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Review

Targeted therapy for sarcomas

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Pages 91-105 | Published online: 17 Mar 2014

References

  • JoensuuHRobertsPJSarlomo-RikalaMEffect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gastrointestinal stromal tumorN Engl J Med2001344141052105611287975
  • van OosteromATJudsonIVerweijJEuropean Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma GroupSafety and efficacy of imatinib (STI571) in metastatic gastrointestinal stromal tumours: a phase I studyLancet 272001358929114211423
  • DemetriGDvon MehrenMBlankeCDEfficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumorsN Engl J Med2002347747248012181401
  • BlankeCDDemetriGDvon MehrenMLong-term results from a randomized phase II trial of standard-versus higher-dose imatinib mesylate for patients with unresectable or metastatic gastrointestinal stromal tumors expressing KITJ Clin Oncol200826462062518235121
  • BenjaminRSChoiHMacapinlacHAWe should desist using RECIST, at least in GISTJ Clin Oncol200725131760176417470866
  • HeinrichMCOwzarKCorlessCLCorrelation of kinase genotype and clinical outcome in the North American Intergroup Phase III Trial of imatinib mesylate for treatment of advanced gastrointestinal stromal tumor: CALGB 150105 Study by Cancer and Leukemia Group B and Southwest Oncology GroupJ Clin Oncol200826335360536718955451
  • Debiec-RychterMSciotRLe CesneAEORTC Soft Tissue and Bone Sarcoma GroupItalian Sarcoma GroupAustralasian GastroIntestinal Trials GroupKIT mutations and dose selection for imatinib in patients with advanced gastrointestinal stromal tumoursEur J Cancer20064281093110316624552
  • BlayJYLe CesneARay-CoquardIProspective multicentric randomized phase III study of imatinib in patients with advanced gastrointestinal stromal tumors comparing interruption versus continuation of treatment beyond 1 year: the French Sarcoma GroupJ Clin Oncol20072591107111317369574
  • Le CesneARay-CoquardIBuiBNFrench Sarcoma GroupDiscontinuation of imatinib in patients with advanced gastrointestinal stromal tumours after 3 years of treatment: an open-label multicentre randomised phase 3 trialLancet Oncol2010111094294920864406
  • DemetriGDvan OosteromATGarrettCREfficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: a randomised controlled trialLancet200636895441329133817046465
  • GeorgeSvon MehrenMHeinrichMCA multicenter phase II study of regorafenib in patients (pts) with advanced gastrointestinal stromal tumor (GIST), after therapy with imatinib (IM) and sunitinib (SU)J Clin Oncol20112915 May 20 Supplement10007
  • DemetriGDReichardtPKangY-KRandomized phase III trial of regorafenib in patients (pts) with metastatic and/or unresectable gastrointestinal stromal tumor (GIST) progressing despite prior treatment with at least imatinib (IM) and sunitinib (SU): GRID trialJ Clin Oncol201230 Abstract LBA10008
  • AdenisALe CesneANguyenBBMasitinib mesylate in imatinib-resistant advanced GIST: a randomized phase II trialJ Clin Oncol201230 Abstract 10007
  • Le CesneABlayJYBuiBNPhase II study of oral masitinib mesilate in imatinib-naïve patients with locally advanced or metastatic gastro-intestinal stromal tumour (GIST)Eur J Cancer20104681344135120211560
  • TrentJCWalthenKvon MehrenMA phase II study of dasatinib for patients with imatinib-resistant gastrointestinal stromal tumor (GIST)J Clin Oncol201129 Abstract 10006
  • SchöffskiPReichardtPBlayJYA phase I-II study of everolimus (RAD001) in combination with imatinib in patients with imatinib-resistant gastrointestinal stromal tumorsAnn Oncol201021101990199820507881
  • DematteoRPBallmanKVAntonescuCRAmerican College of Surgeons Oncology Group (ACOSOG) Intergroup Adjuvant GIST Study TeamAdjuvant imatinib mesylate after resection of localised, primary gastrointestinal stromal tumour: a randomised, double-blind, placebo-controlled trialLancet200928373(9669)1097110419303137
