An Efficient, Lung-Targeted, Drug-Delivery System To Treat Asthma Via Microparticles

References

• WHO. Global Status Report on Noncommunicable Diseases 2014. World Health Organization; 2014.
   Google Scholar
• Network BTSSIG. British guideline on the management of asthma. Thorax. 2008;63:iv1. doi:10.1136/thx.2008.09774118463203
   PubMed Web of Science ®Google Scholar
• Chatterjee A, Kubendran S, King J, DeVol R Chronic disease and wellness in america, measuring the economic burden in a changing nation. Technical Report; 2014.
   Google Scholar
• McDonald VM, Hiles SA, Jones KA, Clark VL, Yorke J. Health‐related quality of life burden in severe asthma. Med J Aust. 2018;209(S2):S28–S33. doi:10.5694/mja2.2018.209.issue-S230453870
   PubMed Web of Science ®Google Scholar
• Lakshminarayanan S. Role of government in public health: current scenario in India and future scope. J Family Community Med. 2011;18(1):26–30. doi:10.4103/1319-1683.7863521694957
   PubMedGoogle Scholar
• Dharmage SC, Perret JL, Custovic A. Epidemiology of asthma in children and adults. Front Pediatr. 2019;7:246. doi:10.3389/fped.2019.0024631275909
   PubMed Web of Science ®Google Scholar
• Kumar A, Zhang X, Liang X-J. Gold nanoparticles: emerging paradigm for targeted drug delivery system. Biotechnol Adv. 2013;31(5):593–606. doi:10.1016/j.biotechadv.2012.10.00223111203
   PubMed Web of Science ®Google Scholar
• Tripathi K. Essentials of medical pharmacology, Jaypee Brothers. Med Pub Ltd New Delhi Edn. 2003;5:93–94.
   Google Scholar
• Harsha NS, Rani RS. Drug targeting to lungs by way of microspheres. Arch Pharm Res. 2006;29(7):598–604. doi:10.1007/BF0296927216903082
   PubMed Web of Science ®Google Scholar
• Billington CK, Penn RB, Hall IP. β(2) Agonists. Handb Exp Pharmacol. 2017;237:23–40.27878470
   PubMedGoogle Scholar
• Nakpheng T, Songkarak S, Suwandecha T, Sritharadol R, Chunhachaichana C, Srichana T. Evidences for salbutamol metabolism by respiratory and liver cell lines. Drug Metab Pharmacokinet. 2017;32(2):127–134. doi:10.1016/j.dmpk.2016.11.00628318879
   PubMed Web of Science ®Google Scholar
• Rowland M. Influence of route of administration on drug availability. J Pharm Sci. 1972;61(1):70–74. doi:10.1002/jps.26006101115019220
   PubMed Web of Science ®Google Scholar
• Sellers WFS. Inhaled and intravenous treatment in acute severe and life-threatening asthma. Br J Anaesth. 2012;110(2):183–90.23234642
   PubMed Web of Science ®Google Scholar
• Shakeri-Zadeh A, Shiran M-B, Khoee S, Sharifi AM, Ghaznavi H, Khoei S. A new magnetic nanocapsule containing 5-fluorouracil: in vivo drug release, anti-tumor, and pro-apoptotic effects on CT26 cells allograft model. J Biomater Appl. 2014;29(4):548–556. doi:10.1177/088532821453694024913615
   PubMed Web of Science ®Google Scholar
• Shakeri-Zadeh A, Khoee S, Shiran M-B, Sharifi AM, Khoei S. Synergistic effects of magnetic drug targeting using a newly developed nanocapsule and tumor irradiation by ultrasound on CT26 tumors in BALB/c mice. J Mater Chem B. 2015;3(9):1879–1887. doi:10.1039/C4TB01708K
   PubMed Web of Science ®Google Scholar
• Swider E, Koshkina O, Tel J, Cruz LJ, de Vries IJM, Srinivas M. Customizing poly(lactic-co-glycolic acid) particles for biomedical applications. Acta Biomater. 2018;73:38–51. doi:10.1016/j.actbio.2018.04.00629653217
   PubMed Web of Science ®Google Scholar
• Radha GV, Rani TS, Sarvani B. A review on proniosomal drug delivery system for targeted drug action. J Basic Clin Pharm. 2013;4(2):42–48. doi:10.4103/0976-0105.11360924808669
   PubMedGoogle Scholar
• Kutscher HL, Chao P, Deshmukh M, et al. Threshold size for optimal passive pulmonary targeting and retention of rigid microparticles in rats. J Control Release. 2010;143(1):31–37. doi:10.1016/j.jconrel.2009.12.01920043961
   PubMed Web of Science ®Google Scholar
• Hoshyar N, Gray S, Han H, Bao G. The effect of nanoparticle size on in vivo pharmacokinetics and cellular interaction. Nanomedicine (Lond). 2016;11(6):673–692. doi:10.2217/nnm.16.527003448
   PubMed Web of Science ®Google Scholar
• Virmani T, Gupta J. Pharmaceutical application of microspheres: an approach for the treatment of various diseases. Int J Pharm Sci Res. 2017;8:3252–3260.
