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Original Research

Tetramethylpyrazine improved the survival of multiterritory perforator flaps by inducing angiogenesis and suppressing apoptosis via the Akt/Nrf2 pathway

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Pages 1437-1447 | Published online: 01 May 2019

References

  • Tang J, Fang T, Song D, Liang J, Yu F, Wang C. Free deep inferior epigastric artery perforator flap for reconstruction of soft-tissue defects in extremities of children. Microsurgery. 2013;33(8):612–619. doi: 10.1002/micr.22127.
  • Zeltzer AA, Van Landuyt K. Reconstruction of a massive lower limb soft-tissue defect by giant free DIEAP flap. J Plast Reconstr Aesthet Surg. 2012;65(2):e42–45. doi:10.1016/j.bjps.2011.09.04622051442
  • Qing L, Wu P, Yu F, Zhou Z, Tang J. Use of dual-skin paddle anterolateral thigh perforator flaps in the reconstruction of complex defect of the foot and ankle. J Plast Reconstr Aesthet Surg. 2018. doi:10.1016/j.bjps.2018.05.029
  • Qing L, Wu P, Liang J, Yu F, Wang C, Tang J. Use of flow-through anterolateral thigh perforator flaps in reconstruction of complex extremity defects. J Reconstr Microsurg. 2015;31(8):571–578. doi:10.1055/s-0035-155513826220433
  • Tang J, Fang T, Song D, Liang J, Yu F, Wang C. Free deep inferior epigastric artery perforator flap for reconstruction of soft-tissue defects in extremities of children. Microsurgery. 2013;33(8):612–619. doi:10.1002/micr.2212723843221
  • Hamilton K, Wolfswinkel EM, Weathers WM, et al. The delay phenomenon: a compilation of knowledge across specialties. Craniomaxillofac Trauma Reconstr. 2014;7(2):112–118. doi:10.1055/s-0034-137135525071876
  • Lin R, Lin J, Li S, et al. Effects of the traditional Chinese medicine baicalein on the viability of random pattern skin flaps in rats. Drug Des Devel Ther. 2018;12:2267–2276. doi:10.2147/DDDT.S173371
  • Lin R, Chen H, Callow D, et al. Multifaceted effects of astragaloside IV on promotion of random pattern skin flap survival in rats. Am J Transl Res. 2017;9(9):4161–4172.28979690
  • Zhou KL, Zhang YH, Lin DS, Tao XY, Xu HZ. Effects of calcitriol on random skin flap survival in rats. Sci Rep. 2016;6:18945. doi:10.1038/srep1894526732750
  • Gill PS, Hunt JP, Guerra AB, et al. A 10-year retrospective review of 758 DIEP flaps for breast reconstruction. Plast Reconstr Surg. 2004;113(4):1153–1160.15083015
  • Wang L, Zhou ZW, Yang LH, et al. Vasculature characterization of a multiterritory perforator flap: an experimental study. J Reconstr Microsurg. 2017;33(4):292–297. doi:10.1055/s-0036-159801128099976
  • Wang L, Jin Z, Wang J, et al. Detrimental effect of Hypoxia-inducible factor-1alpha-induced autophagy on multiterritory perforator flap survival in rats. Sci Rep. 2017;7(1):11791. doi:10.1038/s41598-017-12034-x28924179
  • Yun I, Lew DH, Kim YS, et al. The effect of omeprazole usage on the viability of random pattern skin flaps in rats. Wound Repair Regener. 2017;78(6):e5–e9.
  • Wang LR, Cai LY, Lin DS, Cao B, Li ZJ. Effect of electroacupuncture at the zusanli point (stomach-36) on dorsal random pattern skin flap survival in a rat model. Dermatologic Surg. 2017;43(10):1213–1220. doi:10.1097/DSS.0000000000001178
  • Li K, Wang L, Rehman MU, et al. Preconditioning of bone marrow-derived mesenchymal stromal cells by tetramethylpyrazine enhances cell migration and improves functional recovery after focal cerebral ischemia in rats. Sci Rep. 2017;8(1):112.
  • Hu JZ, Wang XK, Cao Y, et al. Tetramethylpyrazine facilitates functional recovery after spinal cord injury by inhibiting MMP2, MMP9, and vascular endothelial cell apoptosis. Curr Neurovasc Res. 2017;14(2):110–116. doi:10.2174/156720261466617031311411528294065
  • Chen H, Cao J, Zhu Z, et al. A novel tetramethylpyrazine derivative protects against glutamate-induced cytotoxicity through PGC1alpha/Nrf2 and PI3K/Akt signaling pathways. Front Neurosci. 2018;12:567. doi:10.3389/fnins.2018.0004430158850
