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Review

Management Strategies Of Palmar Hyperhidrosis: Challenges And Solutions

ORCID Icon, ORCID Icon, ORCID Icon & ORCID Icon
Pages 733-744 | Published online: 04 Oct 2019

References

  • Nawrocki S, Cha J. The etiology, diagnosis and management of hyperhidrosis: a comprehensive review. Part I. Etiology and clinical work-up. J Am Acad Dermatol. 2019 Epub ahead of print. doi:10.1016/j.jaad.2018.11.066
  • Wechter T, Feldman SR, Taylor SL. The treatment of primary focal hyperhidrosis. Skin Therapy Lett. 2019;24:1–7.
  • Romero FR, Haddad GR, Miot HA, Cataneo DC. Palmar hyperhidrosis: clinical, pathophysiological, diagnostic and therapeutic aspects. An Bras Dermatol. 2016;91:716–725.28099590
  • Kamudoni P, Mueller B, Halford J, Schouveller A, Stacey B, Salek MS. The impact of hyperhidrosis on patients’ daily life and quality of life: a qualitative investigation. Health Qual Life Outcomes. 2017;15:121.28595584
  • Solish N, Bertucci V, Dansereau A, et al. A comprehensive approach to the recognition, diagnosis, and severity-based treatment of focal hyperhidrosis: recommendations of the Canadian Hyperhidrosis Advisory Committee. Dermatol Surg. 2007;33:908–923.17661933
  • Hornberger J, Grimes K, Naumann M, et al. Recognition, diagnosis, and treatment of primary focal hyperhidrosis. J Am Acad Dermatol. 2004;51:274–286.15280848
  • Wade R, Llewellyn A, Jones-Diette J, et al. Interventional management of hyperhidrosis in secondary care: a systematic review. Br J Dermatol. 2018;179:599–608.29573391
  • McConaghy JR, Fosselman D. Hyperhidrosis: management options. Am Fam Physician. 2018;97:729–734.30215934
  • Zur E. Topical treatment of primary focal hyperhidrosis, part 1. Int J Pharm Compd. 2019;23:23–31.30668532
  • Hoorens I, Ongenae K. Primary focal hyperhidrosis: current treatment options and a step-by-step approach. J Eur Acad Dermatol Venereol. 2012;26:1–8.
  • Nawrocki S, Cha J. The etiology, diagnosis and management of hyperhidrosis: a comprehensive review. Part II. Therapeutic options. J Am Acad Dermatol. 2019 [Epub ahead of print]. doi:10.1016/j.jaad.2018.11.066
  • Woolery-Lloyd H, Valins W. Aluminum chloride hexahydrate in a salicylic Acid gel: a novel topical agent for hyperhidrosis with decreased irritation. J Clin Aesthet Dermatol. 2009;2:28–31.
  • Benohanian A, Dansereau A, Bolduc C, Bloom E. Localized hyperhidrosis treated with aluminum chloride in a salicylic acid gel base. Int J Dermatol. 1998;37:701–703.9762825
  • Innocenzi D, Lupi F, Bruni F, Frasca M, Panetta C, Milani M. Efficacy of a new aluminium salt thermophobic foam in the treatment of axillary and palmar primary hyperhidrosis: a pilot exploratory trial. Curr Med Res Opin. 2005;21:1949–1953.16368045
  • Hosp C, Hamm H. Safety of available and emerging drug therapies for hyperhidrosis. Expert Opin Drug Saf. 2017;16:1039–1049.28699790
  • Oliver B, Free R, Aires D. Preapplication of white petroleum jelly to adjacent skin to prevent aluminum chloride-induced irritant dermatitis. J Am Acad Dermatol. 2017;77:e7.28619576
  • White JW Jr. Treatment of primary hyperhidrosis. Mayo Clin Proc. 1986;61:951–956.3095597
  • Kim DH, Kim TH, Lee SH, Lee AY. Treatment of palmar hyperhidrosis with tap water iontophoresis: a randomized, sham-controlled, single-blind, and parallel-designed clinical trial. Ann Dermatol. 2017;29:728–734.29200761
  • Pariser DM, Ballard A. Iontophoresis for palmar and plantar hyperhidrosis. Dermatol Clin. 2014;32:491–494. doi:10.1016/j.det.2014.06.00925152342
  • Grabell DA, Hebert AA. Current and emerging medical therapies for primary hyperhidrosis. Dermatol Ther. 2017;7:25–36.
