Annatto-Derived Tocotrienol Promotes Mineralization of MC3T3-E1 Cells by Enhancing BMP-2 Protein Expression via Inhibiting RhoA Activation and HMG-CoA Reductase Gene Expression

References

• RachnerTD, KhoslaS, HofbauerLC. Osteoporosis: now and the future. Lancet. 2011;377(9773):1276–1287. doi:10.1016/S0140-6736(10)62349-521450337
   PubMed Web of Science ®Google Scholar
• WHO. Assessment of fracture risk and its application to screening for postmenopausal osteoporosis: report of a WHO study group [meeting held in Rome from 22 to 25 June 1992]. 1994 10.3168/jds.S0022-0302(94)77044-2
   Google Scholar
• RosenCJ. Postmenopausal osteoporosis. N Engl J Med. 2005;353(6):595–603. doi:10.1056/NEJMcp04380116093468
   PubMed Web of Science ®Google Scholar
• WillsonT, NelsonSD, NewboldJ, NelsonRE, LaFleurJ. The clinical epidemiology of male osteoporosis: a review of the recent literature. Clin Epidemiol. 2015;7:65.25657593
   PubMed Web of Science ®Google Scholar
• DhanwalDK, DennisonEM, HarveyNC, CooperC. Epidemiology of hip fracture: worldwide geographic variation. Indian J Orthop. 2011;45(1):15. doi:10.4103/0019-5413.7365621221218
   PubMed Web of Science ®Google Scholar
• TellaSH, GallagherJC. Prevention and treatment of postmenopausal osteoporosis. J Steroid Biochem Mol Biol. 2014;142:155–170. doi:10.1016/j.jsbmb.2013.09.00824176761
   PubMed Web of Science ®Google Scholar
• RussowG, JahnD, AppeltJ, MärdianS, TsitsilonisS, KellerJ. Anabolic therapies in osteoporosis and bone regeneration. Int J Mol Sci. 2019;20(1):83. doi:10.3390/ijms20010083
   Web of Science ®Google Scholar
• LibermanUA, WeissSR, BröllJ, et al. Effect of oral alendronate on bone mineral density and the incidence of fractures in postmenopausal osteoporosis. N Engl J Med. 1995;333(22):1437–1444. doi:10.1056/NEJM1995113033322017477143
   PubMed Web of Science ®Google Scholar
• CejkaD, BeneschT, KrestanC, et al. Effect of teriparatide on early bone loss after kidney transplantation. Am J Transplant. 2008;8(9):1864–1870. doi:10.1111/ajt.2008.8.issue-918786230
   PubMed Web of Science ®Google Scholar
• Wan HasanW, Kok-yongC, JollyJ, AbdNG, Ima-NirwanaS. Identifying potential therapeutics for osteoporosis by exploiting the relationship between mevalonate pathway and bone metabolism. Endocr Metab Immune Disord Drug Targets. 2018;18:450–457.29683099
   PubMed Web of Science ®Google Scholar
• QiaoLJ, KangKL, HeoJS. Simvastatin promotes osteogenic differentiation of mouse embryonic stem cells via canonical Wnt/β-catenin signaling. Mol Cells. 2011;32(5):437–444. doi:10.1007/s10059-011-0107-622058016
   PubMed Web of Science ®Google Scholar
• OxlundH, AndreassenTT. Simvastatin treatment partially prevents ovariectomy-induced bone loss while increasing cortical bone formation. Bone. 2004;34(4):609–618. doi:10.1016/j.bone.2003.12.01415050891
   PubMed Web of Science ®Google Scholar
• MundyG, GarrettR, HarrisS, et al. Stimulation of bone formation in vitro and in rodents by statins. Science. 1999;286(5446):1946–1949. doi:10.1126/science.286.5446.194610583956
   PubMed Web of Science ®Google Scholar
• ZhangFL, CaseyPJ. Protein prenylation: molecular mechanisms and functional consequences. Annu Rev Biochem. 1996;65(1):241–269. doi:10.1146/annurev.bi.65.070196.0013258811180
   PubMed Web of Science ®Google Scholar
