Muscle function in COPD: a complex interplay

References

• LopezADMurrayCCThe global burden of disease, 1990–2020Nat Med1998411124112439809543
   PubMed Web of Science ®Google Scholar
• ManWDKempPMoxhamJPolkeyMISkeletal muscle dysfunction in COPD: clinical and laboratory observationsClin Sci (Lond)2009117725126419681758
   PubMed Web of Science ®Google Scholar
• GosselinkRTroostersTDecramerMPeripheral muscle weakness contributes to exercise limitation in COPDAm J Respir Crit Care Med199615339769808630582
   PubMed Web of Science ®Google Scholar
• SimpsonKKillianKMcCartneyNStubbingDGJonesNLRandomised controlled trial of weightlifting exercise in patients with chronic airflow limitationThorax199247270751549826
   PubMed Web of Science ®Google Scholar
• DecramerMGosselinkRTroostersTVerschuerenMEversGMuscle weakness is related to utilization of health care resources in COPD patientsEur Respir J19971024174239042643
   PubMed Web of Science ®Google Scholar
• SwallowEBReyesDHopkinsonNSQuadriceps strength predicts mortality in patients with moderate to severe chronic obstructive pulmonary diseaseThorax200762211512017090575
   PubMed Web of Science ®Google Scholar
• ManWMustfaNNikoletouDEffect of salmeterol on respiratory muscle activity during exercise in poorly reversible COPDThorax200459647147615170026
   PubMed Web of Science ®Google Scholar
• Gray-DonaldKGibbonsLShapiroSHMacklemPTMartinJGNutritional status and mortality in chronic obstructive pulmonary diseaseAm J Respir Crit Care Med199615339619668630580
   PubMed Web of Science ®Google Scholar
• BernardSLeBlancPWhittomFPeripheral muscle weakness in patients with chronic obstructive pulmonary diseaseAm J Respir Crit Care Med199815826296349700144
   PubMed Web of Science ®Google Scholar
• ManWDHopkinsonNSHarrafFNikoletouDPolkeyMIMoxhamJAbdominal muscle and quadriceps strength in chronic obstructive pulmonary diseaseThorax200560971872215923239
   PubMed Web of Science ®Google Scholar
• ManWSolimanMNikoletouDNon-volitional assessment of skeletal muscle strength in patients with chronic obstructive pulmonary diseaseThorax200358866566912885979
   PubMed Web of Science ®Google Scholar
• AllaireJMaltaisFDoyonJFPeripheral muscle endurance and the oxidative profile of the quadriceps in patients with COPDThorax200459867367815282387
   PubMed Web of Science ®Google Scholar
• ManWDSolimanMGGearingJSymptoms and quadriceps fatigability after walking and cycling in chronic obstructive pulmonary diseaseAm J Respir Crit Care Med2003168556256712829456
   PubMed Web of Science ®Google Scholar
• MadorMJDenizOAggarwalAKufelTJQuadriceps fatigability after single muscle exercise in patients with chronic obstructive pulmonary diseaseAm J Respir Crit Care Med2003168110210812689846
   PubMed Web of Science ®Google Scholar
• CoronellCOrozco-LeviMMendezRRamirez-SarmientoAGáldizJBGeaJRelevance of assessing quadriceps endurance in patients with COPDEur Respir J200424112913615293615
   PubMed Web of Science ®Google Scholar
• MathurSTakaiKPMacintyreDLReidDEstimation of thigh muscle mass with magnetic resonance imaging in older adults and people with chronic obstructive pulmonary diseasePhys Ther200888221923018056754
   PubMed Web of Science ®Google Scholar
• SeymourJMWardKSidhuPSUltrasound measurement of rectus femoris cross-sectional area and the relationship with quadriceps strength in COPDThorax200964541842319158125
   PubMed Web of Science ®Google Scholar
• MarquisKDebigaréRLacasseYMidthigh muscle cross-sectional area is a better predictor of mortality than body mass index in patients with chronic obstructive pulmonary diseaseAm J Respir Crit Care Med2002166680981312231489
   PubMed Web of Science ®Google Scholar
• GoskerHREngelenMPvan MamerenHMuscle fiber type IIX atrophy is involved in the loss of fat-free mass in chronic obstructive pulmonary diseaseAm J Clin Nutr200276111311912081824
   PubMed Web of Science ®Google Scholar
• GoskerHRZeegersMPWoutersEFScholsAMMuscle fibre type shifting in the vastus lateralis of patients with COPD is associated with disease severity: a systematic review and meta-analysisThorax2007621194494917526675
   PubMed Web of Science ®Google Scholar
