Advanced search
Publication Cover
Drug Design, Development and Therapy Volume 13, 2019 - Issue
Submit an article Journal homepage
427
Views
69
CrossRef citations to date
0
Altmetric
Original Research

Pharmacokinetics and Safety of Esketamine in Chinese Patients Undergoing Painless Gastroscopy in Comparison with Ketamine: A Randomized, Open-Label Clinical Study

Jing Wang1 Center for Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha, Hunan410013, People’s Republic of China;2 Department of Pharmacy, The Third Xiangya Hospital, Central South University, Changsha, Hunan410013, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0003-3218-4265
ORCID Icon,
Jie Huang1 Center for Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha, Hunan410013, People’s Republic of China;3 Clinical Trails Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan410013, People’s Republic of China
,
Shuang Yang1 Center for Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha, Hunan410013, People’s Republic of China;3 Clinical Trails Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan410013, People’s Republic of China
,
Chang Cui1 Center for Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha, Hunan410013, People’s Republic of China;3 Clinical Trails Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan410013, People’s Republic of China
,
Ling Ye1 Center for Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha, Hunan410013, People’s Republic of China;3 Clinical Trails Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan410013, People’s Republic of China
,
Sai-ying Wang4 Department of Anesthesiology, The Third Xiangya Hospital, Central South University, Changsha, Hunan410013, People’s Republic of China
,
Guo-ping Yang1 Center for Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha, Hunan410013, People’s Republic of China;3 Clinical Trails Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan410013, People’s Republic of ChinaCorrespondence[email protected] [email protected]
ORCID Iconhttps://orcid.org/0000-0001-5930-586X
ORCID Icon &
Qi Pei1 Center for Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha, Hunan410013, People’s Republic of China;2 Department of Pharmacy, The Third Xiangya Hospital, Central South University, Changsha, Hunan410013, People’s Republic of China
 show all
Pages 4135-4144 | Published online: 06 Dec 2019

