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Pathophysiology, management and treatment of smoke inhalation injury

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Pages 283-297 | Published online: 09 Jan 2014

References

  • Alcorta R. Smoke inhalation & acute cyanide poisoning. Hydrogen cyanide poisoning proves increasingly common in smoke-inhalation victims. JEMS29(8), S6–S15 (2004).
  • Harrington DT, Biffl WL, Cioffi WG. The Station nightclub fire. J. Burn Care Rehabil.26(2), 141–143 (2005).
  • Yurt RW, Bessey PQ, Bauer GJ et al. A regional burn center’s response to a disaster: September 11, 2001, and the days beyond. J. Burn Care Rehabil.26(2), 117–124 (2005).
  • CDC. Rapid assessment of injuries among survivors of the terrorist attack on the World Trade Center – New York City, September 2001. JAMA287(7), 835–838 (2002).
  • Jordan MH, Hollowed KA, Turner DG, Wang DS, Jeng JC. The Pentagon attack of September 11, 2001: a burn center’s experience. J. Burn Care Rehabil.26(2), 109–116 (2005).
  • Dai NT, Chen TM, Cheng TY et al. The comparison of early fluid therapy in extensive flame burns between inhalation and noninhalation injuries. Burns24(7), 671–675 (1998).
  • Shirani KZ, Pruitt BA Jr, Mason AD Jr. The influence of inhalation injury and pneumonia on burn mortality. Ann. Surg.205(1), 82–87 (1987).
  • Suzuki M, Aikawa N, Kobayashi K, Higuchi R. Prognostic implications of inhalation injury in burn patients in Tokyo. Burns31(3), 331–336 (2005).
  • Tredget EE, Shankowsky HA, Taerum TV, Moysa GL, Alton JD. The role of inhalation injury in burn trauma. A Canadian experience. Ann. Surg.212(6), 720–727 (1990).
  • Schwela DH. Public health and the Air Management Information System (AMIS). Epidemiology10(5), 647–655 (1999).
  • Schwela D. Cooking smoke: a silent killer. People Planet6(3), 24–25 (1997).
  • Woodson LC. Diagnosis and grading of inhalation injury. J. Burn Care Res.30(1), 143–145 (2009).
  • Gamsu G, Weintraub RM, Nadel JA. Clearance of tantalum from airways of different caliber in man evaluated by a roentgenographic method. Am. Rev. Respir. Dis.107(2), 214–224 (1973).
  • Traber DL, Herndon DN, Enkhbaatar P, Maybauer MO, Maybauer DM. The pathophysiology of inhalation injury. In: Total Burn Care. Herndon DN (Ed.). Saunders Elsevier, PA, USA 248–261 (2007).
  • Clark WR, Bonaventura M, Myers W. Smoke inhalation and airway management at a regional burn unit: 1974–1983. Part I: diagnosis and consequences of smoke inhalation. J. Burn Care Rehabil.10(1), 52–62 (1989).
  • Friedl HP, Till GO, Trentz O, Ward PA. Roles of histamine, complement and xanthine oxidase in thermal injury of skin. Am. J. Pathol.135(1), 203–217 (1989).
  • Granger DN. Role of xanthine oxidase and granulocytes in ischemia–reperfusion injury. Am. J. Physiol.255(6 Pt 2), H1269–H1275 (1988).
  • Maybauer MO, Maybauer DM, Herndon DN, Traber DL. The role of superoxide dismutase in systemic inflammation. Shock25(2), 206–207 (2006).
  • Herndon DN, Abston S, Stein MD. Increased thromboxane B2 levels in the plasma of burned and septic burned patients. Surg. Gynecol. Obstet.159(3), 210–213 (1984).
  • Vindenes H, Ulvestad E, Bjerknes R. Increased levels of circulating interleukin-8 in patients with large burns: relation to burn size and sepsis. J. Trauma39(4), 635–640 (1995).
  • Tari C, Baranink J. Upper airway neurological mechanisms. Curr. Opin Allergy Clin. Immunol.2, 1149 (2002).
  • Demling RH. Smoke inhalation lung injury: an update. Eplasty8, e27 (2008).
  • Navar PD, Saffle JR, Warden GD. Effect of inhalation injury on fluid resuscitation requirements after thermal injury. Am. J. Surg.150(6), 716–720 (1985).
