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Original Research

Metabolism of remimazolam in primary human hepatocytes during continuous long-term infusion in a 3-D bioreactor system

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Pages 1033-1047 | Published online: 02 Apr 2019

References

  • KilpatrickGJMcIntyreMSCoxRFCNS 7056: a novel ultra-short-acting benzodiazepineAnesthesiology20071071606617585216
  • HosokawaMStructure and catalytic properties of carboxylesterase isozymes involved in metabolic activation of prodrugsMolecules200813241243118305428
  • AntonikLJGoldwaterDRKilpatrickGJTilbrookGSBorkettKMA placebo- and midazolam-controlled phase I single ascending-dose study evaluating the safety, pharmacokinetics, and pharmacodynamics of remimazolam (CNS 7056): Part I. safety, efficacy, and basic pharmacokineticsAnesth Analg2012115227428322190555
  • BorkettKMRiffDSSchwartzHIA phase IIA, randomized, double-blind study of remimazolam (CNS 7056) versus midazolam for sedation in upper gastrointestinal endoscopyAnesth Analg2015120477178025502841
  • PambiancoDJBorkettKMRiffDSA phase IIb study comparing the safety and efficacy of remimazolam and midazolam in patients undergoing colonoscopyGastrointest Endosc201683598499226363333
  • WorthingtonMTAntonikLJGoldwaterDRA phase Ib, dose-finding study of multiple doses of remimazolam (CNS 7056) in volunteers undergoing colonoscopyAnesth Analg201311751093110024108261
  • PetersenKUPre-clinical profile of remimazolam and pharmacokineticsOral presentation at: 37th Annual Meeting of the Japan Society for Clinical AnaesthesiaNovember 4 2017Tokyo, Japan
  • GerlachJCMutigKSauerIMUse of primary human liver cells originating from discarded grafts in a bioreactor for liver support therapy and the prospects of culturing adult liver stem cells in bioreactors: a morphologic studyTransplantation200376578178614501853
  • SauerIMZeilingerKPlessGExtracorporeal liver support based on primary human liver cells and albumin dialysis – treatment of a patient with primary graft non-functionJ Hepatol200339464965312971979
  • ZeilingerKSchreiterTDarnellMScaling down of a clinical three-dimensional perfusion multicompartment hollow fiber liver bioreactor developed for extracorporeal liver support to an analytical scale device useful for hepatic pharmacological in vitro studiesTissue Eng Part C Methods201117554955621210724
  • HoffmannSAMüller-VieiraUBiemelKAnalysis of drug metabolism activities in a miniaturized liver cell bioreactor for use in pharmacological studiesBiotechnol Bioeng2012109123172318122688505
  • FreyerNGreuelSKnöspelFMicroscale 3D liver bioreactor for in vitro hepatotoxicity testing under perfusion conditionsBioengineering20185124
  • KnöspelFJacobsFFreyerNIn vitro model for hepatotoxicity studies based on primary human hepatocyte cultivation in a perfused 3D bioreactor systemInt J Mol Sci201617458427092500
  • LübberstedtMMüller-VieiraUBiemelKMSerum-free culture of primary human hepatocytes in a miniaturized hollow-fibre membrane bioreactor for pharmacological in vitro studiesJ Tissue Eng Regen Med2015991017102623165723
  • KegelVDehardeDPfeifferEZeilingerKSeehoferDDammGProtocol for isolation of primary human hepatocytes and corresponding major populations of non-parenchymal liver cellsJ Vis Exp2016109e5306927077489
  • PfeifferEKegelVZeilingerKFeatured article: isolation, characterization, and cultivation of human hepatocytes and non-parenchymal liver cellsExp Biol Med20152405645656
  • RajanNHabermehlJCotéM-FDoillonCJMantovaniDPreparation of ready-to-use, storable and reconstituted type I collagen from rat tail tendon for tissue engineering applicationsNat Protoc20071627532758
  • LivakKJSchmittgenTDAnalysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) MethodMethods200125440240811846609
  • TormosAMTaléns-ViscontiRBonora-CentellesAPérezSSastreJOxidative stress triggers cytokinesis failure in hepatocytes upon isolationFree Radic Res201549892793425744598
  • BellCCDankersACALauschkeVMComparison of hepatic 2D sandwich cultures and 3D spheroids for long-term toxicity applications: a multicenter studyToxicol Sci2018162265566629329425
  • SchyschkaLSánchezJJWangZHepatic 3D cultures but not 2D cultures preserve specific transporter activity for acetaminophen-induced hepatotoxicityArch Toxicol20138781581159323728527
  • ElautGHenkensTPapeleuPMolecular mechanisms underlying the dedifferentiation process of isolated hepatocytes and their culturesCurr Drug Metab20067662966016918317
  • GitlinLSchulzePOhlaSBongardHJBelderDSurface modification of PDMS microfluidic devices by controlled sulfuric acid treatment and the application in CHIP electrophoresisElectrophoresis201536344945625257973
  • GokaltunAYarmushMLAsatekinAUstaOBRecent advances in nonbiofouling PDMS surface modification strategies applicable to microfluidic technologyTechnology20170501112
  • UngerJKKuehleinGSchroersAGerlachJCRossaintRAdsorption of xenobiotics to plastic tubing incorporated into dynamic in vitro systems used in pharmacological research – limits and progressBiomaterials200122142031203711426882
  • ZhouYHuPJiangJMetabolite characterization of a novel sedative drug, remimazolam in human plasma and urine using ultra high-performance liquid chromatography coupled with synapt high-definition mass spectrometryJ Pharm Biomed Anal2017137788328104560
  • BuchwaldPBodorNRecent advances in the design and development of soft drugsPharmazie201469640341324974571
  • SneydJRRigby-JonesAENew drugs and technologies, intravenous anaesthesia is on the move (again)Br J Anaesth2010105324625420650920