  • JoensuuHErikssonMHatrmannKTwelve versus 36 months of adjuvant imatinib (IM) as treatment of operable GIST with a high risk of recurrence: Final results of a randomized trial (SSGXVIII/AIO)Proc Am Soc Clin Oncol2011 Abstract LBA1
  • EisenbergBLHarrisJBlankeCDPhase II trial of neoadjuvant/adjuvant imatinib mesylate (IM) for advanced primary and metastatic/recurrent operable gastrointestinal stromal tumor (GIST): early results of RTOG 0132/ACRIN 6665J Surg Oncol2009991424718942073
  • McAuliffeJCHuntKKLazarAJA randomized, phase II study of preoperative plus postoperative imatinib in GIST: evidence of rapid radiographic response and temporal induction of tumor cell apoptosisAnn Surg Oncol200916491091918953611
  • RutkowskiPVan GlabbekeMRankinCJEuropean Organisation for Research and Treatment of Cancer Soft Tissue/Bone Sarcoma GroupSouthwest Oncology GroupImatinib mesylate in advanced dermatofibrosarcoma protuberans: pooled analysis of two phase II clinical trialsJ Clin Oncol201028101772177920194851
  • KérobDPorcherRVérolaOImatinib mesylate as a preoperative therapy in dermatofibrosarcoma: results of a multicenter phase II study on 25 patientsClin Cancer Res201016123288329520439456
  • CasaliPGMessinaAStacchiottiSImatinib mesylate in chordomaCancer200410192086209715372471
  • StacchiottiSLonghiAFerraresiVPhase II study of imatinib in advanced chordomaJ Clin Oncol201230991492022331945
  • MercierFGuiotMCBojanowskiMWTreatment of chordoma with imatinib complicated by intracranial hemorrhage: a case showing dissociation between biological effect and therapeutic outcomeJ Neurooncol2012107243543722120582
  • StacchiottiSTamboriniEMarrariAResponse to sunitinib malate in advanced alveolar soft part sarcomaClin Cancer Res20091531096110419188185
  • StacchiottiSNegriTZaffaroniNSunitinib in advanced alveolar soft part sarcoma: evidence of a direct antitumor effectAnn Oncol20112271682169021242589
  • GardnerKJudsonILeahyMActivity of cediranib, a highly potent and selective VEGF signaling inhibitor, in alveolar soft part sarcomaJ Clin Oncol20092715s Abstract 10523
  • National Cancer InstitutePhase II study of cediranib (AZD2171) in patients with alveolar soft part sarcoma Available from: http://clinicaltrials.gov/show/NCT00942877. NLM identifier: NCT00942877Accessed July 25, 2013
  • ParkMSPatelSRLudwigJAActivity of temozolomide and bevacizumab in the treatment of locally advanced, recurrent, and metastatic hemangiopericytoma and malignant solitary fibrous tumorCancer2011117214939494721480200
  • StacchiottiSNegriTPalassiniESunitinib malate and figitumumab in solitary fibrous tumor: patterns and molecular bases of tumor responseMol Cancer Ther2010951286129720457621
  • Ray-CoquardIItalianoABompasEFrench Sarcoma Group (GSF/GETO)Sorafenib for patients with advanced angiosarcoma: a phase II Trial from the French Sarcoma Group (GSF/GETO)Oncologist201172260266
  • MakiRGD’AdamoDRKeohanMLPhase II study of sorafenib in patients with metastatic or recurrent sarcomasJ Clin Oncol200927193133314019451436
  • AgulnikMYarberJLOkunoSHAn open-label, multicenter, phase II study of bevacizumab for the treatment of angiosarcoma and epithelioid hemangioendotheliomasAnn Oncol201324125726322910841
  • SleijferSRay-CoquardIPapaiZPazopanib, a multikinase angiogenesis inhibitor, in patients with relapsed or refractory advanced soft tissue sarcoma: a phase II study from the European organisation for research and treatment of cancer-soft tissue and bone sarcoma group (EORTC study 62043)J Clin Oncol200927193126313219451427
  • van der GraafWTBlayJYChawlaSPEORTC Soft Tissue and Bone Sarcoma GroupPALETTE study groupPazopanib for metastatic soft-tissue sarcoma (PALETTE): a randomised, double-blind, placebo-controlled phase 3 trialLancet201237998291879188622595799