  • Cox RA, Burke AS, Soejima K et al. Airway obstruction in sheep with burn and smoke inhalation injuries. Am. J. Respir. Cell Mol. Biol.29(3 Pt 1), 295–302 (2003).
  • Perez Fontan JJ. On lung nerves and neurogenic injury. Ann. Med.34(4), 226–240 (2002).
  • Fontan JJ, Cortright DN, Krause JE et al. Substance P and neurokinin-1 receptor expression by intrinsic airway neurons in the rat. Am. J. Physiol. Lung Cell. Mol. Physiol.278(2), L344–L355 (2000).
  • Rehberg S, Maybauer MO, Maybauer DM et al. The role of nitric oxide and reactive nitrogen species in experimental ARDS. Front. Biosci. (In press) (2009).
  • Steudel W, Kirmse M, Weimann J et al. Exhaled nitric oxide production by nitric oxide synthase-deficient mice. Am. J. Respir. Crit. Care Med.162(4 Pt 1), 1262–1267 (2000).
  • Westphal M, Enkhbaatar P, Schmalstieg FC et al. Neuronal nitric oxide synthase inhibition attenuates cardiopulmonary dysfunctions after combined burn and smoke inhalation injury in sheep. Crit. Care Med.36(4), 1196–1204 (2008).
  • Fink MP. Role of reactive oxygen and nitrogen species in acute respiratory distress syndrome. Curr. Opin. Crit. Care8(1), 6–11 (2002).
  • Gero D, Szabo C. Poly(ADP-ribose) polymerase: a new therapeutic target? Curr. Opin. Anaesthesiol.21(2), 111–121 (2008).
  • Pacher P, Szabo C. Role of the peroxynitrite-poly(ADP-ribose) polymerase pathway in human disease. Am. J. Pathol.173(1), 2–13 (2008).
  • Szabo C. DNA strand breakage and activation of poly-ADP ribosyltransferase: a cytotoxic pathway triggered by peroxynitrite. Free Radic. Biol. Med.21(6), 855–869 (1996).
  • Lobo SM, Orrico SR, Queiroz MM et al. Pneumonia-induced sepsis and gut injury: effects of a poly-(ADP-ribose) polymerase inhibitor. J. Surg. Res.129(2), 292–297 (2005).
  • Jagtap P, Szabo C. Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors. Nat. Rev. Drug Discov.4(5), 421–440 (2005).
  • Chiarugi A, Moskowitz MA. Poly(ADP-ribose) polymerase-1 activity promotes NF-κB-driven transcription and microglial activation: implication for neurodegenerative disorders. J. Neurochem.85(2), 306–317 (2003).
  • Li LF, Ouyang B, Choukroun G et al. Stretch-induced IL-8 depends on c-Jun NH2-terminal and nuclear factor-κB-inducing kinases. Am. J. Physiol. Lung Cell. Mol. Physiol.285(2), L464–L475 (2003).
  • Yamaza T, Masuda KF, Tsukiyama Y et al. NF-κB activation and iNOS expression in the synovial membrane of rat temporomandibular joints after induced synovitis. J. Dent. Res.82(3), 183–188 (2003).
  • Herndon DN, Traber DL, Niehaus GD, Linares HA, Traber LD. The pathophysiology of smoke inhalation injury in a sheep model. J. Trauma24(12), 1044–1051 (1984).
  • Traber DL, Enkhbaatar P. Thermal lung injury and acute smoke inhalation. In: Fishman’s Pulmonary Diseases and Disorders. Fishman DA (Ed.). McGraw-Hill Medical Publishing Company, NY, USA (2008).
  • Traber DL, Hawkins HK, Enkhbaatar P et al. The role of the bronchial circulation in the acute lung injury resulting from burn and smoke inhalation. Pulm. Pharmacol. Ther.20(2), 163–166 (2007).
  • Traber DL, Traber LD. Airway blood flow changes and airway obstruction following lung injury. Arch. Physiol. Biochem.111(4), 297–300 (2003).
  • Enkhbaatar P, Herndon DN, Traber DL. Use of nebulized heparin in the treatment of smoke inhalation injury. J. Burn Care Res.30(1), 159–162 (2009).
