344
Views
18
CrossRef citations to date
0
Altmetric
Original Research

Coenzyme q10 liquid supplementation in dyslipidemic subjects with statin-related clinical symptoms: a double-blind, randomized, placebo-controlled study

, &
Pages 3647-3655 | Published online: 21 Oct 2019

References

  • Kaikkonen J, Nyyssönen K, Tuomainen TP, Ristonmaa U, Salonen JT. Determinants of plasma coenzyme Q10 in humans. FEBS Lett. 1999;443:163–166. doi:10.1016/s0014-5793(98)01712-89989597
  • Lockwood K, Moesgaard S, Yamamoto T, Folkers K. Progress on therapy of breast cancer with vitamin Q10 and the regression of metastases. Biochem Biophys Res Commun. 1995;212:172–177. doi:10.1006/bbrc.1995.19527612003
  • Soja AM, Mortensen SA. Treatment of congestive heart failure with coenzyme Q10 illuminated by meta-analyses of clinical trials. Mol Aspects Med. 1997;18:s159–s168. doi:10.1016/S0098-2997(97)00042-39266518
  • Ogasahara S, Engel AG, Frens D, Mack D. Muscle coenzyme Q deficiency in familial mitochondrial encephalomyopathy. Proc Natl Acad Sci USA. 1989;86:2379–2382. doi:10.1073/pnas.86.7.23792928337
  • Folkers K, Langsjoen P, Willis R, et al. Lovastatin decreases coenzyme Q levels in humans. Proc Natl Acad Sci USA. 1990;87:8931–8934. doi:10.1073/pnas.87.22.89312247468
  • Päivä H, Thelen KM, Van Coster R, et al. High-dose statins and skeletal muscle metabolism in humans: a randomized, controlled trial. Clin Pharmacol Ther. 2005;78:60–68. doi:10.1016/j.clpt.2005.03.00616003294
  • Folkers K, Vadhanavikit S, Mortensen SA. Biochemical rationale and myocardial tissue data on the effective therapy of cardiomyopathy with coenzyme Q10. Proc Natl Acad Sci USA. 1985;82:901–904. doi:10.1073/pnas.82.3.9013856239
  • Deichmann R, Lavie C, Andrews S, Ochsner J. Coenzyme q10 and statin-induced mitochondrial dysfunction. Ochsner J. 2010;10(1):16–21.21603349
  • Derosa G, D’Angelo A, Franzetti IG, et al. Efficacy and safety of ezetimibe/simvastatin association on non-diabetic and diabetic patients with polygenic hypercholesterolemia or combined hyperlipidemia and previously intolerant to standard statin treatment. J Clin Pharm Ther. 2009;34(3):267–276.19650249
  • Derosa G, Romano D, D’Angelo A, Maffioli P. Berberis aristata combined with Silybum marianum on lipid profile in patients not tolerating statins at high doses. Atherosclerosis. 2015;239(1):87–92. doi:10.1016/j.atherosclerosis.2014.12.04325577665
  • Harper CR, Jacobsen TA. Evidence-based management of statin myopathy. Curr Atheroscler Rep. 2010;12(5):322–330. doi:10.1007/s11883-010-0120-920628837
  • Rosenson RS, Baker SK, Jacobson TA, Kopecky SL, Parker BA. The national lipid association’s muscle safety expert panel. an assessment by the statin muscle safety task force: 2014 update. J Clin Lipidol. 2014;8(3 Suppl):S58–S71. doi:10.1016/j.jacl.2014.03.00424793443
  • Chopra RK, Goldman R, Sinatra SP, Bhagavan HN. Relative bioavailability of Coenzyme Q10 formulations in human subjects. Int J Nutr Res. 1998;68:109–113.
  • Miles MV, Horn P, Miles L, Tang P, Steele P, DeGrauw T. Bioequivalence of coenzyme Q10 from over-the-counter supplements. Nutr Res. 2002;919–929. doi:10.1016/S0271-5317(02)00402-5
  • Zmitek J, Smidovnik A, Fir M, et al. Relative bioavailability of two forms of a novel water-soluble coenzyme Q10. Ann Nutr Metab. 2008;52(4):281–287. doi:10.1159/00012966118645245
  • Beg S, Javed S, Kohli K. Bioavailability enhancement of coenzyme Q10: an extensive review of patents. Recent Pat Drug Deliv Formul. 2010;4(3):245–255.20863275
  • Klose S, Borner K. Enzymatische Bestimmung des Gesamtcholesterins mit dem [Enzymatic dosage of total cholesterolemia by Greiner Selective Analyzer (GSA II)]. J Clin Chem Clin Biochem. 1978;15:121–130.
  • Wahlefeld AW. Triglycerides determination after enzymatic hydrolysis In: Bergmeyer HU, editor. Methods of Enzymatic Analysis. 2nd ed. New York: Academic Press; 1974:18–31.
  • Havel RJ, Eder HA, Bragdon JH. The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. J Clin Invest. 1955;34:1345–1353. doi:10.1172/JCI10318213252080
  • Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low density lipoprotein in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972;18:499–502.4337382