• MatozakiT, NakanishiH, TakaiY. Small G-protein networks:: their crosstalk and signal cascades. Cell Signal. 2000;12(8):515–524. doi:10.1016/S0898-6568(00)00102-911027944
   PubMed Web of Science ®Google Scholar
• HarmeyD, StenbeckG, NobesCD, LaxAJ, GrigoriadisAE. Regulation of osteoblast differentiation by Pasteurella multocida toxin (PMT): a role for Rho GTPase in bone formation. J Bone Miner Res. 2004;19(4):661–670. doi:10.1359/JBMR.04010515005854
   PubMed Web of Science ®Google Scholar
• OhnakaK, ShimodaS, NawataH, et al. Pitavastatin enhanced BMP-2 and osteocalcin expression by inhibition of Rho-associated kinase in human osteoblasts. Biochem Biophys Res Commun. 2001;287(2):337–342. doi:10.1006/bbrc.2001.559711554731
   PubMed Web of Science ®Google Scholar
• PeraMF, AndradeJ, HoussamiS, et al. Regulation of human embryonic stem cell differentiation by BMP-2 and its antagonist noggin. J Cell Sci. 2004;117(7):1269–1280. doi:10.1242/jcs.0097014996946
   PubMed Web of Science ®Google Scholar
• ChenG, DengC, LiY-P. TGF-β and BMP signaling in osteoblast differentiation and bone formation. Int J Biol Sci. 2012;8(2):272. doi:10.7150/ijbs.292922298955
   PubMed Web of Science ®Google Scholar
• SenCK, KhannaS, RoyS. Tocotrienols: vitamin E beyond tocopherols. Life Sci. 2006;78(18):2088–2098. doi:10.1016/j.lfs.2005.12.00116458936
   PubMed Web of Science ®Google Scholar
• Ima-NirwanaS, SuhanizaS. Effects of tocopherols and tocotrienols on body composition and bone calcium content in adrenalectomized rats replaced with dexamethasone. J Med Food. 2004;7(1):45–51. doi:10.1089/10966200432298469915117552
   PubMed Web of Science ®Google Scholar
• ChinK-Y, Ima NirwanaS. The biological effects of tocotrienol on bone. Drug Des Devel Ther. 2015;9:2049–2061. doi:10.2147/DDDT.S79660
   PubMed Web of Science ®Google Scholar
• DengL, DingY, PengY, et al. γ-Tocotrienol protects against ovariectomy-induced bone loss via mevalonate pathway as HMG-CoA reductase inhibitor. Bone. 2014;67:200–207. doi:10.1016/j.bone.2014.07.00625019595
   PubMed Web of Science ®Google Scholar
• TanB, FoleyJ. Tocotrienols and geranylgeraniol from Bixa orellana byproducts. Google Patents. 2002.
   Google Scholar
• TanB, LlobreraJ. Annatto extract compositions including tocotrienols and tocopherols and methods of use. Google Patents. 2009.
   Google Scholar
• ChinK-Y, Abdul-MajeedS, FoziNFM, Ima-NirwanaS. Annatto tocotrienol improves indices of bone static histomorphometry in osteoporosis due to testosterone deficiency in rats. Nutrients. 2014;6(11):4974–4983. doi:10.3390/nu611497425389899
   PubMed Web of Science ®Google Scholar
• Abdul-MajeedS, MohamedN, SoelaimanI-N. Effects of tocotrienol and lovastatin combination on osteoblast and osteoclast activity in estrogen-deficient osteoporosis. Evid Based Complementary Alternat Med. 2012;2012. doi:10.1155/2012/960742
   PubMed Web of Science ®Google Scholar
• Abdul-MajeedS, MohamedN, SoelaimanI-N. The use of delta-tocotrienol and lovastatin for anti-osteoporotic therapy. Life Sci. 2015;125:42–48. doi:10.1016/j.lfs.2014.12.01225534439
   PubMed Web of Science ®Google Scholar
• Wan HasanWN, GhafarNA, ChinK-Y, Ima-NirwanaS. Annatto-derived tocotrienol stimulates osteogenic activity in preosteoblastic MC3T3-E1 cells: a temporal sequential study. Drug Des Devel Ther. 2018;12:1715. doi:10.2147/DDDT.S168935
