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Review

Multikinase inhibitors in the treatment of thyroid cancer: specific role of lenvatinib

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Pages 129-139 | Published online: 10 Apr 2014

References

  • PellegritiGFrascaFRegalbutoCSquatritoSVigneriRWorldwide increasing incidence of thyroid cancer: update on epidemiology and risk factorsJ Cancer Epidemiol2013201396521223737785
  • ChenAJemalAWardEMIncreasing incidence of differentiated thyroid cancer in the United States,1988–2005Cancer2009115163801380719598221
  • Cancer Research UK orgThyroid cancer incidence statistics Available from: http://www.cancerresearchuk.org/cancer-info/cancerstats/types/thyroid/incidence/uk-thyroid-cancer-incidence-statistics-geogAccessed November 5, 2013
  • National Comprehensive Cancer NetworkThyroid Carcinoma (version 2.2013) Available from: http://www.nccn.org/professionals/physician_gls/pdf/thyroid.pdfAccessed November 5, 2013
  • National Cancer InstituteSurveillance Epidemiology and End Results Program: SEER Stat Facts: Thyroid Cancer2011 Available from: http://seer.cancer.gov/statfacts/html/thyro.html-incidence-mortalityAccessed November 5, 2013
  • Eustatia-RuttenCFCorssmitEPBiermaszNRPereiraAMRomijnJASmitJWSurvival and death causes in differentiated thyroid carcinomaJ Clin Endocrinol Metab200691131331916263822
  • DuranteCHaddyNBaudinELong-term outcome of 444 patients with distant metastases from papillary and follicular thyroid carcinoma: benefits and limits of radioiodine therapyJ Clin Endocrinol Metab20069182892289916684830
  • ShermanSICytotoxic chemotherapy for differentiated thyroid carcinomaClin Oncol (R Coll Radiol)201022646446820452757
  • WellsSAJrRobinsonBGGagelRFVandetanib in patients with locally advanced or metastatic medullary thyroid cancer: a randomized, double-blind Phase III trialJ Clin Oncol201230213414122025146
  • EliseiRSchlumbergerMJMüllerSPCabozantinib in progressive medullary thyroid cancerJ Clin Oncol201331293639364624002501
  • PawsonTRegulation and targets of receptor tyrosine kinasesEur J Cancer200238Suppl 5S3S1012528767
  • NikiforovaMNNikiforovYEMolecular genetics of thyroid cancer: implications for diagnosis, treatment and prognosisExpert Rev Mol Diagn200881839518088233
  • Ricarte-FilhoJCRyderMChitaleDAMutational profile of advanced primary and metastatic radioactive iodine-refractory thyroid cancers reveals distinct pathogenetic roles for BRAF, PIK3CA, and AKT1Cancer Res200969114885489319487299
  • KrauseDSVan EttenRATyrosine kinases as targets for cancer therapyN Engl J Med2005353217218716014887
  • AntonelliAFallahiPFerrariSMDedifferentiated thyroid cancer: a therapeutic challengeBiomed Pharmacother200862855956318725177
  • NikiforovYEThyroid carcinoma: molecular pathways and therapeutic targetsMod Pathol200821Suppl 2S37S4318437172
  • KrollTGSarrafPPecciariniLPAX8-PPARgamma1 fusion oncogene in human thyroid carcinoma [corrected]Science200028954831357136010958784
  • HouPLiuDXingMFunctional characterization of the T1799-1801del and A1799-1816ins BRAF mutations in papillary thyroid cancerCell Cycle20076337737917297294
  • SajiMRingelMDThe PI3K-Akt-mTOR pathway in initiation and progression of thyroid tumorsMol Cell Endocrinol20103211202819897009
  • MulliganLMKwokJBHealeyCSGerm-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2ANature199336364284584608099202
