128
Views
11
CrossRef citations to date
0
Altmetric
Review

Ziv-aflibercept in metastatic colorectal cancer

&
Pages 13-25 | Published online: 16 Dec 2013

References

  • FerlayJShinHRBrayFFormanDMathersCParkinDMEstimates of worldwide burden of cancer in 2008: GLOBOCAN 2008Int J Cancer2010127122893291721351269
  • BartlettDLChuECan metastatic colorectal cancer be cured?Oncology (Williston Park)201226326627522545311
  • GallagherDJKemenyNMetastatic colorectal cancer: from improved survival to potential cureOncology2010783–423724820523084
  • CarmelietPJainRKAngiogenesis in cancer and other diseasesNature2000407680124925711001068
  • FerraraNGerberHPLeCouterJThe biology of VEGF and its receptorsNat Med20039666967612778165
  • VerheulHMVoestEESchlingemannROAre tumours angiogenesis-dependent?J Pathol2004202151314694516
  • ZetterBRAngiogenesis and tumor metastasisAnnu Rev Med1998494074249509272
  • FolkmanJAnti-angiogenesis: new concept for therapy of solid tumorsAnn Surg197217534094165077799
  • BergersGBenjaminLETumorigenesis and the angiogenic switchNat Rev Cancer20033640141012778130
  • RafiiSLydenDBenezraRHattoriKHeissigBVascular and haematopoietic stem cells: novel targets for anti-angiogenesis therapy?Nat Rev Cancer200221182683512415253
  • ZadehGKoushanKBaopingQShannonPGuhaARole of angiopoietin-2 in regulating growth and vascularity of astrocytomasJ Oncol2010201065923120467564
  • WeidnerNIntratumor microvessel density as a prognostic factor in cancerAm J Pathol199514719197541613
  • CatalanoVTurdoADi FrancoSDieliFTodaroMStassiGTumor and its microenvironment: A synergistic interplaySemin Cancer Biol2013
  • FerraraNVascular endothelial growth factor: basic science and clinical progressEndocr Rev200425458161115294883
  • NagyJAVasileEFengDVascular permeability factor/vascular endothelial growth factor induces lymphangiogenesis as well as angiogenesisJ Exp Med2002196111497150612461084
  • KerbelRSTumor angiogenesisN Engl J Med2008358192039204918463380
  • FerraraNVascular endothelial growth factor as a target for anticancer therapyOncologist20049Suppl 121015178810
  • HicklinDJEllisLMRole of the vascular endothelial growth factor pathway in tumor growth and angiogenesisJ Clin Oncol20052351011102715585754
  • ShweikiDItinASofferDKeshetEVascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesisNature199235963988438451279431
  • SunWAngiogenesis in metastatic colorectal cancer and the benefits of targeted therapyJ Hematol Oncol201256323057939
  • KutCMac GabhannFPopelASWhere is VEGF in the body? A meta-analysis of VEGF distribution in cancerBr J Cancer200797797898517912242
  • DvorakHFVascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapyJ Clin Oncol200220214368438012409337
  • ShibuyaMDifferential roles of vascular endothelial growth factor receptor-1 and receptor-2 in angiogenesisJ Biochem Mol Biol200639546947817002866
  • ShibuyaMVascular endothelial growth factor receptor-1 (VEGFR-1/Flt-1): a dual regulator for angiogenesisAngiogenesis200694225230 discussion 23117109193
  • AnisimovALeppänenVMTvorogovDThe basis for the distinct biological activities of vascular endothelial growth factor receptor-1 ligandsSci Signal20136282ra5223821770
  • FischerCMazzoneMJonckxBCarmelietPFLT1 and its ligands VEGFB and PlGF: drug targets for anti-angiogenic therapy?Nat Rev Cancer200881294295619029957
  • PavcoPABouhanaKSGallegosAMAntitumor and anti-metastatic activity of ribozymes targeting the messenger RNA of vascular endothelial growth factor receptorsClin Cancer Res2000652094210310815937
  • HiratsukaSMaruYOkadaASeikiMNodaTShibuyaMInvolvement of Flt-1 tyrosine kinase (vascular endothelial growth factor receptor-1) in pathological angiogenesisCancer Res20016131207121311221852
  • CarmelietPMoonsLLuttunASynergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditionsNat Med20017557558311329059
  • XuLCochranDMTongRTPlacenta growth factor overexpression inhibits tumor growth, angiogenesis, and metastasis by depleting vascular endothelial growth factor homodimers in orthotopic mouse modelsCancer Res20066683971397716618713
  • CaoDHouMGuanYSJiangMYangYGouHFExpression of HIF-1alpha and VEGF in colorectal cancer: association with clinical outcomes and prognostic implicationsBMC Cancer2009943220003271
  • YonekuraHSakuraiSLiuXPlacenta growth factor and vascular endothelial growth factor B and C expression in microvascular endothelial cells and pericytes. Implication in autocrine and paracrine regulation of angiogenesisJ Biol Chem199927449351723517810575000
  • NashADBacaMWrightCScotneyPDThe biology of vascular endothelial growth factor-B (VEGF-B)Pulm Pharmacol Ther2006191616916286239
  • ZhangFTangZHouXVEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inh, ibits pathological angiogenesisProc Natl Acad Sci U S A2009106156152615719369214
  • JayasingheCSimiantonakiNKirkpatrickCJVEGF-B expression in colorectal carcinomas and its relevance for tumor progressionHistol Histopathol201328564765323417498
  • JussilaLAlitaloKVascular growth factors and lymphangiogenesisPhysiol Rev200282367370012087132
  • WangTBChenZGWeiXQWeiBDongWGSerum vascular endothelial growth factor-C and lymphoangiogenesis are associated with the lymph node metastasis and prognosis of patients with colorectal cancerANZ J Surg2011811069469922295309
  • StackerSAAchenMGThe VEGF signaling pathway in cancer: the road aheadChin J Cancer201332629730223419196
  • SuJLYenCJChenPSThe role of the VEGF-C/VEGFR-3 axis in cancer progressionBr J Cancer200796454154517164762
  • MartinsSFGarciaEALuzMAPardalFRodriguesMFilhoALClinicopathological correlation and prognostic significance of VEGF-A, VEGF-C, VEGFR-2 and VEGFR-3 expression in colorectal cancerCancer Genomics Proteomics2013102556723603341
  • HuangHBhatAWoodnuttGLappeRTargeting the ANGPT-TIE2 pathway in malignancyNat Rev Cancer201010857558520651738
  • QiaoLWongBCRole of Notch signaling in colorectal cancerCarcinogenesis200930121979198619793799
  • JubbAMTurleyHMoellerHCExpression of delta-like ligand 4 (Dll4) and markers of hypoxia in colon cancerBr J Cancer2009101101749175719844231
  • BeneditoRRochaSFWoesteMNotch-dependent VEGFR3 upregulation allows angiogenesis without VEGF-VEGFR2 signallingNature2012484739211011422426001
  • HanrahanVCurrieMJGunninghamSPThe angiogenic switch for vascular endothelial growth factor (VEGF)-A, VEGF-B, VEGF-C, and VEGF-D in the adenoma-carcinoma sequence during colorectal cancer progressionJ Pathol2003200218319412754739
  • KangSMMaedaKOnodaNCombined analysis of p53 and vascular endothelial growth factor expression in colorectal carcinoma for determination of tumor vascularity and liver metastasisInt J Cancer19977455025079355971
  • RmaliKAPuntisMCJiangWGTumour-associated angiogenesis in human colorectal cancerColorectal Dis20079131417181841
  • SaifMWAnti-VEGF agents in metastatic colorectal cancer (mCRC): are they all alike?Cancer Manag Res2013510311523807861
  • SungCYSonMWAhnTSJungDJLeeMSBaekMJExpression of placenta growth factor in colorectal carcinomasJ Korean Soc Coloproctol201228631532023346511
  • HurwitzHFehrenbacherLNovotnyWBevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancerN Engl J Med2004350232335234215175435
  • GiantonioBJCatalanoPJMeropolNJEastern Cooperative Oncology Group Study E3200Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: results from the Eastern Cooperative Oncology Group Study E3200J Clin Oncol200725121539154417442997
