Curcumin Attenuates Oxaliplatin-Induced Liver Injury and Oxidative Stress by Activating the Nrf2 Pathway

References

• BaiX, ChenY, HouX, HuangM, JinJ. Emerging role of NRF2 in chemoresistance by regulating drug-metabolizing enzymes and efflux transporters. Drug Metab Rev. 2016;48(4):541–567. doi:10.1080/03602532.2016.119723927320238
   PubMed Web of Science ®Google Scholar
• RiddellIA. Cisplatin and oxaliplatin: our current understanding of their actions. Met Ions Life Sci. 2018;18. doi:10.1515/9783110470734-007
   PubMedGoogle Scholar
• JardimDL, RodriguesCA, NovisYA, RochaVG, HoffPM. Oxaliplatin-related thrombocytopenia. Ann Oncol. 2012;23(8):1937–1942. doi:10.1093/annonc/mds07422534771
   PubMed Web of Science ®Google Scholar
• Rubbia-BrandtL, LauwersGY, WangH, et al. Sinusoidal obstruction syndrome and nodular regenerative hyperplasia are frequent oxaliplatin-associated liver lesions and partially prevented by bevacizumab in patients with hepatic colorectal metastasis. Histopathology. 2010;56(4):430–439. doi:10.1111/j.1365-2559.2010.03511.x20459550
   PubMed Web of Science ®Google Scholar
• Rubbia-BrandtL, AudardV, SartorettiP, et al. Severe hepatic sinusoidal obstruction associated with oxaliplatin-based chemotherapy in patients with metastatic colorectal cancer. Ann Oncol. 2004;15(3):460–466. doi:10.1093/annonc/mdh09514998849
   PubMed Web of Science ®Google Scholar
• VautheyJN, PawlikTM, RiberoD, et al. Chemotherapy regimen predicts steatohepatitis and an increase in 90-day mortality after surgery for hepatic colorectal metastases. J Clin Oncol. 2006;24(13):2065–2072. doi:10.1200/JCO.2005.05.307416648507
   PubMed Web of Science ®Google Scholar
• NakanoH, OussoultzoglouE, RossoE, et al. Sinusoidal injury increases morbidity after major hepatectomy in patients with colorectal liver metastases receiving preoperative chemotherapy. Ann Surg. 2008;247(1):118–124. doi:10.1097/SLA.0b013e31815774de18156931
   PubMed Web of Science ®Google Scholar
• TamandlD, KlingerM, EipeldauerS, et al. Sinusoidal obstruction syndrome impairs long-term outcome of colorectal liver metastases treated with resection after neoadjuvant chemotherapy. Ann Surg Oncol. 2011;18(2):421–430. doi:10.1245/s10434-010-1317-420844968
   PubMed Web of Science ®Google Scholar
• TajimaH, OhtaT, MiyashitaT, et al. Oxaliplatin-based chemotherapy induces extravasated platelet aggregation in the liver. Mol Clin Oncol. 2015;3(3):555–558. doi:10.3892/mco.2015.51226137266
   PubMedGoogle Scholar
• RobinsonSM, MannJ, VasilakiA, et al. Pathogenesis of FOLFOX induced sinusoidal obstruction syndrome in a murine chemotherapy model. J Hepatol. 2013;59(2):318–326. doi:10.1016/j.jhep.2013.04.01423624001
   PubMed Web of Science ®Google Scholar
• de AndradeKQ, MouraFA, dos SantosJM, de AraujoOR, de Farias SantosJC, GoulartMO. Oxidative stress and inflammation in hepatic diseases: therapeutic possibilities of N-Acetylcysteine. Int J Mol Sci. 2015;16(12):30269–30308. doi:10.3390/ijms16122622526694382
   PubMed Web of Science ®Google Scholar
• LinY, LiY, HuX, et al. The hepatoprotective role of reduced glutathione and its underlying mechanism in oxaliplatin-induced acute liver injury. Oncol Lett. 2018;15(2):2266–2272. doi:10.3892/ol.2017.759429403564
   PubMed Web of Science ®Google Scholar
• ZouX, WangY, PengC, et al. Magnesium isoglycyrrhizinate has hepatoprotective effects in an oxaliplatininduced model of liver injury. Int J Mol Med. 2018;42(4):2020–2030. doi:10.3892/ijmm.2018.378730066834