  • Siah TW, Hampton PJ. The effectiveness of tap water iontophoresis for palmoplantar hyperhidrosis using a monday, wednesday, and friday treatment regime. Dermatol Online J. 2013;19:14.
  • Khademi Kalantari K, Zeinalzade A, Kobarfard F, Nazary Moghadam S. The effect and persistency of 1% aluminum chloride hexahydrate iontophoresis in the treatment of primary palmar hyperhidrosis. Iran J Pharm Res. 2011;10:641–645.24250398
  • Shen JL, Lin GS, Li WM. A new strategy of iontophoresis for hyperhidrosis. J Am Acad Dermatol. 1990;22:239–241.2312804
  • Leow MQH, Tey HL. Treatment of primary palmar hyperhidrosis using glycopyrrolate iontophoresis: intensity of electrical current used, efficacy and side effects. Indian J Dermatol Venereol Leprol. 2017;83:387–388.28272059
  • Chia HY, Tan AS, Chong WS, Tey HL. Efficacy of iontophoresis with glycopyrronium bromide for treatment of primary palmar hyperhidrosis. J Eur Acad Dermatol Venereol. 2012;26:1167–1170.21812834
  • Dolianitis C, Scarff CE, Kelly J, Sinclair R. Iontophoresis with glycopyrrolate for the treatment of palmoplantar hyperhidrosis. Australas J Dermatol. 2004;45:208–212.15527429
  • Hill BH. Poldine iontophoresis in the treatment of palmar and plantar hyperhidrosis. Australas J Dermatol. 1976;17:92–93.1037367
  • Abell E, Morgan K. The treatment of idiopathic hyperhidrosis by glycopyrronium bromide and tap water iontophoresis. Br J Dermatol. 1974;91:87–91.4855129
  • Andrade PC, Flores GP, Uscello Jde F, Miot HA, Morsoleto MJ. Use of iontophoresis or phonophoresis for delivering onabotulinumtoxinA in the treatment of palmar hyperidrosis: a report on four cases. An Bras Dermatol. 2011;86:1243–1246.22281927
  • Davarian S, Kalantari KK, Rezasoltani A, Rahimi A. Effect and persistency of botulinum toxin iontophoresis in the treatment of palmar hyperhidrosis. Australas J Dermatol. 2008;49:75–79.18412805
  • Kavanagh GM, Shams K. Botulinum toxin type A by iontophoresis for primary palmar hyperhidrosis. J Am Acad Dermatol. 2006;55:S115–7.17052528
  • Kavanagh GM, Oh C, Shams K. BOTOX delivery by iontophoresis. Br J Dermatol. 2004;151:1093–1095.15541093
  • Choi YH, Lee SJ, Kim DW, Lee WJ, Na GY. Open clinical trial for evaluation of efficacy and safety of a portable “dry-type” iontophoretic device in treatment of palmar hyperhidrosis. Dermatol Surg. 2013;39:578–583.23379993
  • Stashak AB, Brewer JD. Management of hyperhidrosis. Clin Cosmet Investig Dermatol. 2014;7:285–299.
  • Weinberg T, Solish N, Murray C. Botulinum neurotoxin treatment of palmar and plantar hyperhidrosis. Dermatol Clin. 2014;32:505–515.25152344
  • Mannava S, Mannava KA, Nazir OF, et al. Treatment of palmar hyperhidrosis with botulinum neurotoxin a. J Hand Surg Am. 2013;38:398–400.23267759
  • Samizadeh S, De Boulle K. Botulinum neurotoxin formulations: overcoming the confusion. Clin Cosmet Investig Dermatol. 2018;11:273–287.
