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Expert Review of Vaccines Volume 11, 2012 - Issue 10
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Review

Spray drying and vaccine stabilization

David McAdams PATH, 2201 Westlake Avenue, Suite 200, Seattle, WA 98121, USA; PATH, 2201 Westlake Avenue, Suite 200, Seattle, WA 98121, USA
,
Dexiang Chen PATH, 2201 Westlake Avenue, Suite 200, Seattle, WA 98121, USA; PATH, 2201 Westlake Avenue, Suite 200, Seattle, WA 98121, USA
&
Debra Kristensen PATH, 2201 Westlake Avenue, Suite 200, Seattle, WA 98121, USA; PATH, 2201 Westlake Avenue, Suite 200, Seattle, WA 98121, USA. [email protected]
Pages 1211-1219 | Published online: 09 Jan 2014

References

  • Haining WN, Anderson DG, Little SR et al. pH-triggered microparticles for peptide vaccination. J. Immunol. 173(4), 2578–2585 (2004).
  • Geeraedts F, Saluja V, ter Veer W et al. Preservation of the immunogenicity of dry-powder influenza H5N1 whole inactivated virus vaccine at elevated storage temperatures. AAPS J. 12(2), 215–222 (2010).
  • Fleming RS. The spray process of drying. Ind. Eng. Chem. 13(5), 447–449 (1921).
  • Peace RM, Campbell J, Polo J, Crenshaw J, Russell L, Moeser A. Spray-dried porcine plasma influences intestinal barrier function, inflammation, and diarrhea in weaned pigs. J. Nutr. 141(7), 1312–1317 (2011).
  • Lauten EH, Pulliam BL, DeRousse J, Bhatta D, Edwards DA. Gene expression, bacteria viability and survivability following spray drying of Mycobacterium smegmatis. Materials 3(4), 2684–2724 (2010).
  • Fourie PB, Germishuizen WA, Wong YL, Edwards DA. Spray drying TB vaccines for pulmonary administration. Expert Opin. Biol. Ther. 8(7), 857–863 (2008).
  • Lin WH, Griffin DE, Rota PA et al. Successful respiratory immunization with dry powder live-attenuated measles virus vaccine in rhesus macaques. Proc. Natl Acad. Sci. U.S.A. 108(7), 2987–2992 (2011).
  • Ohtake S, Martin RA, Yee L et al. Heat-stable measles vaccine produced by spray drying. Vaccine 28(5), 1275–1284 (2010).
  • Huyge K, Van Reeth K, De Beer T et al. Suitability of differently formulated dry powder Newcastle disease vaccines for mass vaccination of poultry. Eur. J. Pharm. Biopharm. 80(3), 649–656 (2012).
  • Wong YL, Sampson S, Germishuizen WA et al. Drying a tuberculosis vaccine without freezing. Proc. Natl Acad. Sci. U.S.A. 104(8), 2591–2595 (2007).
  • WHO. Report of Expert Committee on Biological Standardization. Requirements for measles vaccine (live). Addendum 1981, Technical Report Series no. 673, Annex 6. WHO, Geneva, Switzerland. (1982).
  • Kisich KO, Higgins MP, Park I et al. Dry powder measles vaccine: particle deposition, virus replication, and immune response in cotton rats following inhalation. Vaccine 29(5), 905–912 (2011).
  • Chen D, Kapre S, Goel A et al. Thermostable formulations of a hepatitis B vaccine and a meningitis A polysaccharide conjugate vaccine produced by a spray drying method. Vaccine 28(31),5093–5099 (2010).
  • Maa YF, Ameri M, Shu C, Payne LG, Chen D. Influenza vaccine powder formulation development: spray-freeze-drying and stability evaluation. J. Pharm. Sci. 93(7), 1912–1923 (2004).
  • Maa YF, Zhao L, Payne LG, Chen D. Stabilization of alum-adjuvanted vaccine dry powder formulations: mechanism and application. J. Pharm. Sci. 92(2), 319–332 (2003).
  • Garmise RJ, Staats HF, Hickey AJ. Novel dry powder preparations of whole inactivated influenza virus for nasal vaccination. AAPS PharmSciTech 8(4), E81 (2007).
  • Dean HJ, Chen D. Epidermal powder immunization against influenza. Vaccine 23(5), 681–686 (2004).
