Icariin Alleviates IL-1β-Induced Matrix Degradation By Activating The Nrf2/ARE Pathway In Human Chondrocytes

References

• Felson DT, Anderson JJ, Naimark A, et al. The prevalence of knee osteoarthritis in the elderly. The Framingham Osteoarthritis Study. Arthritis Rheum. 1987;30:914–918. doi:10.1002/art.17803008113632732
   PubMed Web of Science ®Google Scholar
• Fernandes JC, Martel-Pelletier J, Pelletier JP. The role of cytokines in osteoarthritis pathophysiology. Biorheology. 2002;39:237–246.12082286
   PubMed Web of Science ®Google Scholar
• Kapoor M, Martel-Pelletier J, Lajeunesse D, et al. Role of proinflammatory cytokines in the pathophysiology of osteoarthritis. Nat Rev Rheumatol. 2011;7:33–42. doi:10.1038/nrrheum.2010.19621119608
   PubMed Web of Science ®Google Scholar
• Hayami T, Funaki H, Yaoeda K, et al. Expression of the cartilage derived anti-angiogenic factor chondromodulin-I decreases in the early stage of experimental osteoarthritis. J Rheumatol. 2003;30:2207–2217.14528519
   PubMed Web of Science ®Google Scholar
• Martel-Pelletier J, Alaaeddine N, Pelletier JP. Cytokines and their role in the pathophysiology of osteoarthritis. Front Biosci. 1999;4:694–703. doi:10.2741/A387
   PubMedGoogle Scholar
• Dinarello CA, Arend W, Sims J, et al. IL-1 family nomenclature. Nat Immunol. 2010;11:973. doi:10.1038/ni1110-97320959797
   PubMed Web of Science ®Google Scholar
• Dinarello CA. Immunological and inflammatory functions of the interleukin-1 family. Annu Rev Immunol. 2009;27:519–550. doi:10.1146/annurev.immunol.021908.13261219302047
   PubMed Web of Science ®Google Scholar
• Dinarello CA, Simon A, Van der Meer JW. Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases. Nature Rev Drug Discov. 2012;11:633–652. doi:10.1038/nrd380022850787
   PubMed Web of Science ®Google Scholar
• Gabay C, Lamacchia C, Palmer G. IL-1 pathways in inflammation and human diseases. Nature Rev Rheumatol. 2010;6:232–241. doi:10.1038/nrrheum.2010.420177398
   PubMed Web of Science ®Google Scholar
• Sims JE, Smith DE. The IL-1 family: regulators of immunity. Nat Rev Immunol. 2010;10:89–102. doi:10.1038/nri269120081871
   PubMed Web of Science ®Google Scholar
• Chen CJ, Kono H, Golenbock D, et al. Identification of a key pathway required for the sterile inflammatory response triggered by dying cells. Nat Med. 2007;13:851–856. doi:10.1038/nm160317572686
   PubMed Web of Science ®Google Scholar
• Rider P, Carmi Y, Guttman O, et al. IL-1α and IL-1β recruit different myeloid cells and promote different stages of sterile inflammation. J Immunol. 2011;187:4835–4843. doi:10.4049/jimmunol.110204821930960
   PubMed Web of Science ®Google Scholar
• Berda-Haddad Y, Robert S, Salers P, et al. Sterile inflammation of endothelial cell-derived apoptotic bodies is mediated by interleukin-1alpha. Proc Natl Acad Sci USA. 2011;108:20684–20689. doi:10.1073/pnas.111684810822143786
   PubMed Web of Science ®Google Scholar
• Dinarello CA. The IL-1 family and inflammatory diseases. Clin Exp Rheumatol. 2002;20:1–13.
