Advanced search
Publication Cover
Drug Design, Development and Therapy Volume 13, 2019 - Issue
Submit an article Journal homepage
156
Views
5
CrossRef citations to date
0
Altmetric
Case Series

A study of refractory cases of persistent epithelial defects associated with dry eye syndrome and recurrent corneal erosions successfully treated with cyclosporine A 0.05% eye drops

Pietro Emanuele Napoli1 Department of Surgical Sciences, Eye Clinic, University of Cagliari, Cagliari, ItalyCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-7020-0823
ORCID Icon,
Mirco Braghiroli1 Department of Surgical Sciences, Eye Clinic, University of Cagliari, Cagliari, ItalyORCID Iconhttps://orcid.org/0000-0003-1025-7822
ORCID Icon,
Claudio Iovino1 Department of Surgical Sciences, Eye Clinic, University of Cagliari, Cagliari, ItalyORCID Iconhttps://orcid.org/0000-0003-1984-0555
ORCID Icon,
Giuseppe Demarinis1 Department of Surgical Sciences, Eye Clinic, University of Cagliari, Cagliari, ItalyORCID Iconhttps://orcid.org/0000-0002-9298-1963
ORCID Icon &
Maurizio Fossarello1 Department of Surgical Sciences, Eye Clinic, University of Cagliari, Cagliari, Italy;2 Clinica Oculistica, San Giovanni di Dio Hospital, Azienda Ospedaliera Universitaria di Cagliari, Cagliari, ItalyORCID Iconhttps://orcid.org/0000-0003-1520-7760
ORCID Icon
Pages 2001-2008 | Published online: 19 Jun 2019

References

  • Rolando M, Zierhut M. The ocular surface and tear film and their dysfunction in dry eye disease. Surv Ophthalmol. 2001;45:S203–S210.11587144
  • Napoli PE, Nioi M, Iovino C, Sanna R, d’Aloja E, Fossarello M. Ocular surface and respiratory tract damages from occupational, sub-chronic exposure to fluorspar: case report and other considerations. Int Ophthalmol. 2019;39(5):1175-8.
  • Katzman LR, Jeng BH. Management strategies for persistent epithelial defects of the cornea. Saudi J Ophthalmol. 2014;28(3):168–172. doi:10.1016/j.sjopt.2014.06.01125278792
  • Napoli PE, Nioi M, d’Aloja E, Fossarello M. The bull’s eye pattern of the tear film in humans during visual fixation on en-face optical coherence tomography. Sci Rep. 2019;9(1):1413. doi:10.1038/s41598-018-38260-530723239
  • Bron AJ, Evans VE, Smith JA. Grading of corneal and conjunctival staining in the context of other dry eye tests. Cornea. 2003;22(7):640–650.14508260
  • Dahlgren, M.A., Dhaliwal A, Huang AJ. Persistent epithelial defects In: Albert D, Miller J, Azar D, Blodi B, editors. Albert & Jakobiec’s Principles and Practice of Ophthalmology. 3rded. Philadelphia, Pennsylvania, USA: Elsevier; 2008:749–759. ISBN 9780323313575.
  • Chen YT, Huang CW, Huang FC, Tseng SY, Tseng SH. The cleavage plane of corneal epithelial adhesion complex in traumatic recurrent corneal erosion. Mol Vis. 2006;12:196–204.16604052
  • Craig JP, Nelson JD, Azar DT, et al. TFOS DEWS II report executive summary. Ocul Surf. 2017;15:802–812. doi:10.1016/j.jtos.2017.08.00328797892
  • Marshall LL, Roach JM. Treatment of dry eye disease. Consult Pharm. 2016;31:96–106. doi:10.4140/TCP.n.2016.9626842687
  • Napoli PE, Coronella F, Satta GM, Galantuomo MS, Fossarello M, Huang J. Evaluation of the adhesive properties of the cornea by means of optical coherence tomography in patients with meibomian gland dysfunction and lacrimal tear deficiency. PLoS One. 2014;9(12):e115762. doi:10.1371/journal.pone.011576225536051
  • Nioi M, Napoli PE, Demontis R, Locci E, Fossarello M, d’Aloja E. Morphological analysis of corneal findings modifications after death: a preliminary OCT study on an animal model. Exp Eye Res. 2018;169:20–27. doi:10.1016/j.exer.2018.01.01329360448
  • Napoli PE, Satta GM, Coronella F, Fossarello M. Spectral-domain optical coherence tomography study on dynamic changes of human tears after instillation of artificial tears. Invest Ophthalmol Vis Sci. 2014;55(7):4533–4540. doi:10.1167/iovs.14-1466624985473
  • Wise RJ, Sobel RK, Allen RC. Meibography: a review of techniques and technologies. Saudi J Ophthalmol. 2012;26:349–356. doi:10.1016/j.sjopt.2012.08.00723961019
  • Shimazaki J, Sakata M, Tsubota K. Ocular surface changes and discomfort in patients with meibomian gland dysfunction. Arch Ophthalmol. 1995;113:1266–1270.7575257
  • Napoli PE, Coronella F, Satta GM, Iovino C, Sanna R, Fossarello M. A simple novel technique of infrared meibography by means of spectral-domain optical coherence tomography: a cross-sectional clinical study. PLoS One. 2016;11(10):e0165558. doi:10.1371/journal.pone.016555827798696
  • Kiang E, Tesavibul N, Yee R, Kellaway J, Przepiorka D. The use of topical cyclosporin A in ocular graft-versus-host-disease. Bone Marrow Transplant. 1998;22(2):147. doi:10.1038/sj.bmt.17013009707022
  • Wan KH, Li J, Alvin LY. Efficacy and safety of topical 0.05% cyclosporine eye drops in the treatment of dry eye syndrome: a systematic review and meta-analysis. Ocul Surf. 2015;13(3):213–225. doi:10.1016/j.jtos.2014.12.00626045239
  • Napoli PE, Coronella F, Satta GM, Zucca IA, Fossarello M. A novel OCT technique to measure in vivo the corneal adhesiveness for sodium carboxymethylcellulose in humans and its validity in the diagnosis of dry eye. Invest Ophthalmol Vis Sci. 2014;55(5):3179–3185. doi:10.1167/iovs.13-1361324764061
  • Barber LD, Pflugfelder SC, Tauber J, Foulks GN. Phase III safety evaluation of cyclosporine 0.1% ophthalmic emulsion administered twice daily to dry eye disease patients for up to 3 years. Ophthalmology. 2005;112:1790–1794. doi:10.1016/j.ophtha.2005.05.01316102833
  • Stevenson D, Tauber J, Reis BL. Efficacy and safety of cyclosporin A ophthalmic emulsion in the treatment of moderate-to-severe dry eye disease: a dose-ranging, randomized trial. Ophthalmology. 2000;107:967–974.10811092

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.