   Google Scholar
• Hong X, Wei L, Ma L, Chen Y, Liu Z, Yuan W. Novel preparation method for sustained-release PLGA microspheres using water-in-oil-in-hydrophilic-oil-in-water emulsion. Int J Nanomedicine. 2013;8:2433–2441. doi:10.2147/IJN.S4518623882140
   PubMed Web of Science ®Google Scholar
• National Research Council Committee on Prudent Practices for Handling SDCL. Prudent Practices in the Laboratory: Handling and Disposal of Chemicals. National Academy Press; 1995.
   Google Scholar
• Branchu S, Forbes RT, York P, Petrén S, Nyqvist H, Camber O. Hydroxypropyl-beta-cyclodextrin inhibits spray-drying-induced inactivation of beta-galactosidase. J Pharm Sci. 1999;88(9):905–911. doi:10.1021/js980481910479352
   PubMed Web of Science ®Google Scholar
• Freitas S, Merkle HP, Gander B. Ultrasonic atomisation into reduced pressure atmosphere—envisaging aseptic spray-drying for microencapsulation. J Control Release. 2004;95(2):185–195. doi:10.1016/j.jconrel.2003.11.00514980767
   PubMed Web of Science ®Google Scholar
• Arpagaus C. A novel laboratory-scale spray dryer to produce nanoparticles. Drying Technol. 2012;30(10):1113–1121. doi:10.1080/07373937.2012.686949
   Web of Science ®Google Scholar
• Littringer EM, Zellnitz S, Hammernik K, Adamer V, Friedl H, Urbanetz NA. Spray drying of aqueous salbutamol sulfate solutions using the nano spray dryer B-90—the impact of process parameters on particle size. Drying Technol. 2013;31(12):1346–1353. doi:10.1080/07373937.2013.793701
   Web of Science ®Google Scholar
• Nagaraja SH, Al-Dhubiab BE, Tekade RK, et al. Novel preparation and effective delivery of mucoadeshive nanoparticles containing anti-diabetic drug. Indian J Pharm Edu Res. 2019;53(2):S43–S49. doi:10.5530/ijper.53.2s.47
   Web of Science ®Google Scholar
• Khare P, Jain S. Influence of rheology of dispersion media in the preparation of polymeric microspheres through emulsification method. AAPS PharmSciTech. 2009;10(4):1295–1300. doi:10.1208/s12249-009-9315-119882250
   PubMed Web of Science ®Google Scholar
• Wu G, Chen L, Li H, Deng C-L, Chen X-F. Comparing microspheres with different internal phase of polyelectrolyte as local drug delivery system for bone tuberculosis therapy. Biomed Res Int. 2014;2014:297808.24707480
   PubMed Web of Science ®Google Scholar
• Jones AK, Bejugam NK, Nettey H, Addo R, D’Souza MJ. Spray-dried doxorubicin-albumin microparticulate systems for treatment of multidrug resistant melanomas. J Drug Target. 2011;19(6):427–433. doi:10.3109/1061186X.2010.50427020678033
   PubMed Web of Science ®Google Scholar
• Zhang X, Chen F, Ni J. A novel method to prepare magnetite chitosan microspheres conjugated with methotrexate (MTX) for the controlled release of MTX as a magnetic targeting drug delivery system. Drug Deliv. 2009;16(5):280–288. doi:10.1080/1071754090298955519538010
   PubMed Web of Science ®Google Scholar
• Venkatesan P, Manavalan R, Valliappan K. Preparation and evaluation of sustained release loxoprofen loaded microspheres. J Basic Clin Pharm. 2011;2(3):159–162.24826017
   PubMedGoogle Scholar
• Harsha S, Al-Khars M, Al-Hassan M, et al. Pharmacokinetics and tissue distribution of spray-dried carboplatin microspheres: lung targeting via intravenous route. Arch Pharm Res. 2014;37(3):352–360. doi:10.1007/s12272-013-0151-123712379
   PubMed Web of Science ®Google Scholar
