Genipin Induces Autophagy and Suppresses Cell Growth of Oral Squamous Cell Carcinoma via PI3K/AKT/MTOR Pathway

References

• IshidaK, TomitaH, NakashimaT, et al. Current mouse models of oral squamous cell carcinoma: genetic and chemically induced models. Oral Oncol. 2017;73:16. doi:10.1016/j.oraloncology.2017.07.02828939069
   PubMed Web of Science ®Google Scholar
• BHK, CWS, JKC, et al. HSPD1 repressed E-cadherin expression to promote cell invasion and migration for poor prognosis in oral squamous cell carcinoma. Sci Rep. 2019;9(1):8932. doi:10.1038/s41598-019-45489-131222140
   PubMed Web of Science ®Google Scholar
• AriyoshiY, ShimaharaM, OmuraK, et al. Epidemiological study of malignant tumors in the oral and maxillofacial region: survey of member institutions of the Japanese society of oral and maxillofacial surgeons, 2002. Int J Clin Oncol. 2008;13(3):220–228. doi:10.1007/s10147-007-0756-918553231
   PubMed Web of Science ®Google Scholar
• PrasadG, McculloughM. Chemokines and cytokines as salivary biomarkers for the early diagnosis of oral cancer. Int J Dent. 2013;2013:813756. doi:10.1155/2013/81375624376459
   PubMedGoogle Scholar
• FuTY, HouYY, ChuST, et al. Manganese superoxide dismutase and glutathione peroxidase as prognostic markers in patients with buccal mucosal squamous cell carcinomas. Head Neck. 2011;33(11):1606–1615. doi:10.1002/hed.2165321990225
   PubMed Web of Science ®Google Scholar
• WarnakulasuriyaS. Living with oral cancer: epidemiology with particular reference to prevalence and life-style changes that influence survival. Oral Oncol. 2010;46(6):407–410. doi:10.1016/j.oraloncology.2010.02.01520403722
   PubMed Web of Science ®Google Scholar
• SongW, TangY, QiaoJ, et al. The short-term safety evaluation of corneal crosslinking agent- genipin. Ophthalmic Res. 2019;62(3):141–149. doi:10.1159/00049957131112970
   PubMed Web of Science ®Google Scholar
• LiY, PanH, LiX, et al. Role of intestinal microbiota-mediated genipin dialdehyde intermediate formation in geniposide-induced hepatotoxicity in rats. Toxicol Appl Pharmacol. 2019;15(377):114624. doi:10.1016/j.taap.2019.114624
   Web of Science ®Google Scholar
• SomersP, DeSF, CornelissenM, et al. Genipin blues: an alternative non-toxic crosslinker for heart valves? J Heart Valve Dis. 2008;17(6):682–688.19137802
   PubMed Web of Science ®Google Scholar
• InaoM, MochidaS, MatsuiA, et al. Japanese herbal medicine Inchin-ko-to as a therapeutic drug for liver fibrosis. J Hepatol. 2004;41(4):584–591. doi:10.1016/j.jhep.2004.06.03315464238
   PubMed Web of Science ®Google Scholar
• LeeSY, KimHJ, OhSC, LeeDH. Genipin inhibits the invasion and migration of colon cancer cells by the suppression of HIF-1alpha accumulation and VEGF expression. Food Chem Toxicol. 2018;116(Pt B):70–76. doi:10.1016/j.fct.2018.04.00529630948
   PubMed Web of Science ®Google Scholar
• YeJ, LiJ, WangX, LiL. Medicinal supplement genipin induces p53 and Bax-dependent apoptosis in colon cancer cells. Oncol Lett. 2018;16(3):2957–2964. doi:10.3892/ol.2018.902530127884
   PubMed Web of Science ®Google Scholar
• KimBR, JeongYA, NaYJ, et al. Genipin suppresses colorectal cancer cells by inhibiting the sonic hedgehog pathway. Oncotarget. 2017;8(60):101952–101964. doi:10.18632/oncotarget.2188229254217