  • BlayJYEl SayadiHThiessePGarretJRay-CoquardIComplete response to imatinib in relapsing pigmented villonodular synovitis/tenosynovial giant cell tumor (PVNS/TGCT)Ann Oncol200819482182218296418
  • GelderblomHPérolDChevreauCAn open-label international multicentric phase II study of nilotinib in progressive pigmented villo-nodular synovitis (PVNS) not amenable to a conservative surgical treatmentJ Clin Oncol201331 Abstract 10516
  • ButrynskiJED’AdamoDRHornickJLCrizotinib in ALK-rearranged inflammatory myofibroblastic tumorN Engl J Med2010363181727173320979472
  • ScotlandiKPicciPTargeting insulin-like growth factor 1 receptor in sarcomasCurr Opin Oncol200820441942718525338
  • PrieurATirodeFCohenPDelattreOEWS/FLI-1 silencing and gene profiling of Ewing cells reveal downstream oncogenic pathways and a crucial role for repression of insulin-like growth factor binding protein 3Mol Cell Biol200424167275728315282325
  • PappoASPatelSCrowleyJActivity of R1507, a monoclonal antibody to the insulin-like growth factor-1 receptor (IGF1R), in patients (pts) with recurrent or refractory Ewing’s sarcoma family of tumors (ESFT): Results of a phase II SARC studyJ Clin Oncol20102815s Abstract 10000
  • TapWDDemetriGBarnettePPhase II study of ganitumab, a fully human anti-type-1 insulin-like growth factor receptor antibody, in patients with metastatic Ewing family tumors or desmoplastic small round cell tumorsJ Clin Oncol201230151849185622508822
  • OlmosDPostel-VinaySMolifeLRSafety, pharmacokinetics, and preliminary activity of the anti-IGF-1R antibody figitumumab (CP-751,871) in patients with sarcoma and Ewing’s sarcoma: a phase 1 expansion cohort studyLancet Oncol201011212913520036194
  • JuergensHDawNCGeoergerBPreliminary efficacy of the anti-insulin-like growth factor type 1 receptor antibody figitumumab in patients with refractory Ewing sarcomaJ Clin Oncol201129344534454022025154
  • SubbiahVNaingABrownRETargeted morphoproteomic profiling of Ewing’s sarcoma treated with insulin-like growth factor 1 receptor (IGF1R) inhibitors: response/resistance signaturesPLoS One 6201164e18424
  • ThomasDHenshawRSkubitzKDenosumab in patients with giant-cell tumour of bone: an open-label, phase 2 studyLancet Oncol201011327528020149736
  • BranstetterDGNelsonSDManivelJCDenosumab induces tumor reduction and bone formation in patients with giant-cell tumor of boneClin Cancer Res201218164415442422711702
  • DicksonMATapWDKeohanMLPhase II Trial of the CDK4 Inhibitor PD0332991 in Patients With Advanced CDK4-Amplified Well-Differentiated or Dedifferentiated LiposarcomaJ Clin Oncol201331162024202823569312
  • ItalianoALe CesneACassierPAGDC-0449 in patients with advanced chondrosarcomas: A French Sarcoma Group (FSG)/French and US. National Cancer Institutes phase II collaborative studyJ Clin Oncol201330 Abstract 10005
  • GounderMMDicksonMAWuNA first-in-human, phase Ib combination study to assess safety, pharmacokinetics (PK), and pharmacodynamics (PD) of a hedgehog inhibitor, GDC-0449, with a Notch inhibitor, RO4929097, in patients with advanced sarcomaJ Clin Oncol201330 Abstract 10004
  • VézinaCKudelskiASehgalSNRapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principleJ Antibiot (Tokyo)197528107217261102508
  • BakerHSidorowiczASehgalSNVézinaCRapamycin (AY-22,989), a new antifungal antibiotic. III. In vitro and in vivo evaluationJ Antibiot (Tokyo)197831653954528309
  • EngCPSehgalSNVézinaCActivity of rapamycin (AY-22,989) against transplanted tumorsJ Antibiot (Tokyo)19843710123112376501094
  • WiederrechtGJSabersCJBrunnGJMartinMMDumontFJAbrahamRTMechanism of action of rapamycin: new insights into the regulation of G1-phase progression in eukaryotic cellsProg Cell Cycle Res1995153719552353
  • SteckPAPershouseMAJasserSAIdentification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancersNat Genet19971543563629090379