• Fan Y, Shan-Guang W, Yu-Fang P, Feng-Lan S, Tao L. Preparation and characteristics of erythromycin microspheres for lung targeting. Drug Dev Ind Pharm. 2009;35(6):639–645. doi:10.1080/0363904080251224319259878
   PubMed Web of Science ®Google Scholar
• Perreault S, Ong H, Du Souich P. Salbutamol disposition and dynamics in conscious rabbits: influence of the route of administration and of the dose. J Pharmacokinet Biopharm. 1992;20(5):461–476. doi:10.1007/BF010614661287197
   PubMedGoogle Scholar
• Soriano-Ursúa MA, Correa-Basurto J, Romero-Huerta J, Elizalde-Solis O, Galicia-Luna LA, Trujillo-Ferrara JG. Pharmacokinetic parameters and a theoretical study about metabolism of BR-AEA (a salbutamol derivative) in rabbit. J Enzyme Inhib Med Chem. 2010;25(3):340–346. doi:10.3109/1475636090317945019874116
   PubMed Web of Science ®Google Scholar
• Zhao RZ, Yuan D, Liu SJ, Chen YJ, Liu LJ, Zhao Y. Liver targeting effect of vinegar-baked Radix Bupleuri on rhein in rats. J Ethnopharmacol. 2010;132(2):421–428. doi:10.1016/j.jep.2010.08.02120728515
   PubMed Web of Science ®Google Scholar
• Gupta PK, Hung CT. Quantitative evaluation of targeted drug delivery systems. Int J Pharm. 1989;56(3):217–226. doi:10.1016/0378-5173(89)90018-5
   Web of Science ®Google Scholar
• Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods. 1983;65(1–2):55–63. doi:10.1016/0022-1759(83)90303-46606682
   PubMed Web of Science ®Google Scholar
• Zhivotosky B, Orrenius S. Assessment of apoptosis and necrosis by DNA fragmentation and morphological criteria. Current Protoc Cell Biol. 2001;Chapter 18:Unit18.13.
   PubMedGoogle Scholar
• Basnakian AG, James SJ. A rapid and sensitive assay for the detection of DNA fragmentation during early phases of apoptosis. Nucleic Acids Res. 1994;22(13):2714–2715. doi:10.1093/nar/22.13.27148041637
   PubMed Web of Science ®Google Scholar
• Tyagi LK, Kori ML, Study S. In-vivo evaluation of lornoxicam loaded ethyl cellulose microspheres. Int J Pharm Sci Drug Res. 2014;6(1):26–30.
   Google Scholar
• Mistry A, Ravikumar P. Development and evaluation of azelaic acid based ethosomes for topical delivery for the treatment of acne. Indian J Pharm Educ. 2016;50:S232–S243. doi:10.5530/ijper
   Web of Science ®Google Scholar
• Patel BB, Patel JK, Chakraborty S, Shukla D. Revealing facts behind spray dried solid dispersion technology used for solubility enhancement. Saudi Pharm J. 2015;23(4):352–365. doi:10.1016/j.jsps.2013.12.01327134535
   PubMed Web of Science ®Google Scholar
• Nijdam JJ, Langrish TAG. The effect of surface composition on the functional properties of milk powders. J Food Eng. 2006;77(4):919–925. doi:10.1016/j.jfoodeng.2005.08.020
   Web of Science ®Google Scholar
• Bilancetti L, Poncelet D, Loisel C, Mazzitelli S, Nastruzzi C. A statistical approach to optimize the spray drying of starch particles: application to dry powder coating. AAPS PharmSciTech. 2010;11(3):1257–1267. doi:10.1208/s12249-010-9492-y20706878
   PubMed Web of Science ®Google Scholar
• Bozdag S, Calis S, Kas HS, Ercan MT, Peksoy I, Hincal AA. In vitro evaluation and intra-articular administration of biodegradable microspheres containing naproxen sodium. J Microencapsul. 2001;18(4):443–456. doi:10.1080/0265204001001864111428674
   PubMed Web of Science ®Google Scholar
• Ramaiah B, Nagaraja SH, Kapanigowda UG, Boggarapu PR, Subramanian R. High azithromycin concentration in lungs by way of bovine serum albumin microspheres as targeted drug delivery: lung targeting efficiency in albino mice. DARU J Pharm Sci. 2016;24:14. doi:10.1186/s40199-016-0153-x
