Mechanistic research holds promise for bacterial vaccines and phage therapies for Pseudomonas aeruginosa

References

• KaufmanMRJiaJZengLHaUChowMJinSPseudomonas aeruginosa mediated apoptosis requires the ADP-ribosylating activity of exoSMicrobiology2000146Pt 102531254111021928
   PubMed Web of Science ®Google Scholar
• JonesRNMicrobial etiologies of hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumoniaClin Infect Dis201051Suppl 1S81S8720597676
   PubMed Web of Science ®Google Scholar
• CookeGSHillAVGenetics of susceptibility to human infectious diseaseNat Rev Genet200121296797711733749
   PubMed Web of Science ®Google Scholar
• KameiACoutinho-SledgeYSGoldbergJBPriebeGPPierGBMucosal vaccination with a multivalent, live-attenuated vaccine induces multifactorial immunity against Pseudomonas aeruginosa acute lung infectionInfect Immun20117931289129921149583
   PubMed Web of Science ®Google Scholar
• ChuanchuenRMurataTGotohNSchweizerHPSubstrate-dependent utilization of OprM or OpmH by the Pseudomonas aeruginosa MexJK efflux pumpAntimicrob Agents Chemother20054952133213615855547
   PubMed Web of Science ®Google Scholar
• SilhavyTJKahneDWalkerSThe bacterial cell envelopeCold Spring Harb Perspect Biol201025a00041420452953
   PubMed Web of Science ®Google Scholar
• ChenQMaYRossACOpposing cytokine-specific effects of all trans-retinoic acid on the activation and expression of signal transducer and activator of transcription (STAT)-1 in THP-1 cellsImmunology2002107219920812383199
   PubMed Web of Science ®Google Scholar
• SchmielDHMoranEEKeiserPBBrandtBLZollingerWDImportance of antibodies to lipopolysaccharide in natural and vaccine-induced serum bactericidal activity against Neisseria meningitidis group BInfect Immun201179104146415621768280
   PubMed Web of Science ®Google Scholar
• de MattosKASarnoENPessolaniMCBozzaPTDeciphering the contribution of lipid droplets in leprosy: multifunctional organelles with roles in Mycobacterium leprae pathogenesisMem Inst Oswaldo Cruz2012107Suppl 115616623283467
   PubMed Web of Science ®Google Scholar
• HamiltonVTStoneDMCantorGHTranslocation of the B cell receptor to lipid rafts is inhibited in B cells from BLV-infected, persistent lymphocytosis cattleVirology2003315113514714592766
   PubMed Web of Science ®Google Scholar
• KnirelYABystrovaOVKocharovaNAZähringerUPierGBConserved and variable structural features in the lipopolysaccharide of Pseudomonas aeruginosaJ Endotoxin Res200612632433617254386
   PubMedGoogle Scholar
• TrentMSBiosynthesis, transport, and modification of lipid ABiochem Cell Biol2004821718615052329
   PubMed Web of Science ®Google Scholar
• Gazzano-SantoroHParentJBConlonPJCharacterization of the structural elements in lipid a required for binding of a recombinant fragment of bactericidal/permeability-increasing protein rBPI23Infect Immun1995636220122057768599
   PubMed Web of Science ®Google Scholar
• QinXZerrDMMcnuttMABerryJEBurnsJLKapurRPPseudomonas aeruginosa syntrophy in chronically colonized airways of cystic fibrosis patientsAntimicrob Agents Chemother201256115971598122964251
   PubMed Web of Science ®Google Scholar
• ArbatskyNPDrzewieckaDPalusiakAStructure of a Kdocontaining O polysaccharide representing Proteus O79, a newly described serogroup for some clinical Proteus genomospecies isolates from PolandCarbohydr Res201337910010523896084
   PubMed Web of Science ®Google Scholar
• SharmaAKrauseAWorgallSRecent developments for Pseudomonas vaccinesHum Vaccin2011710999101121941090
   PubMed Web of Science ®Google Scholar
• VincentJLVaccine development and passive immunization for Pseudomonas aeruginosa in critically ill patients: a clinical updateFuture Microbiol20149445746324810345
   PubMed Web of Science ®Google Scholar
• TaniguchiYNishizawaTHondaTDevelopment and potential use of a monoclonal antibody to the lipopolysaccharide of Pantoea agglomerans (IP-PA1)Anticancer Res2007276A3701370617970031
   PubMed Web of Science ®Google Scholar
• DigiandomenicoARaoJHarcherKIntranasal immunization with heterologously expressed polysaccharide protects against multiple Pseudomonas aeruginosa infectionsProc Natl Acad Sci U S A2007104114624462917360574
