Efficacy and safety of total glucosides of paeony combined with methotrexate and leflunomide for active rheumatoid arthritis: a meta-analysis

References

• Cross M, Smith E, Hoy D, et al. The global burden of rheumatoid arthritis: estimates from the global burden of disease 2010 study. Ann Rheum Dis. 2014;73(7):1316–1322. doi:10.1136/annrheumdis-2013-20462724550173
   PubMed Web of Science ®Google Scholar
• Li R, Sun J, Ren LM, et al. Epidemiology of eight common rheumatic diseases in China: a large-scale cross-sectional survey in Beijing. Rheumatology (Oxford). 2012;51(4):721–729. doi:10.1093/rheumatology/ker37022179737
   PubMed Web of Science ®Google Scholar
• Smolen JS, Landewe R, Bijlsma J, et al. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2016 update. Ann Rheum Dis. 2017;76(6):960–977. doi:10.1136/annrheumdis-2016-21071528264816
   PubMed Web of Science ®Google Scholar
• Katchamart W, Trudeau J, Phumethum V, Bombardier C. Efficacy and toxicity of methotrexate (MTX) monotherapy versus MTX combination therapy with non-biological disease-modifying antirheumatic drugs in rheumatoid arthritis: a systematic review and meta-analysis. Ann Rheum Dis. 2009;68(7):1105–1112. doi:10.1136/ard.2008.09986119054823
   PubMed Web of Science ®Google Scholar
• Nam JL, Takase-Minegishi K, Ramiro S, et al. Efficacy of biological disease-modifying antirheumatic drugs: a systematic literature review informing the 2016 update of the EULAR recommendations for the management of rheumatoid arthritis. Ann Rheum Dis. 2017;76(6):1113–1136. doi:10.1136/annrheumdis-2016-21071328283512
   PubMed Web of Science ®Google Scholar
• Singh JA, Hossain A, Tanjong GE, Mudano AS, Tugwell P, Wells GA. Biologic or tofacitinib monotherapy for rheumatoid arthritis in people with traditional disease-modifying anti-rheumatic drug (DMARD) failure: a cochrane systematic review and network meta-analysis (NMA). Cochrane Database Syst Rev. 2016;11:D12437. doi:10.1002/14651858.CD011360.pub2
   Web of Science ®Google Scholar
• Zhang W, Dai SM. Mechanisms involved in the therapeutic effects of Paeonia lactiflora Pallas in rheumatoid arthritis. Int Immunopharmacol. 2012;14(1):27–31. doi:10.1016/j.intimp.2012.06.00122705050
   PubMed Web of Science ®Google Scholar
• Parker S, May B, Zhang C, Zhang AL, Lu C, Xue CC. A pharmacological review of bioactive constituents of Paeonia lactiflora Pallas and Paeonia veitchii Lynch. Phytother Res. 2016;30(9):1445–1473. doi:10.1002/ptr.565327279421
   PubMed Web of Science ®Google Scholar
• Jia XY, Chang Y, Sun XJ, et al. Total glucosides of paeony inhibit the proliferation of fibroblast-like synoviocytes through the regulation of G proteins in rats with collagen-induced arthritis. Int Immunopharmacol. 2014;18(1):1–6. doi:10.1016/j.intimp.2013.09.00724161745
   PubMed Web of Science ®Google Scholar
• Chen Z, Li X, Li Z, Xu L, Li X. Reduced hepatotoxicity by total glucosides of paeony in combination treatment with leflunomide and methotrexate for patients with active rheumatoid arthritis. Int Immunopharmacol. 2013;15(3):474–477. doi:10.1016/j.intimp.2013.01.02123415907
   PubMed Web of Science ®Google Scholar
• Xiang N, Li X, Zhang M, et al. Total glucosides of paeony can reduce the hepatotoxicity caused by Methotrexate and Leflunomide combination treatment of active rheumatoid arthritis. Int Immunopharmacol. 2015;28(1):802–807. doi:10.1016/j.intimp.2015.08.00826292180
   PubMed Web of Science ®Google Scholar
• Moher D, Shamseer L, Clarke M, et al. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Syst Rev. 2015;4:1. doi:10.1186/2046-4053-4-125554246
   PubMed Web of Science ®Google Scholar
• Shi LP, Zhu MH, He Y. Effect of total glucosides of paeony combined with leflunomide on IL-1β, IL-6 and TNF-α in rheumatoid arthritis. Chin J Pract Med. 2011;38(3):1–3.
   Google Scholar
• Wang YP. Therapeutic effect and comparison of liver damage of two combined schemes on rheumatoid arthritis. Public Medical Forum Magazine 2012;16(13):1644–1646.
   Google Scholar
• Zheng HM, Jue HY, Yang YH. Effects of total glucosides of paeony on lipid profile in patients with rheumatoid arthritis. Chin J Basic Med Traditional Chin Med. 2014;20(06):832–834.
   Google Scholar
• Wang Y. Effect of combination of total glucosides of paeony and immunosuppressive on transaminase in treatment of rheumatoid arthritis. J Clin Med Lit. 2015;2(11):2132.
   Google Scholar
• Zhang H, Fan HT. Efficacy of total glucosides of paeony on blood lipid in patients with rheumatoid Arthritis. Chin J Clin Pharmacol. 2016;32(07):597–599.
   Google Scholar
• Tan K, Xiang Y, Yuan L, Dai YF. Therapeutic effect of total glucosides of paeony, methotrexate and leflunomide in the treatment of severe active rheumatoid arthritis. World Latest Med Inf. 2018;18(06):159–160.