  • NeshatMSMellinghoffIKTranCEnhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTORProc Natl Acad Sci U S A20019818103141031911504908
  • FrumanDAWoodMAGjertsonCKKatzHRBurakoffSJBiererBEFK506 binding protein 12 mediates sensitivity to both FK506 and rapamycin in murine mast cellsEur J Immunol19952525635717533090
  • SekulićAHudsonCCHommeJLA direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cellsCancer Res200060133504351310910062
  • JefferiesHBFumagalliSDennisPBReinhardCPearsonRBThomasGRapamycin suppresses 5′TOP mRNA translation through inhibition of p70s6kEMBO J19971612369337049218810
  • GingrasACRaughtBSonenbergNeIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translationAnnu Rev Biochem19996891396310872469
  • SabatiniDMmTOR and cancer: insights into a complex relationshipNat Rev Cancer20066972973416915295
  • LoewithRJacintoEWullschlegerSTwo TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth controlMol Cell200210345746812408816
  • ZengZSarbassov dosDSamudioIJRapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AMLBlood200710983509351217179228
  • KimDHSarbassovDDAliSMmTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machineryCell2002110216317512150925
  • HaraKMarukiYLongXRaptor, a binding partner of target of rapamycin (TOR), mediates TOR actionCell2002110217718912150926
  • YonezawaKTokunagaCOshiroNYoshinoKRaptor, a binding partner of target of rapamycinBiochem Biophys Res Commun2004313243744114684181
  • HarrisTELawrenceJCJrTOR signalingSci STKE20032003212re1514668532
  • NojimaHTokunagaCEguchiSThe mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motifJ Biol Chem200327818154611546412604610
  • WullschlegerSLoewithRHallMNTOR signaling in growth and metabolismCell2006124347148416469695
  • JiangBHLiuLZRole of mTOR in anticancer drug resistance: perspectives for improved drug treatmentDrug Resist Updat2008113637618440854
  • KimDHSarbassovDDAliSMGbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTORMol Cell200311489590412718876
  • FriasMAThoreenCCJaffeJDmSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2sCurr Biol200616181865187016919458
  • SarbassovDDAliSMKimDHRictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeletonCurr Biol200414141296130215268862
  • WullschlegerSLoewithROppligerWHallMNMolecular organization of target of rapamycin complex 2J Biol Chem200528035306973070416002396
  • PearceLRHuangXBoudeauJIdentification of Protor as a novel Rictor-binding component of mTOR complex-2Biochem J2007405351352217461779
  • JacintoELoewithRSchmidtAMammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitiveNat Cell Biol20046111122111815467718
  • FaivreSKroemerGRaymondECurrent development of mTOR inhibitors as anticancer agentsNat Rev Drug Discov20065867168816883305
  • KurmashevaRTHuangSHoughtonPJPredicted mechanisms of resistance to mTOR inhibitorsBr J Cancer200695895596016953237
  • RicciRMaggianoNCastriFRole of PTEN in gastrointestinal stromal tumor progressionArch Pathol Lab Med2004128442142515043466
  • SaitoTOdaYKawaguchiKPTEN/MMAC1 gene mutation is a rare event in soft tissue sarcomas without specific balanced translocationsInt J Cancer2003104217517812569572
  • WanXHelmanLJLevels of PTEN protein modulate Akt phosphorylation on serine 473, but not on threonine 308, in IGF-II-overexpressing rhabdomyosarcomas cellsOncogene200322508205821114603261
  • GibbonsJJDiscafaniCPetersonRThe effect of CCI-779, a novel macrolide anti-tumor agent, on the growth of human tumor cells in vitro and in nude mouse in vivoProc Am Assoc Cancer Res199940301 Abstract 2000
  • HidalgoMBucknerJCErlichmanCA phase I and pharmacokinetic study of temsirolimus (CCI-779) administered intravenously daily for 5 days every 2 weeks to patients with advanced cancerClin Cancer Res200612195755576317020981