   PubMed Web of Science ®Google Scholar
• NajafzadehFShapouriRRahnemaMRokhsartalab AzarSKianmehrAPseudomonas aeruginosa PAO-1 lipopolysaccharide– diphtheria toxoid conjugate vaccine: preparation, characterization and immunogenicityJundishapur J Microbiol201586e1771226301059
   PubMed Web of Science ®Google Scholar
• HemachandraSKambojKCopferJPierGGreenLLSchreiberJRHuman monoclonal antibodies against Pseudomonas aeruginosa lipopolysaccharide derived from transgenic mice containing megabase human immunoglobulin loci are opsonic and protective against fatal Pseudomonas sepsisInfect Immun20016942223222911254577
   PubMed Web of Science ®Google Scholar
• AlleweltMColemanFTGroutMPriebeGPPierGBAcquisition of expression of the Pseudomonas aeruginosa ExoU cytotoxin leads to increased bacterial virulence in a murine model of acute pneumonia and systemic spreadInfect Immun20006873998400410858214
   PubMed Web of Science ®Google Scholar
• ShirleyDAMcarthurMAThe utility of human challenge studies in vaccine development: lessons learned from choleraVaccine20112011131324482781
   PubMedGoogle Scholar
• DaganRGivon-LaviNGreenbergDFritzellBSiegristCANasopharyngeal carriage of Streptococcus pneumoniae shortly before vaccination with a pneumococcal conjugate vaccine causes serotype-specific hyporesponsiveness in early infancyJ Infect Dis2010201101570157920384496
   PubMed Web of Science ®Google Scholar
• NagyGPalkovicsTOttoA“Gently rough”: the vaccine potential of a Salmonella enterica regulatory lipopolysaccharide mutantJ Infect Dis2008198111699170618922095
   PubMed Web of Science ®Google Scholar
• QueYALazarHWolffMAssessment of panobacumab as adjunctive immunotherapy for the treatment of nosocomial Pseudomonas aeruginosa pneumoniaEur J Clin Microbiol Infect Dis201433101861186724859907
   PubMed Web of Science ®Google Scholar
• DennehyRMccleanSImmunoproteomics: the key to discovery of new vaccine antigens against bacterial respiratory infectionsCurr Protein Pept Sci201213880781523305366
   PubMed Web of Science ®Google Scholar
• HalesBAMorganJAHartCAWinstanleyCVariation in flagellin genes and proteins of Burkholderia cepaciaJ Bacteriol19981805111011189495748
   PubMed Web of Science ®Google Scholar
• HarmsADehioCIntruders below the radar: molecular pathogenesis of Bartonella sppClin Microbiol Rev2012251427822232371
   PubMed Web of Science ®Google Scholar
• BurrowsLLPseudomonas aeruginosa twitching motility: type IV pili in actionAnnu Rev Microbiol20126649352022746331
   PubMed Web of Science ®Google Scholar
• ZhangJXuKAmbatiBYuFSToll-like receptor 5-mediated corneal epithelial inflammatory responses to Pseudomonas aeruginosa flagellinInvest Ophthalmol Vis Sci200344104247425414507868
   PubMed Web of Science ®Google Scholar
• de ZoeteMRvan PuttenJPWagenaarJAVaccination of chickens against CampylobacterVaccine200725305548555717224215
   PubMed Web of Science ®Google Scholar
• HegerleNChoiMSinclairJDevelopment of a broad spectrum glycoconjugate vaccine to prevent wound and disseminated infections with Klebsiella pneumoniae and Pseudomonas aeruginosaPLoS One2018139e020314330188914
   PubMed Web of Science ®Google Scholar
• YangJZhangELiuFFlagellins of Salmonella typhi and non-pathogenic Escherichia coli are differentially recognized through the NLRC4 pathway in macrophagesJ Innate Immun201461475723816851
   PubMed Web of Science ®Google Scholar
• CampodónicoVLLlosaNJBentancorLVMaira-LitranTPierGBEfficacy of a conjugate vaccine containing polymannuronic acid and flagellin against experimental Pseudomonas aeruginosa lung infection in miceInfect Immun20117983455346421628521
   PubMed Web of Science ®Google Scholar
• FarajniaSPeerayehSNTanomandAProtective efficacy of recombinant exotoxin A–flagellin fusion protein against Pseudomonas aeruginosa infectionCan J Microbiol2015611606425496361
   PubMed Web of Science ®Google Scholar
• BehrouzBMahdaviMAmirmozafariNImmunogenicity of Pseudomonas aeruginosa recombinant B-type fagellin as a vaccine candidate: protective efficacy in a murine burn wound sepsis modelBurns Epub201652
