Advanced search
Publication Cover
Drug Design, Development and Therapy Volume 13, 2019 - Issue
Submit an article Journal homepage
148
Views
6
CrossRef citations to date
0
Altmetric
Original Research

Pharmacokinetic comparison of a fixed-dose combination versus concomitant administration of amlodipine, olmesartan, and rosuvastatin in healthy adult subjects

Minkyung Oh1 Department of Pharmacology and PharmacoGenomics Research Center, Inje University College of Medicine, Busan, Republic of Korea
,
Jae-Gook Shin1 Department of Pharmacology and PharmacoGenomics Research Center, Inje University College of Medicine, Busan, Republic of Korea;2 Department of Clinical Pharmacology, Inje University Busan Paik Hospital, Busan, Republic of Korea
,
Sangzin Ahn1 Department of Pharmacology and PharmacoGenomics Research Center, Inje University College of Medicine, Busan, Republic of Korea
,
Bo Hoon Kim3 Formulation Research Team, Daewoong Pharma, Seoul, Republic of Korea
,
Ji Yeon Kim3 Formulation Research Team, Daewoong Pharma, Seoul, Republic of Korea
,
Hyun Ju Shin4 Clinical Research Team, Daewoong Pharma, Seoul, Republic of Korea
,
Hyun Ju Shin4 Clinical Research Team, Daewoong Pharma, Seoul, Republic of Korea
&
Jong-Lyul Ghim1 Department of Pharmacology and PharmacoGenomics Research Center, Inje University College of Medicine, Busan, Republic of Korea;2 Department of Clinical Pharmacology, Inje University Busan Paik Hospital, Busan, Republic of KoreaCorrespondence[email protected]
 show all
Pages 991-997 | Published online: 03 Apr 2019

References

  • Roger VL, Go AS, Lloyd-Jones DM, et al. Heart disease and stroke statistics—2011 update: a report from the American Heart Association. Circulation 2011;123(4):e18-e209.
  • Yeon OK, Yun JHS. The Statics of Deaths in 2013. Daejeon, Republic of Korea: The Korean National Statistical Office(KNSO); 2013.
  • Frampton JE, Scott LJ. Amlodipine/valsartan single-pill combination. Am J Cardiovasc Drug. 2009;9(5):309–330. doi:10.2165/11201120-000000000-00000
  • Schwocho LR, Masonson HN. Pharmacokinetics of CS‐866, a new angiotensin II receptor blocker, in healthy subjects. J Clin Pharmacol. 2001;41(5):515–527.11361048
  • Li Y, Jiang X, Lan K, Zhang R, Li X, Jiang Q. Pharmacokinetic properties of rosuvastatin after single-dose, oral administration in Chinese volunteers: a randomized, open-label, three-way crossover study. Clin Ther. 2007;29(10):2194–2203. doi:10.1016/j.clinthera.2007.10.00518042475
  • Jackson R, Lawes CM, Bennett DA, Milne RJ, Rodgers A. Treatment with drugs to lower blood pressure and blood cholesterol based on an individual’s absolute cardiovascular risk. Lancet. 2005;365(9457):434–441. doi:10.1016/S0140-6736(05)70240-315680460
  • Dezii C. A retrospective study of persistence with single-pill combination therapy vs. concurrent two-pill therapy in patients with hypertension. Managed Care (Langhorne, Pa). 2000;9(9 Suppl):2–6.
  • Verma AA, Khuu W, Tadrous M, Gomes T, Mamdani MM. Fixed-dose combination antihypertensive medications, adherence, and clinical outcomes: A population-based retrospective cohort study. PLoS Med. 2018;15(6):e1002584. doi:10.1371/journal.pmed.100259329889841
  • Lee S-Y, Kim J-R, Jung JA, Huh W, Bahng MY, Ko J-W. Bioequivalence evaluation of two amlodipine salts, besylate and orotate, each in a fixed-dose combination with olmesartan in healthy subjects. Drug Des Devel Ther. 2015;9:2811. doi:10.2147/DDDT.S82820
  • Oh MJ, Hwang HH, Kim HG, et al. Bioequivalence study of a new fixed-dose combination tablet containing S-amlodipine nicotinate and olmesartan medoxomil in healthy Korean male subjects. Clin Ther. 2017;39(7):1371–1379. doi:10.1016/j.clinthera.2017.05.35528625505
  • Park J-Y, Kim K-A, Lee G-S, et al. Randomized, open-label, two-period crossover comparison of the pharmacokinetic and pharmacodynamic properties of two amlodipine formulations in healthy adult male Korean subjects. Clin Ther. 2004;26(5):715–723.15220015
  • Rohatagi S, Lee J, Shenouda M, et al. Pharmacokinetics of amlodipine and olmesartan after administration of amlodipine besylate and olmesartan medoxomil in separate dosage forms and as a fixed‐dose combination. J Clin Pharmacol. 2008;48(11):1309–1322. doi:10.1177/009127000832217618974285
  • Collaboration PS. Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. Lancet. 2002;360(9349):1903–1913. doi:10.1016/S0140-6736(02)11911-812493255
  • Chobanian AV, Bakris GL, Black HR, et al. The seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure: the JNC 7 report. Jama. 2003;289(19):2560–2571. doi:10.1001/jama.289.19.256012748199
  • Nishimura RA, Otto CM, Bonow RO, et al. 2017 AHA/ACC focused update of the 2014 AHA/ACC guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. J Am Coll Cardiol. 2017;70(2):252–289. doi:10.1016/j.jacc.2017.03.01128315732
  • The Statistics of 5th Korea National Health and Nutrition Examination Survey (KNHANES V-S) in 2011. Korea Centers for Disease Control and Prevention; 2011.
  • Mokrini F, Waeyenberge L, Viaene N, Moens M The Statistics of the 8th Korea Youth Risk Behavior Web-based Survey(KYRBWS) in 2012. Korea Centers for Disease Control and Prevention; 2012. doi:10.1094/PDIS-11-11-0999-PDN
  • Johnson ML, Pietz K, Battleman DS, Beyth RJ. Prevalence of comorbid hypertension and dyslipidemia and associated cardiovascular disease. Heart Dis. 2004;2:3.
  • Williams B, Mancia G, Spiering W, et al. 2018 ESC/ESH guidelines for the management of arterial hypertension. Eur Heart J. 2018;39(33):3021–3104. doi:10.1093/eurheartj/ehy33930165516

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.