  • Abdi S, Herndon D, McGuire J, Traber L, Traber DL. Time course of alterations in lung lymph and bronchial blood flows after inhalation injury. J. Burn Care Rehabil.11(6), 510–515 (1990).
  • Seeger W, Stohr G, Wolf HR, Neuhof H. Alteration of surfactant function due to protein leakage: special interaction with fibrin monomer. J. Appl. Physiol.58(2), 326–338 (1985).
  • Ciano PS, Colvin RB, Dvorak AM, McDonagh J, Dvorak HF. Macrophage migration in fibrin gel matrices. Lab. Invest.54(1), 62–70 (1986).
  • Sakurai H, Schmalstieg FC, Traber LD, Hawkins HK, Traber DL. Role of L-selectin in physiological manifestations after burn and smoke inhalation injury in sheep. J. Appl. Physiol.86(4), 1151–1159 (1999).
  • Abdi S, Herndon DN, Traber LD et al. Lung edema formation following inhalation injury: role of the bronchial blood flow. J. Appl. Physiol.71(2), 727–734 (1991).
  • Efimova O, Volokhov AB, Iliaifar S, Hales CA. Ligation of the bronchial artery in sheep attenuates early pulmonary changes following exposure to smoke. J. Appl. Physiol.88(3), 888–893 (2000).
  • Hales CA, Barkin P, Jung W et al. Bronchial artery ligation modifies pulmonary edema after exposure to smoke with acrolein. J. Appl. Physiol.67(3), 1001–1006 (1989).
  • Sakurai H, Johnigan R, Kikuchi Y et al. Effect of reduced bronchial circulation on lung fluid flux after smoke inhalation in sheep. J. Appl. Physiol.84(3), 980–986 (1998).
  • Sakurai H, Soejima K, Nozaki M, Traber LD, Traber DL. Effect of ablated airway blood flow on systemic and pulmonary microvascular permeability after smoke inhalation in sheep. Burns33(7), 885–891 (2007).
  • Basadre JO, Sugi K, Traber DL et al. The effect of leukocyte depletion on smoke inhalation injury in sheep. Surgery104(2), 208–215 (1988).
  • Abdi S, Traber LD, Herndon DN, Rogers CS, Traber DL. Effects of ibuprofen on airway vascular response to cotton smoke injury. Eur. J. Pharmacol.293(4), 475–481 (1995).
  • Sakurai H, Traber LD, Traber DL. Altered systemic organ blood flow after combined injury with burn and smoke inhalation. Shock9(5), 369–374 (1998).
  • Demling RH, Knox J, Youn YK, LaLonde C. Oxygen consumption early postburn becomes oxygen delivery dependent with the addition of smoke inhalation injury. J. Trauma32(5), 593–598; discussion 599 (1992).
  • Soejima K, Schmalstieg FC, Sakurai H, Traber LD, Traber DL. Pathophysiological analysis of combined burn and smoke inhalation injuries in sheep. Am. J. Physiol. Lung Cell. Mol. Physiol.280(6), L1233–L1241 (2001).
  • Rehberg S, Maybauer MO, Maybauer DM et al. The antioxidants Vitamin E and Vitamin C for nutritional support in critical ill patients: beneficial or harmful? Adv. Anaesthesiol. Crit. Care1(1), 11–19 (2009).
  • Horton JW. Free radicals and lipid peroxidation mediated injury in burn trauma: the role of antioxidant therapy. Toxicology189(1–2), 75–88 (2003).
  • Nguyen TT, Cox CS, Traber DL et al. Free radical activity and loss of plasma antioxidants, vitamin E, and sulfhydryl groups in patients with burns: the 1993 Moyer Award. J. Burn Care Rehabil.14(6), 602–609 (1993).
  • Berger MM, Shenkin A. Update on clinical micronutrient supplementation studies in the critically ill. Curr. Opin. Clin. Nutr. Metab. Care9(6), 711–716 (2006).
  • Carbon monoxide-related deaths – United States, 1999–2004. Morb. Mortal. Wkly Rep.56(50), 1309–1312 (2007).
  • Weaver LK. Carbon monoxide poisoning. Crit. Care Clin.15(2), 297–317, viii (1999).
  • Prien T, Traber DL. Toxic smoke compounds and inhalation injury – a review. Burns Incl. Therm. Inj.14(6), 451–460 (1988).
