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Theme: Schizophrenia - Review

The pharmacological management of violence in schizophrenia: a structured review

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Pages 53-63 | Published online: 09 Jan 2014

References

  • Fazel S, Grann M. The population impact of severe mental illness on violent crime. Am. J. Psychiatry163(8), 1397–1403 (2006).
  • Milton J, Amin S, Singh S et al. Aggressive incidents in first-episode psychosis. Br. J. Psychiatry178, 433–440 (2001).
  • Fazel S, Gulati G, Linsell L, Geddes J, Grann M. Schizophrenia and violence: systematic review and meta-analysis. PLoS Med.6(8), e1000120 (2009).
  • Shaw J, Hunt I, Flynn S et al. Rates of mental disorder in people convicted of homicide. National clinical survey. Br. J. Psychiatry188, 143–147 (2006).
  • Gottlieb P, Gabrielsen G, Kramp P. Psychotic homicides in Copenhagen from 1959 to 1983. Acta Psychiatr. Scand.76(3), 285–292 (1987).
  • Fazel S, Grann M. Psychiatric morbidity among homicide offenders: a Swedish population study. Am. J. Psychiatry161(11), 2129–2131 (2004).
  • Arango C, Calcedo Barba A, González-Salvador T, Calcedo Ordóñez A. Violence in inpatients with schizophrenia: a prospective study. Schizophr. Bull.25(3), 493–503 (1999).
  • Barlow K, Grenyer B, Ilkiw-Lavalle O. Prevalence and precipitants of aggression in psychiatric inpatient units. Austr. NZ J. Psychiatry34(6), 967–974 (2002).
  • Humphreys M, Johnstone M, MacMillan J, Taylor P. Dangerous behaviour preceding first admissions for schizophrenia. Br. J. Psychiatry161, 501–505 (1992).
  • Soyka M, Morhart-Klute V, Schoech H. Delinquency and criminal offenses in former schizophrenic inpatients 7–12 years following discharge. Eur. Arch. Psychiatry Clin. Neurosci.254(5), 289–294 (2004).
  • Appelbaum P, Robbins P, Monahan J. Violence and delusions: data from the MacArthur violence risk assessment study. Am. J. Psychiatry157, 566–572 (2000).
  • Wallace C, Mullen P, Burgess P. Criminal offending in schizophrenia over a 25-year period marked by deinstitutionalization and increasing prevalence of comorbid substance use disorders. Am. J. Psychiatry161(4), 716–727 (2004).
  • Fazel S, Långström N, Hjern A, Grann M, Lichtenstein P. Schizophrenia, substance abuse, and violent crime. JAMA301(19), 2016–2023 (2009).
  • Swartz M, Swanson J, Hiday V, Borum R, Wagner H, Burns B. Violence and severe mental illness: the effects of substance abuse and nonadherence to medication. Am. J. Psychiatry155(2), 226–231 (1998).
  • Nolan K, Volavka J, Mohr P, Czobor P. Psychopathy and violent behavior among patients with schizophrenia or schizoaffective disorder. Psychiatr. Serv.50, 787–792 (1999).
  • Tengström A, Hodgins S, Grann M, Långström N, Kullgren G. The role of psychopathy and substance use disorders: schizophrenia and criminal offending. Crim. Justice Behav.31(4), 367–391 (2004).
  • NICE guidelines: Antisocial personality disorder: treatment, management and prevention. NICE clinical guideline 77. National Institute of Health and Clinical Excellence, London, UK (2009).
  • Duggan C, Huband N, Smailagic N, Ferriter M, Adams C. The use of psychological treatments for people with personality disorder: a systematic review of randomized controlled trials. Pers. Ment. Health1(2), 95–125 (2007).
  • Duggan C, Huband N, Smailagic N, Ferriter M, Adams C. The use of pharmacological treatments for people with personality disorder: a systematic review of randomized controlled trials. Pers. Ment. Health2(3), 119–170 (2008).
  • Citrome L, Volavka J. Management of violence in schizophrenia. Psychiatr. Ann.30(1), 41–52 (2000).
  • Volavka J, Citrome L. Heterogeneity of violence in schizophrenia and implications for long-term treatment. Int. J. Clin. Pract.62(8), 1237–1245 (2008).