   PubMed Web of Science ®Google Scholar
• Palomo J, Dietrich D, Martin P, et al. The interleukin (IL)-1 cytokine family–balance between agonists and antagonists in inflammatory diseases. Cytokine. 2015;76:25–37. doi:10.1016/j.cyto.2015.06.01726185894
   PubMed Web of Science ®Google Scholar
• Haddad JJ, Safieh-Garabedian B, Saadé NE, et al. Chemioxyexcitation (delta pO2/ROS)-dependent release of IL-1 beta, IL-6 and TNF-alpha: evidence of cytokines as oxygen-sensitive mediators in the alveolar epithelium. Cytokine. 2001;13:138–147. doi:10.1006/cyto.2000.078911161456
   PubMed Web of Science ®Google Scholar
• Shin HC, Hwang HJ, Kang KJ, et al. An antioxidative and antiinflammatory agent for potential treatment of osteoarthritis from Ecklonia cava. Arch Pharm Res. 2006;29:165–171. doi:10.1007/BF0297427916526282
   PubMed Web of Science ®Google Scholar
• Motohashi H, Yamamoto M. Nrf2-Keap1 defines a physiologically important stress response mechanism. Trends Mol Med. 2004;10:549–557. doi:10.1016/j.molmed.2004.09.00315519281
   PubMed Web of Science ®Google Scholar
• Sykiotis GP, Bohmann D. Keap1/Nrf2 signaling regulates oxidative stress tolerance and lifespan in Drosophila. Dev Cell. 2008;14:76–85. doi:10.1016/j.devcel.2007.12.00218194654
   PubMed Web of Science ®Google Scholar
• Zhang Z, Zhou S, Jiang X, et al. The role of the Nrf2/Keap1 pathway in obesity and metabolic syndrome. Rev Endocr Metab Disord. 2015;16:35–45. doi:10.1007/s11154-014-9305-925540093
   PubMed Web of Science ®Google Scholar
• Li J, Ichikawa T, Villacorta L, et al. Nrf2 protects against maladaptive cardiac responses to hemodynamic stress. Arterioscler Thromb Vasc Biol. 2009;29:1843–1850. doi:10.1161/ATVBAHA.109.18948019592468
   PubMed Web of Science ®Google Scholar
• Hintsala HR, Jokinen E, Haapasaari KM, et al. Nrf2/Keap1 pathway and expression of oxidative stress lesions 8-hydroxy-2ʹ-deoxyguanosine and nitrotyrosine in melanoma. Anticancer Res. 2016;36:1497–1506.27069125
   PubMed Web of Science ®Google Scholar
• Ma H, He X, Yang Y, et al. The genus Epimedium: an ethnopharmacological and phytochemical review. J Ethnopharmacol. 2011;134:519–541. doi:10.1016/j.jep.2011.01.00121215308
   PubMed Web of Science ®Google Scholar
• Zhao J, Ohba S, Shinkai M, et al. Icariin induces osteogenic differentiation in vitro in a BMP- and Runx2-dependent manner. Biochem Biophys Res Commun. 2008;369:444–448. doi:10.1016/j.bbrc.2008.02.05418295595
   PubMed Web of Science ®Google Scholar
• Cui J, Zhu M, Zhu S, et al. Inhibitory effect of icariin on Ti-induced inflammatory osteoclastogenesis. J Surg Res. 2014;192:447–453. doi:10.1016/j.jss.2014.05.03824969548
   PubMed Web of Science ®Google Scholar
• Li L, Sun J, Xu C, et al. Icariin ameliorates cigarette smoke induced inflammatory responses via suppression of NF-kappaB and modulation of GR in vivo and in vitro. PLoS One. 2014;9:e102345. doi:10.1371/journal.pone.010234525089961
   PubMed Web of Science ®Google Scholar
• Zhang Y, Wei Y, Zhu Z, et al. Icariin enhances radiosensitivity of colorectal cancer cells by suppressing NF-kappaB activity. Cell Biochem Biophys. 2014;69:303–310. doi:10.1007/s12013-013-9799-x24590261
   PubMed Web of Science ®Google Scholar
• Zeng L, Wang W, Rong XF, et al. Chondroprotective effects and multi-target mechanisms of Icariin in IL-1 beta-induced human SW 1353 chondrosarcoma cells and a rat osteoarthritis model. Int Immunopharmacol. 2014;18:175–181. doi:10.1016/j.intimp.2013.11.02124295650
   PubMed Web of Science ®Google Scholar
• Zeng L, Rong XF, Li RH, et al. Icariin inhibits MMP1, MMP3 and MMP13 expression through MAPK pathways in IL1betastimulated SW1353 chondrosarcoma cells. Mol Med Rep. 2017;15:2853–2858. doi:10.3892/mmr.2017.631228447732
