syndrome as a neurological manifestation of Behçet’s disease. Can. J. Neurol. Sci.25, 82–85(1998).
  • Borhani Haghighi A, Aflaki E, Ketabchi L. The prevalence and characteristics of different types of headache in patients with Behçet’s disease. Headache48, 424–429 (2008)
  • Saip S, Siva A, Altintas A et al. Headache in Behçet’s syndrome. Headache45, 911–919 (2005)
  • Calikoglu E, Onder M, Cosar B, Candansayar S. Depression, anxiety levels and general psychological profile in Behçet’s disease. Dermatology203(3), 238–240 (2001).
  • Davis LE, Hodgin VG, Kornfeld M. Recurrent meningoencephalitis with recovery from Behçet’s disease. West. J. Med.145, 238–239 (1986).
  • Appenzeller S, de Castro R, de Queiroz LS et al. Brain tumor-like lesion in Behçet disease. Rheumatol. Int.26, 577–580 (2006).
  • Schmolck H. Large thalamic mass due to neuro-Behçet disease. Neurology965, 436 (2005).
  • Yesilot N, Mutlu M, Gungor O, Baykal B, Serdaroglu P, Akman-Demir G. Clinical characteristics and course of spinal cord involvement in Behçet’s disease. Eur. J. Neurol.14(7), 729–737 (2007).
  • Wechsler B, Vidailhet M, Piette JC et al. Cerebral venous thrombosis in Behcet’s disease: clinical study and long-term follow-up of 25 cases. Neurology42, 614–618 (1992).
  • Krespi Y, Akman-Demir G, Poyraz M et al. Cerebral vasculitis and ischaemic stroke in Behçet’s disease: report of one case and review of the literature. Eur. J. Neurol.8(6), 719–722 (2001).
  • Borahni Haghighi A, Sharifzad HR, Matin S, Rezaee S. The pathological presentations of neuro-Behçet disease: a case report and review of the literature. Neurologist13(4), 209–214 (2007).
  • Yoshimura J, Toyama M, Sekihara Y et al. Neuro-Behcet disease mimicking a thalamic tumor. No Shinkei Geka29, 527–531 (2001).
  • Matsuo K, Yamada K, Nakajima K et al. Neuro-Behçet disease mimicking brain tumor. Am. J. Neuroradiol.26, 650–653 (2005).
  • Arai T, Mizukami K, Sasaki M et al. Clinicopathological study on a case of neuro-Behçet disease: in special reference to MRI, SPECT and neuropathological findings. Jpn. J. Psychiatry Neurol.48, 77–84 (1994).
  • Hadfield MG, Aydin F, Lippman HR et al. Neuro-Behçet disease. Clin. Neuropathol.15, 249–255 (1996).
  • Borhani Haghighi A. Comment on “Histopathology of central nervous system lesions in Behçet’s disease”. J. Neurol. Sci.270(1–2), 211 (2008).
  • International Study Group for Behçet’s Disease. Criteria for diagnosis of Behçet’s disease. Lancet335, 1078–1080 (1990).
  • Borhani Haghighi A, Aflaki E, Haghshenas S, Savagheb S, Davoudi S. Psychometric evaluation of patients with Behçet’s disease. Iranian J. Med. Sci.32(2), 110–113 (2008).
  • Kang DW, Chu K, Cho JY et al. Diffusion weighted magnetic resonance imaging in neuro-Behçet’s disease. J. Neurol. Neurosurg. Psychiatry70, 412–413 (2001).
  • Nussel F, Wegmuller H, Laseyras F et al. Neuro-Behçet’s: acute and sequential aspects by MRI and MRS. Eur. Neurol.31, 399–402 (1991).
  • Kocek N, Islak C, Siva A et al. CNS involvement in Neuro-Behçet syndrome: an MR study. Am. J. Neuroradol.20, 1015–1024 (1999).
  • Akman-Demir G, Bahar S, Coban O, Tasci B, Serdaroglu P. Cranial MRI in Behçet’s disease: 134 examinations of 98 patients. Neuroradiology45(12), 851–859 (2003).
  • Bohlega S, Al–Kawi MZ, El–Ramahi K. Factors hampering prognosis in neuro-Behçet’s disease. Neurology48(Suppl. 3), A98 (1997)
  • Siva A, Kantarcy O, Saip S. Hamuryudan V, Altyntas A, Yazici H. Neuro-Behçet syndrome: prognostic factors and survival. J. Neurol.245, 362 (1998).