  • Citrome L, Volavka J, Czobor P et al. Effects of clozapine, olanzapine, risperidone, and haloperidol on hostility among patients with schizophrenia. Psychiatr. Serv.52, 1510–1514 (2001).
  • Krakowski M, Czobor P, Citrome L, Bark N, Cooper T. Atypical antipsychotic agents in the treatment of violent patients with schizophrenia and schizoaffective disorder. Arch. Gen. Psychiatry63(6), 622–629 (2006).
  • Aleman A, Kahn R. Effects of the atypical antipsychotic risperidone on hostility and aggression in schizophrenia: a meta-analysis of controlled trials. Eur. Neuropsychopharmacol.11(4), 289–293 (2001).
  • Hosák L Libiger J. Antiepileptic drugs in schizophrenia: a review. Eur. Psychiatry17(7), 371–378 (2002).
  • Dose M, Hellweg R, Yassouridis A, Theison M, Emrich M. Combined treatment of schizophrenic psychoses with haloperidol and valproate. Pharmacopsychiatry31(4), 122–112 (1998).
  • De Vogelaer J. Carbamazepine in the treatment of psychotic and behavioral disorders. A pilot study. J. Psych. Neuros. Acta Psychiatr. Belg.81(6), 532–541 (1981).
  • Atkins D, Briss P, Eccles M et al. Systems for grading the quality of evidence and the strength of recommendations II: pilot study of a new system. BMC Health Serv. Res.5, 25 (2005).
  • Guyat G, Oxman A, Vist G et al. GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ336, 924–926 (2008).
  • Ascher-Svanum H, Faries D, Zhu B et al. Medication adherence and long-term functional outcomes in the treatment of schizophrenia in usual care. J. Clin. Psychiatry76, 453–460 (2006).
  • Alia-Klein N, O’Rourke T, Goldstein R et al. Insight into illness and adherence to psychotropic medications are separately associated with violence severity in a forensic sample. Aggress. Behav.33, 86–96 (2007).
  • Lindenmayer J, Liu-Seifert H, Kulkarni P et al. Medication nonadherence and treatment outcome in patients with schizophrenia or schizoaffective disorder with suboptimal prior response. J. Clin. Psychiatry70(7), 990–996 (2009).
  • Arango C, Bombín I, González-Salvador T, García-Cabeza I, Bobes J. Randomised clinical trial comparing oral versus depot formulations of zuclopenthixol in patients with schizophrenia and previous violence. Eur. Psychiatry21(1), 34–40 (2005).
  • Hennen J, Baldessarini R. Suicidal risk during treatment with clozapine: a meta-analysis. Schizophr. Res.73(2), 139–145 (2005).
  • Volavka J, Czobor P, Nolan K et al. Overt aggression and psychotic symptoms in patients with schizophrenia treated with clozapine, olanzapine, risperidone, or haloperidol. J. Clin. Psychopharmacol.24(2), 225–228 (2004).
  • Swanson J, Swartz M, Van Dorn R et al. Comparison of antipsychotic medication effects on reducing violence in people with schizophrenia. Br. J. Psychiatry193(1), 37–43 (2008).
  • Volavka J, Zito J, Vitrai J et al. Clozapine effects on hostility and aggression in schizophrenia. J. Clin. Psychiatry13, 287–289 (1993).
  • Swanson J, Swartz M, Elbogen E. Effectiveness of atypical antipsychotic medications in reducing violent behavior among persons with schizophrenia in community-based treatment. Schizophr. Bull.30(1), 3–20 (2004).
  • Bitter I, Czobor P, Dossenbach M, Volavka J. Effectiveness of clozapine, olanzapine, quetiapine, risperidone, and haloperidol monotherapy in reducing hostile and aggressive behavior in outpatients treated for schizophrenia: a prospective naturalistic study (IC-SOHO). Eur. Psychiatry20(5–6), 403–408 (2005).
  • Arango C, Bernardo M. The effect of quetiapine on aggression and hostility in patients with schizophrenia. Hum. Psychopharmacol.20(4), 237–241 (2005).
  • Citrome L, Volavka J, Czobor P, Brook S, Loebel A, Mandel F. Efficacy of ziprasidone against hostility in schizophrenia: post hoc analysis of randomized, open-label study data. J. Clin. Psychiatry67(4), 638–642 (2006).