  • ChenHXCleckJNAdverse effects of anticancer agents that target the VEGF pathwayNat Rev Clin Oncol20096846547719581909
  • NalluriSRChuDKeresztesRZhuXWuSRisk of venous thromboembolism with the angiogenesis inhibitor bevacizumab in cancer patients: a meta-analysisJAMA2008300192277228519017914
  • HolashJDavisSPapadopoulosNVEGF-Trap: a VEGF blocker with potent antitumor effectsProc Natl Acad Sci U S A20029917113931139812177445
  • WilhelmSMDumasJAdnaneLRegorafenib (BAY 73-4506): a new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activityInt J Cancer2011129124525521170960
  • GrotheyAVan CutsemESobreroACORRECT Study GroupRegorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trialLancet2013381986330331223177514
  • RudgeJSHolashJHyltonDVEGF Trap complex formation measures production rates of VEGF, providing a biomarker for predicting efficacious angiogenic blockadeProc Natl Acad Sci U S A200710447183631837018000042
  • PapadopoulosNMartinJRuanQBinding and neutralization of vascular endothelial growth factor (VEGF) and related ligands by VEGF Trap, ranibizumab and bevacizumabAngiogenesis201215217118522302382
  • GayaATseVA preclinical and clinical review of aflibercept for the management of cancerCancer Treat Rev201238548449322264850
  • LockhartACRothenbergMLDupontJPhase I study of intravenous vascular endothelial growth factor trap, aflibercept, in patients with advanced solid tumorsJ Clin Oncol201028220721419949018
  • YoshinoTYamazakiKYamaguchiKA phase I study of intravenous aflibercept with FOLFIRI in Japanese patients with previously treated metastatic colorectal cancerInvest New Drugs201331491091723179335
  • Van CutsemEKhayatDVerslypeCPhase I dose-escalation study of intravenous aflibercept administered in combination with irinotecan, 5-fluorouracil and leucovorin in patients with advanced solid tumoursEur J Cancer2013491172422921183
  • KhayatDTejparSSpanoJPIntravenous aflibercept administered in combination with irinotecan, 5-fluorouracil and leucovorin in patients with advanced solid tumours: results from the expansion cohort of a phase I studyEur J Cancer201349479079723312881
  • TangPACohenSJKollmannsbergerCPhase II clinical and pharmacokinetic study of aflibercept in patients with previously treated metastatic colorectal cancerClin Cancer Res201218216023603122977191
  • Van CutsemEPeetersMSienaSOpen-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancerJ Clin Oncol200725131658166417470858
  • KarapetisCSKhambata-FordSJonkerDJK-ras mutations and benefit from cetuximab in advanced colorectal cancerN Engl J Med2008359171757176518946061
  • PericayCFolprechtGSaundersMPhase 2 randomized, non-comparative, open-label study of aflibercept and modified FOLFOX6 in the first-line treatment of metastatic colorectal cancer (AFFIRM)Ann Oncol201223Supplement 4iv16
  • Van CutsemETaberneroJLakomyRAddition of aflibercept to fluorouracil, leucovorin, and irinotecan improves survival in a phase III randomized trial in patients with metastatic colorectal cancer previously treated with an oxaliplatin-based regimenJ Clin Oncol201230283499350622949147
  • RuffPFerryDPapamichaelDLakomyRO-0017 observed benefit of aflibercept in mCRC patients ≥65 years old: results of a pre-specified age-based analysis of the VELOUR studyAnn Oncol2013244iv18
  • FolkmanJTumor angiogenesis: therapeutic implicationsN Engl J Med197128521118211864938153
  • ChuEAn update on the current and emerging targeted agents in metastatic colorectal cancerClin Colorectal Cancer201211111321752724
  • TroianiTMartinelliEOrdituraMDe VitaFCiardielloFMorgilloFBeyond bevacizumab: new anti-VEGF strategies in colorectal cancerExpert Opin Investig Drugs2012217949959