  • Traber DL, Maybauer MO, Maybauer DM, Westphal M, Traber LD. Inhalational and acute lung injury. Shock24(Suppl. 1), 82–87 (2005).
  • Hardy KR, Thom SR. Pathophysiology and treatment of carbon monoxide poisoning. J. Toxicol. Clin. Toxicol.32(6), 613–629 (1994).
  • Kealey GP. Carbon monoxide toxicity. J. Burn Care Res.30(1), 146–147 (2009).
  • Westphal M, Morita N, Enkhbaatar P et al. Carboxyhemoglobin formation following smoke inhalation injury in sheep is interrelated with pulmonary shunt fraction. Biochem. Biophys. Res. Commun.311(3), 754–758 (2003).
  • Hall AH, Rumack BH. Clinical toxicology of cyanide. Ann. Emerg. Med.15(9), 1067–1074 (1986).
  • Barillo DJ. Diagnosis and treatment of cyanide toxicity. J. Burn Care Res.30(1), 148–152 (2009).
  • Baud FJ, Barriot P, Toffis V et al. Elevated blood cyanide concentrations in victims of smoke inhalation. N. Engl. J. Med.325(25), 1761–1766 (1991).
  • Silverman SH, Purdue GF, Hunt JL, Bost RO. Cyanide toxicity in burned patients. J. Trauma28(2), 171–176 (1988).
  • Davies JW. Toxic chemicals versus lung tissue – an aspect of inhalation injury revisited. The Everett Idris Evans memorial lecture – 1986. J. Burn Care Rehabil.7(3), 213–222 (1986).
  • Lee MJ, O’Connell DJ. The plain chest radiograph after acute smoke inhalation. Clin. Radiol.39(1), 33–37 (1988).
  • Endorf FW, Gamelli RL. Inhalation injury, pulmonary perturbations, and fluid resuscitation. J. Burn Care Res.28(1), 80–83 (2007).
  • Marek K, Piotr W, Stanislaw S et al. Fibreoptic bronchoscopy in routine clinical practice in confirming the diagnosis and treatment of inhalation burns. Burns33(5), 554–560 (2007).
  • Brown DL, Archer SB, Greenhalgh DG et al. Inhalation injury severity scoring system: a quantitative method. J. Burn Care Rehabil.17(6 Pt 1), 552–557 (1996).
  • Edelman DA, White MT, Tyburski JG, Wilson RF. Factors affecting prognosis of inhalation injury. J. Burn Care Res.27(6), 848–853 (2006).
  • Sellers BJ, Davis BL, Larkin PW, Morris SE, Saffle JR. Early prediction of prolonged ventilator dependence in thermally injured patients. J. Trauma43(6), 899–903 (1997).
  • Cancio LC, Chavez S, Alvarado-Ortega M et al. Predicting increased fluid requirements during the resuscitation of thermally injured patients. J. Trauma56(2), 404–413; discussion 413–404 (2004).
  • Dries DJ. Key questions in ventilator management of the burn-injured patient (second of two parts). J. Burn Care Res.30(2), 211–220 (2009).
  • Plurad D, Martin M, Green D et al. The decreasing incidence of late posttraumatic acute respiratory distress syndrome: the potential role of lung protective ventilation and conservative transfusion practice. J. Trauma63(1), 1–7; discussion 8 (2007).
  • Mlcak R, Herndon DN. Respiratory care. In: Total Burn Care. Herndon DN (Ed.). WB Saunders, PA, USA, 242–267 (2002).
  • Fabian TC. Empiric therapy for pneumonia in the surgical intensive care unit. Am. J. Surg.179(2 Suppl. 1), 18–23 (2000).
  • Peck MD, Koppelman T. Low-tidal-volume ventilation as a strategy to reduce ventilator-associated injury in ALI and ARDS. J. Burn Care Res.30(1), 172–175 (2009).
  • The Acute Respiratory Distress Syndrome Network. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N. Engl. J. Med.342(18), 1301–1308 (2000).
  • Brower RG, Lanken PN, MacIntyre N et al. Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome. N. Engl. J. Med.351(4), 327–336 (2004).
  • Gattinoni L, Tognoni G, Pesenti A et al. Effect of prone positioning on the survival of patients with acute respiratory failure. N. Engl. J. Med.345(8), 568–573 (2001).