   PubMedGoogle Scholar
• WuYLiDWangYPseudomonas aeruginosa promotes autophagy to suppress macrophage-mediated bacterial eradicationInt Immunopharmacol20163821422227295610
   PubMed Web of Science ®Google Scholar
• KipnisESawaTWiener-KronishJTargeting mechanisms of Pseudomonas aeruginosa pathogenesisMed Mal Infect2006362789116427231
   PubMed Web of Science ®Google Scholar
• TashiroYYawataYToyofukuMUchiyamaHNomuraNInterspecies interaction between Pseudomonas aeruginosa and other microorganismsMicrobes Environ2013281132423363620
   PubMed Web of Science ®Google Scholar
• SilvermanJMAgnelloDMZhengHHaemolysin coregulated protein is an exported receptor and chaperone of type VI secretion substratesMol Cell201351558459323954347
   PubMed Web of Science ®Google Scholar
• del TordelloEDanilchankaOMccluskeyAJMekalanosJJType VI secretion system sheaths as nanoparticles for antigen displayProc Natl Acad Sci U S A2016113113042304726929342
   PubMed Web of Science ®Google Scholar
• FernandesPJGuoQWaagDMDonnenbergMSThe type IV pilin of Burkholderia mallei is highly immunogenic but fails to protect against lethal aerosol challenge in a murine modelInfect Immun20077563027303217403869
   PubMed Web of Science ®Google Scholar
• KostakiotiMHadjifrangiskouMHultgrenSJBacterial biofilms: development, dispersal, and therapeutic strategies in the dawn of the postantibiotic eraCold Spring Harb Perspect Med201334a01030623545571
   PubMed Web of Science ®Google Scholar
• MarkoVAKilmurySLNMacneilLTBurrowsLLPseudomonas aeruginosa type IV minor pilins and PilY1 regulate virulence by modulating FimS-AlgR activityPLoS Pathog2018145e100707429775484
   PubMed Web of Science ®Google Scholar
• SilverblattFJHost–parasite interaction in the rat renal pelvis: a possible role for pili in the pathogenesis of pyelonephritisJ Exp Med19741406169617114610081
   PubMed Web of Science ®Google Scholar
• DarlingKEEvansTJEffects of nitric oxide on Pseudomonas aeruginosa infection of epithelial cells from a human respiratory cell line derived from a patient with cystic fibrosisInfect Immun20037152341234912704103
   PubMed Web of Science ®Google Scholar
• Al-MujainiAAl-KharusiNThakralAWaliUKBacterial keratitis: perspective on epidemiology, clinico-pathogenesis, diagnosis and treatmentSultan Qaboos Univ Med J20099218419521509299
   PubMedGoogle Scholar
• HorzempaJHeldTKCrossASImmunization with a Pseudomonas aeruginosa 1244 pilin provides O-antigen-specific protectionClin Vaccine Immunol200815459059718272666
   PubMedGoogle Scholar
• CiganaCLorèNIBernardiniMLBragonziADampening host sensing and avoiding recognition in Pseudomonas aeruginosa pneumoniaJ Biomed Biotechnol20112011110
   Google Scholar
• KubeDMFletcherDDavisPBRelation of exaggerated cytokine responses of CF airway epithelial cells to PAO1 adherenceRespir Res200566916008840
   PubMed Web of Science ®Google Scholar
• KumarVSharmaANeutrophils: Cinderella of innate immune systemInt Immunopharmacol201010111325133420828640
   PubMed Web of Science ®Google Scholar
• KungVLOzerEAHauserARThe accessory genome of Pseudomonas aeruginosaMicrobiol Mol Biol Rev201074462164121119020
   PubMed Web of Science ®Google Scholar
• PriebeGPWalshRLCederrothTAIL-17 is a critical component of vaccine-induced protection against lung infection by lipopolysaccharide-heterologous strains of Pseudomonas aeruginosaJ Immunol200818174965497518802100
   PubMed Web of Science ®Google Scholar
• MiossecPKornTKuchrooVKInterleukin-17 and type 17 helper T cellsN Engl J Med2009361988889819710487
   PubMed Web of Science ®Google Scholar
• SadikotRTBlackwellTSChristmanJWPrinceASPathogen–host interactions in Pseudomonas aeruginosa pneumoniaAm J Respir Crit Care Med2005171111209122315695491
   PubMed Web of Science ®Google Scholar
• RoachSKSchoreyJSDifferential regulation of the mitogen-activated protein kinases by pathogenic and nonpathogenic mycobacteriaInfect Immun20027063040305212010996
   PubMed Web of Science ®Google Scholar
