Activation of the P38/CREB/MMP13 axis is associated with osteoarthritis

References

• Kinds MB, Welsing PM, Vignon EP, et al. A systematic review of the association between radiographic and clinical osteoarthritis of hip and knee. Osteoarthritis Cartilage. 2011;19(7):768–778. doi:10.1016/j.joca.2011.01.01521281726
   PubMed Web of Science ®Google Scholar
• Hauk L. Treatment of knee osteoarthritis: a clinical practice guideline from the AAOS. Am Fam Physician. 2014;89(11):918–920.25077402
   PubMed Web of Science ®Google Scholar
• Rogers EL, Reynard LN, Loughlin J. The role of inflammation-related genes in osteoarthritis. Osteoarthritis Cartilage. 2015;23(11):1933–1938. doi:10.1016/j.joca.2015.01.00326521739
   PubMed Web of Science ®Google Scholar
• Haq SA, Davatchi F, Dahaghin S, et al. Development of a questionnaire for identification of the risk factors for osteoarthritis of the knees in developing countries. A pilot study in Iran and Bangladesh. An ILAR-COPCORD phase III study. Int J Rheum Dis. 2010;13(3):203–214. doi:10.1111/j.1756-185X.2010.01529.x20704616
   PubMed Web of Science ®Google Scholar
• Smith GJ. The role of collagenolytic matrix metalloproteinases in the loss of articular cartilage in osteoarthritis. Front Biosci. 2006;11:3081–3095.16720377
   PubMed Web of Science ®Google Scholar
• Burrage PS, Mix KS, Brinckerhoff CE. Matrix metalloproteinases: role in arthritis. Front Biosci. 2006;11:529–543.16146751
   PubMed Web of Science ®Google Scholar
• Aida Y, Maeno M, Suzuki N, Shiratsuchi H, Motohashi M, Matsumura H. The effect of IL-1beta on the expression of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in human chondrocytes. Life Sci. 2005;77(25):3210–3221. doi:10.1016/j.lfs.2005.05.05215979654
   PubMed Web of Science ®Google Scholar
• Kobayashi M, Squires GR, Mousa A, et al. Role of interleukin-1 and tumor necrosis factor alpha in matrix degradation of human osteoarthritic cartilage. Arthritis Rheum. 2005;52(1):128–135. doi:10.1002/art.2077615641080
   PubMed Web of Science ®Google Scholar
• Vincenti MP, Brinckerhoff CE. Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factors. Arthritis Res. 2002;4(3):157–164. doi:10.1186/ar40112010565
   PubMedGoogle Scholar
• Shiomi T, Lemaitre V, D’Armiento J, Okada Y. Matrix metalloproteinases, a disintegrin and metalloproteinases, and a disintegrin and metalloproteinases with thrombospondin motifs in non-neoplastic diseases. Pathol Int. 2010;60(7):477–496. doi:10.1111/j.1440-1827.2010.02547.x20594269
   PubMed Web of Science ®Google Scholar
• Roach HI, Yamada N, Cheung KS, et al. Association between the abnormal expression of matrix-degrading enzymes by human osteoarthritic chondrocytes and demethylation of specific CpG sites in the promoter regions. Arthritis Rheum. 2005;52(10):3110–3124. doi:10.1002/art.2130016200590
   PubMed Web of Science ®Google Scholar
• Ha YJ, Choi YS, Kang EH, et al. SOCS1 suppresses IL-1beta-induced C/EBPbeta expression via transcriptional regulation in human chondrocytes. Exp Mol Med. 2016;48:e241. doi:10.1038/emm.2016.4727339399
   PubMed Web of Science ®Google Scholar
• Bui C, Barter MJ, Scott JL, et al. cAMP response element-binding (CREB) recruitment following a specific CpG demethylation leads to the elevated expression of the matrix metalloproteinase 13 in human articular chondrocytes and osteoarthritis. Faseb J. 2012;26(7):3000–3011. doi:10.1096/fj.12-20636722505473
   PubMed Web of Science ®Google Scholar
• Pritzker KP, Gay S, Jimenez SA, et al. Osteoarthritis cartilage histopathology: grading and staging. Osteoarthritis Cartilage. 2006;14(1):13–29. doi:10.1016/j.joca.2005.07.01416242352
   PubMed Web of Science ®Google Scholar
• Chen P, Xia C, Mei S, et al. Intra-articular delivery of sinomenium encapsulated by chitosan microspheres and photo-crosslinked GelMA hydrogel ameliorates osteoarthritis by effectively regulating autophagy. BIOMATERIALS. 2016;81:1–13. doi:10.1016/j.biomaterials.2015.12.00626713680
   PubMed Web of Science ®Google Scholar
• Gosset M, Berenbaum F, Thirion S, Jacques C. Primary culture and phenotyping of murine chondrocytes. Nat Protoc. 2008;3(8):1253–1260. doi:10.1038/nprot.2008.9518714293
   PubMed Web of Science ®Google Scholar
• Wang M, Sampson ER, Jin H, et al. MMP13 is a critical target gene during the progression of osteoarthritis. Arthritis Res Ther. 2013;15(1):R5. doi:10.1186/ar413323298463
   PubMed Web of Science ®Google Scholar