References

  • Domino EF, Chodoff P, Corssen G. Pharmacologic effects of CI-581, a new dissociative anesthetic, in man. Clin Pharmacol Ther. 1965;6:279–291. doi:10.1002/cpt19656327914296024
  • Mion G, Villevieille T. Ketamine pharmacology: an update (pharmacodynamics and molecular aspects, recent findings). CNS Neurosci Ther. 2013;19(6):370–380. doi:10.1111/cns.1209923575437
  • Salloum NC, Fava M, Freeman MP, et al. Efficacy of intravenous ketamine treatment in anxious versus nonanxious unipolar treatment-resistant depression. Depress Anxiety. 2019;36(3):235–243. doi:10.1002/da.2287530597688
  • Frey TM, Florin TA, Caruso M, Zhang N, Zhang Y, Mittiga MR. Effect of intranasal ketamine vs fentanyl on pain reduction for extremity injuries in children: the PRIME randomized clinical trial. JAMA Pediatr. 2019;173(2):140–146. doi:10.1001/jamapediatrics30592476
  • Kapur J. Role of NMDA receptors in the pathophysiology and treatment of status epilepticus. Epilepsia Open. 2018;3(Suppl 2):165–168. doi:10.1002/epi4.1227030564775
  • Domino EF. Taming the ketamine tiger. Anesthesiology. 2010;113(3):678–684. doi:10.1097/ALN.0b013e3181ed09a220693870
  • Laskowski K, Stirling A, McKay WP, Lim HJ. A systematic review of intravenous ketamine for postoperative analgesia. Can J Anaesth. 2011;58(10):911–923. doi:10.1007/s12630-011-9560-021773855
  • Bell RF, Dahl JB, Moore RA, Kalso E. Peri-operative ketamine for acute post-operative pain: a quantitative and qualitative systematic review (Cochrane review). Acta Anaesthesiol Scand. 2005;49(10):1405–1428. doi:10.1111/j.1399-6576.2005.00814.x16223384
  • Peltoniemi MA, Hagelberg NM, Olkkola KT, Saari TI. Ketamine: a review of clinical pharmacokinetics and pharmacodynamics in anesthesia and pain therapy. Clin Pharmacokinet. 2016;55(9):1059–1077. doi:10.1007/s40262-016-0383-627028535
  • Sinner B, Graf BM. Ketamine. Handb Exp Pharmacol. 2008;182:313–333. doi:10.1007/978-3-540-74806-9_15
  • Zanos P, Moaddel R, Morris PJ, et al. Ketamine and ketamine metabolite pharmacology: insights into therapeutic mechanisms. Pharmacol Rev. 2018;70(3):621–660. doi:10.1124/pr.116.015198err29945898
  • Himmelseher S, Pfenninger E. [The clinical use of S-(+)-ketamine – a determination of its place]. Anasthesiol Intensivmed Notfallmed Schmerzther. 1998;33(12):764–770. doi:10.1055/s-2007-9948519893910
  • Adams HA, Werner C. [From the racemate to the eutomer: (S)-ketamine. Renaissance of a substance?] Anaesthesist. 1997;46(12):1026–1042. doi:10.1007/s0010100505039451486
  • White PF, Schuttler J, Shafer A, Stanski DR, Horai Y, Trevor AJ. Comparative pharmacology of the ketamine isomers. Studies in volunteers. Br J Anaesth. 1985;57(2):197–203. doi:10.1093/bja/57.2.1973970799
  • Zou L, Tian SY, Quan X, Ye TH. [Psychedelic effects of subanesthetic doses of ketamine]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2009;31(1):68–72.19317064
  • Bowdle TA, Radant AD, Cowley DS, Kharasch ED, Strassman RJ, Roy-Byrne PP. Psychedelic effects of ketamine in healthy volunteers: relationship to steady-state plasma concentrations. Anesthesiology. 1998;88(1):82–88. doi:10.1097/00000542-199801000-000159447860
  • Pfenninger EG, Durieux ME, Himmelseher S. Cognitive impairment after small-dose ketamine isomers in comparison to equianalgesic racemic ketamine in human volunteers. Anesthesiology. 2002;96(2):357–366. doi:10.1097/00000542-200202000-0002211818769
  • Engelhardt W, Stahl K, Marouche A, Hartung E. [Recovery time after (S)-ketamine or ketamine racemate. Recovery time after short anesthesia in volunteers]. Anaesthesist. 1998;47(3):184–192. doi:10.1007/s0010100505469567151
  • Geisslinger G, Hering W, Thomann P, Knoll R, Kamp HD, Brune K. Pharmacokinetics and pharmacodynamics of ketamine enantiomers in surgical patients using a stereoselective analytical method. Br J Anaesth. 1993;70(6):666–671. doi:10.1093/bja/70.6.6668329260
  • Ihmsen H, Geisslinger G, Schuttler J. Stereoselective pharmacokinetics of ketamine: R(-)-ketamine inhibits the elimination of S(+)-ketamine. Clin Pharmacol Ther. 2001;70(5):431–438. doi:10.1067/mcp.2001.11972211719729
  • State Food and Drug Administration. Good clinical practice guideline. Available from: http://www.sda.gov.cn/WS01/CL0053/24473.html. Accessed 86, 2003.
  • State Food and Drug Administration. Guidelines for the study of clinical pharmacokinetics of chemical drugs. Available from: http://samr.cfda.gov.cn/WS01/CL1616/83420.html. Accessed 318, 2005.
  • US Food and Drug Administration. Guidance for industry of statistical approaches to establishing bioequivalence. Available from: https://www.fda.gov/media/70958/download. Accessed 1, 2001.
  • Sigtermans M, Dahan A, Mooren R, et al. S(+)-ketamine effect on experimental pain and cardiac output: a population pharmacokinetic-pharmacodynamic modeling study in healthy volunteers. Anesthesiology. 2009;111(4):892–903. doi:10.1097/ALN.0b013e3181b437b119741495

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.