Dexmedetomidine protects PC12 cells from lidocaine-induced cytotoxicity via downregulation of Stathmin 1

References

• Verlinde M, Hollmann MW, Stevens MF, Hermanns H, Werdehausen R, Lirk P. Local anesthetic-induced neurotoxicity. Int J Mol Sci. 2016;17(3):339. doi:10.3390/ijms1703033926959012
   PubMed Web of Science ®Google Scholar
• Myers RR, Kalichman MW, Reisner LS, Powell HC. Neurotoxicity of local anesthetics: altered perineurial permeability, edema, and nerve fiber injury. Anesthesiology. 1986;64(1):29–35.3942334
   PubMed Web of Science ®Google Scholar
• Radwan IA, Saito S, Goto F. The neurotoxicity of local anesthetics on growing neurons: a comparative study of lidocaine, bupivacaine, mepivacaine, and ropivacaine. Anesthesia Analg. 2002;94(2):319–324.
   PubMed Web of Science ®Google Scholar
• Rashiq S, Dick BD. Post-surgical pain syndromes: a review for the non-pain specialist. Can J Anesthesia. 2014;61(2):123–130. doi:10.1007/s12630-013-0072-y
   PubMed Web of Science ®Google Scholar
• Pollock JE. Neurotoxicity of intrathecal local anaesthetics and transient neurological symptoms. Best Pract Res Clin Anaesthesiol. 2003;17(3):471–484. doi:10.1016/S1521-6896(02)00113-114529015
   PubMedGoogle Scholar
• Werdehausen R, Braun S, Hermanns H, et al. The influence of adjuvants used in regional anesthesia on lidocaine-induced neurotoxicity in vitro. Reg Anesth Pain Med. 2011;36(5):436–443. doi:10.1097/AAP.0b013e318226ba6221857277
   PubMed Web of Science ®Google Scholar
• Goldblum E, Atchabahian A. The use of 2‐chloroprocaine for spinal anaesthesia. Acta Anaesthesiol Scand. 2013;57(5):545–552. doi:10.1111/aas.1207123320599
   PubMed Web of Science ®Google Scholar
• Sekimoto K, Tobe M, Saito S. Local anesthetic toxicity: acute and chronic management. Acute Med Surg. 2017;4(2):152–160. doi:10.1002/ams2.26529123854
   PubMed Web of Science ®Google Scholar
• Lee W, Park C, Shin T, et al. Only tetracaine and not other local anaesthetics induce apoptosis in rat cortical astrocytes. Br J Anaesth. 2009;103(5):719–725. doi:10.1093/bja/aep23719720611
   PubMed Web of Science ®Google Scholar
• Okamoto A, Tanaka M, Sumi C, et al. The antioxidant N-acetyl cysteine suppresses lidocaine-induced intracellular reactive oxygen species production and cell death in neuronal SH-SY5Y cells. BMC Anesthesiol. 2016;16(1):104. doi:10.1186/s12871-016-0273-327776485
   PubMed Web of Science ®Google Scholar
• Tabrizi L, Chiniforoshan H. New water-soluble palladium (II) complexes of lidocaine and phenylcyanamide derivative ligands: cytotoxicity and cellular response mechanisms. Invest New Drugs. 2016;34(6):723–732. doi:10.1007/s10637-016-0393-027644694
   PubMed Web of Science ®Google Scholar
• Giovannitti JA Jr, Thoms SM, Crawford JJ. Alpha-2 adrenergic receptor agonists: a review of current clinical applications. Anesth Prog. 2015;62(1):31–38. doi:10.2344/0003-3006-62.1.3125849473
   PubMedGoogle Scholar
• Marhofer P, Brummett CM. Safety and efficiency of dexmedetomidine as adjuvant to local anesthetics. Curr Opin Anaesthesiol. 2016;29(5):632–637. doi:10.1097/ACO.000000000000036427258154
   PubMed Web of Science ®Google Scholar