   PubMed Web of Science ®Google Scholar
• SchwingelTE, KleinCP, NicolettiNF, et al. Effects of the compounds resveratrol, rutin, quercetin, and quercetin nanoemulsion on oxaliplatin-induced hepatotoxicity and neurotoxicity in mice. Naunyn Schmiedebergs Arch Pharmacol. 2014;387(9):837–848. doi:10.1007/s00210-014-0994-024908156
   PubMed Web of Science ®Google Scholar
• ZanguiM, AtkinSL, MajeedM, SahebkarA. Current evidence and future perspectives for curcumin and its analogues as promising adjuncts to oxaliplatin: state-of-the-art. Pharmacol Res. 2019;141:343–356. doi:10.1016/j.phrs.2019.01.02030641277
   PubMed Web of Science ®Google Scholar
• GoelA, AggarwalBB. Curcumin, the golden spice from Indian saffron, is a chemosensitizer and radiosensitizer for tumors and chemoprotector and radioprotector for normal organs. Nutr Cancer. 2010;62(7):919–930. doi:10.1080/01635581.2010.50983520924967
   PubMed Web of Science ®Google Scholar
• LeeHS, LiL, KimHK, et al. The protective effects of Curcuma longa Linn. extract on carbon tetrachloride-induced hepatotoxicity in rats via upregulation of Nrf2. J Microbiol Biotechnol. 2010;20(9):1331–1338. doi:10.4014/jmb.1002.0301020890099
   PubMed Web of Science ®Google Scholar
• YuC, MeiXT, ZhengYP, XuDH. Zn(II)-curcumin protects against hemorheological alterations, oxidative stress and liver injury in a rat model of acute alcoholism. Environ Toxicol Pharmacol. 2014;37(2):729–737. doi:10.1016/j.etap.2014.02.01124607687
   PubMed Web of Science ®Google Scholar
• QiuP, SunJ, ManS, et al. Curcumin attenuates N-nitrosodiethylamine-induced liver injury in mice by utilizing the method of metabonomics. J Agric Food Chem. 2017;65(9):2000–2007. doi:10.1021/acs.jafc.6b0479728198625
   PubMed Web of Science ®Google Scholar
• GaoS, DuanX, WangX, et al. Curcumin attenuates arsenic-induced hepatic injuries and oxidative stress in experimental mice through activation of Nrf2 pathway, promotion of arsenic methylation and urinary excretion. Food Chem Toxicol. 2013;59:739–747. doi:10.1016/j.fct.2013.07.03223871787
   PubMed Web of Science ®Google Scholar
• CavaleriF. Presenting a new standard drug model for turmeric and its prized extract, curcumin. Int J Inflam. 2018;2018:5023429. doi:10.1155/2018/502342929568482
   PubMed Web of Science ®Google Scholar
• LuoDD, ChenJF, LiuJJ, et al. Tetrahydrocurcumin and octahydrocurcumin, the primary and final hydrogenated metabolites of curcumin, possess superior hepatic-protective effect against acetaminophen-induced liver injury: role of CYP2E1 and Keap1-Nrf2 pathway. Food Chem Toxicol. 2019;123:349–362. doi:10.1016/j.fct.2018.11.01230423402
   PubMed Web of Science ®Google Scholar
• Said SalemNI, NoshyMM, SaidAA. Modulatory effect of curcumin against genotoxicity and oxidative stress induced by cisplatin and methotrexate in male mice. Food Chem Toxicol. 2017;105:370–376. doi:10.1016/j.fct.2017.04.00728428088
   PubMed Web of Science ®Google Scholar
• ChenJ, ChungDW. Inflammation, von Willebrand factor, and ADAMTS13. Blood. 2018;132(2):141–147. doi:10.1182/blood-2018-02-76900029866815
   PubMed Web of Science ®Google Scholar
• El ChediakA, HaydarAA, HakimA, et al. Increase in spleen volume as a predictor of oxaliplatin toxicity. Ther Clin Risk Manag. 2018;14:653–657. doi:10.2147/TCRM29695909
   PubMed Web of Science ®Google Scholar
• KangJ, ParkJS, AhnSG, et al. Protective effect of Korean red ginseng on oxaliplatin-mediated splenomegaly in colon cancer. Ann Surg Treat Res. 2018;95(3):161–167. doi:10.4174/astr.2018.95.3.16130182023