  • Cade J. Lithium salts in the treatment of psychotic excitement. Med. J. Aust.2(10), 349–352 (1949).
  • Van Putten T, Sanders D. Lithium in treatment failures. J. Nerv. Ment. Dis.161(4), 255–264 (1975).
  • Prado-Lima P, Knijnik L, Juruena M, Padilla A. Lithium reduces maternal child abuse behaviour: a preliminary report. J. Clin. Pharm. Ther.26(4), 279–282 (2001).
  • Shear M. Effect of lithium on human aggression. Nature230(12), 113–114 (1971).
  • Sheard M, Marini J, Bridges C, Wagner E. The effect of lithium on impulsive aggressive behavior in man. Am. J. Psychiatry133, 1409–1413 (1976).
  • Tupin J, Smith D, Clanon T, Kim L, Nugent A, Group A. The long-term use of lithium in aggressive prisoners. Compr. Psychiatry14(4), 311–317 (1973).
  • Dorrego M, Canevaro L, Kuzis G, Sabe L, Starkstein A. A randomized, double-blind, crossover study of methylphenidate and lithium in adults with attention-deficit/hyperactivity disorder. J. Neuropsychiatry Clin. Neurosci.14, 289–295 (2002).
  • Lawson W, Nanos J. Effects of divalproex on behaviour of jail inmates. Prog. Neuropsychopharmacol.32(3), 209–210 (2008).
  • Huband N, Ferriter M, Nathan R, Jones H. Antiepileptics for aggression and associated impulsivity. Cochrane Database Syst. Rev.(2), CD003499 (2010).
  • Citrome L, Casey D, Daniel D, Wozniak P, Kochan L, Tracy K. Adjunctive divalproex and hostility among patients with schizophrenia receiving olanzapine or risperidone. Psychiatr. Serv.55, 290–294 (2004).
  • Kelly D, Conley R, Feldman S, Yu Y, McMahon R, Richardson C. Adjunct divalproex or lithium to clozapine in treatment-resistant schizophrenia. Psychiatr. Q.77(1), 81–95 (2006).
  • Citrome L, Shope C, Nolan K, Czobor K, Volavka J. Risperidone alone versus risperidone plus valproate in the treatment of patients with schizophrenia and hostility. Int. Clin. Psychopharmacol.22(6), 356–362 (2007).
  • Gobbi G, Gaudreau P, Leblanc N. Efficacy of topiramate, valproate, and their combination on aggression/agitation behavior in patients with psychosis. J. Clin. Psychopharmacol.26(5), 467–473 (2006).
  • Carney S, Cowen P, Geddes J et al. Efficacy and safety of electroconvulsive therapy in depressive disorders: a systematic review and meta-analysis. Lancet361(9360), 799–780 (2003).
  • Tharyan P, Adams C. Electroconvulsive therapy for schizophrenia. Cochrane Database Syst. Rev.(2), CD000076 (2005).
  • Swanson J, Swartz M, Van Dorn R et al. A national study of violent behavior in persons with schizophrenia. Arch. Gen. Psychiatry63, 490–499 (2006).
  • Smith K, Surphilis W, Gynther M, Shimkunas A. ECT–chlorpromazine and chlorpromazine compared in the treatment of schizophrenia. J. Nerv. Ment. Dis.144, 284–290 (1967).
  • Hirose S, Ashby C, Mills M. Effectiveness of ECT combined with risperidone against aggression in schizophrenia. J. ECT17(1), 22–26 (2001).
  • Maoz G, Stein D, Meged S et al. The antiaggressive action of combined haloperidol–propranolol treatment in schizophrenia. Eur. Psychol.5(4), 312–325 (2000).
  • Alpert M, Allan E, Citrome L et al. A double-blind, placebo-controlled study of adjunctive nadolol in the management of violent psychiatric patients. Psychopharmacol. Bull.26(3), 367–371 (1990).
  • Allan E, Alpert M, Sison C et al. Adjunctive nadolol in the treatment of acutely aggressive schizophrenic patients. J. Clin. Psychiatry57, 455–459 (1996).
  • Ratey J, Sorgi P, O’Driscoll G et al. Nadolol to treat aggression and psychiatric symptomatology in chronic psychiatric inpatients: a double-blind, placebo-controlled study. J. Clin. Psychiatry53, 41–46 (1992).