  • Hatemi G, Silman A, Bang D et al. EULAR recommendations for the management of Behçet’s disease: report of a task force of the European Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT). Ann. Rheum. Dis.67(12), 1656–1662 (2008).
  • Davatchi F. New and innovative therapies for Behçet’s disease . APLAR J. Rheumatol.7, 141–145 (2004).
  • Mat C, Yurdakul S, Uysal S et al. A double-blind trial of depot corticosteroids in Behçet’s syndrome. Rheumatology (Oxford)45(3), 348–352 (2006).
  • de Souza-Ramalho P, D’Almeida MF, Freitas JP, Pinto J. Behçet’s disease in Portugal. Acta Med. Port.4(2), 79–82 (1991).
  • Yazici H, Pazarli H, Barnes CG et al. A controlled trial of azathioprine in Behçet’s syndrome. N. Engl. J. Med.322(5), 326–328 (1990).
  • Hamuryudan V, Ozyazgan Y, Hizli N et al. Azathioprine in Behçet’s syndrome: effects on long-term prognosis. Arthritis Rheum.40(4), 769–774 (1997).
  • Sies C, Florkowski C, George P et al.Measurement of thiopurine methyl transferase activity guides dose-initiation and prevents toxicity from azathioprine. NZ Med. J.118(1210), U1324 (2005).
  • Garrick V, Atwal P, Barclay AR, McGrogan P, Russell RK. Successful implementation of a nurse-led teaching programme to administer methotrexate in the community setting to children with Crohn’s disease. Aliment Pharmacol. Ther. (2008) (Epub ahead of print).
  • Chikura B, Sathi N, Lane S, Dawson JK. Variation of immunological response in methotrexate-induced pneumonitis. Rheumatology (Oxford)47(11), 1647–1650 (2008).
  • Hirohata S, Suda H, Hashimoto T. Low-dose weekly methotrexate for progressive neuropsychiatric manifestations in Behçet’s disease. J. Neurol. Sci.159(2), 181–185 (1998).
  • Kikuchi H, Aramaki K, Hirohata S. Low dose MTX for progressive neuro-Behçet’s disease. A follow-up study for 4 years. Adv. Exp. Med. Biol.528, 575–578 (2003).
  • Ziereisen F, Dan B, Azzi N, Ferster A, Damry N, Christophe C. Reversible acute methotrexate leukoencephalopathy: atypical brain MR imaging features. Pediatr. Radiol.36(3), 205–212 (2006).
  • Saenz A, Ausejo M, Shea B, Wells G, Welch V, Tugwell P. Pharmacotherapy for Behçet’s syndrome. Cochrane Database Syst. Rev.2, CD001084 (2000).
  • Hamza M, Meddeb S, Mili I, Ouertani A. [Bolus of cyclophosphamide and methylprednisolone in uveitis in Behçet’s disease. Preliminary results with the use of new criteria of evaluation]. Ann. Med. Interne (Paris)143(7), 438–441 (1992).
  • Du LT, Fain O, Wechsler B, Cochereau I et al. [Value of ‘bolus’ cyclophosphamide injections in Behçet’s disease. Experience of 17 cases]. Presse Med.19(9), 1355–1358 (1990).
  • Boura P, Tselios K, Kamali S, Skendros P, Sarantopoulos A, Topouzis F. Concurrent relapsing central nervous system and ocular involvement in a case of life-threatening Adamantiades-Behçet disease (ABD). Neurol. Sci.27(6), 432–435 (2006).
  • Siva A, Fresko II. Behçet’s disease. Curr. Treat. Options Neurol.2(5), 435–448 (2000).
  • Watanabe T, Shimoji S, Sugiyama Y, Tsukamoto T, Yamamoto T. [Pulse-dose cyclophosphamide therapy for steroid-refractory autoimmune neurological diseases]. Rinsho Shinkeigaku35(6), 611–616 (1995).
  • Melillo N, Sangle S, Stanford MR, Andrews TC, D’Cruz DP. Low-dose intra-venous cyclophosphamide therapy in a patient with neurological complications of Behçet’s disease. Clin Rheumatol.26(8), 1365–1367 (2007).
  • Travis LB, Curtis RE, Glimelius B et al. Bladder and kidney cancer following cyclophosphamide therapy for non-Hodgkins lymphoma. J. Natl Cancer Inst.87, 524–530 (1995).
  • Mateos-Colino A, Gonzalez-Gay MA, Cereijo MJ, Santiago J, Rabuñal R, Brañas F. [Neuro-Behçet: a follow-up of 4 cases treated with chlorambucil]. An. Med. Interna12(12), 600–602 (1995).