   PubMed Web of Science ®Google Scholar
• Sze SC, Tong Y, Ng TB, et al. Herba Epimedii: anti-oxidative properties and its medical implications. Molecules. 2010;15:7861–7870. doi:10.3390/molecules1511786121060294
   PubMed Web of Science ®Google Scholar
• Li M, Zhang Y, Cao Y, et al. Icariin ameliorates palmitate-induced insulin resistance through reducing thioredoxin-interacting protein (TXNIP) and suppressing ER stress in C2C12 myotubes. Front Pharmacol. 2018;9. doi:10.3389/fphar.2018.01180
   Web of Science ®Google Scholar
• Macrae VE, Davey MG, McTeir L, et al. Inhibition of PHOSPHO1 activity results in impaired skeletal mineralization during limb development of the chick. Bone. 2010;46:1146–1155. doi:10.1016/j.bone.2009.12.01820053388
   PubMed Web of Science ®Google Scholar
• Farndale RW, Buttle DJ, Barrett AJ. Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue. Biochim Biophys Acta. 1986;883:173–177. doi:10.1016/0304-4165(86)90306-53091074
   PubMed Web of Science ®Google Scholar
• Li C, Li Q, Mei Q, et al. Pharmacological effects and pharmacokinetic properties of icariin, the major bioactive component in Herba Epimedii. Life Sci. 2015;126:57–68. doi:10.1016/j.lfs.2015.01.00625634110
   PubMed Web of Science ®Google Scholar
• Han Y, Li X, Yan M, et al. Oxidative damage induces apoptosis and promotes calcification in disc cartilage endplate cell through ROS/MAPK/NF-kappaB pathway: implications for disc degeneration. Biochem Biophys Res Commun. 2017;0435:S0006291X17305788.
   Google Scholar
• Jallali N, Ridha H, Thrasivoulou C, et al. Vulnerability to ROS-induced cell death in ageing articular cartilage: the role of antioxidant enzyme activity. Osteoarthritis Cartilage. 2005;13:614–622. doi:10.1016/j.joca.2005.02.01115979014
   PubMed Web of Science ®Google Scholar
• Downs I, Liu J, Aw TY, et al. The ROS scavenger, NAC, regulates hepatic Valpha14iNKT cells signaling during Fas mAb-dependent fulminant liver failure. PLoS One. 2012;7:e38051. doi:10.1371/journal.pone.003805122701598
   PubMed Web of Science ®Google Scholar
• Shimamoto K, Hayashi H, Taniai E, et al. Antioxidant N-acetyl-L-cysteine (NAC) supplementation reduces reactive oxygen species (ROS)-mediated hepatocellular tumor promotion of indole-3-carbinol (I3C) in rats. J Toxicol Sci. 2011;36:775–786. doi:10.2131/jts.36.77522129741
   PubMed Web of Science ®Google Scholar
• Delise AM, Tuan RS. Analysis of N-cadherin function in limb mesenchymal chondrogenesis in vitro. Dev Dyn. 2002;225:195–204. doi:10.1002/(ISSN)1097-017712242719
   PubMed Web of Science ®Google Scholar
• Mello MA, Tuan RS. High density micromass cultures of embryonic limb bud mesenchymal cells: an in vitro model of endochondral skeletal development. In Vitro Cell Dev Biol Anim. 1999;35:262–269. doi:10.1007/s11626-999-0070-010475272
   PubMed Web of Science ®Google Scholar
• Marchev AS, Dimitrova PA, Burns AJ, et al. Oxidative stress and chronic inflammation in osteoarthritis: can NRF2 counteract these partners in crime? Ann N Y Acad Sci. 2017;1401:114–135. doi:10.1111/nyas.2017.1401.issue-128662306
   PubMed Web of Science ®Google Scholar
• Qiu L, Song Z, Setaluri V. Oxidative stress and vitiligo: the Nrf2-ARE signaling connection. J Invest Dermatol. 2014;134:2074–2076. doi:10.1038/jid.2014.24125029322
   PubMed Web of Science ®Google Scholar
• Abdul-Aziz A, MacEwan DJ, Bowles KM, et al. Oxidative stress responses and NRF2 in human leukaemia. Oxid Med Cell Longev. 2015;2015:1–7. doi:10.1155/2015/454659
   Web of Science ®Google Scholar
• Akino N, Wada-Hiraike O, Terao H, et al. Activation of Nrf2 might reduce oxidative stress in human granulosa cells. Mol Cell Endocrinol. 2017;470:S0303720717305221.