• LyczakJBCannonCLPierGBLung infections associated with cystic fibrosisClin Microbiol Rev200215219422211932230
   PubMed Web of Science ®Google Scholar
• KorpiFIrajianGMahadaviMActive immunization with recombinant Pila protein protects against Pseudomonas aeruginosa infection in a mouse burn wound modelJ Microbiol Biotechnol Epub2015918
   PubMedGoogle Scholar
• KorpiFHashemiFBIrajianGFatemiMJLaghaeiPBehrouzBFlagellin and pilin immunization against multi-drug resistant Pseudomonas aeruginosa protects mice in the burn wound sepsis modelImmunol Lett201617681727210422
   PubMed Web of Science ®Google Scholar
• KrokenARChenCKEvansDJYahrTLFleiszigSMJThe impact of ExoS on Pseudomonas aeruginosa internalization by epithelial cells is independent of fleQ and correlates with bistability of type three secretion system gene expressionMBio201893e0066829717012
   PubMed Web of Science ®Google Scholar
• LeeVTSmithRSTümmlerBLorySActivities of Pseudomonas aeruginosa effectors secreted by the type III secretion system in vitro and during infectionInfect Immun20057331695170515731070
   PubMed Web of Science ®Google Scholar
• PukatzkiSMaATRevelATSturtevantDMekalanosJJType VI secretion system translocates a phage tail spike-like protein into target cells where it cross-links actinProc Natl Acad Sci U S A200710439155081551317873062
   PubMed Web of Science ®Google Scholar
• HauserARJainMBar-MeirMMccolleySAClinical significance of microbial infection and adaptation in cystic fibrosisClin Microbiol Rev2011241297021233507
   PubMed Web of Science ®Google Scholar
• SatoHFrankDWMulti-functional characteristics of the Pseudomonas aeruginosa type III needle-tip protein, PcrV; comparison to orthologs in other gram-negative bacteriaFront Microbiol2011214221772833
   PubMed Web of Science ®Google Scholar
• JonesCJWozniakDJPsl produced by mucoid Pseudomonas aeruginosa contributes to the establishment of biofilms and immune evasionMBio201783e008641728634241
   PubMed Web of Science ®Google Scholar
• DigiandomenicoAKellerAEGaoCA multifunctional bispecific antibody protects against Pseudomonas aeruginosaSci Transl Med20146262262ra155
   PubMed Web of Science ®Google Scholar
• LeHNQuetzJSTranVGMEDI3902 correlates of protection against severe Pseudomonas aeruginosa pneumonia in a rabbit acute pneumonia modelAntimicrobial Agents Chemother2018625e0256517
   PubMed Web of Science ®Google Scholar
• EpaulardODerouaziMMargeritCOptimization of a type III secretion system-based Pseudomonas aeruginosa live vector for antigen deliveryClin Vaccine Immunol200815230831318094108
   PubMedGoogle Scholar
• O’DonnellHMcsorleySJSalmonella as a model for non-cognate Th1 cell stimulationFront Immunol2014562125540644
   PubMed Web of Science ®Google Scholar
• JonesMAHulmeSDBarrowPAWigleyPThe Salmonella pathogenicity island 1 and Salmonella pathogenicity island 2 type III secretion systems play a major role in pathogenesis of systemic disease and gastrointestinal tract colonization of Salmonella enterica serovar Typhimurium in the chickenAvian Pathol200736319920317497331
   PubMed Web of Science ®Google Scholar
• WangYGouellecALChakerHAsrihHPolackBToussaintBOptimization of antitumor immunotherapy mediated by type III secretion system-based live attenuated bacterial vectorsJ Immunother201235322323422421940
   PubMed Web of Science ®Google Scholar
• DerouaziMWangYMarluROptimal epitope composition after antigen screening using a live bacterial delivery vectorBioeng Bugs201011516021327126
   PubMedGoogle Scholar
• SawaTItoENguyenVHHaightMAnti-PcrV antibody strategies against virulent Pseudomonas aeruginosaHum Vaccin Immunother201410102843285225483637
   PubMed Web of Science ®Google Scholar
• WuWHuangJDuanBTh17-stimulating protein vaccines confer protection against Pseudomonas aeruginosa pneumoniaAm J Respir Crit Care Med2012186542042722723292
   PubMed Web of Science ®Google Scholar
• ThomasLDKydJMBastinDADunkleyMLCrippsAWImmunisation with non-integral OMPs promotes pulmonary clearance of Pseudomonas aeruginosaFEMS Immunol Med Microbiol2003372–315516012832119
   PubMed Web of Science ®Google Scholar