  • Stock MC, Downs JB, Frolicher DA. Airway pressure release ventilation. Crit. Care Med.15(5), 462–466 (1987).
  • Mlcak RP. Airway pressure release ventilation. J. Burn Care Res.30(1), 176–177 (2009).
  • Putensen C, Zech S, Wrigge H et al. Long-term effects of spontaneous breathing during ventilatory support in patients with acute lung injury. Am. J. Respir. Crit. Care Med.164(1), 43–49 (2001).
  • Varpula T, Jousela I, Niemi R, Takkunen O, Pettila V. Combined effects of prone positioning and airway pressure release ventilation on gas exchange in patients with acute lung injury. Acta Anaesthesiol. Scand.47(5), 516–524 (2003).
  • Harrington D. Volumetric diffusive ventilator. J. Burn Care Res.30(1), 175–176 (2009).
  • Carman B, Cahill T, Warden G, McCall J. A prospective, randomized comparison of the volume diffusive respirator vs conventional ventilation for ventilation of burned children. 2001 ABA paper. J. Burn Care Rehabil.23(6), 444–448 (2002).
  • Rue LW 3rd, Cioffi WG, Mason AD, McManus WF, Pruitt BA Jr. Improved survival of burned patients with inhalation injury. Arch. Surg.128(7), 772–778; discussion 778–780 (1993).
  • Froese AB. High-frequency oscillatory ventilation for adult respiratory distress syndrome: let’s get it right this time! Crit. Care Med.25(6), 906–908 (1997).
  • Cartotto R. Use of high frequency oscillatory ventilation in inhalation injury. J. Burn Care Res.30(1), 178–181 (2009).
  • Cartotto R, Ellis S, Gomez M, Cooper A, Smith T. High frequency oscillatory ventilation in burn patients with the acute respiratory distress syndrome. Burns30(5), 453–463 (2004).
  • Alpard SK, Zwischenberger JB, Tao W, Deyo DJ, Bidani A. Reduced ventilator pressure and improved P/F ratio during percutaneous arteriovenous carbon dioxide removal for severe respiratory failure. Ann. Surg.230(2), 215–224 (1999).
  • Zwischenberger JB, Wang D, Lick SD et al. The paracorporeal artificial lung improves 5-day outcomes from lethal smoke/burn-induced acute respiratory distress syndrome in sheep. Ann. Thorac. Surg.74(4), 1011–1016; discussion 1017–1018 (2002).
  • Zwischenberger JB, Savage C, Witt SA et al. Arterio-venous CO2 removal (AVCO2R) perioperative management: rapid recovery and enhanced survival. J. Invest. Surg.15(1), 15–21 (2002).
  • Schmalstieg FC, Keeney SE, Rudloff HE et al. Arteriovenous CO2 removal improves survival compared to high frequency percussive and low tidal volume ventilation in a smoke/burn sheep acute respiratory distress syndrome model. Ann. Surg.246(3), 512–521; discussion 521–513 (2007).
  • Morina P, Herrera M, Venegas J et al. Effects of nebulized salbutamol on respiratory mechanics in adult respiratory distress syndrome. Intensive Care Med.23(1), 58–64 (1997).
  • Zhang H, Kim YK, Govindarajan A et al. Effect of adrenoreceptors on endotoxin-induced cytokines and lipid peroxidation in lung explants. Am. J. Respir. Crit. Care Med.160(5 Pt 1), 1703–1710 (1999).
  • van der Poll T, Coyle SM, Barbosa K, Braxton CC, Lowry SF. Epinephrine inhibits tumor necrosis factor-α and potentiates interleukin 10 production during human endotoxemia. J. Clin. Invest.97(3), 713–719 (1996).
  • McAuley DF, Frank JA, Fang X, Matthay MA. Clinically relevant concentrations of β2-adrenergic agonists stimulate maximal cyclic adenosine monophosphate-dependent airspace fluid clearance and decrease pulmonary edema in experimental acid-induced lung injury. Crit. Care Med.32(7), 1470–1476 (2004).
  • Sartori C, Allemann Y, Duplain H et al. Salmeterol for the prevention of high-altitude pulmonary edema. N. Engl. J. Med.346(21), 1631–1636 (2002).