  • Lu C, Zhang J, Shi X, et al. Neuroprotective effects of tetramethylpyrazine against dopaminergic neuron injury in a rat model of Parkinson’s disease induced by MPTP. Int J Biol Sci. 2014;10(4):350–357. doi:10.7150/ijbs.836624719552
  • Wang C, Li Y, Yang X, et al. Tetramethylpyrazine and astragaloside IV synergistically ameliorate left ventricular remodeling and preserve cardiac function in a rat myocardial infarction model. J Cardiovasc Pharmacol. 2017;69(1):34–40. doi:10.1097/FJC.000000000000043727676326
  • Du W, Wu PF, Qing LM, et al. Systemic and flap inflammatory response associates with thrombosis in flap venous crisis. Inflammation. 2015;38(1):298–304. doi:10.1007/s10753-014-0033-925448261
  • Qing L, Lei P, Tang J, et al. Inflammatory response associated with choke vessel remodeling in the extended perforator flap model. Exp Ther Med. 2017;13(5):2012–2018. doi:10.3892/etm.2017.420528565801
  • Ho WK, Wen HL, Lee CM. Tetramethylpyrazine for treatment of experimentally induced stroke in Mongolian gerbils. Stroke. 1989;20(1):96–99.2911841
  • Xiao X, Liu Y, Qi C, et al. Neuroprotection and enhanced neurogenesis by tetramethylpyrazine in adult rat brain after focal ischemia. Neurol Res. 2010;32(5):547–555. doi:10.1179/174313209X41453320501058
  • Wang C, Wang P, Zeng W, Li W. Tetramethylpyrazine improves the recovery of spinal cord injury via Akt/Nrf2/HO-1 pathway. Bioorg Med Chem Lett. 2016;26(4):1287–1291. doi:10.1016/j.bmcl.2016.01.01526786697
  • Gong X, Ivanov VN, Hei TK. 2,3,5,6-Tetramethylpyrazine (TMP) down-regulated arsenic-induced heme oxygenase-1 and ARS2 expression by inhibiting Nrf2, NF-kappaB, AP-1 and MAPK pathways in human proximal tubular cells. Arch Toxicol. 2016;90(9):2187–2200. doi:10.1007/s00204-015-1600-z26404762
  • Wang Y, Guo G, Yang BR, et al. Synergistic effects of Chuanxiong-Chishao herb-pair on promoting angiogenesis at network pharmacological and pharmacodynamic levels. Chin J Integr Med. 2017;23(9):654–662. doi:10.1007/s11655-017-2408-x28551771
  • Cai X, Chen Z, Pan X, et al. Inhibition of angiogenesis, fibrosis and thrombosis by tetramethylpyrazine: mechanisms contributing to the SDF-1/CXCR4 axis. PLoS One. 2014;9(2):e88176. doi:10.1371/journal.pone.008817624505417
  • Jia Y, Wang Z, Zang A, Jiao S, Chen S, Fu Y. Tetramethylpyrazine inhibits tumor growth of lung cancer through disrupting angiogenesis via BMP/Smad/Id-1 signaling. Int J Oncol. 2016;48(5):2079–2086. doi:10.3892/ijo.2016.344326984046
  • Tang JH, Zhang HM, Zhang ZH, Zhang XL. Effect of tetramethylpyrazine combined with cisplatin on VEGF, KLF4 and ADAMTS1 in Lewis lung cancer mice. Asian Pac J Trop Med. 2017;10(8):813–818. doi:10.1016/j.apjtm.2017.08.00128942831
  • Harder Y, Amon M, Erni D, Menger MD. Evolution of ischemic tissue injury in a random pattern flap: a new mouse model using intravital microscopy. J Surg Res. 2004;121(2):197–205. doi:10.1016/j.jss.2004.03.02615501459
  • Bai Q, Lyu Z, Yang X, Pan Z, Lou J, Dong T. Epigallocatechin-3-gallate promotes angiogenesis via up-regulation of Nfr2 signaling pathway in a mouse model of ischemic stroke. Behav Brain Res. 2017;321:79–86. doi:10.1016/j.bbr.2016.12.03728042007
  • Abdelsalam RM, Safar MM. Neuroprotective effects of vildagliptin in rat rotenone Parkinson’s disease model: role of RAGE-NFkappaB and Nrf2-antioxidant signaling pathways. J Neurochem. 2015;133(5):700–707. doi:10.1111/jnc.1308725752913
  • Aliaghaei A, Khodagholi F, Ahmadiani A. Conditioned media of choroid plexus epithelial cells induces Nrf2-activated phase II antioxidant response proteins and suppresses oxidative stress-induced apoptosis in PC12 cells. J Mol Neurosci. 2014;53(4):617–625. doi:10.1007/s12031-014-0228-424488602
  • Chen NN, Wang JP, Liu HF, et al. The bone marrow mononuclear cells reduce the oxidative stress of cerebral infarction through PI3K/AKT/NRF2 signaling pathway. Eur Rev Med Pharmacol Sci. 2017;21(24):5729–5735. doi:10.26355/eurrev_201712_1401929272009
  • Hu J, Cao Y, Wu T, Li D, Lu H. Micro-CT as a tool to investigate the efficacy of tetramethylpyrazine in a rat spinal cord injury model. Spine. 2016;41(16):1272–1278. doi:10.1097/BRS.000000000000154626953664