   Web of Science ®Google Scholar
• Li X, Anton N, Arpagaus C, Belleteix F, Vandamme TF. Nanoparticles by spray drying using innovative new technology: the Büchi nano spray dryer B-90. J Control Release. 2010;147(2):304–310. doi:10.1016/j.jconrel.2010.07.11320659510
   PubMed Web of Science ®Google Scholar
• Mitra A, Dey B. Chitosan microspheres in novel drug delivery systems. Indian J Pharm Sci. 2011;73(4):355–366. doi:10.4103/0250-474X.9560722707817
   PubMed Web of Science ®Google Scholar
• Harsha S. Dual drug delivery system for targeting H. pylori in the stomach: preparation and in vitro characterization of amoxicillin-loaded Carbopol® nanospheres. Int J Nanomedicine. 2012;7:4787–4796. doi:10.2147/IJN.S3431222969298
   PubMed Web of Science ®Google Scholar
• Arpagaus C. Nano spray dryer B-90: literature review and applications. Büchi Inf Bull. 2011;63:8.
   Google Scholar
• Anandharamakrishnan C, Ishwarya SP. Spray Drying Techniques for Food Ingredient Encapsulation. Wiley; 2015.
   Google Scholar
• Miller DA, Gil M, Williams Iii ROO, Watts ABB, Miller DAA. Spray-Drying Technology Formulating Poorly Water Soluble Drugs. Vol. 3 New York: Springer; 2012:363–442.
   Google Scholar
• De Jaeghere F, Allémann E, Doelker E, et al. pH-Dependent dissolving nano- and microparticles for improved peroral delivery of a highly lipophilic compound in dogs. Aaps J. 2001;3(1):92–99. doi:10.1208/ps030108
   Google Scholar
• Yeo Y, Park K. Control of encapsulation efficiency and initial burst in polymeric microparticle systems. Arch Pharm Res. 2004;27(1):1–12. doi:10.1007/BF0298003714969330
   PubMed Web of Science ®Google Scholar
• Skinner DV. Cambridge Textbook of Accident And Emergency Medicine. Cambridge University Press 1997.
   Google Scholar
• Huang X, Brazel CS. On the importance and mechanisms of burst release in matrix-controlled drug delivery systems. J Control Release. 2001;73(2–3):121–136. doi:10.1016/S0168-3659(01)00248-611516493
   PubMed Web of Science ®Google Scholar
• Fu Y, Kao WJ. Drug release kinetics and transport mechanisms of non-degradable and degradable polymeric delivery systems. Expert Opin Drug Deliv. 2010;7(4):429–444. doi:10.1517/1742524100360225920331353
   PubMed Web of Science ®Google Scholar
• Labiris NR, Dolovich MB. Pulmonary drug delivery. Part II: the role of inhalant delivery devices and drug formulations in therapeutic effectiveness of aerosolized medications. Br J Clin Pharmacol. 2003;56(6):600–612. doi:10.1046/j.1365-2125.2003.01893.x14616419
   PubMed Web of Science ®Google Scholar
• Wang H, Xu Y, Zhou X. Docetaxel-loaded chitosan microspheres as a lung targeted drug delivery system: in vitro and in vivo evaluation. Int J Mol Sci. 2014;15(3):3519–3532. doi:10.3390/ijms1503351924577314
   PubMed Web of Science ®Google Scholar
• Yang F, Kang J, Yang F, Zhao Z, Kong T, Zeng Z. Preparation and evaluation of enrofloxacin microspheres and tissue distribution in rats. J Vet Sci. 2015;16(2):157–164. doi:10.4142/jvs.2015.16.2.15725643802
   PubMed Web of Science ®Google Scholar
• Tawfeek HM. Evaluation of PEG and mPEG-co-(PGA-co-PDL) microparticles loaded with sodium diclofenac. Saudi Pharm J. 2013;21(4):387–397. doi:10.1016/j.jsps.2012.11.00624227959
   PubMed Web of Science ®Google Scholar