   PubMedGoogle Scholar
• HennessyBT, SmithDL, RamPT, LuY, MillsGB. Exploiting the PI3K/AKT pathway for cancer drug discovery. Nat Rev Drug Discov. 2005;4(12):988–1004. doi:10.1038/nrd190216341064
   PubMed Web of Science ®Google Scholar
• CarneroA, Blanco-AparicioC, RennerO, LinkW, LealJF. The PTEN/PI3K/AKT signalling pathway in cancer, therapeutic implications. Curr Cancer Drug Targets. 2008;8(3):187–198. doi:10.2174/15680090878429365918473732
   PubMed Web of Science ®Google Scholar
• JimenezC, HernandezC, PimentelB, CarreraAC. The p85 regulatory subunit controls sequential activation of phosphoinositide 3-kinase by Tyr kinases and ras. J Biol Chem. 2002;277:41556–41562. doi:10.1074/jbc.M20589320012196526
   PubMed Web of Science ®Google Scholar
• DuranI, KortmanskyJ, SinghD, et al. A Phase II clinical and pharmacodynamic study of temsirolimus in advanced neuroendocrine carcinomas. Br J Cancer. 2006;95:1148–1154. doi:10.1038/sj.bjc.660341917031397
   PubMed Web of Science ®Google Scholar
• MuruganAK, MunirajanAK, TsuchidaN. Genetic deregulation of the PIK3CA oncogene in oral cancer. Cancer Lett. 2013;338(2):193–203. doi:10.1016/j.canlet.2013.04.00523597702
   PubMed Web of Science ®Google Scholar
• KimBR, JeongYA, NaYJ, et al. Genipin inhibits the growth of human bladder cancer cells via inactivation of PI3K/Akt signaling. Oncotarget. 2017;8(60):101952–101964. doi:10.18632/oncotarget.2188229254217
   PubMedGoogle Scholar
• OmuraK. Current status of oral cancer treatment strategies: surgical treatments for oral squamous cell carcinoma. Int J Clin Oncol. 2014;19(3):423. doi:10.1007/s10147-014-0689-z24682763
   PubMed Web of Science ®Google Scholar
• PhilipsR, MartinD, EskanderA, et al. Effect of adjuvant radiotherapy treatment center volume on overall survival. Oral Oncol. 2018;78:46–51. doi:10.1016/j.oraloncology.2018.01.00429496057
   PubMed Web of Science ®Google Scholar
• HaJ, SungIY, SonJH, StoneM, OrdR, ChoYC. Analysis of speech and tongue motion in normal and post-glossectomy speaker using cine MRI. J Appl Oral Sci. 2016;24(5):472–480. doi:10.1590/1678-77572015042127812617
   PubMed Web of Science ®Google Scholar
• SroussiHY, EpsteinJB, BensadounRJ, et al. Common oral complications of head and neck cancer radiation therapy: mucositis, infections, saliva change, fibrosis, sensory dysfunctions, dental caries, periodontal disease, and osteoradionecrosis. Cancer Med. 2017;6(12). doi:10.1002/cam4.1221
   PubMed Web of Science ®Google Scholar
• KakoeiS, HaghdoostAA, RadM, et al. Xerostomia after radiotherapy and its effect on quality of life in head and neck cancer patients. Arch Iran Med. 2012;15(4):214–218.22424038
   PubMed Web of Science ®Google Scholar
• NystHJ, TanIB, StewartFA, BalmAJ. Is photodynamic therapy a good alternative to surgery and radiotherapy in the treatment of head and neck cancer? Photodiagnosis Photodyn Ther. 2009;6(1):3–11. doi:10.1016/j.pdpdt.2009.03.00219447366
   PubMed Web of Science ®Google Scholar
• LiZheng, ZhangT-B, JiaD-H, et al. Genipin inhibits the growth of human bladder cancer cells via inactivation of PI3K/Akt signaling. Oncol Lett. 2018;15(2):2619–2624. doi:10.3892/ol.2017.758829434982
   PubMed Web of Science ®Google Scholar