  • Basciani M, Di Rienzo F, Bizzarrini M, Zanchi M, Copetti M, Intiso D. Efficacy of botulinum toxin type B for the treatment of primary palmar hyperhidrosis: a prospective, open, single-blind, multi-centre study. Arch Dermatol Res. 2014;306:497–503.24522897
  • Rajagopal R, Mallya NB. Comparative evaluation of botulinum toxin versus iontophoresis with topical aluminium chloride hexahydrate in treatment of palmar hyperhidrosis. Med J Armed Forces India. 2014;70:247–252.25378778
  • Campanati A, Giuliodori K, Martina E, Giuliano A, Ganzetti G, Offidani A. Onabotulinumtoxin type A (Botox(®)) versus Incobotulinumtoxin type A (Xeomin(®)) in the treatment of focal idiopathic palmar hyperhidrosis: results of a comparative double-blind clinical trial. J Neural Transm. 2014;121:21–26.24052109
  • Campanati A, Giuliodori K, Giuliano A, et al. Treatment of palmar hyperhidrosis with botulinum toxin type A: results of a pilot study based on a novel injective approach. Arch Dermatol Res. 2013;305:691–697.23800969
  • Baumann L, Slezinger A, Halem M, et al. Double-blind, randomized, placebo-controlled pilot study of the safety and efficacy of Myobloc (botulinum toxin type B) for the treatment of palmar hyperhidrosis. Dermatol Surg. 2005;31:263–270.15841624
  • Lowe NJ, Yamauchi PS, Lask GP, Patnaik R, Iyer S. Efficacy and safety of botulinum toxin type a in the treatment of palmar hyperhidrosis: a double-blind, randomized, placebo-controlled study. Dermatol Surg. 2002;28:822–827.12269876
  • Lecouflet M, Leux C, Fenot M, Célerier P, Maillard H. Duration of efficacy increases with the repetition of botulinum toxin A injections in primary palmar hyperhidrosis: a study of 28 patients. J Am Acad Dermatol. 2014;70:1083–1087.24630001
  • Lowe PL, Lowe NJ. Botulinum toxin type B: pH change reduces injection pain, retains efficacy. Dermatol Surg. 2014;40:1328–1333.25350125
  • Shetty MK; IADVL Dermatosurgery Task Force. Guidelines on the use of botulinum toxin type A. Indian J Dermatol Venereol Leprol. 2008;74(Suppl):S13–22.18688099
  • Gregoriou S, Rigopoulos D, Makris M, et al. Effects of botulinum toxin-a therapy for palmar hyperhidrosis in plantar sweat production. Dermatol Surg. 2010;36:496–498.20180837
  • Iannitti T, Palmieri B, Aspiro A, Di Cerbo A. A preliminary study of painless and effective transdermal botulinum toxin A delivery by jet nebulization for treatment of primary hyperhidrosis. Drug Des Devel Ther. 2014;8:931–935.
  • Kang A, Burns E, Glaser DA. Botulinum toxin A for palmar hyperhidrosis: associated pain, duration, and reasons for discontinuation of therapy. Dermatol Surg. 2015;41:297–298.25654203
  • Cruddas L, Baker DM. Treatment of primary hyperhidrosis with oral anticholinergic medications: a systematic review. J Eur Acad Dermatol Venereol. 2017;31:952–963.27976476
  • Delort S, Marchi E, Corrêa MA. Oxybutynin as an alternative treatment for hyperhidrosis. An Bras Dermatol. 2017;92:217–220.28538882
  • Wolosker N, Teivelis MP, Krutman M, et al. Long-term efficacy of oxybutynin for palmar and plantar hyperhidrosis in children younger than 14 years. Pediatr Dermatol. 2015;32:663–667.25490865
  • Wolosker N, Teivelis MP, Krutman M, et al. Long-term results of oxybutynin treatment for palmar hyperhidrosis. Clin Auton Res. 2014;24:297–303.25427685
  • Wolosker N, Schvartsman C, Krutman M, et al. Efficacy and quality of life outcomes of oxybutynin for treating palmar hyperhidrosis in children younger than 14 years old. Pediatr Dermatol. 2014;31:48–53.23627681
  • Wolosker N, de Campos JR, Kauffman P, Puech-Leão P. A randomized placebo-controlled trial of oxybutynin for the initial treatment of palmar and axillary hyperhidrosis. J Vasc Surg. 2012;55:1696–1700.22341836