  • Perkins GD, Gao F, Thickett DR. In vivo and in vitro effects of salbutamol on alveolar epithelial repair in acute lung injury. Thorax63(3), 215–220 (2008).
  • Palmieri TL, Enkhbaatar P, Sheridan R, Traber DL, Greenhalgh DG. Studies of inhaled agents in inhalation injury. J. Burn Care Res.30(1), 169–171 (2009).
  • Palmieri TL. Use of β-agonists in inhalation injury. J. Burn Care Res.30(1), 156–159 (2009).
  • Enkhbaatar P, Kikuchi Y, Traber LD et al. Effect of inhaled nitric oxide on pulmonary vascular hyperpermeability in sheep following smoke inhalation. Burns31(8), 1013–1019 (2005).
  • Booke M, Bradford DW, Hinder F et al. Inhaled nitric oxide selectively reduces pulmonary hypertension after ovine smoke inhalation but does not improve oxygenation. J. Burn Care Rehabil.18(1 Pt 1), 27–33 (1997).
  • Kowal-Vern A, Walenga JM, McGill V, Gamelli RL. The impact of antithrombin (H) concentrate infusions on pulmonary function in the acute phase of thermal injury. Burns27(1), 52–60 (2001).
  • Olson ST, Bjork I, Sheffer R et al. Role of the antithrombin-binding pentasaccharide in heparin acceleration of antithrombin–proteinase reactions. Resolution of the antithrombin conformational change contribution to heparin rate enhancement. J. Biol. Chem.267(18), 12528–12538 (1992).
  • Adhikari NK, Burns KE, Friedrich JO et al. Effect of nitric oxide on oxygenation and mortality in acute lung injury: systematic review and meta-analysis. BMJ334(7597), 779 (2007).
  • Sokol J, Jacobs SE, Bohn D. Inhaled nitric oxide for acute hypoxic respiratory failure in children and adults: a meta-analysis. Anesth. Analg.97(4), 989–998 (2003).
  • Taylor RW, Zimmerman JL, Dellinger RP et al. Low-dose inhaled nitric oxide in patients with acute lung injury: a randomized controlled trial. JAMA291(13), 1603–1609 (2004).
  • Westphal M, Maybauer DM, Maybauer MO. Who is the bad guy in acute respiratory distress syndrome? Neuronal nitric oxide synthase, inducible nitric oxide synthase, or both? Crit. Care Med.37(1), 363–364 (2009).
  • Brown M, Desai M, Traber LD, Herndon DN, Traber DL. Dimethylsulfoxide with heparin in the treatment of smoke inhalation injury. J. Burn Care Rehabil.9(1), 22–25 (1988).
  • Murakami K, Enkhbaatar P, Morita N, Westphal M, Traber DL. The elevation of airway antithrombin level in smoke inhalation with pneumonia in sheep. Crit. Care Med.31, A28 (2003).
  • Enkhbaatar P, Cox RA, Traber LD et al. Aerosolized anticoagulants ameliorate acute lung injury in sheep after exposure to burn and smoke inhalation.Crit. Care Med.35(12), 2805–2810 (2007).
  • Enkhbaatar P, Esechie A, Wang J et al. Combined anticoagulants ameliorate acute lung injury in sheep after burn and smoke inhalation. Clin. Sci. (Lond.)114(4), 321–329 (2008).
  • Desai MH, Mlcak R, Richardson J, Nichols R, Herndon DN. Reduction in mortality in pediatric patients with inhalation injury with aerosolized heparin/N-acetylcystine [correction of acetylcystine] therapy. J. Burn Care Rehabil.19(3), 210–212 (1998).
  • LaLonde C, Nayak U, Hennigan J, Demling R. Plasma catalase and glutathione levels are decreased in response to inhalation injury. J. Burn Care Rehabil.18(6), 515–519 (1997).
  • Morita N, Shimoda K, Traber MG et al. Vitamin E attenuates acute lung injury in sheep with burn and smoke inhalation injury. Redox Rep.11(2), 61–70 (2006).
  • Morita N, Traber MG, Enkhbaatar P et al. Aerosolized α-tocopherol ameliorates acute lung injury following combined burn and smoke inhalation injury in sheep. Shock25(3), 277–282 (2006).