• WestritschnigKHochreiterRWallnerGFirbasCSchwameisMJilmaBA randomized, placebo-controlled Phase I study assessing the safety and immunogenicity of a Pseudomonas aeruginosa hybrid outer membrane protein OprF/I vaccine (IC43) in healthy volunteersHum Vaccin Immunother201410117018324064511
   PubMed Web of Science ®Google Scholar
• MerakouCSchaefersMMPriebeGPProgress toward the elusive Pseudomonas aeruginosa vaccineSurg Infect (Larchmt) Epub20181115
   PubMed Web of Science ®Google Scholar
• LiuCPanXXiaBConstruction of a protective vaccine against lipopolysaccharide-heterologous Pseudomonas aeruginosa strains based on expression profiling of outer membrane proteins during infectionFront Immunol20189173730093906
   PubMed Web of Science ®Google Scholar
• StoverCKPhamXQErwinALComplete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogenNature2000406679995996410984043
   PubMed Web of Science ®Google Scholar
• ArnoldHBumannDFeliesMEnhanced immunogenicity in the murine airway mucosa with an attenuated Salmonella live vaccine expressing OprF–OprI from Pseudomonas aeruginosaInfect Immun200472116546655315501786
   PubMed Web of Science ®Google Scholar
• GöckeKBaumannUHagemannHMucosal vaccination with a recombinant OprF-I vaccine of Pseudomonas aeruginosa in healthy volunteers: comparison of a systemic vs a mucosal booster scheduleFEMS Immunol Med Microbiol2003372–316717112832121
   PubMedGoogle Scholar
• RudinARiiseGCHolmgrenJAntibody responses in the lower respiratory tract and male urogenital tract in humans after nasal and oral vaccination with cholera toxin B subunitInfect Immun19996762884289010338495
   PubMed Web of Science ®Google Scholar
• BumannDBehreCBehreKSystemic, nasal and oral live vaccines against Pseudomonas aeruginosa: a clinical trial of immunogenicity in lower airways of human volunteersVaccine201028370771319887136
   PubMed Web of Science ®Google Scholar
• LyczakJBCommensal bacteria increase invasion of intestinal epithelium by Salmonella enterica serovar TyphiInfect Immun200371116610661414573683
   PubMed Web of Science ®Google Scholar
• WestritschnigKHochreiterRWallnerGFirbasCSchwameisMJilmaBA randomized, placebo-controlled Phase I study assessing the safety and immunogenicity of a Pseudomonas aeruginosa hybrid outer membrane protein OprF/I vaccine (IC43) in healthy volunteersHum Vaccin Immunother201410117018324064511
   PubMed Web of Science ®Google Scholar
• DöringGMeisnerCSternMFlagella Vaccine Trial Study GroupA double-blind randomized placebo-controlled Phase III study of a Pseudomonas aeruginosa flagella vaccine in cystic fibrosis patientsProc Natl Acad Sci U S A200710426110201102517585011
   PubMed Web of Science ®Google Scholar
• BombergerJMMaceachranDPCoutermarshBAYeSO’TooleGAStantonBALong-distance delivery of bacterial virulence factors by Pseudomonas aeruginosa outer membrane vesiclesPLoS Pathog200954e100038219360133
   PubMed Web of Science ®Google Scholar
• EllisTNLeimanSAKuehnMJNaturally produced outer membrane vesicles from Pseudomonas aeruginosa elicit a potent innate immune response via combined sensing of both lipopolysaccharide and protein componentsInfect Immun20107893822383120605984
   PubMed Web of Science ®Google Scholar
• LeeDHKimSHKangWAdjuvant effect of bacterial outer membrane vesicles with penta-acylated lipopolysaccharide on antigen-specific T cell primingVaccine201129468293830121893142
   PubMed Web of Science ®Google Scholar
• ZughaierSSteeghsLvan der LeyPStephensDSTLR4-dependent adjuvant activity of Neisseria meningitidis lipid AVaccine200725224401440917466419
   PubMed Web of Science ®Google Scholar
• GorringeAHalliwellDMathesonMReddinKFinneyMHudsonMThe development of a meningococcal disease vaccine based on Neisseria lactamica outer membrane vesiclesVaccine20052317–182210221315755597
   PubMed Web of Science ®Google Scholar
• FransenFStengerRMPoelenMCDifferential effect of TLR2 and TLR4 on the immune response after immunization with a vaccine against Neisseria meningitidis or Bordetella pertussisPLoS One2010512e1569221203418
   PubMed Web of Science ®Google Scholar