   PubMed Web of Science ®Google Scholar
• ImaiK, EmiY, IyamaKI, et al. Splenic volume may be a useful indicator of the protective effect of bevacizumab against oxaliplatin-induced hepatic sinusoidal obstruction syndrome. Eur J Surg Oncol. 2014;40(5):559–566. doi:10.1016/j.ejso.2013.12.00924388740
   PubMed Web of Science ®Google Scholar
• OvermanMJ, MaruDM, CharnsangavejC, et al. Oxaliplatin-mediated increase in spleen size as a biomarker for the development of hepatic sinusoidal injury. J Clin Oncol. 2010;28(15):2549–2555. doi:10.1200/JCO.2009.27.570120406923
   PubMed Web of Science ®Google Scholar
• JadejaRN, UpadhyayKK, DevkarRV, KhuranaS. Naturally occurring Nrf2 activators: potential in treatment of liver injury. Oxid Med Cell Longev. 2016;2016:3453926. doi:10.1155/2016/345392628101296
   PubMed Web of Science ®Google Scholar
• KweekelDM, GelderblomH, GuchelaarHJ. Pharmacology of oxaliplatin and the use of pharmacogenomics to individualize therapy. Cancer Treat Rev. 2005;31(2):90–105. doi:10.1016/j.ctrv.2004.12.00615847979
   PubMed Web of Science ®Google Scholar
• BuldakRJ, BuldakL, KuklaM, GabrielA, Zwirska-KorczalaK. Significance of selected antioxidant enzymes in cancer cell progression. Pol J Pathol. 2014;65(3):167–175. doi:10.5114/pjp.2014.4577925372413
   PubMed Web of Science ®Google Scholar
• ChenZ, MaX, ZhuY, et al. Paeoniflorin ameliorates ANIT-induced cholestasis by activating Nrf2 through an PI3K/Akt-dependent pathway in rats. Phytother Res. 2015;29(11):1768–1775. doi:10.1002/ptr.v29.1126269092
   PubMed Web of Science ®Google Scholar
• YuanL, KaplowitzN. Glutathione in liver diseases and hepatotoxicity. Mol Aspects Med. 2009;30(1–2):29–41. doi:10.1016/j.mam.2008.08.00318786561
   PubMed Web of Science ®Google Scholar
• FuY, ZhengS, LinJ, RyerseJ, ChenA. Curcumin protects the rat liver from CCl4-caused injury and fibrogenesis by attenuating oxidative stress and suppressing inflammation. Mol Pharmacol. 2008;73(2):399–409. doi:10.1124/mol.107.03981818006644
   PubMed Web of Science ®Google Scholar
• BattinelliEM, MarkensBA, ItalianoJE Jr. Release of angiogenesis regulatory proteins from platelet alpha granules: modulation of physiologic and pathologic angiogenesis. Blood. 2011;118(5):1359–1369. doi:10.1182/blood-2011-02-33452421680800
   PubMed Web of Science ®Google Scholar
• AnandP, KunnumakkaraAB, NewmanRA, AggarwalBB. Bioavailability of curcumin: problems and promises. Mol Pharm. 2007;4(6):807–818. doi:10.1021/mp700113r17999464
   PubMed Web of Science ®Google Scholar
• BoarescuPM, ChirilaI, BulboacaAE, et al. Effects of curcumin nanoparticles in isoproterenol-induced myocardial infarction. Oxid Med Cell Longev. 2019;2019:7847142. doi:10.1155/2019/7847142. eCollection 2019.31205590
   PubMed Web of Science ®Google Scholar
• MohajeriM, SadeghizadehM, NajafiF, JavanM. Polymerized nano-curcumin attenuates neurological symptoms in EAE model of multiple sclerosis through down regulation of inflammatory and oxidative processes and enhancing neuroprotection and myelin repair. Neuropharmacology. 2015;99:156–167. doi:10.1016/j.neuropharm.2015.07.01326211978
   PubMed Web of Science ®Google Scholar
• Jalili-NikM, SoltaniA, MoussaviS, et al. Current status and future prospective of Curcumin as a potential therapeutic agent in the treatment of colorectal cancer. J Cell Physiol. 2018;233(9):6337–6345. doi:10.1002/jcp.26368
   PubMed Web of Science ®Google Scholar