  • RaymondEAlexandreJFaivreSSafety and pharmacokinetics of escalated doses of weekly intravenous infusion of CCI-779, a novel mTOR inhibitor, in patients with cancerJ Clin Oncol200422122336234715136596
  • AtkinsMBHidalgoMStadlerWMRandomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinomaJ Clin Oncol200422590991814990647
  • HudesGCarducciMTomczackPA phase 3, randomized, 3-arm study of temsirolimus (TEMSR) or interferon-alpha (IFN) or the combination of TEMSR + IFN in the treatment of first-line, poor-risk patients with advanced renal cell carcinoma (adv RCC)J Clin Oncol20062418S June 20 SupplementLBA4
  • ChanSScheulenMEJohnstonSPhase II study of temsirolimus (CCI-779), a novel inhibitor of mTOR, in heavily pretreated patients with locally advanced or metastatic breast cancerJ Clin Oncol200523235314532215955899
  • CarpenterJTRochéHCamponeMRandomized 3-arm, phase 2 study of temsirolimus (CCI-779) in combination with letrozole in postmenopausal women with locally advanced or metastatic breast cancerJ Clin Oncol20052316S June 1 Supplement564
  • GalanisEBucknerJCMaurerMJNorth Central Cancer Treatment GroupPhase II trial of temsirolimus (CCI-779) in recurrent glioblastoma multiforme: a North Central Cancer Treatment Group StudyJ Clin Oncol200523235294530415998902
  • FourouzeshBBucknerJAdjeiAPhase I, bioavailability and pharmacokinetic study of oral dosage of CCI-779 administered to patients with advanced solid malignancies. Proceedings of the 13th EORTC-NCI-AACr symposiumEur J Cancer200238Suppl 7S54 Abstract 16811858966
  • O’ReillyTVaxelaireJMullerMIn vivo activity of RAD001, an orally active rapamycin derivative, in experimental tumor modelsProc Am Assoc Cancer Res200243 Abstract 359
  • LaneHASchnellCTheuerAAntiangiogenic activity of RAD001, an orally active anticancer agentProc Amer Assoc Cancer Res200243184
  • O’DonnellAFaivreSJudsonIA phase I study of the oral mTOR inhibitor RAD001 as monotherapy to identify the optimal biologically effective dose using toxicity, pharmacokinetic (PK) and pharmacodynamic (PD) endpoints in patients with solid tumorsProc Am Soc Clin Oncol200322200 Abstract 803
  • AmatoRJMisellatiAKhanMChiangSA phase II trial of RAD001 in patients (Pts) with metastatic renal cell carcinoma (MRCC)J Clin Oncol20062418S June 20 Supplement4530
  • LerutERoskamsTGoossensEMolecular pharmacodynamic (MPD) evaluation of dose and schedule of RAD001 (everolimus) in patients with operable prostate carcinoma (PC)J Clin Oncol20052316S June 1 Supplement3071
  • ReardonDQuinnJARichJNA phase I trial of imatinib, hydroxyurea and RAD001 for patients with recurrent malignant gliomaJ Clin Oncol20062418S June 20 Supplement1580
  • YaoJCPhanAChangDZPhase II study of RAD001 (everolimus) and depot octreotide (sandostatin LAR) in advanced low grade neuroendocrine carcinoma (LGNET)J Clin Oncol20072518S June 20 Supplement450317906216
  • MiltonDTKrisMGAzzoliCGPhase I/II trial of gefitinib and RAD001 (everolimus) in patients (pts) with advanced non-small cell lung cancer (NSCLC)J Clin Oncol20052316S June 1 Supplement7104
  • ClacksonTMetcalfCARiveraVMBroad anti-tumor activity of ap23573, an mTOR inhibitor in clinical developmentProc Am Soc Clin Oncol200322220 Abstract 882
  • MitaMRowinskyEKGoldstonMLPhase I, pharmacokinetic (PK) and pharmacodynamic (PD) study of AP23573, an mTOR inhibitor administered IV daily X5 every other week in patients with refractory or advanced malignanciesJ Clin Oncol20042214S Abstract 3076
  • DesaiAAJanishLBerkLRA phase I trial of a novel mTOR inhibitor AP23573 administered weekly (wkly) in patients (pts) with refractory or advanced malignancies: A pharmacokinetic (PK) and pharmacodynamic (PD) analysisJ Clin Oncol20042214S July 15 Supplement3150
  • PerottiAMaurMViganòLPhase Ib pharmacokinetic (PK) and pharmacodynamic (PD) study to define the optimal dose for combining the mTOR inhibitor AP23573 with capecitabine (CAPE)J Clin Oncol20062418S June 20 Supplement3065