• Perez-Zoghbi J, Zhu W, Grafe M, Brambrink A. Dexmedetomidine-mediated neuroprotection against sevoflurane-induced neurotoxicity extends to several brain regions in neonatal rats. Bja. 2017;119(3):506–516. doi:10.1093/bja/aex22228969317
   PubMedGoogle Scholar
• Rodriguez-Gonzalez R, Sobrino T, Veiga S, et al. Neuroprotective effects of dexmedetomidine conditioning strategies: evidences from an in vitro model of cerebral ischemia. Life Sci. 2016;144:162–169. doi:10.1016/j.lfs.2015.12.00726655164
   PubMed Web of Science ®Google Scholar
• Pan W, Lin L, Zhang N, et al. Neuroprotective effects of dexmedetomidine against hypoxia-induced nervous system injury are related to inhibition of NF-κB/COX-2 pathways. Cell Mol Neurobiol. 2016;36(7):1179–1188. doi:10.1007/s10571-015-0315-226683659
   PubMed Web of Science ®Google Scholar
• Shen M, Wang S, Wen X, et al. Dexmedetomidine exerts neuroprotective effect via the activation of the PI3K/Akt/mTOR signaling pathway in rats with traumatic brain injury. Biomed Pharmacother. 2017;95:885–893. doi:10.1016/j.biopha.2017.08.12528903184
   PubMed Web of Science ®Google Scholar
• Xu H, Zhao B, She Y, Song X. Dexmedetomidine ameliorates lidocaine-induced spinal neurotoxicity via inhibiting glutamate release and the PKC pathway. Neurotoxicology. 2018;69:77–83. doi:10.1016/j.neuro.2018.09.00430240660
   PubMed Web of Science ®Google Scholar
• Wang Q, She Y, Bi X, Zhao B, Ruan X, Tan Y. Dexmedetomidine protects PC12 cells from lidocaine-induced cytotoxicity through downregulation of COL3A1 mediated by miR-let-7b. DNA Cell Biol. 2017;36(7):518–528. doi:10.1089/dna.2016.362328436683
   PubMed Web of Science ®Google Scholar
• Wang Q, Tan Y, Zhang N, et al. Dexmedetomidine inhibits activation of the MAPK pathway and protects PC12 and NG108-15 cells from lidocaine-induced cytotoxicity at its maximum safe dose. Biomed Pharmacother. 2017;91:162–166. doi:10.1016/j.biopha.2017.04.08428463790
   PubMed Web of Science ®Google Scholar
• Andersen SS. Spindle assembly and the art of regulating microtubule dynamics by MAPs and Stathmin/Op18. Trends Cell Biol. 2000;10(7):261–267.10856928
   PubMed Web of Science ®Google Scholar
• Rubin CI, Atweh GF. The role of stathmin in the regulation of the cell cycle. J Cell Biochem. 2004;93(2):242–250. doi:10.1002/jcb.2018715368352
   PubMed Web of Science ®Google Scholar
• Niethammer P, Bastiaens P, Karsenti E. Stathmin-tubulin interaction gradients in motile and mitotic cells. Science. 2004;303(5665):1862–1866. doi:10.1126/science.109410815031504
   PubMed Web of Science ®Google Scholar
• Rana S, Maples PB, Senzer N, Nemunaitis J. Stathmin 1: a novel therapeutic target for anticancer activity. Expert Rev Anticancer Ther. 2008;8(9):1461–1470. doi:10.1586/14737140.8.9.146118759697
   PubMed Web of Science ®Google Scholar
• Chen J, Abi-Daoud M, Wang A, et al. Stathmin 1 is a potential novel oncogene in melanoma. Oncogene. 2013;32(10):1330. doi:10.1038/onc.2012.32222665054
   PubMed Web of Science ®Google Scholar
• Nemunaitis J. Stathmin 1: A Protein with Many Tasks. New Biomarker and Potential Target in Cancer. Taylor & Francis; 2012;16(7):631–634. doi:10.3390/ijms17030339
