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Original Research

Synthesis, activity, and docking study of phenylthiazole acids as potential agonists of PPARγ

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Pages 1807-1815 | Published online: 30 May 2016

References

  • EvansRMMangelsdorfDJNuclear receptors, RXR, and the big bangCell2014157125526624679540
  • BensingerSJTontonozPIntegration of metabolism and inflammation by lipid-activated nuclear receptorsNature2008454720347047718650918
  • GronemeyerHGustafssonJ-ALaudetVPrinciples for modulation of the nuclear receptor superfamilyNat Rev Drug Discov200431195096415520817
  • ChawlaARepaJJEvansRMMangelsdorfDJNuclear receptors and lipid physiology: opening the X-filesScience200129455481866187011729302
  • Grygiel-GórniakBPeroxisome proliferator-activated receptors and their ligands: nutritional and clinical implications – a reviewNutr J2014131124405527
  • KliewerSASundsethSSJonesSAFatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γProc Natl Acad Sci U S A1997949431843239113987
  • BergerJMollerDEThe mechanisms of action of PPARsAnnu Rev Med200253140943511818483
  • WrightHMClishCBMikamiTA synthetic antagonist for the peroxisome proliferator-activated receptor γ inhibits adipocyte differentiationJ Biol Chem200027531873187710636887
  • Marion-LetellierRSavoyeGGhoshSFatty acids, eicosanoids and PPAR gammaEur J Pharmacol Epub20151126
  • AhmadianMSuhJMHahNPPARγ signaling and metabolism: the good, the bad and the futureNat Med201399555756623652116
  • TripathiACGuptaSJFatimaGNSonarPKVermaASarafSK4-thiazolidinones: the advances continueEur J Med Chem201472527724355348
  • da SilvaFMCdos SantosJCCamposJLOStructure-based identification of novel PPAR gamma ligandsBioorg Med Chem Lett201323215795580224075729
  • OhashiMGamoKOyamaTMiyachiHPeroxisome proliferator-activated receptor gamma (PPARγ) has multiple binding points that accommodate ligands in various conformations: structurally similar PPARγ partial agonists bind to PPARγ LBD in different conformationsBioorg Med Chem Lett201525142758276226025876
  • OhashiMOyamaTMiyachiHDifferent structures of the two peroxisome proliferator-activated receptor gamma (PPARγ) ligand-binding domains in homodimeric complex with partial agonist, but not full agonistBioorg Med Chem Lett201525132639264425987371
  • XuQHuangLLiuJDesign, synthesis and biological evaluation of thiazole- and indole-based derivatives for the treatment of type II diabetesEur J Med Chem201252708122483089
  • SakamotoJKimuraHMoriyamaSActivation of human peroxisome proliferator-activated receptor (PPAR) subtypes by pioglitazoneBiochem Biophys Res Commun2000278370471111095972
  • UsuiSSuzukiTHattoriYDesign, synthesis, and biological activity of novel PPARγ ligands based on rosiglitazone and 15d-PGJ2Bioorg Med Chem Lett20051561547155115745794
  • Vidal-PuigAJimenez-LiñanMLowellBBRegulation of PPAR gamma gene expression by nutrition and obesity in rodentsJ Clin Invest1996971125538647948
  • GoodsellDSMorrisGMOlsonAJAutomated docking of flexible ligands: applications of AutoDockJ Mol Recognit199691158723313
  • CosconatiSForliSPerrymanALHarrisRGoodsellDSOlsonAJVirtual screening with AutoDock: theory and practiceExpert Opin Drug Discov20105659760721532931
  • MorrisGMHueyROlsonAJUsing autodock for ligand-receptor dockingCurr Protoc Bioinformatics2008814140
  • PronkSPállSSchulzRGROMACS 4.5: a high-throughput and highly parallel open source molecular simulation toolkitBioinformatics201329784585423407358
  • da SilvaAWSVrankenWFACPYPE-antechamber python parser interfaceBMC Res Notes20125136722824207
  • CaiHYanGZhangXGorbenkoOWangHZhuWDiscovery of highly selective inhibitors of human fatty acid binding protein 4 (FABP4) by virtual screeningBioorg Med Chem Lett201020123675367920471252
  • FangMWebsterTFFergusonPLStapletonHMCharacterizing the peroxisome proliferator-activated receptor (PPARγ) ligand binding potential of several major flame retardants, their metabolites, and chemical mixtures in house dustEnviron Health Perspect2015123216617225314719
  • RossiAMTaylorCWAnalysis of protein-ligand interactions by fluorescence polarizationNat Protoc20116336538721372817