  • Hamahata A, Enkhbaatar P, Kraft ER et al. γ-tocopherol nebulization by a lipid aerosolization device improves pulmonary function in sheep with burn and smoke inhalation injury. Free Radic. Biol. Med.45(4), 425–433 (2008).
  • Galli F, Piroddi M, Lannone A et al. A comparison between the antioxidant and peroxynitrite-scavenging functions of the Vitamin E metabolites α- and γ-carboxyethyl-6-hydroxychromans. Int. J. Vitam. Nutr. Res.74(5), 362–373 (2004).
  • Tyml K, Li F, Wilson JX. Septic impairment of capillary blood flow requires nicotinamide adenine dinucleotide phosphate oxidase but not nitric oxide synthase and is rapidly reversed by ascorbate through an endothelial nitric oxide synthase-dependent mechanism. Crit. Care Med.36(8), 2355–2362 (2008).
  • Tanaka H, Matsuda H, Shimazaki S, Hanumadass M, Matsuda T. Reduced resuscitation fluid volume for second-degree burns with delayed initiation of ascorbic acid therapy. Arch. Surg.132(2), 158–161 (1997).
  • Galley HF, Davies MJ, Webster NR. Ascorbyl radical formation in patients with sepsis: effect of ascorbate loading. Free Radic. Biol. Med.20(1), 139–143 (1996).
  • Tanaka H, Matsuda T, Miyagantani Y et al. Reduction of resuscitation fluid volumes in severely burned patients using ascorbic acid administration: a randomized, prospective study. Arch. Surg.135(3), 326–331 (2000).
  • Enkhbaatar P, Traber DL. Pathophysiology of acute lung injury in combined burn and smoke inhalation injury. Clin. Sci. (Lond.)107(2), 137–143 (2004).
  • Niedermayr M, Schramm W, Kamolz L et al. Antithrombin deficiency and its relationship to severe burns. Burns33(2), 173–178 (2007).
  • Latenser BA. Use of antithrombin III in inhalation injury. J. Burn Care Res.30(1), 186–188 (2009).
  • Murakami K, McGuire R, Cox RA et al. Recombinant antithrombin attenuates pulmonary inflammation following smoke inhalation and pneumonia in sheep. Crit. Care Med.31(2), 577–583 (2003).
  • Juurlink DN, Buckley NA, Stanbrook MB et al. Hyperbaric oxygen for carbon monoxide poisoning. Cochrane Database Syst. Rev.1, CD002041 (2005).
  • Chen KK, Rose CL, Clorves GHA. Comparative values of several antidotes in cyanide poisoning. Am. J. Med. Sci.188, 767–781 (1934).
  • Maybauer DM, Traber DL, Radermacher P, Herndon DN, Maybauer MO. Treatment strategies for acute smoke inhalation injury. Anaesthesist55(9), 980–982, 984–988 (2006).
  • Fortin JL, Giocanti JP, Ruttimann M, Kowalski JJ. Prehospital administration of hydroxocobalamin for smoke inhalation-associated cyanide poisoning: 8 years of experience in the Paris Fire Brigade. Clin. Toxicol. (Phila.)44(Suppl. 1), 37–44 (2006).
  • Kafka G, Maybauer DM, Traber DL, Maybauer MO. Treatment of inhalation injury in preclinical emergency medicine. Notfall Rettungsmed.10, 529–540 (2007).
  • Cohen MA, Guzzardi LJ. Inhalation of products of combustion. Ann. Emerg. Med.12(10), 628–632 (1983).
  • Brivet F, Delfraissy JF, Duche M, Bertrand P, Dormont J. Acute cyanide poisoning: recovery with non-specific supportive therapy. Intensive Care Med.9(1), 33–35 (1983).
  • Caravati EM, Litovitz TL. Pediatric cyanide intoxication and death from an acetonitrile-containing cosmetic. JAMA260(23), 3470–3473 (1988).
  • Graham DL, Laman D, Theodore J, Robin ED. Acute cyanide poisoning complicated by lactic acidosis and pulmonary edema. Arch. Intern. Med.137(8), 1051–1055 (1977).
  • Clark CJ, Campbell D, Reid WH. Blood carboxyhaemoglobin and cyanide levels in fire survivors. Lancet1(8234), 1332–1335 (1981).
  • Palmieri TL. Inhalation injury consensus conference: conclusions. J. Burn Care Res.30(1), 209–210 (2009).

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