  • Tang PH, Miles MV, DeGrauw A, Hershey A, Pesce A. HPLC analysis of reduced and oxidized coenzyme Q(10) in human plasma. Clin Chem. 2001;47(2):256–265.11159774
  • Winer BJ. Statistical Principles in Experimental Design. 2nd ed. New York (USA): McGraw-Hill; 1971.
  • Qu H, Guo M, Chai H, Wang WT, Gao ZY, Shi DZ. Effects of coenzyme Q10 on statin-induced myopathy: an updated meta-analysis of randomized controlled trials. J Am Heart Assoc. 2018;7(19):e009835. doi:10.1161/JAHA.118.00852830371340
  • Caso G, Kelly P, McNurlan MA, Lawson WE. Effect of coenzyme Q10 on myopathic symptoms in patients treated with statins. Am J Cardiol. 2007;99:1409–1412. doi:10.1016/j.amjcard.2006.12.06317493470
  • Fedacko J, Pella D, Fedackova P, et al. Coenzyme Q10 and selenium in statin-associated myopathy treatment. Can J Physiol Pharmacol. 2013;91:165–170. doi:10.1139/cjpp-2012-011823458201
  • Skarlovnik A, Janic M, Lunder M, Turk M, Sabovic M. Coenzyme Q10 supplementation decreases statin-related mild-to-moderate muscle symptoms: a randomized clinical study. Med Sci Monit. 2014;20:2183–2188. doi:10.12659/MSM.89077725375075
  • Toth S, Sajty M, Pekarova T, et al. Addition of omega-3 fatty acid and coenzyme Q10 to statin therapy in patients with combined dyslipidemia. J Basic Clin Physiol Pharmacol. 2017;28:327–336. doi:10.1515/jbcpp-2016-014928541926
  • Banach M, Serban C, Ursoniu S, et al. Statin therapy and plasma coenzyme Q10 concentrations: a systematic review and meta-analysis of placebo-controlled trials. Pharmacol Res. 2015;99:329–336. doi:10.1016/j.phrs.2015.07.00826192349
  • Qu H, Meng YY, Chai H, et al. The effect of statin treatment on circulating coenzyme Q10 concentrations: an updated meta-analysis of randomized controlled trials. Eur J Med Res. 2018;23(1):57. doi:10.1186/s40001-018-0306-030414615
  • Mikashinovich ZI, Belousova ES, Sarkisyan OG. Impairment of energy dependent processes in the muscle tissue as a pathogenetic mechanism of statin-induced myopathy. Bull Exp Biol Med. 2017;162:433–435. doi:10.1007/s10517-017-3633-128239789
  • Farsi F, Mohammadshahi M, Alavinejad P, Rezazadeh A, Zarei M, Engali KA. Functions of coenzyme Q10 supplementation on liver enzymes, markers of systemic inflammation, and adipokines in patients affected by nonalcoholic fatty liver disease: a double-blind, placebo-controlled, randomized clinical trial. J Am Coll Nutr. 2016;35(4):346–353. doi:10.1080/07315724.2015.102105726156412
  • Keogh A, Fenton S, Leslie C, et al. Randomised double-blind, placebo-controlled trial of coenzyme Q, therapy in class II and III systolic heart failure. Heart Lung Circ. 2003;12(3):135–141.18705154
  • Belardinelli R, Muçaj A, Lacalaprice F, et al. Coenzyme Q10 improves contractility of dysfunctional myocardium in chronic heart failure. Biofactors. 2005;25(1–4):137–145.16873938
  • Marrs JC, Kostoff MD. Discontinuation of statins: what are the risks? Curr Atheroscler Rep. 2016;18(7):41. doi:10.1007/s11883-016-0596-z27221503
  • Young JM, Molyneux SL, Reinheimer AM, et al. Relationship between plasma coenzyme Q10, asymmetric dimethylarginine and arterial stiffness in patients with phenotypic or genotypic familial hypercholesterolemia on long-term statin therapy. Atherosclerosis. 2011;218(1):188–193. doi:10.1016/j.atherosclerosis.2011.04.03421640350
  • Larijani VN, Ahmadi N, Zeb I, Khan F, Flores F, Budoff M. Beneficial effects of aged garlic extract and coenzyme Q10 on vascular elasticity and endothelial function: the FAITH randomized clinical trial. Nutrition. 2013;29(1):71–75. doi:10.1016/j.nut.2012.03.01622858191
  • Hodgson JM, Watts GF, Playford DA, Burke V, Croft KD. Coenzyme Q10 improves blood pressure and glycaemic control: a controlled trial in subjects with type 2 diabetes. Eur J Clin Nutr. 2002;56(11):1137–1142. doi:10.1038/sj.ejcn.160146412428181
  • Singh RB, Niaz MA, Rastogi SS, Shukla PK, Thakur AS. Effect of hydrosoluble coenzyme Q10 on blood pressures and insulin resistance in hypertensive patients with coronary artery disease. J Hum Hypertens. 1999;13(3):203–208.10204818
  • Jorat MV, Tabrizi R, Mirhosseini N, et al. The effects of coenzyme Q10 supplementation on lipid profiles among patients with coronary artery disease: a systematic review and meta-analysis of randomized controlled trials. Lipids Health Dis. 2018;17(1):230. doi:10.1186/s12944-018-0876-430296936