• WhittomFJobinJSimardPMHistochemical and morphological characteristics of the vastus lateralis muscle in patients with chronic obstructive pulmonary diseaseMed Sci Sports Exerc19983010146714749789845
   PubMed Web of Science ®Google Scholar
• JobinJMaltaisFDoyonJFChronic obstructive pulmonary disease: capillarity and fiber type characteristics of skeletal muscleJ Cardiopulm Rehabil19981864324379857275
   PubMedGoogle Scholar
• MaltaisFSimardAASimardCJobinJDesgagnésPLeBlancPOxidative capacity of the skeletal muscle and lactic acid kinetics during exercise in normal subjects and in patients with COPDAm J Respir Crit Care Med199615312882938542131
   PubMed Web of Science ®Google Scholar
• JakobssonPJorfeldtLHenrikssonJMetabolic enzyme activity in the quadriceps femoris muscle in patients with severe chronic obstructive pulmonary diseaseAm J Respir Crit Care Med19951512 Pt 13743777842194
   PubMed Web of Science ®Google Scholar
• KutsuzawaTShioyaSKuritaDHaidaMOhtaYYamabayashiHMuscle energy metabolism and nutritional status in patients with chronic obstructive pulmonary disease. A 31P magnetic resonance studyAm J Respir Crit Care Med199515226476527633721
   PubMed Web of Science ®Google Scholar
• MaltaisFJobinJSullivanMJMetabolic and hemodynamic responses of lower limb during exercise in patients with COPDJ Appl Physiol1998845157315809572801
   PubMed Web of Science ®Google Scholar
• SwallowEBGoskerHRWardKAA novel technique for nonvolitional assessment of quadriceps muscle endurance in humansJ Appl Physiol2007103373974617569771
   PubMed Web of Science ®Google Scholar
• NewellSZMcKenzieDKGandeviaSCInspiratory and skeletal muscle strength and endurance and diaphragmatic activation in patients with chronic airflow limitationThorax198944119039122595630
   PubMed Web of Science ®Google Scholar
• GeaJGPastoMCarmonaMAOrozco-LeviMPalomequeJBroquetasJMetabolic characteristics of the deltoid muscle in patients with chronic obstructive pulmonary diseaseEur Respir J200117593994511488330
   PubMed Web of Science ®Google Scholar
• SatoYAsohTHondaYFujimatsuYHiguchiIOizumiKMorphologic and histochemical evaluation of muscle in patients with chronic pulmonary emphysema manifesting generalized emaciationEur Neurol19973721161219058068
   PubMed Web of Science ®Google Scholar
• SimilowskiTYanSGauthierAPMacklemPTBellemareFContractile properties of the human diaphragm during chronic hyperinflationN Engl J Med1991325139179231881417
   PubMed Web of Science ®Google Scholar
• LevineSKaiserLLeferovichJTikunovBCellular adaptations in the diaphragm in chronic obstructive pulmonary diseaseN Engl J Med199733725179918069400036
   PubMed Web of Science ®Google Scholar
• MercadierJJSchwartzKSchiaffinoSMyosin heavy chain gene expression changes in the diaphragm of patients with chronic lung hyperinflationAm J Physiol19982744 Pt 1L5275349575870
   PubMedGoogle Scholar
• DoucetMDebigaréRJoanisseDRAdaptation of the diaphragm and the vastus lateralis in mild-to-moderate COPDEur Respir J200424697197915572541
   PubMed Web of Science ®Google Scholar
• OttenheijmCAHeunksLMSieckGCDiaphragm dysfunction in chronic obstructive pulmonary diseaseAm J Respir Crit Care Med2005172220020515849324
   PubMed Web of Science ®Google Scholar
• StubbingsAKMooreAJDusmetMPhysiological properties of human diaphragm muscle fibres and the effect of chronic obstructive pulmonary diseaseJ Physiol2008586Pt 102637265018372305
   PubMed Web of Science ®Google Scholar
• LevineSNguyenTKaiserLRHuman diaphragm remodeling associated with chronic obstructive pulmonary disease: clinical implicationsAm J Respir Crit Care Med2003168670671312857719
   PubMed Web of Science ®Google Scholar
• Orozco-LeviMGeaJLloretaJLSubcellular adaptation of the human diaphragm in chronic obstructive pulmonary diseaseEur Respir J199913237137810065684
   PubMed Web of Science ®Google Scholar
• LevineSGregoryCNguyenTBioenergetic adaptation of individual human diaphragmatic myofibers to severe COPDJ Appl Physiol20029231205121311842060
   PubMed Web of Science ®Google Scholar
• PolkeyMIKyroussisDHamnegardCHDiaphragm performance during maximal voluntary ventilation in chronic obstructive pulmonary diseaseAm J Respir Crit Care Med199715526426489032207