  • LearoydDLMessinaMZedeniusJRobinsonBGMolecular genetics of thyroid tumors and surgical decision-makingWorld J Surg200024892393310865036
  • HolbroTCivenniGHynesNEThe ErbB receptors and their role in cancer progressionExp Cell Res200328419911012648469
  • Rodríguez-AntonaCPallaresJMontero-CondeCOverexpression and activation of EGFR and VEGFR2 in medullary thyroid carcinomas is related to metastasisEndocr Relat Cancer201017171619776290
  • BottaroDPRubinJSFalettoDLIdentification of the hepatocyte growth factor receptor as the c-met proto-oncogene productScience199125149958028041846706
  • KleinMPicardEVignaudJMVascular endothelial growth factor gene and protein: strong expression in thyroiditis and thyroid carcinomaJ Endocrinol19991611414910194527
  • BunoneGVigneriPMarianiLExpression of angiogenesis stimulators and inhibitors in human thyroid tumors and correlation with clinical pathological featuresAm J Pathol199915561967197610595926
  • KerbelRSTumor angiogenesisN Engl J Med2008358192039204918463380
  • EggoMCHopkinsJMFranklynJAJohnsonGDSandersDSSheppardMCExpression of fibroblast growth factors in thyroid cancerJ Clin Endocrinol Metab1995803100610117533768
  • WescheJHaglundKHaugstenEMFibroblast growth factors and their receptors in cancerBiochem J2011437219921321711248
  • HaugstenEMWiedlochaAOlsnesSWescheJRoles of fibroblast growth factor receptors in carcinogenesisMol Cancer Res20108111439145221047773
  • St BernardRZhengLLiuWWinerDAsaSLEzzatSFibroblast growth factor receptors as molecular targets in thyroid carcinomaEndocrinology200514631145115315564323
  • BergersGHanahanDModes of resistance to anti-angiogenic therapyNat Rev Cancer20088859260318650835
  • DieciMVArnedosMAndreFSoriaJCFibroblast growth factor receptor inhibitors as a cancer treatment: from a biologic rationale to medical perspectivesCancer Discov20133326427923418312
  • PolverinoACoxonAStarnesCAMG 706, an oral, multikinase inhibitor that selectively targets vascular endothelial growth factor, platelet-derived growth factor, and kit receptors, potently inhibits angiogenesis and induces regression in tumor xenograftsCancer Res200666178715872116951187
  • ShermanSIWirthLJDrozJPMotesanib diphosphate in progressive differentiated thyroid cancerN Engl J Med20083591314218596272
  • SchlumbergerMJEliseiRBastholtLPhase II study of safety and efficacy of motesanib in patients with progressive or symptomatic, advanced or metastatic medullary thyroid cancerJ Clin Oncol200927233794380119564535
  • CohenEERosenLSVokesEEAxitinib is an active treatment for all histologic subtypes of advanced thyroid cancer: results from a Phase II studyJ Clin Oncol200826294708471318541897
  • LocatiLLicitraLAgateIPhase 2 trial of axitinib for advanced thyroid cancer: preliminary activity resultsPresented at the Fifth European Conference on Head and Neck OncologyPoznan, PolandApril 18–21, 2012
  • KloosRTRingelMDKnoppMVPhase II trial of sorafenib in metastatic thyroid cancerJ Clin Oncol200927101675168419255327
  • Gupta-AbramsonVTroxelABNelloreAPhase II trial of sorafenib in advanced thyroid cancerJ Clin Oncol200826294714471918541894
  • HoftijzerHHeemstraKAMorreauHBeneficial effects of sorafenib on tumor progression, but not on radioiodine uptake, in patients with differentiated thyroid carcinomaEur J Endocrinol2009161692393119773371
  • AhmedMBarbachanoYRiddellAAnalysis of the efficacy and toxicity of sorafenib in thyroid cancer: a Phase II study in a UK based populationEur J Endocrinol2011165231532221566072