   Google Scholar
• Higgins JPT, Green S, eds. Cochrane Handbook for Systematic Reviews of Interventions. Version 5.1.0 [updated March 2011]. London: The Cochrane Collaboration; 2011.
   Google Scholar
• Billix M. Effects of total glucoseides of paeony in combination treatment with methotrexate and leflunomide on liver function for rheumatoid arthritis. China Health Care & Nutrition 2017;09(02):262–263.
   Google Scholar
• Yu WJ, Xu J, Liang Y, Li M, Sha H. Clinical observation of total paeony glycoside capsule combined with methotrexate and leflunomide in the treatment of rheumatoid arthritis. Sichuan Med J. 2018;39(01):83–85.
   Google Scholar
• Wang Y, Li JX, Li XF. Comparison of efficacy and safety of total glucosides of paeony combined with methotrexate and leflunomind in the treatment of rheumatoid arthritis. National Medical Frontiers of China 2011;6(19):16–17.
   Google Scholar
• Li ZJ, Xu L, Li XP, et al. Total glucosides of paeony can affect hepatic dysfunction of patients with moderate or severe liver damage caused by methotrexate and leflunomide in rheumatoid arthritis patients. Chinese Journal of Rheumatology 2013;17(3):169–172.
   Google Scholar
• Xu HM, Wei W, Jia XY, Chang Y, Zhang L. Effects and mechanisms of total glucosides of paeony on adjuvant arthritis in rats. J Ethnopharmacol. 2007;109(3):442–448. doi:10.1016/j.jep.2006.08.01917000070
   PubMed Web of Science ®Google Scholar
• Zhou Z, Lin J, Huo R, et al. Total glucosides of paeony attenuated functional maturation of dendritic cells via blocking TLR4/5 signaling in vivo. Int Immunopharmacol. 2012;14(3):275–282. doi:10.1016/j.intimp.2012.07.01222846756
   PubMed Web of Science ®Google Scholar
• Xu XX, Qi XM, Zhang W, et al. Effects of total glucosides of paeony on immune regulatory toll-like receptors TLR2 and 4 in the kidney from diabetic rats. Phytomedicine. 2014;21(6):815–823. doi:10.1016/j.phymed.2013.12.00324462407
   PubMed Web of Science ®Google Scholar
• Zhang XJ, Li Z, Leung WM, Liu L, Xu HX, Bian ZX. The analgesic effect of paeoniflorin on neonatal maternal separation-induced visceral hyperalgesia in rats. J Pain. 2008;9(6):497–505. doi:10.1016/j.jpain.2007.12.00918387856
   PubMed Web of Science ®Google Scholar
• Yang DQ, You LP, Song PH, Zhang LX, Bai YP. A randomized controlled trial comparing total glucosides of paeony capsule and compound glycyrrhizin tablet for alopecia areata. Chin J Integr Med. 2012;18(8):621–625. doi:10.1007/s11655-012-1173-022855038
   PubMed Web of Science ®Google Scholar
• Taurog JD, Chhabra A, Colbert RA. Ankylosing Spondylitis and axial Spondyloarthritis. N Engl J Med. 2016;375(13):1303.
   PubMedGoogle Scholar
• Zhou L, Cao T, Wang Y, et al. Clinical observation on the treatment of oral lichen planus with total glucosides of paeony capsule combined with corticosteroids. Int Immunopharmacol. 2016;36:106–110. doi:10.1016/j.intimp.2016.03.03527129091
   PubMed Web of Science ®Google Scholar
• Luo J, Jin DE, Yang GY, et al. Total glucosides of paeony for rheumatoid arthritis: a systematic review of randomized controlled trials. Complement Ther Med. 2017;34:46–56. doi:10.1016/j.ctim.2017.07.01028917375
   PubMed Web of Science ®Google Scholar
• Jin L, Li C, Li Y, Wu B. Clinical efficacy and safety of total glucosides of paeony for primary Sjogren‘s syndrome: a systematic review. Evid Based Complement Alternat Med. 2017;2017:3242301. doi:10.1155/2017/324230128642798
   PubMed Web of Science ®Google Scholar
• De Vera MA, Choi H, Abrahamowicz M, Kopec J, Lacaille D. Impact of statin discontinuation on mortality in patients with rheumatoid arthritis: a population-based study. Arthritis Care Res (Hoboken). 2012;64(6):809–816. doi:10.1002/acr.2164322467274
   PubMed Web of Science ®Google Scholar
• Primdahl J, Clausen J, Horslev-Petersen K. Results from systematic screening for cardiovascular risk in outpatients with rheumatoid arthritis in accordance with the EULAR recommendations. Ann Rheum Dis. 2013;72(11):1771–1776. doi:10.1136/annrheumdis-2013-20368223852694
   PubMed Web of Science ®Google Scholar
• Li J, Chen CX, Shen YH. Effects of total glucosides from paeony (Paeonia lactiflora Pall) roots on experimental atherosclerosis in rats. J Ethnopharmacol. 2011;135(2):469–475. doi:10.1016/j.jep.2011.03.04521453765
   PubMed Web of Science ®Google Scholar
• Zhang L, Yang B, Yu B. Paeoniflorin protects against nonalcoholic fatty liver disease induced by a high-fat diet in mice. Biol Pharm Bull. 2015;38(7):1005–1011. doi:10.1248/bpb.b14-0089225972092
   PubMed Web of Science ®Google Scholar
• Li X, Shen J, Zhong Z, et al. Paeoniflorin ameliorates schistosomiasis liver fibrosis through regulating IL-13 and its signalling molecules in mice. Parasitology. 2010;137(8):1213–1225. doi:10.1017/S003118201000003X20398436
   PubMed Web of Science ®Google Scholar