   PubMed Web of Science ®Google Scholar
• PolkeyMIKyroussisDKeiltySEExhaustive treadmill exercise does not reduce twitch transdiaphragmatic pressure in patients with COPDAm J Respir Crit Care Med199515239599647663810
   PubMed Web of Science ®Google Scholar
• LevineSNguyenTFrisciaMParasternal intercostal muscle remodeling in severe chronic obstructive pulmonary diseaseJ Appl Physiol200610151297130216777998
   PubMed Web of Science ®Google Scholar
• GeaJOrozco-LeviMAguarMCAdaptive changes concerning the types of fibres and isoforms of myosin in the external intercostal muscle of COPD patientsEur Respir J19969160S
   Google Scholar
• SeymourJMSpruitMAHopkinsonNSThe prevalence of quadriceps weakness in COPD and the relationship with disease severityEur Respir J2010361818819897554
   PubMed Web of Science ®Google Scholar
• SerresIGautierVVarrayAPréfautCImpaired skeletal muscle endurance related to physical inactivity and altered lung function in COPD patientsChest199811349009059554623
   PubMed Web of Science ®Google Scholar
• GoskerHRKubatBSchaartGvan der VusseGJWoutersEFScholsAMMyopathological features in skeletal muscle of patients with chronic obstructive pulmonary diseaseEur Respir J200322228028512952261
   PubMed Web of Science ®Google Scholar
• DegensHSanchez HornerosJMHeijdraYFDekhuijzenPNHopmanMTSkeletal muscle contractility is preserved in COPD patients with normal fat-free massActa Physiol Scand2005184323524215954991
   PubMedGoogle Scholar
• OttenheijmCAHeunksLMDekhuijzenRPDiaphragm adaptations in patients with COPDRespir Res2008911218218129
   PubMed Web of Science ®Google Scholar
• van den BorstBKosterAYuBIs age-related decline in lean mass and physical function accelerated by obstructive lung disease or smoking?Thorax2011661196196921724748
   PubMed Web of Science ®Google Scholar
• WatzHWaschkiBMeyerTMagnussenHPhysical activity in patients with COPDEur Respir J200933226227219010994
   PubMed Web of Science ®Google Scholar
• KonSSManWDMuscle mass and strength in obstructive lung disease: a smoking gun?Thorax2011661193393521813620
   PubMed Web of Science ®Google Scholar
• PolkeyMIMoxhamJAttacking the disease spiral in chronic obstructive pulmonary diseaseClin Med20066219019616688981
   PubMed Web of Science ®Google Scholar
• BossenbroekLde GreefMHWempeJBKrijnenWPTen HackenNHDaily physical activity in patients with chronic obstructive pulmonary disease: a systematic reviewCOPD20118430631921728804
   PubMedGoogle Scholar
• DecramerMRennardSTroostersTCOPD as a lung disease with systemic consequences – clinical impact, mechanisms, and potential for early interventionCOPD20085423525618671149
   PubMedGoogle Scholar
• PittaFTroostersTSpruitMAProbstVSDecramerMGosselinkRCharacteristics of physical activities in daily life in chronic obstructive pulmonary diseaseAm J Respir Crit Care Med2005171997297715665324
   PubMed Web of Science ®Google Scholar
• GoskerHRLencerNHFranssenFMvan der VusseGJWoutersEFScholsAMStriking similarities in systemic factors contributing to decreased exercise capacity in patients with severe chronic heart failure or COPDChest200312351416142412740256
   PubMed Web of Science ®Google Scholar
• SpruitMGosselinkRTroostersTMuscle force during an acute exacerbation in hospitalised patients with COPD and its relationship with CXCL8 and IGF-IThorax200358975275612947130
   PubMed Web of Science ®Google Scholar
• SeymourJMMooreLJolleyCJOutpatient pulmonary rehabilitation following acute exacerbations of COPDThorax201065542342820435864
   PubMed Web of Science ®Google Scholar
• TroostersTProbstVSCrulTResistance training prevents deterioration in quadriceps muscle function during acute exacerbations of chronic obstructive pulmonary diseaseAm J Respir Crit Care Med2010181101072107720133927
   PubMed Web of Science ®Google Scholar
• Garcia-AymerichJFarreroEFélezMAIzquierdoJMarradesRMAntóJMEstudi del Factors de Risc d’Agudització de la MPOC investigatorsRisk factors of readmission to hospital for a COPD exacerbation: a prospective studyThorax200358210010512554887
   PubMed Web of Science ®Google Scholar