• Thalhamer T, McGrath MA, Harnett MM. MAPKs and their relevance to arthritis and inflammation. Rheumatology (Oxford). 2008;47(4):409–414. doi:10.1093/rheumatology/kem29718187523
   PubMed Web of Science ®Google Scholar
• Geng Y, Valbracht J, Lotz M. Selective activation of the mitogen-activated protein kinase subgroups c-Jun NH2 terminal kinase and p38 by IL-1 and TNF in human articular chondrocytes. J Clin Invest. 1996;98(10):2425–2430. doi:10.1172/JCI1190568941662
   PubMed Web of Science ®Google Scholar
• Zayed N, Afif H, Chabane N, et al. Inhibition of interleukin-1beta-induced matrix metalloproteinases 1 and 13 production in human osteoarthritic chondrocytes by prostaglandin D2. Arthritis Rheum. 2008;58(11):3530–3540. doi:10.1002/art.2395818975308
   PubMed Web of Science ®Google Scholar
• Kapoor M, Martel-Pelletier J, Lajeunesse D, Pelletier JP, Fahmi H. Role of proinflammatory cytokines in the pathophysiology of osteoarthritis. Nat Rev Rheumatol. 2011;7(1):33–42. doi:10.1038/nrrheum.2010.19621119608
   PubMed Web of Science ®Google Scholar
• Kanwar JR, Kanwar RK, Burrow H, Baratchi S. Recent advances on the roles of NO in cancer and chronic inflammatory disorders. Curr Med Chem. 2009;16(19):2373–2394.19601787
   PubMed Web of Science ®Google Scholar
• Sun HY, Hu KZ, Yin ZS. Inhibition of the p38-MAPK signaling pathway suppresses the apoptosis and expression of proinflammatory cytokines in human osteoarthritis chondrocytes. CYTOKINE. 2017;90:135–143. doi:10.1016/j.cyto.2016.11.00227907835
   PubMed Web of Science ®Google Scholar
• Joos H, Albrecht W, Laufer S, Brenner RE. Differential effects of p38MAP kinase inhibitors on the expression of inflammation-associated genes in primary, interleukin-1beta-stimulated human chondrocytes. Br J Pharmacol. 2010;160(5):1252–1262. doi:10.1111/j.1476-5381.2010.00760.x20590617
   PubMed Web of Science ®Google Scholar
• Maudens P, Seemayer CA, Pfefferle F, Jordan O, Allemann E. Nanocrystals of a potent p38 MAPK inhibitor embedded in microparticles: therapeutic effects in inflammatory and mechanistic murine models of osteoarthritis. J Control Release. 2018;276:102–112. doi:10.1016/j.jconrel.2018.03.00729524442
   PubMed Web of Science ®Google Scholar
• Frost RA, Nystrom GJ, Lang CH. Stimulation of insulin-like growth factor binding protein-1 synthesis by interleukin-1beta: requirement of the mitogen-activated protein kinase pathway. ENDOCRINOLOGY. 2000;141(9):3156–3164. doi:10.1210/endo.141.9.764110965886
   PubMed Web of Science ®Google Scholar
• Funding AT, Johansen C, Kragballe K, Iversen L. Mitogen- and stress-activated protein kinase 2 and cyclic AMP response element binding protein are activated in lesional psoriatic epidermis. J Invest Dermatol. 2007;127(8):2012–2019. doi:10.1038/sj.jid.570082117429437
   PubMed Web of Science ®Google Scholar
• Ross S, Chen T, Yu V, et al. High-content screening analysis of the p38 pathway: profiling of structurally related p38alpha kinase inhibitors using cell-based assays. Assay Drug Dev Technol. 2006;4(4):397–409. doi:10.1089/adt.2006.4.39716945013
   PubMed Web of Science ®Google Scholar
• Ma J, Ma Y, Liu X, et al. Gambogic acid inhibits osteoclast formation and ovariectomy-induced osteoporosis by suppressing the JNK, p38 and Akt signalling pathways. Biochem J. 2015;469(3):399–408. doi:10.1042/BJ2015015126205493
   PubMed Web of Science ®Google Scholar
• Liu Y, Ge J, Li Q, et al. Anisomycin induces apoptosis of glucocorticoid resistant acute lymphoblastic leukemia CEM-C1 cells via activation of mitogen-activated protein kinases p38 and JNK. NEOPLASMA. 2013;60(1):101–110. doi:10.4149/neo_2013_01423067223
   PubMed Web of Science ®Google Scholar
• Zhao TC, Zhang L, Liu JT, Guo TL. Disruption of Nox2 and TNFRp55/p75 eliminates cardioprotection induced by anisomycin. Am J Physiol Heart Circ Physiol. 2012;303(10):H1263–H1272. doi:10.1152/ajpheart.00306.201222982779
   PubMed Web of Science ®Google Scholar
• Shafer LM, Slice LW. Anisomycin induces COX-2 mRNA expression through p38(MAPK) and CREB independent of small GTPases in intestinal epithelial cells. Biochim Biophys Acta. 2005;1745(3):393–400. doi:10.1016/j.bbamcr.2005.07.00216054711
   PubMed Web of Science ®Google Scholar
• Liu Y, Ge J, Li Q, et al. Low-dose anisomycin sensitizes glucocorticoid-resistant T-acute lymphoblastic leukemia CEM-C1 cells to dexamethasone-induced apoptosis through activation of glucocorticoid receptor and p38-MAPK/JNK. Leuk Lymphoma. 2014;55(9):2179–2188. doi:10.3109/10428194.2013.86666424597985
   PubMed Web of Science ®Google Scholar