Increased branching and sialylation of N-linked glycans correlate with an improved pharmacokinetic profile for BAY 81–8973 compared with other full-length rFVIII products

John M Teare1 Biological Development, Bayer US LLC Pharmaceuticals, Berkeley, CA, USA, [email protected]Correspondence[email protected]

David S Kates1 Biological Development, Bayer US LLC Pharmaceuticals, Berkeley, CA, USA, [email protected]

Anita Shah2 Pharmacokinetics Pharmacodynamics Hematology, Bayer US LLC Pharmaceuticals, Whippany, NJ, USA

Stephen Garger1 Biological Development, Bayer US LLC Pharmaceuticals, Berkeley, CA, USA, [email protected]

Pages 941-948 | Published online: 22 Mar 2019

Cite this article
CrossMark

Full Article
Figures & data
References
Citations
Metrics
Licensing
Reprints & Permissions
View PDF PDF View EPUB EPUB

References

SrivastavaABrewerAKMauser-BunschotenEPGuidelines for the management of hemophiliaHaemophilia2013191e1e4722776238
PubMed Web of Science ®Google Scholar
BjörkmanSFolkessonAJönssonSPharmacokinetics and dose requirements of factor VIII over the age range 3–74 years: a population analysis based on 50 patients with long-term prophylactic treatment for haemophilia AEur J Clin Pharmacol2009651098999819557401
PubMed Web of Science ®Google Scholar
TiedeAHalf-life extended factor VIII for the treatment of hemophilia AJ Thromb Haemost201513suppl 1S176S17926149020
PubMed Web of Science ®Google Scholar
SethuramanNStadheimTAChallenges in therapeutic glycoprotein productionCurr Opin Biotechnol200617434134616828275
PubMed Web of Science ®Google Scholar
LentingPJNeelsJGvan den BergBMThe light chain of factor VIII comprises a binding site for low density lipoprotein receptor-related proteinJ Biol Chem199927434237342373910446132
PubMed Web of Science ®Google Scholar
LentingPJPegonJNChristopheODDenisCVFactor VIII and von Willebrand factor – too sweet for their own goodHaemophilia201016suppl 519419920590881
PubMed Web of Science ®Google Scholar
SoláRJGriebenowKGlycosylation of therapeutic proteins: an effective strategy to optimize efficacyBioDrugs201024192120055529
PubMed Web of Science ®Google Scholar
FukudaMNSasakiHLopezLFukudaMSurvival of recombinant erythropoietin in the circulation: the role of carbohydratesBlood198973184892910371
PubMed Web of Science ®Google Scholar
StockertRJThe asialoglycoprotein receptor: relationships between structure, function, and expressionPhysiol Rev19957535916097624395
PubMed Web of Science ®Google Scholar
GargerSSeversJReganLBay 81-8973, a full-length recombinant factor VIII: manufacturing processes and product characteristicsHaemophilia2017232e67e7827995680
PubMed Web of Science ®Google Scholar
IshaqueAThriftJMurphyJEKonstantinovKOver-expression of Hsp70 in BHK-21 cells engineered to produce recombinant factor VIII promotes resistance to apoptosis and enhances secretionBiotechnol Bioeng200797114415517054114
PubMed Web of Science ®Google Scholar
Maas EnriquezMThriftJGargerSKatterleYBay 81-8973, a full-length recombinant factor VIII: human heat shock protein 70 improves the manufacturing process without affecting clinical safetyProtein Expr Purif201612711111527436242
PubMed Web of Science ®Google Scholar
BraakmanIHebertDNProtein folding in the endoplasmic reticulumCold Spring Harb Perspect Biol201355a01320123637286
PubMed Web of Science ®Google Scholar
AnumulaKRDhumeSTHigh resolution and high sensitivity methods for oligosaccharide mapping and characterization by normal phase high performance liquid chromatography following derivatization with highly fluorescent anthranilic acidGlycobiology1998876856949621109
PubMed Web of Science ®Google Scholar
SamuelsNKatesDLiuJSeversJCharacterizing the glycosylation state of therapeutic recombinant glycoproteinsKohlerJPatrieSMass Spectrometry of Glycoproteins. Methods in Molecular Biology (Methods and Protocols)951Totowa: NJHumana Press2013323334
Google Scholar
ShahADelesenHGargerSLalezariSPharmacokinetic properties of Bay 81-8973, a full-length recombinant factor VIIIHaemophilia201521676677125952661
PubMed Web of Science ®Google Scholar
ShahASolmsAGarmannDImproved pharmacokinetics with Bay 81-8973 versus antihemophilic factor (recombinant) plasma/albumin-free method: a randomized pharmacokinetic study in patients with severe hemophilia AClin Pharmacokinet20175691045105528005225
PubMed Web of Science ®Google Scholar
BaunsgaardDNielsenADNielsenPFA comparative analysis of heterogeneity in commercially available recombinant factor VIII productsHaemophilia201824688088729726070
PubMed Web of Science ®Google Scholar
MathewPIncreased branching and sialylation of N-linked glycans of rFVIII leads to an improved pharmacokinetic profile for bay 81-8973East Asia Hemophilia ForumOctober 6–8, 2017Taichung, Taiwan
Google Scholar
SeestedTNielsenHMChristensenEIAppaRSThe unsialylated subpopulation of recombinant activated factor VII binds to the asialo-glycoprotein receptor (ASGPR) on primary rat hepatocytesThromb Haemost201010461166117320886190
PubMed Web of Science ®Google Scholar
BlaskoEBrooksARHoEWuJMZhaoXYSubramanyamBHepatocyte clearance and pharmacokinetics of recombinant factor IX glycosylation variantsBiochem Biophys Res Commun2013440448548924036269
PubMed Web of Science ®Google Scholar
ChengKZhouYNeelameghamSDrawGlycan-SNFG: a robust tool to render glycans and glycopeptides with fragmentation informationGlycobiology201727320020528177454
PubMed Web of Science ®Google Scholar
TeareImproved Pharmacokinetic Profile for BAY 81-8973. Due to Increased Branching and Sialylation of N-Linked Glycans of Recombinant Factor VIIIPoster presented at: American Society of HematologyDecember 1–4; 2018San Diago, USA
Google Scholar

Share icon
Back to Top

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.

People also read
Recommended articles
Cited by

To cite this article:

Reference style: APA Chicago Harvard

Citation copied to clipboard

Reference styles above use APA (6th edition), Chicago (16th edition) & Harvard (10th edition)

Download citation

Download a citation file in RIS format that can be imported by citation management software including EndNote, ProCite, RefWorks and Reference Manager.

Choose format: RIS BibTex RefWorks Direct Export

Choose options: Citation Citation & abstract Citation & references

Increased branching and sialylation of N-linked glycans correlate with an improved pharmacokinetic profile for BAY 81–8973 compared with other full-length rFVIII products

References

Information for

Open access

Opportunities

Help and information

Your download is now in progress and you may close this window

Login or register to access this feature

Increased branching and sialylation of N-linked glycans correlate with an improved pharmacokinetic profile for BAY 81–8973 compared with other full-length rFVIII products

References

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date