• Garcia-AymerichJLangePBenetMSchnohrPAntoJMRegular physical activity reduces hospital admission and mortality in chronic obstructive pulmonary disease: a population based cohort studyThorax200661977277816738033
   PubMed Web of Science ®Google Scholar
• Garcia-AymerichJLangePBenetMSchnohrPAntóJMRegular physical activity modifies smoking-related lung function decline and reduces risk of chronic obstructive pulmonary disease: a population-based cohort studyAm J Respir Crit Care Med2007175545846317158282
   PubMed Web of Science ®Google Scholar
• YendeSWatererGWTolleyEAInflammatory markers are associated with ventilatory limitation and muscle dysfunction in obstructive lung disease in well functioning elderly subjectsThorax2006611101616284220
   PubMed Web of Science ®Google Scholar
• DebigaréRMarquisKCôtéCHCatabolic/anabolic balance and muscle wasting in patients with COPDChest20031241838912853506
   PubMed Web of Science ®Google Scholar
• EidAAIonescuAANixonLSInflammatory response and body composition in chronic obstructive pulmonary diseaseAm J Respir Crit Care Med20011648 Pt 11414141811704588
   PubMed Web of Science ®Google Scholar
• WagnerPDPossible mechanisms underlying the development of cachexia in COPDEur Respir J200831349250118310396
   PubMed Web of Science ®Google Scholar
• BarreiroEScholsAMPolkeyMIENIGMA in COPD projectCytokine profile in quadriceps muscles of patients with severe COPDThorax200863210010717875568
   PubMed Web of Science ®Google Scholar
• PetersenAMPenkowaMIversenMElevated levels of IL-18 in plasma and skeletal muscle in chronic obstructive pulmonary diseaseLung2007185316117117436040
   PubMed Web of Science ®Google Scholar
• CrulTSpruitMAGayan-RamirezGMarkers of inflammation and disuse in vastus lateralis of chronic obstructive pulmonary disease patientsEur J Clin Invest2007371189790417883420
   PubMed Web of Science ®Google Scholar
• KoechlinCCouillardASimarDDoes oxidative stress alter quadriceps endurance in chronic obstructive pulmonary disease?Am J Respir Crit Care Med200416991022102715001462
   PubMed Web of Science ®Google Scholar
• ReidMBNitric oxide, reactive oxygen species, and skeletal muscle contractionMed Sci Sports Exerc200133337137611252061
   PubMed Web of Science ®Google Scholar
• BarreiroEde la PuenteBMinguellaJOxidative stress and respiratory muscle dysfunction in severe chronic obstructive pulmonary diseaseAm J Respir Crit Care Med2005171101116112415735057
   PubMed Web of Science ®Google Scholar
• SupinskiGSCallahanLAFree radical-mediated skeletal muscle dysfunction in inflammatory conditionsJ Appl Physiol200710252056206317218425
   PubMed Web of Science ®Google Scholar
• BarreiroERabinovichRMarin-CorralJBarberàJAGeaJRocaJChronic endurance exercise induces quadriceps nitrosative stress in patients with severe COPDThorax2009641131918835959
   PubMed Web of Science ®Google Scholar
• GoskerHRBastAHaenenGRAltered antioxidant status in peripheral skeletal muscle of patients with COPDRespir Med200599111812515672860
   PubMed Web of Science ®Google Scholar
• CouillardAMaltaisFSaeyDExercise-induced quadriceps oxidative stress and peripheral muscle dysfunction in patients with chronic obstructive pulmonary diseaseAm J Respir Crit Care Med2003167121664166912672647
   PubMed Web of Science ®Google Scholar
• BarreiroEGeaJCorominasJMHussainSNNitric oxide synthases and protein oxidation in the quadriceps femoris of patients with chronic obstructive pulmonary diseaseAm J Respir Cell Mol Biol200329677177812816735
   PubMed Web of Science ®Google Scholar
• CouillardAKoechlinCCristolJPVarrayAPrefautCEvidence of local exercise-induced systemic oxidative stress in chronic obstructive pulmonary disease patientsEur Respir J20022051123112912449164
   PubMed Web of Science ®Google Scholar
• HopkinsonNSNickolAHPayneJAngiotensin converting enzyme genotype and strength in chronic obstructive pulmonary diseaseAm J Respir Crit Care Med2004170439539915117739
   PubMed Web of Science ®Google Scholar
• HopkinsonNSEleftheriouKIPayneJ+9/+9 Homozygosity of the bradykinin receptor gene polymorphism is associated with reduced fat-free mass in chronic obstructive pulmonary diseaseAm J Clin Nutr200683491291716600946