  • BroseMSNuttingCJarzabBSorafenib in locally advanced or metastatic patients with radioactive iodine-refractory differentiated thyroid cancer: the Phase III DECISION trialJ Clin Oncol201331Suppl Abstr 4
  • LamETRingelMDKloosRTPhase II clinical trial of sorafenib in metastatic medullary thyroid cancerJ Clin Oncol201028142323233020368568
  • CapdevilaJIglesiasLHalperinISorafenib in metastatic thyroid cancerEndocr Relat Cancer201219220921622285864
  • CohenEENeedlesBMCullenKJPhase 2 study of sunitinib in refractory thyroid cancerJ Clin Oncol200826Suppl Abstr 6025
  • RavaudAFouchardièreCCourbonFSunitinib in patients with refractory advanced thyroid cancer: the THYSU Phase II trialJ Clin Oncol200826Suppl Abstr 6058
  • CarrLLMankoffDAGoulartBHPhase II study of daily sunitinib in FDG-PET-positive, iodine-refractory differentiated thyroid cancer and metastatic medullary carcinoma of the thyroid with functional imaging correlationClin Cancer Res201016215260526820847059
  • De SouzaJABusaidyNZimrinAPhase II trial of sunitinib in medullary thyroid cancer (MTC)J Clin Oncol201015Suppl Abstr 5504
  • BibleKCSumanVJMolinaJREfficacy of pazopanib in progressive, radioiodine-refractory, metastatic differentiated thyroid cancers: results of a Phase 2 consortium studyLancet Oncol2010111096297220851682
  • BibleKCSumanVJMenefeeMEA multiinstitutional Phase 2 trial of pazopanib monotherapy in advanced anaplastic thyroid cancerJ Clin Endocrinol Metab20129793179318422774206
  • WellsSAJrGosnellJEGagelRFVandetanib for the treatment of patients with locally advanced or metastatic hereditary medullary thyroid cancerJ Clin Oncol201028576777220065189
  • RobinsonBGPaz-AresLKrebsAVasselliJHaddadRVandetanib (100 mg) in patients with locally advanced or metastatic hereditary medullary thyroid cancerJ Clin Endocrinol Metab20109562664267120371662
  • LeboulleuxSBastholtLKrauseTVandetanib in locally advanced or metastatic differentiated thyroid cancer: a randomised, double-blind, Phase 2 trialLancet Oncol201213989790522898678
  • KurzrockRShermanSIBallDWActivity of XL184 (cabozantinib), an oral tyrosine kinase inhibitor, in patients with medullary thyroid cancerJ Clin Oncol201129192660266621606412
  • MatsuiJFunahashiYUenakaTWatanabeTTsuruokaAAsadaMMulti-kinase inhibitor E7080 suppresses lymph node and lung metastases of human mammary breast tumor MDA-MB-231 via inhibition of vascular endothelial growth factor-receptor (VEGF-R) 2 and VEGF-R3 kinaseClin Cancer Res200814175459546518765537
  • GrandeEDiezJJZafonCCapdevilaJThyroid cancer: molecular aspects and new therapeutic strategiesJ Thyroid Res2012201284710822848860
  • BossDSGlenHBeijnenJHA Phase I study of E7080, a multitargeted tyrosine kinase inhibitor, in patients with advanced solid tumoursBr J Cancer2012106101598160422516948
  • ShermanSIJarzabBCabanillasMEA Phase II trial of the multitargeted kinase inhibitor E7080 in advanced radioiodine (RAI)-refractory differentiated thyroid cancer (DTC)J Clin Oncol201129Suppl Abstr 5503
  • BallDWShermanSIJarzabBLenvatinib treatment of advanced RAI-refractory differentiated thyroid cancer (DTC): cytokine and angiogenic factor (CAF) profiling in combination with tumor genetic analysis to identify markers associated with responseJ Clin Oncol201230Suppl Abstr 5518
  • SchlumbergerMJarzabBCabanillasMEA Phase II trial of the multitargeted kinase inhibitor lenvatinib (E7080) in advanced medullary thyroid cancer (MTC)J Clin Oncol201230Suppl Abstr 5591