• JiangF, JiangR, ZhuX, ZhangX, ZhanZ. Genipin inhibits TNF-alpha-induced vascular smooth muscle cell proliferation and migration via induction of HO-1. PLoS One. 2013;8(8):e74826. doi:10.1371/journal.pone.007482624013271
   PubMed Web of Science ®Google Scholar
• KoH, KimJM, KimSJ, ShimSH, HaCH, ChangHI. Induction of apoptosis by genipin inhibits cell proliferation in AGS human gastric cancer cells via Egr1/p21 signaling pathway. Bioorg Med Chem Lett. 2015;25(19):4191–4196. doi:10.1016/j.bmcl.2015.08.00526283511
   PubMed Web of Science ®Google Scholar
• KimES, JeongCS, MoonA. Genipin, a constituent of gardenia jasminoides ellis, induces apoptosis and inhibits invasion in MDA-MB-231 breast cancer cells. Oncol Rep. 2012;27(2):567–572. doi:10.3892/or.2011.150822020372
   PubMed Web of Science ®Google Scholar
• KroemerG, LevineB. Autophagic cell death: the story of a misnomer. Nat Rev Mol Cell Biol. 2008;9:1004–1010. doi:10.1038/nrm252918971948
   PubMed Web of Science ®Google Scholar
• BialikS, DasariSK, KimchiA. Autophagy-dependent cell death-where, how and why a cell eats itself to death. J Cell Sci. 2018;131:jcs215152. doi:10.1242/jcs.21515230237248
   PubMed Web of Science ®Google Scholar
• KimKH, LeeMS. Autophagy-a key player in cellular and body meta bolism. Nat Rev Endocrinol. 2014;10:322–337. doi:10.1038/nrendo.2014.3524663220
   PubMed Web of Science ®Google Scholar
• KinarivalaN, PatelR, BoustanyR-M, Al-AhmadA, TrippierPC. Discovery of aromatic carbamates that confer neuroprotective activity by enhancing autophagy and inducing the anti-apoptotic protein B-cell lymphoma 2 (Bcl-2). J Med Chem. 2017;60(23):9739–9756. doi:10.1021/acs.jmedchem.7b0119929110485
   PubMed Web of Science ®Google Scholar
• EdiriweeraMK, TennekoonKH, SamarakoonSR. Role of the PI3K/AKT/mTOR signaling pathway in ovarian cancer: biological and therapeutic significance. Semin Cancer Biol. 2019;59:147–160. doi:10.1016/j.semcancer.2019.05.01231128298
   PubMed Web of Science ®Google Scholar
• WangH, DengX, ZhangJ, et al. Elevated expression of zinc finger protein 703 promotes cell proliferation and metastasis through PI3K/AKT/GSK-3beta signalling in oral squamous cell carcinoma. Cell Physiol Biochem. 2017;44(3):920–934. doi:10.1159/00048536029176314
   PubMedGoogle Scholar
• Vander BroekR, MohanS, EytanDF, ChenZ, Van WaesC. The PI3K/Akt/mTOR axis in head and neck cancer: functions, aberrations, cross-talk, and therapies. Oral Dis. 2015;21(7):815–825. doi:10.1111/odi.2015.21.issue-724219320
   PubMed Web of Science ®Google Scholar
• RizzoG, BlackM, MymrykJS, BarrettJW, NicholsAC. Defining the genomic landscape of head and neck cancers through next-generation sequencing. Oral Dis. 2015;21(1):e11–e24. doi:10.1111/odi.2014.21.issue-124725020
   PubMed Web of Science ®Google Scholar
• ProdromidisG, NikitakisNG, SklavounouA. Immunohistochemical analysis of the activation status of the Akt/mTOR/pS6 signaling pathway in oral lichen planus. Int J Dent. 2013;2013(4):743456. doi:10.1155/2013/74345624228033
   PubMedGoogle Scholar
• SonisST, Amaral MendesR. Could the PI3K canonical pathway be a common link between chronic inflammatory conditions and oral carcinogenesis? J Oral Pathol Med. 2016;45(7):469–474. doi:10.1111/jop.1243626991523
   PubMed Web of Science ®Google Scholar