   PubMed Web of Science ®Google Scholar
• HopkinsonNSLiKWKehoeAVitamin D receptor genotypes influence quadriceps strength in chronic obstructive pulmonary diseaseAm J Clin Nutr200887238539018258629
   PubMed Web of Science ®Google Scholar
• BroekhuizenRGrimbleRFHowellWMPulmonary cachexia, systemic inflammatory profile, and the interleukin 1beta-511 single nucleotide polymorphismAm J Clin Nutr20058251059106416280439
   PubMed Web of Science ®Google Scholar
• EngelenMPScholsAMBakenWCWesselingGJWoutersEFNutritional depletion in relation to respiratory and peripheral skeletal muscle function in out-patients with COPDEur Respir J1994710179317977828687
   PubMed Web of Science ®Google Scholar
• FerreiraIMBrooksDLacasseYGoldsteinRSNutritional support for individuals with COPD: a meta-analysisChest2000117367267810712990
   PubMed Web of Science ®Google Scholar
• Op den KampCMLangenRCHaegensAScholsAMMuscle atrophy in cachexia: can dietary protein tip the balance?Curr Opin Clin Nutr Metab Care200912661161619741519
   PubMed Web of Science ®Google Scholar
• BurdetLde MuraltBSchutzYPichardCFittingJWAdministration of growth hormone to underweight patients with chronic obstructive pulmonary disease. A prospective, randomized, controlled studyAm J Respir Crit Care Med19971566180018069412558
   PubMed Web of Science ®Google Scholar
• CreutzbergECWoutersEFMostertRPluymersRJScholsAMA role for anabolic steroids in the rehabilitation of patients with COPD? A double-blind, placebo-controlled, randomized trialChest200312451733174214605042
   PubMed Web of Science ®Google Scholar
• CasaburiRBhasinSCosentinoLEffects of testosterone and resistance training in men with chronic obstructive pulmonary diseaseAm J Respir Crit Care Med2004170887087815271690
   PubMed Web of Science ®Google Scholar
• ScholsAMPulmonary cachexiaInt J Cardiol200285110111012163214
   PubMed Web of Science ®Google Scholar
• DecramerMLacquetLMFagardRRogiersPCorticosteroids contribute to muscle weakness in chronic airflow obstructionAm J Respir Crit Care Med1994150111168025735
   PubMed Web of Science ®Google Scholar
• HopkinsonNSManWDDayerMJAcute effect of oral steroids on muscle function in chronic obstructive pulmonary diseaseEur Respir J200424113714215293616
   PubMed Web of Science ®Google Scholar
• NaderGAMolecular determinants of skeletal muscle mass: getting the “AKT” togetherInt J Biochem Cell Biol200537101985199616125108
   PubMed Web of Science ®Google Scholar
• RommelCBodineSCClarkeBAMediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathwaysNat Cell Biol20013111009101311715022
   PubMed Web of Science ®Google Scholar
• HaraKYonezawaKKozlowskiMTRegulation of eIF-4E BP1 phosphorylation by mTORJ Biol Chem19972724226457264639334222
   PubMed Web of Science ®Google Scholar
• CrossDAAlessiDRCohenPAndjelkovichMHemmingsBAInhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase BNature199537865597857898524413
   PubMed Web of Science ®Google Scholar
• SandriMSandriCGilbertAFoxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophyCell2004117339941215109499
   PubMed Web of Science ®Google Scholar
• BodineSCLatresEBaumhueterSIdentification of ubiquitin ligases required for skeletal muscle atrophyScience200129455471704170811679633
   PubMed Web of Science ®Google Scholar
• DoucetMRussellAPLégerBMuscle atrophy and hypertrophy signaling in patients with chronic obstructive pulmonary diseaseAm J Respir Crit Care Med2007176326126917478621
   PubMed Web of Science ®Google Scholar
• PlantPJBrooksDFaughnanMCellular markers of muscle atrophy in chronic obstructive pulmonary diseaseAm J Respir Cell Mol Biol201042446147119520920
   PubMed Web of Science ®Google Scholar
• RennieMJAnabolic resistance: the effects of aging, sexual dimorphism, and immobilization on human muscle protein turnoverAppl Physiol Nutr Metab200934337738119448702
   PubMed Web of Science ®Google Scholar
• de BoerMDSelbyAAthertonPThe temporal responses of protein synthesis, gene expression and cell signalling in human quadriceps muscle and patellar tendon to disuseJ Physiol2007585Pt 124125117901116
   PubMed Web of Science ®Google Scholar