• MorleySLPollardAJVaccine prevention of meningococcal disease, coming soon?Vaccine2001205–666668711738731
   PubMed Web of Science ®Google Scholar
• OliverKJReddinKMBracegirdlePNeisseria lactamica protects against experimental meningococcal infectionInfect Immun20027073621362612065503
   PubMed Web of Science ®Google Scholar
• GorringeARTaylorSBrookesCPhase I safety and immunogenicity study of a candidate meningococcal disease vaccine based on Neisseria lactamica outer membrane vesiclesClin Vaccine Immunol20091681113112019553555
   PubMedGoogle Scholar
• ClokieMRMillardADLetarovAVHeaphySPhages in natureBacteriophage201111314521687533
   PubMedGoogle Scholar
• FortiFRoachDRCaforaMDesign of a broad-range bacteriophage cocktail that reduces Pseudomonas aeruginosa biofilms and treats acute infections in two animal modelsAntimicrob Agents Chemother2018626pii:e02573-17
   Web of Science ®Google Scholar
• GuttmanBRRKutterEBasic phage biologyBoca Raton, FLCRC Press2005
   Google Scholar
• d’HerelleFSur un microbe invisible antagoniste des bacilles dys-entériquesC R Acad Sci Hebd Seances Acad Sci D1917165373375
   Google Scholar
• SulakvelidzeAAlavidzeZMorrisJGBacteriophage therapyAntimicrob Agents Chemother200145364965911181338
   PubMed Web of Science ®Google Scholar
• FuWForsterTMayerOCurtinJJLehmanSMDonlanRMBacteriophage cocktail for the prevention of biofilm formation by Pseudomonas aeruginosa on catheters in an in vitro model systemAntimicrob Agents Chemother201054139740419822702
   PubMed Web of Science ®Google Scholar
• PiresDSillankorvaSFaustinoAAzeredoJUse of newly isolated phages for control of Pseudomonas aeruginosa PAO1 and ATCC 10145 biofilmsRes Microbiol2011162879880621782936
   PubMed Web of Science ®Google Scholar
• MorelloESaussereauEMauraDHuerreMTouquiLDebarbieuxLPulmonary bacteriophage therapy on Pseudomonas aeruginosa cystic fibrosis strains: first steps towards treatment and preventionPLoS One201162e1696321347240
   PubMed Web of Science ®Google Scholar
• Torres-BarcelóCArias-SánchezFIVasseMRamsayerJKaltzOHochbergMEA window of opportunity to control the bacterial pathogen Pseudomonas aeruginosa combining antibiotics and phagesPLoS One201499e10662825259735
   PubMed Web of Science ®Google Scholar
• ChanBKAbedonSTLoc-CarrilloCPhage cocktails and the future of phage therapyFuture Microbiol20138676978323701332
   PubMed Web of Science ®Google Scholar
• HallARDe VosDFrimanVPPirnayJPBucklingAEffects of sequential and simultaneous applications of bacteriophages on populations of Pseudomonas aeruginosa in vitro and in wax moth larvaeAppl Environ Microbiol201278165646565222660719
   PubMed Web of Science ®Google Scholar
• WrightAHawkinsCHAnggårdEEHarperDRA controlled clinical trial of a therapeutic bacteriophage preparation in chronic otitis due to antibiotic-resistant Pseudomonas aeruginosa; a preliminary report of efficacyClin Otolaryngol200934434935719673983
   PubMed Web of Science ®Google Scholar
• MarzaJASoothillJSBoydellPCollynsTAMultiplication of therapeutically administered bacteriophages in Pseudomonas aeruginosa infected patientsBurns200632564464616781080
   PubMed Web of Science ®Google Scholar
• MerabishviliMPirnayJPVerbekenGQuality-controlled small-scale production of a well-defined bacteriophage cocktail for use in human clinical trialsPLoS One200943e494419300511
   PubMed Web of Science ®Google Scholar
• LiRFangLTanSType I CRISPR-Cas targets endogenous genes and regulates virulence to evade mammalian host immunityCell Res201626121273128727857054
   PubMed Web of Science ®Google Scholar
• Bondy-DenomyJGarciaBStrumSMultiple mechanisms for CRISPR-Cas inhibition by anti-CRISPR proteinsNature2015526757113613926416740
   PubMed Web of Science ®Google Scholar
• CadyKCBondy-DenomyJHeusslerGEDavidsonARO’TooleGAThe CRISPR/Cas adaptive immune system of Pseudomonas aeruginosa mediates resistance to naturally occurring and engineered phagesJ Bacteriol2012194215728573822885297
   PubMed Web of Science ®Google Scholar
• MaxwellKLGarciaBBondy-DenomyJBonaDHidalgo-ReyesYDavidsonARThe solution structure of an anti-CRISPR proteinNat Commun2016711313427725669
