395
Views
26
CrossRef citations to date
0
Altmetric
Original Research

Effects of quercetin, sitagliptin alone or in combination in testicular toxicity induced by doxorubicin in rats

ORCID Icon, ORCID Icon, & ORCID Icon
Pages 3321-3329 | Published online: 20 Sep 2019

References

  • Hee Lee S, Ho Shin C. Reduced male fertility in childhood cancer survivors. Ann Pediatr Endocrinol Metab. 2013;18:168–172. doi:10.6065/apem24904872
  • Adwas AA, Elkhoely AA, Kabel AM, Abdel-Rahman MN, Eissa AA. Anti-cancer and cardioprotective effects of indol-3-carbinol in doxorubicin-treated mice. J Infect Chemother. 2016;22(1):36–43. doi:10.1016/j.jiac.2015.10.00126603425
  • Pang B, Qiao X, Janssen L, et al. Drug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicin. Nat Commun. 2013;4(1):1908. doi:10.1038/ncomms292123715267
  • Beaud H, van Pelt A, Delbes G. Doxorubicin and vincristine affect undifferentiated rat spermatogonia. Reproduction. 2017;153(6):725–735. doi:10.1530/REP-17-000528258155
  • Türedi S, Yuluğ E, Alver A, Kutlu Ö, Kahraman C. Effects of resveratrol on doxorubicin induced testicular damage in rats. Exp Toxicol Pathol. 2015;67(3):229–235. doi:10.1016/j.etp.2014.12.00225553596
  • Zhang M, Swarts SG, Yin L, et al. Antioxidant properties of quercetin Adv ExpMed Biol. 2011;701:283–289. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21445799
  • McAnulty LS, Miller LE, Hosick PA, Utter AC, Quindry JC, McAnulty SR. Effect of resveratrol and quercetin supplementation on redox status and inflammation after exercise. Appl Physiol Nutr Metab. 2013;38(7):760–765. doi:10.1139/apnm-2012-045523980734
  • Gao C, Chen X, Li J, et al. Myocardial mitochondrial oxidative stress and dysfunction in intense exercise: regulatory effects of quercetin. Eur J Appl Physiol. 2014;114(4):695–705. doi:10.1007/s00421-014-2985-824368555
  • Choi Y, Kang J, Han J, et al. Biochemical and molecular actions of nutrients polyphenolic flavonoids differ in their antiapoptotic efficacy in hydrogen peroxide – treated human vascular endothelial cells. J Nutr. 2003;133:985–991. doi:10.1093/jn/133.8.262212672908
  • D’Andrea G. Quercetin: a flavonol with multifaceted therapeutic applications? Fitoterapia. 2015;106:256–271. doi:10.1016/j.fitote.2015.09.01826393898
  • Inal ME, Akgün A, Kahraman A. Radioprotective effects of exogenous glutathione against whole-body gamma-ray irradiation: age- and gender-related changes in malodialdehyde levels, superoxide dismutase and catalase activities in rat liver. Methods Find Exp Clin Pharmacol. 2005;24(4):209. doi:10.1358/mf.2002.24.4.678452
  • Bharti S, Misro MM, Rai U. Quercetin supplementation restores testicular function and augments germ cell survival in the estrogenized rats. Mol Cell Endocrinol. 2014;383(1–2):10–20. doi:10.1016/j.mce.2013.11.02124316378
  • Eligar VS, Bain SC. A review of sitagliptin with special emphasis on its use in moderate to severe renal impairment. Drug Des Devel Ther. 2013;7:893–903.
  • Chien-Hung L, Chung Ching L. Sitagliptin attenuate inflammatory responses in lipopolysaccharide stimulated cardiomyocytes via nuclear factor κB pathway inhibition. Exp Ther Med. 2016;11:2609–2615. doi:10.3892/etm.2016.325527284355
  • Vaghasiya J, Sheth N, Bhalodia Y, Manek R. Sitagliptin protects renal ischemia reperfusion induced renal damage in diabetes. Regul Pept. 2011;166(1–3):48–54. doi:10.1016/j.regpep.2010.08.00720728477
  • Makdissi A, Ghanim H, Vora M, et al. Sitagliptin exerts an antinflammatory action. J Clin Endocrinol Metab. 2012;97(9):3333–3341. doi:10.1210/jc.2012-154422745245