  • Cantwell R, Brewin J, Glazebrook C et al. Prevalence of substance misuse in first-episode psychosis. Br. J. Psychiatry174, 150–153 (1999).
  • Duke P. Comorbid non-alcohol substance misuse among people with schizophrenia. Epidemiological study in central London. Br. J. Psychiatry179, 509–513 (2001).
  • Fazel S, Grann M, Carlström E, Lichtenstein P, Långström N. Risk factors for violent crime in schizophrenia: a national cohort study of 13,806 patients. J. Clin. Psychiatry70(3), 362–369 (2009).
  • Volavka J, Swanson J. Violent behaviour in mental illness: the role of substance abuse. JAMA304, 3–4 (2010).
  • Wobrock T. Soyka M. Pharmacotherapy of schizophrenia with comorbid substance use disorder – reviewing the evidence and clinical recommendations. Prog. Neuropsychopharmacol. Biol. Psychiatry32(6), 1375–1385 (2006).
  • Green A, Noordsy D, Brunette M, O’Keefe C. Substance abuse and schizophrenia: pharmacotherapeutic intervention. J. Subst. Abuse Treat.34(1), 61–71 (2008).
  • Brown E, Nejtek V, Perantie D et al. Cocaine and amphetamine use in patients with psychiatric illness: a randomized trial of typical antipsychotic continuation or discontinuation. J. Clin. Psychopharmacol.23(4), 384–388 (2003).
  • Berk M, Brook S, Trandafir A. A comparison of olanzapine with haloperidol in cannabis-induced psychotic disorder: a double-blind randomized controlled trial. Int. Clin. Psychopharmacol.14(3), 177–180 (1999).
  • Smelson D, Ziedonis D, Williams J et al. The efficacy of olanzapine for decreasing cue-elicited craving in individuals with schizophrenia and cocaine dependence: a preliminary report. J. Clin. Psychopharmacol.26(1), 9–12 (2006).
  • Sayers S, Campbell E, Kondrich J et al. Cocaine abuse in schizophrenic patients treated with olanzapine versus haloperidol. J. Nerv. Ment. Dis.193(6), 379–386 (2005).
  • Green A, Tohen M, Hamer R et al. First episode schizophrenia-related psychosis and substance use disorders: acute response to olanzapine and haloperidol. Schizophr. Res.66(2–3), 125–135 (2004).
  • Akerele E, Levin F. Comparison of olanzapine to risperidone in substance-abusing individuals with schizophrenia. Am. J. Addict.16(4), 260–268 (2007).
  • Rubio G, Martinez I, Ponce G et al. Long-acting injectable risperidone compared with zuclopenthixol in the treatment of schizophrenia with substance abuse comorbidity. Can. J. Psychiatry51(8), 531–539 (2006).
  • Petrakis I, O’Malley S, Rounsaville B et al. Naltrexone augmentation of neuroleptic treatment in alcohol abusing patients with schizophrenia. Psychopharmacology172(3), 291–297 (2004).
  • Kalyoncu A, Mirsal H, Pektas O et al. Use of lamotrigine to augment clozapine in patients with resistant schizophrenia and comorbid alcohol dependence: a potent anti-craving effect? J. Psychopharmacol.19(3), 301–305 (2005).
  • Chambers J, Yiend J, Barrett B et al. Outcome measures used in forensic mental health research: a structured review. Crim. Behav. Ment. Health19(1), 9–27 (2009).
  • Volavka J, Citrome L. Atypical antipsychotics in the treatment of the persistently aggressive psychotic patient: methodological concerns. Schizophr. Res.35, S23–S33 (1999).
  • Jones P, Barnes T, Davies L et al. Randomized controlled trial of the effect on quality of life of second- vs first-generation antipsychotic drugs in schizophrenia. Cost utility of the latest antipsychotic drugs in schizophrenia study (CUtLASS 1). Arch. Gen. Psychiatry63, 1079–1087 (2006).
  • Rosenheck R, Leslie D, Sindelar J et al. Cost-effectiveness of second-generation antipsychotics and perphenazine in a randomized trial of treatment for chronic schizophrenia. Am. J. Psychiatry163, 2080–2089 (2006).
  • Haw C, Stubbs J. A survey of the off-label use of mood stabilizers in a large psychiatric hospital. J. Psychopharmacol.19(4), 402–407 (2005).

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