  • Wolosker N, de Campos JR, Kauffman P, et al. An alternative to treat palmar hyperhidrosis: use of oxybutynin. Clin Auton Res. 2011;21:389–393.21688168
  • Try C, Messikh R, Elkhyat A, Aubin F, Humbert RP. [Use of oral oxybutynin at 7.5 mg per day in primary hyperhidrosis]. Rev Med Liege. 2012;67:520–526.23167161
  • Kumar MG, Foreman RS, Berk DR, Bayliss SJ. Oral glycopyrrolate for refractory pediatric and adolescent hyperhidrosis. Pediatr Dermatol. 2014;31:e28–30.24266878
  • Walling HW. Systemic therapy for primary hyperhidrosis: a retrospective study of 59 patients treated with glycopyrrolate or clonidine. J Am Acad Dermatol. 2012;66:387–392.21820204
  • Paller AS, Shah PR, Silverio AM, Wagner A, Chamlin SL, Mancini AJ. Oral glycopyrrolate as second-line treatment for primary pediatric hyperhidrosis. J Am Acad Dermatol. 2012;67:918–923.22405644
  • Lee HH, Kim DW, Kim DW, Kim C. Efficacy of glycopyrrolate in primary hyperhidrosis patients. Korean J Pain. 2012;25::28–32.22259713
  • Bajaj V, Langtry JA. Use of oral glycopyrronium bromide in hyperhidrosis. Br J Dermatol. 2007;157:118–121.17459043
  • Del Boz J, Millán-Cayetano JF, Rivas-Ruiz F, de Troya-Martín M. Oral glycopyrrolate after the failure of oral oxybutynin in the treatment of primary hyperhidrosis. Br J Dermatol. 2017;176:821–823.27436700
  • Müller C, Berensmeier A, Hamm H, et al. Efficacy and safety of methantheline bromide (Vagantin(®)) in axillary and palmar hyperhidrosis: results from a multicenter, randomized, placebo-controlled trial. J Eur Acad Dermatol Venereol. 2013;27:1278–1284.23004926
  • Campanati A, Gregoriou S, Kontochristopoulos G, Offidani A. Oxybutynin for the treatment of primary hyperhidrosis: current state of the art. Skin Appendage Disord. 2015;1:6–13.27172124
  • Millán-Cayetano JF, Del Boz J, García-Montero P, García-Harana C, Rivas Ruiz F, de Troya-Martín M. Survival study of treatment adherence by patients given oral oxibutynin for hyperhidrosis. J Eur Acad Dermatol Venereol. 2018;32:1034–1037.29220103
  • Pariser DM, Krishnaraja J, Tremblay TM, Rubison RM, Love TW, McGraw BF. Randomized, placebo- and active-controlled crossover study of the safety and efficacy of THVD-102, a fixed-dose combination of oxybutynin and pilocarpine, in subjects with primary focal hyperhidrosis. J Drugs Dermatol. 2017;16:127–132.28300854
  • Garnock-Jones KP. Glycopyrrolate oral solution: for chronic, severe drooling in pediatric patients with neurologic conditions. Paediatr Drugs. 2012;14:263–269.22646067
  • Wollina U, Köstler E, Schönlebe J, Haroske G. Tumescent suction curettage versus minimal skin resection with subcutaneous curettage of sweat glands in axillary hyperhidrosis. Dermatol Surg. 2008;34:709–716.18318727
  • Goldman A, Wollina U. Subdermal Nd-YAG laser for axillary hyperhidrosis. Dermatol Surg. 2008;34:756–762.18318722
  • Zhang W, Yu D, Wei Y, Xu J, Zhang X. A systematic review and meta-analysis of T2, T3 or T4, to evaluate the best denervation level for palmar hyperhidrosis. Sci Rep. 2017;7:129.28273934
  • Moraites E, Vaughn OA, Hill S. Endoscopic thoracic sympathectomy. Dermatol Clin. 2014;32:541–548.25152348
  • Chen J, Du Q, Lin M, et al. Transareolar single-port needlescopic thoracic sympathectomy under intravenous anesthesia without intubation: a randomized controlled trial. J Laparoendosc Adv Surg Tech A. 2016;26:958–964.27556596
  • Chen JF, Lin M, Chen P, et al. Nonintubated needlescopic thoracic sympathectomy for primary palmar hyperhidrosis: a randomized controlled trial. Surg Laparosc Endosc Percutan Tech. 2016;26:328–333.27438170
  • Yang Y, Zeng L, An Z, Wang L, Hu J. Minimally invasive thoracic sympathectomy for palmar hyperhidrosis via a single unilateral incision approach by the pleura videoscope. J Laparoendoscopic Adv Surg Tech. 2014;24:328–332.