  • O’Duffy JD, Robertson DM, Goldstein NP. Chlorambucil in the treatment of uveitis and meningoencephaliltis of Behçet’s disease. Am. J. Med.76, 75–84 (1984).
  • Kotter I, Gunaydin I, Zierhut M, Stubiger N. The use of interferon a in Behçet disease: review of the literature. Semin. Arthritis Rheum.33, 320–335 (2004).
  • Calguneri M, Ozturk MA, Ertenli I et al. Effects of interferon-α treatment on the clinical course of refractory Behçet’s disease: an open study. Ann. Rheum. Dis.62, 492–493 (2003).
  • Kötter I, Vonthein R, Zierhut M et al. Differential efficacy of human recombinant interferon-α2a on ocular and extraocular manifestations of Behçet disease: results of an open 4-center trial. Semin. Arthritis Rheum.33(5), 311–319 (2004).
  • Nichols JC, Ince A, Akduman L et al. Interferon-α 2a treatment of neuro-Behcet’s disease. J. Neuroophthalmol.21, 109–111 (2001).
  • Kuemmerle-Deschner JB, Tzaribachev N, Deuter C, Zierhut M, Batra M, Koetter I. Interferon-α – a new therapeutic option in refractory juvenile Behçet's disease with CNS involvement. Rheumatology (Oxford)47(7), 1051–1053 (2008)
  • Zouboulis CC, May T. Pathogenesis of Adamantiades-Behçet’s disease. Med. Microbiol. Immunol.192, 149–155 (2003).
  • Reimold AM. TNF a as therapeutic target: new drugs, more applications. Curr. Drug Targets Inflamm. Allergy.1(4), 377–392 (2002).
  • Licata G, Pinto A, Tuttolomondo A et al. Anti-tumour necrosis factor α monoclonal antibody therapy for recalcitrant cerebral vasculitis in a patient with Behçet’s syndrome. Ann. Rheum. Dis.62(3), 280–281 (2003).
  • Sarwar H, McGrath H Jr, Espinoza LR. Successful treatment of long-standing neuro-Behçet’s disease with infliximab. J. Rheumatol.32, 181–183 (2005).
  • Ribi C, Sztajzel R, Delavelle J, Chizzolini C. Efficacy of TNF-α blockade in cyclophosphamide resistant neuro-Behçet disease. J. Neurol. Neurosurg. Psychiatry76(12), 1733–1735 (2005).
  • Alty JE, Monaghan TM, Bamford JM. A patient with neuro-Behçet’s disease is successfully treated with etanercept: further evidence for the value of TNF-α blockade. Clin. Neurol. Neurosurg.109(3), 279–281 (2007).
  • Fujikawa K, Aratake K, Kawakami A et al.Successful treatment of refractory neuro-Behçet’s disease with infliximab: a case report to show its efficacy by magnetic resonance imaging, transcranial magnetic stimulation and cytokine profile. Ann. Rheum. Dis.66, 136–137 (2007).
  • Borhani Haghighi A, Safari A. Anti-tumor necrotic factor antibody for treatment of neuro-Behcet’s disease, a case report. Clin. Neurol. Neurosurg.110(3), 315–316 (2008).
  • van Laar JAM, Missotten T, van Daele PLA, Jamnitski A, Baarsma GS, van Hagen PM. Adalimumab: a new modality for Behçet’s disease? Ann. Rheum. Dis.66, 565–566 (2007).
  • Pipitone N, Olivieri I, Padula A et al. Infliximab for the treatment of neuro-Behçet’s disease: a case series and review of the literature. Arthritis Rheum.59(2), 285–290 (2008).
  • Kikuchi H, Aramaki K, Hirohata S. Effect of infliximab in progressive neuro-Behçet’s syndrome. J. Neurol. Sci.272(1–2), 99–105 (2008).
  • Sfikakis PP, Markomichelakis N, Alpsoy E et al. Anti-TNF therapy in the management of Behçet’s disease – review and basis for recommendations. Rheumatology (Oxford)46(5), 736–741 (2007).
  • Hamuryudan V, Mat C, Saip S et al. Thalidomide in the treatment of the mucocutaneous lesions of the Behçet syndrome. A randomized, double-blind, placebo-controlled trial. Ann. Intern. Med.128(6), 443–450 (1998).
  • Ranselaar CG, Boone RM, Kluin-Nelemans HC. Thalidomide in the treatment of neuro-Behçet’s syndrome. Br. J. Dermatol.115, 367–370 (1986).
  • Sharquie KE, Najim RA, Abu-Raghif AR. Dapsone in Behçet’s disease: a double-blind, placebo-controlled, cross-over study. J. Dermatol.29(5), 267–279 (2002).