• MarimuthuKMurtonAJGreenhaffPLMechanisms regulating muscle mass during disuse atrophy and rehabilitation in humansJ Appl Physiol2011110255556021030670
   PubMed Web of Science ®Google Scholar
• McPherronACLawlerAMLeeSJRegulation of skeletal muscle mass in mice by a new TGF-beta superfamily memberNature1997387662883909139826
   PubMed Web of Science ®Google Scholar
• McPherronACLeeSJDouble muscling in cattle due to mutations in the myostatin geneProc Natl Acad Sci U S A1997942312457124619356471
   PubMed Web of Science ®Google Scholar
• SchuelkeMWagnerKRStolzLEMyostatin mutation associated with gross muscle hypertrophy in a childN Engl J Med2004350262682268815215484
   PubMed Web of Science ®Google Scholar
• ThomasMLangleyBBerryCMyostatin, a negative regulator of muscle growth, functions by inhibiting myoblast proliferationJ Biol Chem200027551402354024310976104
   PubMed Web of Science ®Google Scholar
• LangleyBThomasMBishopASharmaMGilmourSKambadurRMyostatin inhibits myoblast differentiation by down-regulating MyoD expressionJ Biol Chem200227751498314984012244043
   PubMed Web of Science ®Google Scholar
• McFarlaneCPlummerEThomasMMyostatin induces cachexia by activating the ubiquitin proteolytic system through an NF-kappaB- independent, FoxO1-dependent mechanismJ Cell Physiol2006209250151416883577
   PubMed Web of Science ®Google Scholar
• McFarlaneCHennebryAThomasMMyostatin signals through Pax7 to regulate satellite cell self-renewalExp Cell Res2008314231732917949710
   PubMed Web of Science ®Google Scholar
• VogiatzisISimoesDCStratakosGEffect of pulmonary rehabilitation on muscle remodelling in cachectic patients with COPDEur Respir J201036230131020110400
   PubMed Web of Science ®Google Scholar
• LewisMIFournierMStorerTWSkeletal muscle adaptations to testosterone and resistance training in men with COPDJ Appl Physiol200710341299131017673568
   PubMed Web of Science ®Google Scholar
• D-C ManWNatanekSARiddoch-ContrerasJQuadriceps myostatin expression in COPDEur Respir J201036368668820930205
   PubMed Web of Science ®Google Scholar
• SchiaffinoSSandriMMurgiaMActivity-dependent signaling pathways controlling muscle diversity and plasticityPhysiology (Bethesda)20072226927817699880
   PubMed Web of Science ®Google Scholar
• WuHNayaFJMcKinseyTAMEF2 responds to multiple calcium-regulated signals in the control of skeletal muscle fiber typeEMBO J20001991963197310790363
   PubMed Web of Science ®Google Scholar
• NayaFJMercerBSheltonJRichardsonJAWilliamsRSOlsonENStimulation of slow skeletal muscle fiber gene expression by calcineurin in vivoJ Biol Chem200027574545454810671477
   PubMed Web of Science ®Google Scholar
• ChinEROlsonENRichardsonJAA calcineurin-dependent transcriptional pathway controls skeletal muscle fiber typeGenes Dev19981216249925099716403
   PubMed Web of Science ®Google Scholar
• LongYCGlundSGarcia-RovesPMZierathJRCalcineurin regulates skeletal muscle metabolism via coordinated changes in gene expressionJ Biol Chem200728231607161417107952
   PubMed Web of Science ®Google Scholar
• LuquetSLopez-SorianoJHolstDPeroxisome proliferator-activated receptor delta controls muscle development and oxidative capabilityFASEB J200317152299230114525942
   PubMed Web of Science ®Google Scholar
• BeckerJDelayre-OrthezCFrossardNPonsFRegulation of inflammation by PPARs: a future approach to treat lung inflammatory diseases?Fundam Clin Pharmacol200620542944716968414
   PubMed Web of Science ®Google Scholar
• LuquetSGaudelCHolstDRoles of PPAR delta in lipid absorption and metabolism: a new target for the treatment of type 2 diabetesBiochim Biophys Acta20051740231331715949697
   PubMed Web of Science ®Google Scholar
• WangYXZhangCLYuRTRegulation of muscle fiber type and running endurance by PPARdeltaPLoS Biol2004210e29415328533
   PubMed Web of Science ®Google Scholar
• MahoneyDJPariseGMelovSSafdarATarnopolskyMAAnalysis of global mRNA expression in human skeletal muscle during recovery from endurance exerciseFASEB J200519111498150015985525
   PubMed Web of Science ®Google Scholar
• PuigserverPSpiegelmanBMPeroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulatorEndocr Rev2003241789012588810
   PubMed Web of Science ®Google Scholar