  • Henrique de Miranda PA, Christine Duarte Lacerda K, Morais Araújo C, Mario Barichello J, Geraldo Lima W, Caldeira Costa D. Oral formulation of DPP-4 inhibitor plus Quercetin improves metabolic homeostasis in type 1 diabetic rats. Sci Rep. 2018;8:15310. doi:10.1038/s41598-018-33727-x30333575
  • Wendel A. Glutathione peroxidase. Methods Enzymol. 1981;77:325–333.7329310
  • Eitah HE, Maklad YA, Abdelkader NF, Gamal El Din AA, Badawi MA, Kenawy SA. Modulating impacts of quercetin/sitagliptin combination on streptozotocin-induced diabetes mellitus in rats. Toxicol Appl Pharmacol. 2019;365:30–40. doi:10.1016/j.taap.2018.12.01130576699
  • Abdella E, Ahmed R. Suppression of doxorubicin apoptotic, histopathologic, mutagenic and oxidative stress effects in male mice bone marrow and testis tissues by aqueous rosemary leaves extract. Iran J Cancer Prev. 2009;1:35–49.
  • Kabel AM. Zinc/alogliptin combination attenuates testicular toxicity induced by doxorubicin in rats: role of oxidative stress, apoptosis and TGF-β1/NF-κB signaling. Biomed Pharmacother. 2018;97:439–449. doi:10.1016/j.biopha.2017.10.14429091894
  • Swamy AV, Gulliaya S, Thippeswamy A, Koti BC, Manjula DV. Cardioprotective effect of curcumin against doxorubicin-induced myocardial toxicity in albino rats. Indian J Pharmacol. 2012;44(1):73–77. doi:10.4103/0253-7613.9187122345874
  • Na F, Zhang J, Liang C, Ma J, Zhou B, Wang J. Changes in testis protein and metabolic enzyme activities in rats induced changes in testis protein and metabolic enzyme activities in rats induced by sodium fluoride and sulfur dioxide. Res Report Fluoride. 2006;39(3):179–184.
  • Zhang X, Zhang Z, Zhao Y, et al. Alogliptin, a dipeptidyl peptidase-4 inhibitor, alleviates atrial remodeling and improves mitochondrial function and biogenesis in diabetic rabbits. J Am Heart Assoc. 2017;6:e005945. doi:10.1161/JAHA.117.00594528507060
  • Mishra. Doxorubicin mediated oxidative stress induced degeneration of testicular tissues causes male sterility in rats. J Cell Tissue Res. 2007;7(1):861–866.
  • Mizutani H, Tada-Oikawa S, Hiraku Y, Kojima M, Kawanishi S. Mechanism of apoptosis induced by doxorubicin through the generation of hydrogen peroxide. Life Sci. 2005;76(13):1439–1453. doi:10.1016/j.lfs.2004.12.01015680309
  • Hozayen WG. Effect of hesperidin and rutin on doxorubicin induced testicular toxicity in male rats. Int J Food Nutr Sci. 2012;1:31–42.
  • Nuransoy A, Beytur A, Polat A, Samdanci E, Sagir M, Parlakpinar H. Renal Failure Protective effect of sitagliptin against renal ischemia reperfusion injury in rats Protective effect of sitagliptin against renal ischemia reperfusion injury in rats. Ren Fail. 2015;37(4):687–693. doi:10.3109/0886022X.2015.101099125703705
  • Bao W, Morimoto K, Hasegawa T, et al. Orally administered dipeptidyl peptidase-4 inhibitor (alogliptin) prevents abdominal aortic aneurysm formation through an antioxidant effect in rats. J Vasc Surg. 2014;59(4):1098–1108. doi:10.1016/j.jvs.2013.04.04823790558
  • Steven S, Münzel T, Daiber A. Exploiting the pleiotropic antioxidant effects of established drugs in cardiovascular disease. Int J Mol Sci. 2015;16:18185–18223 p. doi:10.3390/ijms16081818526251902
  • Farombi EO, Adedara IA, Akinrinde SA, Ojo OO, Eboh AS. Protective effects of kolaviron and quercetin on cadmium-induced testicular damage and endocrine pathology in rats. Andrologia. 2012;44(4):273–284. doi:10.1111/j.1439-0272.2012.01279.x22356231
  • Prabu SM, Shagirtha K, Renugadevi J. Amelioration of cadmium-induced oxidative stress, impairment in lipids and plasma lipoproteins by the combined treatment with quercetin and α-tocopherol in rats. J Food Sci. 2010;75(7):T132–40. doi:10.1111/j.1750-3841.2010.01757.x21535577