  • Yurdakul S, Mat C, Tüzün Y et al. A double-blind trial of colchicine in Behçet’s syndrome. Arthritis Rheum.44(11), 2686–2692 (2001).
  • Cobellis L, Pecori E, Rigatti F et al.Therapeutic alternatives in Behçet’s syndrome. Clin. Exp. Obstet. Gynecol.34(3), 151–153 (2007).
  • Davatchi F. Treatment of ocular manifestations of Behçet’s disease. Adv. Exp. Med. Biol.528, 487–491 (2003).
  • Kötter I, Günaydin I, Batra M et al. CNS involvement occurs more frequently in patients with Behçet’s disease under cyclosporin A (CSA) than under other medications – results of a retrospective analysis of 117 cases. Clin. Rheumatol.25(4), 482–486 (2006).
  • Meusser S, Eger G, Anders M, Burkhardt H, Kalden JR. [Manifestation of neuro-Behçet disease in cyclosporin A therapy]. Z. Rheumatol.56(1), 31–39 (1997).
  • Kotake S, Higashi K, Yoshikawa K, Sasamoto Y, Okamoto T, Matsuda H. Central nervous systems symptoms in patients with Behçet disease receiving cyclosporine therapy. Ophthalmology106, 586–589 (1999).
  • Inaba G. Behçet’s disease. In: Handbook of Clinical Neurology. Vinken PJ, Bruyn GW, KlawansHL(Eds). Elsevier Science, Amsterdam, The Netherlands (1989).
  • Ishioka M, Ohno S, Nakamura S et al. FK506 treatment of noninfectious uveitis. Am. J. Ophthalmol.118, 723–729 (1994).
  • Igarashi I, Ishigatsubo Y, Ohno S et al. Central nervous system toxicity related to FK506 in patients with Behçet’s disease. Ann. Rheum. Dis.53, 350–351 (1994).
  • Lockwood CM, Hale G, Waldman H, Jayne DR. Remission induction in Behçet’s disease following lymphocyte depletion by the anti-CD52 antibody CAMPATH 1-H. Rheumatology (Oxford)42(12), 1539–1544 (2003).
  • Hirohata S, Isshi K, Oguchi H et al. Cerebrospinal fluid interleukin-6 in progressive neuro-Behçet’s syndrome. Clin. Immunol. Immunopathol.82(1), 12–17 (1997).
  • Borhani Haghighi A, Safari A. Tocilizumab may be a potential addition to our weapons against Q2 neuro-Behçet’s disease. Med. Hypotheses71(1), 156–157 (2008).
  • Stanford M, Whittall T, Bergmeier LA et al. Oral tolerization with peptide 336–351 linked to cholera toxin B subunit in preventing relapses of uveitis in Behçet’s disease. Clin. Exp. Immunol.137, 201–208 (2004).
  • De Cata A, Intiso D, Bernal M et al.. Prolonged remission of neuro-Behçet disease following autologous transplantation. Int. J. Immunopathol. Pharmacol.20(1), 91–96 (2007).
  • Siva A. Vasculitis of the nervous system. J. Neurol.248, 451–468 (2001).
  • Bank I, Weart C. Dural sinus thrombosis in Behçet’s disease. Arthritis Rheum.27, 816–818 (1984).
  • Ahn JK, Lee YS, Jeon CH, Koh EM, Cha HS. Treatment of venous thrombosis associated with Behçet’s disease: immunosuppressive therapy alone versus immunosuppressive therapy plus anticoagulation. Clin. Rheumatol.27(2), 201–205 (2008).
  • Yazici H, Fresko I, Yurdakul S. Behçet’s syndrome: disease manifestations, management, and advances in treatment. Nat. Clin. Pract. Rheumatol.3(3), 148–155 (2007).
  • Alpagut U, Ugurlucan M, Dayioglu E. Major arterial involvement and review of Behçet’s disease. Ann. Vasc. Surg.21(2), 232–239 (2007).
  • Barlas S. Behçet’s disease. An insight from a vascular surgeon’s point of view. Acta Chir. Belg.99(6), 274–281 (1999).
  • Sfikakis PP, Iliopoulos A, Elezoglou A, Kittas C, Stratigos A. Psoriasis induced by anti-tumor necrosis factor therapy: a paradoxical adverse reaction. Arthritis Rheum.52(8), 2513–2518 (2005).
  • Gul A. Standard and novel therapeutic approaches to Behçet’s disease. Drugs67(14), 2013–2022 (2007).

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