• RemelsAHSchrauwenPBroekhuizenRPeroxisome proliferator- activated receptor expression is reduced in skeletal muscle in COPDEur Respir J200730224525217459894
   PubMed Web of Science ®Google Scholar
• RemelsAHGoskerHRSchrauwenPLangenRCScholsAMPeroxisome proliferator-activated receptors: a therapeutic target in COPD?Eur Respir J200831350250818310397
   PubMed Web of Science ®Google Scholar
• ShiHSchefflerJMPleitnerJMModulation of skeletal muscle fiber type by mitogen-activated protein kinase signalingFASEB J20082282990300018417546
   PubMed Web of Science ®Google Scholar
• LemireBBDebigareRDubéAThériaultMECoteCHMaltaisFMAPK signalling in the quadriceps of patients with chronic obstructive pulmonary diseaseJ Appl Physiol2012Epub April19
   Google Scholar
• Riddoch-ContrerasJGeorgeTNatanekSAp38 mitogen-activated protein kinase is not activated in the quadriceps of patients with stable chronic obstructive pulmonary diseaseCOPD20129214215022409248
   PubMedGoogle Scholar
• WilliamsAHLiuNvan RooijEOlsonENMicroRNA control of muscle development and diseaseCurr Opin Cell Biol200921346146919278845
   PubMed Web of Science ®Google Scholar
• ChenJFMandelEMThomsonJMThe role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiationNat Genet200638222823316380711
   PubMed Web of Science ®Google Scholar
• GüllerIRussellAPMicroRNAs in skeletal muscle: their role and regulation in development, disease and functionJ Physiol2010588Pt 214075408720724363
   PubMed Web of Science ®Google Scholar
• van RooijEQuiatDJohnsonBAA family of microRNAs encoded by myosin genes governs myosin expression and muscle performanceDev Cell200917566267319922871
   PubMed Web of Science ®Google Scholar
• McCarthyJJEsserKAPetersonCADupont-VersteegdenEEEvidence of MyomiR network regulation of beta-myosin heavy chain gene expression during skeletal muscle atrophyPhysiol Genomics200939321922619690046
   PubMed Web of Science ®Google Scholar
• LewisARiddoch-ContrerasJNatanekSADownregulation of the serum response factor/miR-1 axis in the quadriceps of patients with COPDThorax2012671263421998125
   PubMed Web of Science ®Google Scholar
• ClopAMarcqFTakedaHA mutation creating a potential illegitimate microRNA target site in the myostatin gene affects muscularity in sheepNat Genet200638781381816751773
   PubMed Web of Science ®Google Scholar
• EliaLContuRQuintavalleMReciprocal regulation of microRNA-1 and insulin-like growth factor-1 signal transduction cascade in cardiac and skeletal muscle in physiological and pathological conditionsCirculation2009120232377238519933931
   PubMed Web of Science ®Google Scholar
• SunYGeYDrnevichJZhaoYBandMChenJMammalian target of rapamycin regulates miRNA-1 and follistatin in skeletal myogenesisJ Cell Biol201018971157116920566686
   PubMed Web of Science ®Google Scholar
• LacasseYGoldsteinRLassersonTJMartinSPulmonary rehabilitation for chronic obstructive pulmonary diseaseCochrane Database Syst Rev20064CD00379317054186
   PubMedGoogle Scholar
• CasaburiRZuWallackRPulmonary rehabilitation for management of chronic obstructive pulmonary diseaseN Engl J Med2009360131329133519321869
   PubMed Web of Science ®Google Scholar
• O’DonnellDELamMWebbKAMeasurement of symptoms, lung hyperinflation, and endurance during exercise in chronic obstructive pulmonary diseaseAm J Respir Crit Care Med19981585 Pt 1155715659817708
   PubMed Web of Science ®Google Scholar
• MadorMJKufelTJPinedaLAEffect of pulmonary rehabilitation on quadriceps fatiguability during exerciseAm J Respir Crit Care Med2001163493093511282768
   PubMed Web of Science ®Google Scholar
• O’DonnellDEMcGuireMSamisLWebbKAGeneral exercise training improves ventilatory and peripheral muscle strength and endurance in chronic airflow limitationAm J Respir Crit Care Med19981575 Pt 1148914979603128
   PubMed Web of Science ®Google Scholar
• ManWDKempPMoxhamJPolkeyMIExercise and muscle dysfunction in COPD: implications for pulmonary rehabilitationClin Sci (Lond)2009117828129119689433
   PubMed Web of Science ®Google Scholar
• CasaburiRPatessioAIoliFZanaboniSDonnerCFWassermanKReductions in exercise lactic acidosis and ventilation as a result of exercise training in patients with obstructive lung diseaseAm Rev Respir Dis199114319181986689