  • PetrelliFBorgonovoKCabidduMFOLFIRI-bevacizumab as first-line chemotherapy in 3500 patients with advanced colorectal cancer: a pooled analysis of 29 published trialsClin Colorectal Cancer201312314515123763824
  • SaltzLBClarkeSDíaz-RubioEBevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: a randomized phase III studyJ Clin Oncol200826122013201918421054
  • BennounaJSastreJArnoldDML18147 Study InvestigatorsContinuation of bevacizumab after first progression in metastatic colorectal cancer (ML18147): a randomised phase 3 trialLancet Oncol2013141293723168366
  • GrenonNNManaging toxicities associated with antiangiogenic biologic agents in combination with chemotherapy for metastatic colorectal cancerClin J Oncol Nurs201317442543323899982
  • MorlockRYuERayJA cost-effectiveness analysis of bevacizumab (BV) plus chemotherapy (CT) versus aflibercept (AFLI) plus CT in patients with metastatic colorectal cancer (mCRC) previously treated with BVJ Clin Oncol (Meeting Abstracts). J Clin Oncol201234 abstr 417
  • KopetzSHoffPMMorrisJSPhase II trial of infusional fluorouracil, irinotecan, and bevacizumab for metastatic colorectal cancer: efficacy and circulating angiogenic biomarkers associated with therapeutic resistanceJ Clin Oncol201028345345920008624
  • WillettCGDudaDGdi TomasoEEfficacy, safety, and biomarkers of neoadjuvant bevacizumab, radiation therapy, and fluorouracil in rectal cancer: a multidisciplinary phase II studyJ Clin Oncol200927183020302619470921
  • LoupakisFCremoliniCFioravantiAPharmacodynamic and pharmacogenetic angiogenesis-related markers of first-line FOLFOXIRI plus bevacizumab schedule in metastatic colorectal cancerBr J Cancer201110481262126921407216
  • FischerCJonckxBMazzoneMAnti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vesselsCell2007131346347517981115
  • ClarkeJMHurwitzHIUnderstanding and targeting resistance to anti-angiogenic therapiesJ Gastrointest Oncol20134325326323997938
  • LieuCHeymachJOvermanMTranHKopetzSBeyond VEGF: inhibition of the fibroblast growth factor pathway and antiangiogenesisClin Cancer Res201117196130613921953501
  • ChenCTHungMCBeyond anti-VEGF: dual-targeting antiangiogenic and antiproliferative therapyAm J Transl Res20135439340323724163
  • Moreno GarciaVBasuBMolifeLRKayeSBCombining antiangiogenics to overcome resistance: rationale and clinical experienceClin Cancer Res201218143750376122547772
  • ChauIJoulainFIqbalSA VELOUR post hoc subset analysis: prognostic groups and treatment outcomes in patients with metastatic colorectal cancer (mCRC) treated with aflibercept and FOLFIRIAnnal Oncol201324suppl 4iv91
  • WilsonPMLaBonteMJLenzHJAssessing the in vivo efficacy of biologic antiangiogenic therapiesCancer Chemother Pharmacol201371111223053262
  • LambrechtsDLenzHJde HaasSCarmelietPSchererSJMarkers of response for the antiangiogenic agent bevacizumabJ Clin Oncol20133191219123023401453
  • AllegraCJYothersGO’ConnellMJPhase III trial assessing bevacizumab in stages II and III carcinoma of the colon: results of NSABP protocol C-08J Clin Oncol2011291111620940184
  • SnoerenNVoestEEBergmanAMA randomized two arm phase III study in patients post radical resection of liver metastases of colorectal cancer to investigate bevacizumab in combination with capecitabine plus oxaliplatin (CAPOX) vs CAPOX alone as adjuvant treatmentBMC Cancer20101054520937118
  • KemenyNEJarnaginWRCapanuMRandomized phase II trial of adjuvant hepatic arterial infusion and systemic chemotherapy with or without bevacizumab in patients with resected hepatic metastases from colorectal cancerJ Clin Oncol201129788488921189384