  • FeldmanEGilesFRobozGA phase 2 clinical trial of AP23573, an mTOR inhibitor, in patients with relapsed or refractory hematologic malignanciesJ Clin Oncol20052316S June 1 Supplement663116170170
  • ChawlaSPTolcherAWStaddonAPUpdated results of a phase II trial of AP23573, a novel mTOR inhibitor, in patients (pts) with advanced soft tissue or bone sarcomasJ Clin Oncol20062418S June 20 Supplement9505
  • BlayJYvan GlabbekeMVerweijJAdvanced soft-tissue sarcoma: a disease that is potentially curable for a subset of patients treated with chemotherapyEur J Cancer2003391646912504660
  • Le CesneABlayJYJudsonIPhase II study of ET-743 in advanced soft tissue sarcomas: a European Organisation for the Research and Treatment of Cancer (EORTC) soft tissue and bone sarcoma group trialJ Clin Oncol200523357658415659504
  • Le CesneAJudsonICrowtherDRandomized phase III study comparing conventional-dose doxorubicin plus ifosfamide versus high-dose doxorubicin plus ifosfamide plus recombinant human granulocyte-macrophage colony-stimulating factor in advanced soft tissue sarcomas: A trial of the European Organization for Research and Treatment of Cancer/Soft Tissue and Bone Sarcoma GroupJ Clin Oncol200018142676268410894866
  • Van GlabbekeMVerweijJJudsonINielsenOSEORTC Soft Tissue and Bone Sarcoma GroupProgression-free rate as the principal end-point for phase II trials in soft-tissue sarcomasEur J Cancer200238454354911872347
  • SankhalaKKChawlaSPIagaruAEarly response evaluation of therapy with AP23573 (an mTOR inhibitor) in sarcoma using [18F]2-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET) scanJ Clin Oncol20052316S June 1 Supplement9028
  • ChawlaSPBlayJRay-CoquardILResults of the phase III, placebo-controlled trial (SUCCEED) evaluating the mTOR inhibitor ridaforolimus (R) as maintenance therapy in advanced sarcoma patients (pts) following clinical benefit from prior standard cytotoxic chemotherapy (CT)J Clin Oncol201129 Abstract 10005
  • OkunoSHMahoneyMRBaileyHHA multicenter phase 2 consortium (P2C) study of the mTOR inhibitor CCI-779 in advanced soft tissue sarcomas (STS)J Clin Oncol20062418S June 20 Supplement9504
  • SchuetzeSMBakerLHMakiRGSirolimus reduced tumor-related morbidity and resulted in biochemical and radiographic response in patients with progressive sarcomaJ Clin Oncol20062418S June 20 Supplement9503
  • HeinrichMCCorlessCLBlankeCDMolecular correlates of imatinib resistance in gastrointestinal stromal tumorsJ Clin Oncol200624294764477416954519
  • van OosteromAReichardtPBlayJ-YA phase I/II trial of the oral mTOR-inhibitor everolimus (E) and imatinib mesylate (IM) in patients (pts) with gastrointestinal stromal tumor (GIST) refractory to IM: study updateJ Clin Oncol20052316S June 1 Supplement9033
  • SchwartzGKTapWDQinLXCixutumumab and temsirolimus for patients with bone and soft-tissue sarcoma: a multicentre, open-label, phase 2 trialLancet Oncol201314437138223477833
  • QuekRWangQMorganJACombination mTOR and IGF-1R inhibition: phase I trial of everolimus and figitumumab in patients with advanced sarcomas and other solid tumorsClin Cancer Res201117487187921177764
  • LeobDMDeLorenzoKAChenARSA dose-finding study of temsirolimus and liposomal doxorubicin for patients with advanced soft tissue or bone sarcomaJ Clin Oncol201129 Abstract 10026
  • MovvaSBocklageTSchmitBPhase I study of irinotecan and temsirolimus in patients with refractory sarcomasJ Clin Oncol201129 Abstract 10027
  • WagnerAJMalinowska-KolodziejIMorganJAClinical activity of mTOR inhibition with sirolimus in malignant perivascular epithelioid cell tumors: targeting the pathogenic activation of mTORC1 in tumorsJ Clin Oncol201028583584020048174
  • ItalianoADelcambreCHosteinITreatment with the mTOR inhibitor temsirolimus in patients with malignant PEComaAnn Oncol20102151135113720215136