   PubMed Web of Science ®Google Scholar
• MaltaisFLeBlancPJobinJIntensity of training and physiologic adaptation in patients with chronic obstructive pulmonary diseaseAm J Respir Crit Care Med199715525555619032194
   PubMed Web of Science ®Google Scholar
• van’t HulAGosselinkRHollanderPPostmusPKwakkelGTraining with inspiratory pressure support in patients with severe COPDEur Respir J2006271657216387937
   PubMed Web of Science ®Google Scholar
• SomfayAPórszászJLeeSMCasaburiREffect of hyperoxia on gas exchange and lactate kinetics following exercise onset in nonhypoxemic COPD patientsChest2002121239340011834648
   PubMed Web of Science ®Google Scholar
• PalangePValliGOnoratiPEffect of heliox on lung dynamic hyperinflation, dyspnea, and exercise endurance capacity in COPD patientsJ Appl Physiol20049751637164215234959
   PubMed Web of Science ®Google Scholar
• VogiatzisIStrategies of muscle training in very severe COPD patientsEur Respir J201138497197521737548
   PubMed Web of Science ®Google Scholar
• Janaudis-FerreiraTHillKGoldsteinRWadellKBrooksDArm exercise training in patients with chronic obstructive pulmonary disease: a systematic reviewJ Cardiopulm Rehabil Prev200929527728319935139
   PubMed Web of Science ®Google Scholar
• GosselinkRDe VosJvan den HeuvelSPSegersJDecramerMKwakkelGImpact of inspiratory muscle training in patients with COPD: what is the evidence?Eur Respir J201137241642521282809
   PubMed Web of Science ®Google Scholar
• MaddocksMMurtonAJWilcockAImproving muscle mass and function in cachexia: non-drug approachesCurr Opin Support Palliat Care20115436136421934503
   PubMedGoogle Scholar
• RoigMReidWDElectrical stimulation and peripheral muscle function in COPD: a systematic reviewRespir Med2009103448549519091537
   PubMed Web of Science ®Google Scholar
• VivodtzevIDebigaréRGagnonPFunctional and muscular effects of neuromuscular electrical stimulation in patients with severe COPD: a randomized clinical trialChest2012141371672522116795
   PubMed Web of Science ®Google Scholar
• AbdellaouiAPréfautCGouziFSkeletal muscle effects of electrostimulation after COPD exacerbation: a pilot studyEur Respir J201138478178821349913
   PubMed Web of Science ®Google Scholar
• GriffithsTLBurrMLCampbellIAResults at 1 year of outpatient multidisciplinary pulmonary rehabilitation: a randomised controlled trialLancet2000355920136236810665556
   PubMed Web of Science ®Google Scholar
• SteinerMCRoubenoffRTal-SingerRPolkeyMIProspects for the development of effective pharmacotherapy targeted at the skeletal muscles in chronic obstructive pulmonary disease: a translational reviewThorax2012Epub May5
   Google Scholar
• RennardSIFogartyCKelsenSCOPD InvestigatorsThe safety and efficacy of infliximab in moderate to severe chronic obstructive pulmonary diseaseAm J Respir Crit Care Med2007175992693417290043
   PubMed Web of Science ®Google Scholar
• YehSSDeGuzmanBKramerTM012 Study GroupReversal of COPD-associated weight loss using the anabolic agent oxandroloneChest2002122242142812171812
   PubMed Web of Science ®Google Scholar
• NagayaNItohTMurakamiSTreatment of cachexia with ghrelin in patients with COPDChest200512831187119316162705
   PubMed Web of Science ®Google Scholar
• NarayananRMohlerMLBohlCEMillerDDDaltonJTSelective androgen receptor modulators in preclinical and clinical developmentNucl Recept Signal20086e01019079612
   PubMedGoogle Scholar
• SumukadasDWithamMDStruthersADMcMurdoMEEffect of perindopril on physical function in elderly people with functional impairment: a randomized controlled trialCMAJ2007177886787417923654
   PubMed Web of Science ®Google Scholar
• DoorduinJSinderbyCABeckJThe calcium sensitizer levosimendan improves human diaphragm functionAm J Respir Crit Care Med20121851909521960535
   PubMed Web of Science ®Google Scholar
• AndeSRChenJMaddikaSThe ubiquitin pathway: an emerging drug target in cancer therapyEur J Pharmacol20096251–319920519835866
   PubMed Web of Science ®Google Scholar
• NarkarVADownesMYuRTAMPK and PPARdelta agonists are exercise mimeticsCell2008134340541518674809
   PubMed Web of Science ®Google Scholar