  • Ng CS, Lau RW, Wong RH, Ho AM, Wan S. Single-port vasoview sympathectomy for palmar hyperhidrosis: a clinical update. J Laparoendosc Adv Surg Tech A. 2014;24:32–34.24229422
  • Romero FR, Cataneo DC, Cataneo AJM. Outcome of percutaneous radiofrequency thoracic sympathectomy for palmar hyperhidrosis. Semin Thorac Cardiovasc Surg. Autumn 2018;30(3):362–366.30006204
  • Purtuloğlu T, Deniz S, Atım A, Tekindur Ş, Gürkök S, Kurt E. A new target of percutaneus sympathic radiofrequency thermocoagulation for treatment of palmar hyperhidrosis: T4. Agri. 2013;25(1):36–40.23588868
  • Nwannunu CE, Limmer AL, Coleman K, et al. Glycopyrronium Tosylate (Qbrexza) for hyperhidrosis. Skin Therapy Lett. 2019;24:1–3.
  • Zur E. Topical treatment of primary focal hyperhidrosis, part 2. Int J Pharm Compd. 2019;23:94–104.31085774
  • Pariser DM, Hebert AA, Drew J, Quiring J, Gopalan R, Glaser DA. Topical glycopyrronium tosylate for the treatment of primary axillary hyperhidrosis: patient-reported outcomes from the ATMOS-1 and ATMOS-2 phase III randomized controlled trials. Am J Clin Dermatol. 2019;20:135–145.30378087
  • Glaser DA, Hebert AA, Nast A, et al. Topical glycopyrronium tosylate for the treatment of primary axillary hyperhidrosis: results from the ATMOS-1 and ATMOS-2 phase 3 randomized controlled trials. J Am Acad Dermatol. 2019;80:128–138.e2.30003988
  • Artzi O, Loizides C, Zur E, Sprecher E. Topical oxybutynin 10% gel for the treatment of primary focal hyperhidrosis: a randomized double-blind placebo-controlled split area study. Acta Derm Venereol. 2017;97:1120–1124.28654131
  • Millán-Cayetano JF, Del Boz J, Toledo-Pastrana T, Nieto-Guindo M, García-Montero P, de Troya-Martín M. Initial study of transdermal oxybutynin for treating hyperhidrosis. J Dermatol. 2017;44:717–720.28106275
  • Qbrexza - A glycopyrronium cloth for axillary hyperhidrosis. Med Lett Drugs Ther. 2019;61:10–11.30856158
  • Baker DM. Topical glycopyrrolate reduces axillary hyperhidrosis. J Eur Acad Dermatol Venereol. 2016;30:2131–2136.27406319
  • Hyun MY, Son IP, Lee Y, et al. Efficacy and safety of topical glycopyrrolate in patients with facial hyperhidrosis: a randomized, multicentre, double-blinded, placebo-controlled, split-face study. J Eur Acad Dermatol Venereol. 2015;29:278–282.24909188
  • Kim WO, Kil HK, Yoon KB, Yoon DM. Topical glycopyrrolate for patients with facial hyperhidrosis. Br J Dermatol. 2008;158:1094–1097.18294315
  • Luh JY, Blackwell TA. Craniofacial hyperhidrosis successfully treated with topical glycopyrrolate. South Med J. 2002;95:756–758.12144084
  • Lueangarun S, Sermsilp C, Tempark T. Topical botulinum toxin type a liposomal cream for primary axillary hyperhidrosis: a double-blind, randomized, split-site, vehicle-controlled study. Dermatol Surg. 2018;44:1094–1101.29659406
  • Safety and efficacy of botulinum toxin type A topical gel for primary axillary hyperhidrosis. Available from: https://clinicaltrials.gov/ct2/show/NCT02565732?term=botulinum+toxin&cond=Hyperhidrosis&rank=6. Accessed 85, 2019
  • Heinig B, Koch A, Wollina U. Palmar hyperhidrosis treated by noninvasive ultrasound stellate ganglion block. Wien Med Wochenschr. 2018;168:250–253.27379849