  • Huang J, Mikszta JA, Ferriter MS et al. Intranasal administration of dry powder anthrax vaccine provides protection against lethal aerosol spore challenge. Hum. Vaccin. 3(3), 90–93 (2007).
  • Huang J, D’Souza AJ, Alarcon JB et al. Protective immunity in mice achieved with dry powder formulation and alternative delivery of plague F1-V vaccine. Clin. Vaccine Immunol. 16(5), 719–725 (2009).
  • Cape SP, Villa JA, Huang ET, Yang TH, Carpenter JF, Sievers RE. Preparation of active proteins, vaccines and pharmaceuticals as fine powders using supercritical or near-critical fluids. Pharm. Res. 25(9), 1967–1990 (2008).
  • McAdams DH, Cape SP, Frederick E, Garcea RL, Sievers RE. Production of an inhalable dry powder HPV vaccine by CAN-BD. Presented at: 2010 International Pharmaceutical Federation Pharmaceutical Sciences World Congress and American Association of Pharmaceutical Scientists Annual Meeting and Exposition. New Orleans, LA, USA, 14 November 2010.
  • Lu D, Hickey AJ. Pulmonary vaccine delivery. Expert Rev. Vaccines 6(2), 213–226 (2007).
  • Hinds WC. Respiratory deposition. In: Aerosol Technology: Properties, Behavior and Measurement of Airborne Particles. Wiley, New York, NY, USA (1999).
  • Garrison LP Jr, Bauch CT, Bresnahan BW, Hazlet TK, Kadiyala S, Veenstra DL. Using cost–effectiveness analysis to support research and development portfolio prioritization for product innovations in measles vaccination. J. Infect. Dis. 204(Suppl. 1), S124–S132 (2011).
  • Vehring R. Pharmaceutical particle engineering via spray drying. Pharm. Res. 25(5), 999–1022 (2008).
  • Lechuga-Ballesteros D, Charan C, Stults CL et al. Trileucine improves aerosol performance and stability of spray-dried powders for inhalation. J. Pharm. Sci. 97(1), 287–302 (2008).
  • Tsapis N, Bennett D, Jackson B, Weitz DA, Edwards DA. Trojan particles: large porous carriers of nanoparticles for drug delivery. Proc. Natl Acad. Sci. U.S.A. 99(19), 12001–12005 (2002).
  • Yang Y, Bajaj N, Xu P, Ohn K, Tsifansky MD, Yeo Y. Development of highly porous large PLGA microparticles for pulmonary drug delivery. Biomaterials 30(10), 1947–1953 (2009).
  • Muttil P, Pulliam B, Garcia-Contreras L et al. Pulmonary immunization of guinea pigs with diphtheria CRM-197 antigen as nanoparticle aggregate dry powders enhance local and systemic immune responses. AAPS J. 12(4), 699–707 (2010).
  • Jin TH, Tsao E, Goudsmit J, Dheenadhayalan V, Sadoff J. Stabilizing formulations for inhalable powders of an adenovirus 35-vectored tuberculosis (TB) vaccine (AERAS-402). Vaccine 28(27), 4369–4375 (2010).
  • Año G, Esquisabel A, Pastor M et al. A new oral vaccine candidate based on the microencapsulation by spray-drying of inactivated Vibrio cholerae. Vaccine 29(34), 5758–5764 (2011).
  • Maa YF, Shu C, Ameri M et al. Optimization of an alum-adsorbed vaccine powder formulation for epidermal powder immunization. Pharm. Res. 20(7), 969–977 (2003).
  • Patel SM, Pikal MJ. Emerging freeze-drying process development and scale-up issues. AAPS Pharm. SciTech. 12(1), 372–378 (2011).
  • Crowe JH, Carpenter JF, Crowe LM. The role of vitrification in anhydrobiosis. Annu. Rev. Physiol. 60, 73–103 (1998).
  • Clausi AL, Merkley SA, Carpenter JF, Randolph TW. Inhibition of aggregation of aluminum hydroxide adjuvant during freezing and drying. J. Pharm. Sci. 97(6), 2049–2061 (2008).
  • Gil M, Vicente J, Gaspar F. Scale-up methodology for pharmaceutical spray drying. Chemistry Today 28(4), 18–22 (2010).
  • Mohanan D, Gander B, Kündig TM, Johansen P. Encapsulation of antigen in poly(d,l-lactide-co-glycolide) microspheres protects from harmful effects of γ-irradiation as assessed in mice. Eur. J. Pharm. Biopharm. 80(2), 274–281 (2012).

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