   PubMed Web of Science ®Google Scholar
• PawlukAStaalsRHTaylorCInactivation of CRISPR-Cas systems by anti-CRISPR proteins in diverse bacterial speciesNat Microbiol2016181608527573108
   PubMed Web of Science ®Google Scholar
• BikardDEulerCWJiangWExploiting CRISPR-Cas nucleases to produce sequence-specific antimicrobialsNat Biotechnol201432111146115025282355
   PubMed Web of Science ®Google Scholar
• CitorikRJMimeeMLuTKSequence-specific antimicrobials using efficiently delivered RNA-guided nucleasesNat Biotechnol201432111141114525240928
   PubMed Web of Science ®Google Scholar
• BarbuEMCadyKCHubbyBPhage therapy in the era of synthetic biologyCold Spring Harb Perspect Biol2016810a02387927481531
   PubMed Web of Science ®Google Scholar
• LabrieSJSamsonJEMoineauSBacteriophage resistance mechanismsNat Rev Microbiol20108531732720348932
   PubMed Web of Science ®Google Scholar
• ZaidiTSPriebeGPPierGBA live-attenuated Pseudomonas aeruginosa vaccine elicits outer membrane protein-specific active and passive protection against corneal infectionInfect Immun200674297598316428743
   PubMed Web of Science ®Google Scholar
• PriebeGPMeluleniGJColemanFTGoldbergJBPierGBProtection against fatal Pseudomonas aeruginosa pneumonia in mice after nasal immunization with a live, attenuated aroA deletion mutantInfect Immun20037131453146112595463
   PubMed Web of Science ®Google Scholar
• RobinsonCMKobeBNSchmittDMGenetic engineering of Francisella tularensis LVS for use as a novel live vaccine platform against Pseudomonas aeruginosa infectionsBioengineered201562828825617059
   PubMed Web of Science ®Google Scholar
• NgTWSaavedra-ÁvilaNAKennedySCCarreñoLJPorcelliSACurrent efforts and future prospects in the development of live myco-bacteria as vaccinesExpert Rev Vaccines201514111493150726366616
   PubMed Web of Science ®Google Scholar
• ChauchetXHannaniDDjebaliSPoly-functional and long-lasting anticancer immune response elicited by a safe attenuated Pseudomonas aeruginosa vector for antigens deliveryMol Ther Oncolytics201631603328035332
   PubMed Web of Science ®Google Scholar
• ShippyDCFadlAAImmunological characterization of a gidA mutant strain of Salmonella for potential use in a live-attenuated vaccineBMC Microbiol201212128623194372
   PubMed Web of Science ®Google Scholar
• LiXHeSZhouXLyn delivers bacteria to lysosomes for eradication through TLR2-initiated autophagy related phagocytosisPLoS Pathog2016121e100536326735693
   PubMed Web of Science ®Google Scholar
• YuanKHuangCFoxJAutophagy plays an essential role in the clearance of Pseudomonas aeruginosa by alveolar macrophagesJ Cell Sci2012125Pt 250751522302984
   PubMed Web of Science ®Google Scholar
• DengQWangYZhangYPseudomonas aeruginosa triggers macrophage autophagy to escape intracellular killing by activation of the NLRP3 inflammasomeInfect Immun2016841566626467446
   PubMed Web of Science ®Google Scholar
• KönigWRole of the immune system in recovery from infectionRespiration199360116248480086
   PubMed Web of Science ®Google Scholar
• WinklerPGhadimiDSchrezenmeirJKraehenbuhlJPMolecular and cellular basis of microflora–host interactionsJ Nutr20071373 Suppl 2756S772S17311973
   PubMed Web of Science ®Google Scholar
• CapozzoAVCuberosLLevineMMPasettiMFMucosally delivered Salmonella live vector vaccines elicit potent immune responses against a foreign antigen in neonatal mice born to naive and immune mothersInfect Immun20047284637464615271924
   PubMed Web of Science ®Google Scholar
• DubinPJKollsJKIL-23 mediates inflammatory responses to mucoid Pseudomonas aeruginosa lung infection in miceAm J Physiol Lung Cell Mol Physiol20072922L519L52817071720
   PubMed Web of Science ®Google Scholar
• HartupeeJLiuCNovotnyMLiXHamiltonTIL-17 enhances chemokine gene expression through mRNA stabilizationJ Immunol200717964135414117785852
   PubMed Web of Science ®Google Scholar
• FanSXuXLiaoYAttenuated phenotype and immunogenic characteristics of a mutated herpes simplex virus 1 strain in the rhesus macaqueViruses2018105234
   PubMed Web of Science ®Google Scholar