   Web of Science ®Google Scholar
• Huber M, Trattnig S, Lintner F. Anatomy, biochemistry, and physiology of articular cartilage. Invest Radiol. 2000;35:573–580. doi:10.1097/00004424-200010000-0000311041151
   PubMed Web of Science ®Google Scholar
• Lai WM, Hou JS, Mow VC. A triphasic theory for the swelling and deformation behaviors of articular cartilage. J Biomech Eng. 1991;113:245–258. doi:10.1115/1.28948801921350
   PubMed Web of Science ®Google Scholar
• Blake DR, Merry P, Unsworth J, et al. Hypoxic-reperfusion injury in the inflamed human joint. Lancet. 1989;1:289–293. doi:10.1016/S0140-6736(89)91305-62563454
   PubMed Web of Science ®Google Scholar
• Merry P, Grootveld M, Lunec J, et al. Oxidative damage to lipids within the inflamed human joint provides evidence of radical-mediated hypoxic-reperfusion injury. Am J Clin Nutr. 1991;53:362–369. doi:10.1093/ajcn/53.1.362S
   Web of Science ®Google Scholar
• Sauer H, Wartenberg M, Hescheler J. Reactive oxygen species as intracellular messengers during cell growth and differentiation. Cell Physiol Biochem. 2001;11:173–186. doi:10.1159/00004780411509825
   PubMed Web of Science ®Google Scholar
• Li T, Xiao J, Wu Z, et al. Transcriptional activation of human MMP-13 gene expression by c-Maf in osteoarthritic chondrocyte. Connect Tissue Res. 2010;51:48–54. doi:10.3109/0300820090298910420067416
   PubMed Web of Science ®Google Scholar
• Tetsunaga T, Nishida K, Furumatsu T, et al. Regulation of mechanical stress-induced MMP-13 and ADAMTS-5 expression by RUNX-2 transcriptional factor in SW1353 chondrocyte-like cells. Osteoarthritis Cartilage. 2011;19:222–232. doi:10.1016/j.joca.2010.11.00421094261
   PubMed Web of Science ®Google Scholar
• Bao H, Chen L. Icariin reduces mitochondrial oxidative stress injury in diabetic rat hearts. Chin Med Mag China. 2011;36:1503–1507.
   Google Scholar
• Tang Y, Jacobi A, Vater C, et al. Icariin promotes angiogenic differentiation and prevents oxidative stress-induced autophagy in endothelial progenitor cells. Stem Cells. 2015 ;33:1863–1877. doi:10.1002/stem.200525787271
   PubMed Web of Science ®Google Scholar
• Ye R, Xu S, Liu Y, et al. Protective effect of Icariin on the development of preimplantation mouse embryos against hydrogen peroxide-induced oxidative injury. Oxid Med Cell Longev. 2017;2017:270453228680528
   PubMed Web of Science ®Google Scholar