   Google Scholar
• Kinarivala N, Shah K, Abbruscato TJ, Trippier PC. Passage variation of PC12 cells results in inconsistent susceptibility to externally induced apoptosis. ACS Chem Neurosci. 2016;8(1):82–88. doi:10.1021/acschemneuro.6b0020827718545
   PubMed Web of Science ®Google Scholar
• Silva RF, Falcao AS, Fernandes A, Gordo AC, Brito MA, Brites D. Dissociated primary nerve cell cultures as models for assessment of neurotoxicity. Toxicol Lett. 2006;163(1):1–9. doi:10.1016/j.toxlet.2005.09.03316257146
   PubMed Web of Science ®Google Scholar
• Werdehausen R, Braun S, Essmann F, et al. Lidocaine induces apoptosis via the mitochondrial pathway independently of death receptor signaling. Anesthesiology. 2007;107(1):136–143. doi:10.1097/01.anes.0000268389.39436.6617585225
   PubMed Web of Science ®Google Scholar
• Li K, Han X. Endoplasmic reticulum stress is involved in the lidocaine-induced apoptosis in SH-SY5Y neuroblastoma cells. J Mol Neurosci. 2015;56(1):122–130. doi:10.1007/s12031-014-0473-625522790
   PubMed Web of Science ®Google Scholar
• Wang L, Liu H, Zhang L, Wang G, Zhang M, Yu Y. Neuroprotection of dexmedetomidine against cerebral ischemia-reperfusion injury in rats: involved in inhibition of NF-κB and inflammation response. Biomol Ther (Seoul). 2017;25(4):383. doi:10.4062/biomolther.2015.18027871154
   PubMed Web of Science ®Google Scholar
• Kinarivala N, Patel R, Boustany R-M, Al-Ahmad A, Trippier PC. Discovery of aromatic carbamates that confer neuroprotective activity by enhancing autophagy and inducing the anti-apoptotic protein B-cell lymphoma 2 (Bcl-2). J Med Chem. 2017;60(23):9739–9756. doi:10.1021/acs.jmedchem.7b0119929110485
   PubMed Web of Science ®Google Scholar
• Makoukji J, Saadeh F, Mansour KA, et al. Flupirtine derivatives as potential treatment for the neuronal ceroid lipofuscinoses. Ann Clin Transl Neurol. 2018;5(9):1089–1103. doi:10.1002/acn3.62530250865
   PubMed Web of Science ®Google Scholar
• Chauhan S, Ahmed Z, Bradfute SB, et al. Pharmaceutical screen identifies novel target processes for activation of autophagy with a broad translational potential. Nat Commun. 2015;6:8620. doi:10.1038/ncomms962026503418
   PubMed Web of Science ®Google Scholar
• Bai T, Yokobori T, Altan B, et al. High STMN1 level is associated with chemo-resistance and poor prognosis in gastric cancer patients. Br J Cancer. 2017;116(9):1177. doi:10.1038/bjc.2017.7628334732
   PubMed Web of Science ®Google Scholar
• Hassan MK, Watari H, Mitamura T, et al. P18/Stathmin 1 is regulated by miR-31 in ovarian cancer in response to taxane. Oncoscience. 2015;2(3):294. doi:10.18632/oncoscience.14325897432
   PubMedGoogle Scholar
• Tan Y, Wang Q, Zhao B, She Y, Bi X. GNB2 is a mediator of lidocaine-induced apoptosis in rat pheochromocytoma PC12 cells. Neurotoxicology. 2016;54:53–64. doi:10.1016/j.neuro.2016.03.01527018092
   PubMed Web of Science ®Google Scholar
• Sorger PK, Dobles M, Tournebize R, Hyman AA. Coupling cell division and cell death to microtubule dynamics. Curr Opin Cell Biol. 1997;9(6):807–814.9425345
   PubMed Web of Science ®Google Scholar