• GootenbergJSAbudayyehOOKellnerMJJoungJCollinsJJZhangFMultiplexed and portable nucleic acid detection platform with Cas13, Cas12a, and Csm6Science2018360638743944429449508
   PubMed Web of Science ®Google Scholar
• de KievitTRIglewskiBHBacterial quorum sensing in pathogenic relationshipsInfect Immun20006894839484910948095
   PubMed Web of Science ®Google Scholar
• JimenezPNKochGThompsonJAXavierKBCoolRHQuaxWJThe multiple signaling systems regulating virulence in Pseudomonas aeruginosaMicrobiol Mol Biol Rev2012761466522390972
   PubMed Web of Science ®Google Scholar
• Abu-SalahTDhandRInhaled antibiotic therapy for ventilator-associated tracheobronchitis and ventilator-associated pneumonia: an updateAdv Ther201128972874721833701
   PubMed Web of Science ®Google Scholar
• Høyland-KroghsboNMPaczkowskiJMukherjeeSQuorum sensing controls the Pseudomonas aeruginosa CRISPR-Cas adaptive immune systemProc Natl Acad Sci U S A2017114113113527849583
   PubMed Web of Science ®Google Scholar
• HancockRESahlHGAntimicrobial and host-defense peptides as new anti-infective therapeutic strategiesNat Biotechnol200624121551155717160061
   PubMed Web of Science ®Google Scholar
• GiulianiAPirriGBozziAdi GiulioAAschiMRinaldiACAntimicrobial peptides: natural templates for synthetic membrane-active compoundsCell Mol Life Sci200865162450246018661101
   PubMed Web of Science ®Google Scholar
• MoanJPengQAn outline of the hundred-year history of PDTAnticancer Res20032353591360014666654
   PubMed Web of Science ®Google Scholar
• DolmansDEFukumuraDJainRKPhotodynamic therapy for cancerNat Rev Cancer20033538038712724736
   PubMed Web of Science ®Google Scholar
• BrownSBMellishKJVerteporfin: a milestone in ophthalmology and photodynamic therapyExpert Opin Pharmacother20012235136111336591
   PubMedGoogle Scholar
• HamblinMRO’DonnellDAMurthyNPolycationic photosensitizer conjugates: effects of chain length and gram classification on the photodynamic inactivation of bacteriaJ Antimicrob Chemother200249694195112039886
   PubMed Web of Science ®Google Scholar
• GrimwoodKKydJMOwenSJMassaHMCrippsAWVaccination against respiratory Pseudomonas aeruginosa infectionHum Vaccin Immunother2015111142025483510
   PubMed Web of Science ®Google Scholar
• BalmerPYorkLJOptimal use of meningococcal serogroup B vaccines: moving beyond outbreak controlTher Adv Vaccines Immunother201863496030182092
   PubMedGoogle Scholar
• GreenLRLucidarmeJDaveNPhase variation of NadA in invasive Neisseria meningitidis isolates impacts on coverage estimates for 4C-MenB, a MenB vaccineJ Clin Microbiol2018569e002041829950334
   PubMed Web of Science ®Google Scholar
• HarrisSLTanCAndrewLThe bivalent factor H binding protein meningococcal serogroup B vaccine elicits bactericidal antibodies against representative non-serogroup B meningococciVaccine201836456867687430269916
   PubMed Web of Science ®Google Scholar
• HassanANazAObaidAPangenome and immuno-proteomics analysis of Acinetobacter baumannii strains revealed the core peptide vaccine targetsBMC Genomics201617173227634541
   PubMed Web of Science ®Google Scholar
• SoaresSCSilvaATrostEThe pan-genome of the animal pathogen Corynebacterium pseudotuberculosis reveals differences in genome plasticity between the biovar ovis and equi strainsPLoS One201381e5381823342011
   PubMed Web of Science ®Google Scholar
• RizwanMNazAAhmadJVacSol: a high throughput in silico pipeline to predict potential therapeutic targets in prokaryotic pathogens using subtractive reverse vaccinologyBMC Bioinformatics201718110628193166
   PubMed Web of Science ®Google Scholar
• DoytchinovaIAFlowerDRVaxiJen: a server for prediction of protective antigens, tumour antigens and subunit vaccinesBMC Bioinformatics200781417207271
   PubMed Web of Science ®Google Scholar
• HeYXiangZMobleyHLVaxign: the first web-based vaccine design program for reverse vaccinology and applications for vaccine developmentJ Biomed Biotechnol201020103–4115
   Google Scholar
• SkwarczynskiMTothIPeptide-based synthetic vaccinesChem Sci20167284285428791117
   PubMed Web of Science ®Google Scholar