   PubMed Web of Science ®Google Scholar
• SongB-L, DeBose-BoydRA. Insig-dependent ubiquitination and degradation of 3-hydroxy-3-methylglutaryl coenzyme A reductase stimulated by δ-and γ-tocotrienols. J Biol Chem. 2006;281(35):25054–25061. doi:10.1074/jbc.M60557520016831864
   PubMed Web of Science ®Google Scholar
• SakakuraY, ShimanoH, SoneH, et al. Sterol regulatory element-binding proteins induce an entire pathway of cholesterol synthesis. Biochem Biophys Res Commun. 2001;286(1):176–183. doi:10.1006/bbrc.2001.537511485325
   PubMed Web of Science ®Google Scholar
• KrycerJR, PhanL, BrownAJ. A key regulator of cholesterol homoeostasis, SREBP-2, can be targeted in prostate cancer cells with natural products. Biochem J. 2012;446(2):191–201. doi:10.1042/BJ2012054522657538
   PubMed Web of Science ®Google Scholar
• LeeMH, ChoYS, HanYM. Simvastatin suppresses self‐renewal of mouse embryonic stem cells by inhibiting RhoA geranylgeranylation. Stem Cells. 2007;25(7):1654–1663. doi:10.1634/stemcells.2006-075317464088
   PubMed Web of Science ®Google Scholar
• HaradaT, YamasakiA, ChikumiH, et al. γ-Tocotrienol reduces human airway smooth muscle cell proliferation and migration. Pulm Pharmacol Ther. 2015;32:45–52. doi:10.1016/j.pupt.2015.04.00325956071
   PubMed Web of Science ®Google Scholar
• YangZ, XiaoH, JinH, KooPT, TsangDJ, YangCS. Synergistic actions of atorvastatin with γ-tocotrienol and celecoxib against human colon cancer HT29 and HCT116 cells. Int J Cancer. 2010;126(4):852–863. doi:10.1002/ijc.2476619626588
   PubMed Web of Science ®Google Scholar
• SugiyamaM, KodamaT, KonishiK, AbeK, AsamiS, OikawaS. Compactin and simvastatin, but not pravastatin, induce bone morphogenetic protein-2 in human osteosarcoma cells. Biochem Biophys Res Commun. 2000;271(3):688–692. doi:10.1006/bbrc.2000.269710814523
   PubMed Web of Science ®Google Scholar
• ChinK-Y, Abdul-MajeedS, MohamedN, Ima-NirwanaS. The effects of tocotrienol and lovastatin co-supplementation on bone dynamic histomorphometry and bone morphogenetic protein-2 expression in rats with estrogen deficiency. Nutrients. 2017;9(2):143. doi:10.3390/nu9020143
   PubMed Web of Science ®Google Scholar
• TsujiK, CoxK, BandyopadhyayA, HarfeBD, TabinCJ, RosenV. BMP4 is dispensable for skeletogenesis and fracture-healing in the limb. J Bone Joint Surg Am Vol. 2008;90(Suppl 1):14–18. doi:10.2106/JBJS.G.01109
   PubMed Web of Science ®Google Scholar
• ShuB, ZhangM, XieR, et al. BMP2, but not BMP4, is crucial for chondrocyte proliferation and maturation during endochondral bone development. J Cell Sci. 2011;124(Pt 20):3428–3440. doi:10.1242/jcs.08365921984813
   PubMed Web of Science ®Google Scholar
• TsujiK, CoxK, GamerL, GrafD, EconomidesA, RosenV. Conditional deletion of BMP7 from the limb skeleton does not affect bone formation or fracture repair. J Orthop Res. 2010;28(3):384–389. doi:10.1002/jor.2099619780203
   PubMed Web of Science ®Google Scholar
• BandyopadhyayA, TsujiK, CoxK, HarfeBD, RosenV, TabinCJ. Genetic analysis of the roles of BMP2, BMP4, and BMP7 in limb patterning and skeletogenesis. PLoS Gnet. 2006;2(12):e216. doi:10.1371/journal.pgen.0020216
   PubMed Web of Science ®Google Scholar
• WongSK, ChinK-Y, SuhaimiFH, AhmadF, Ima-NirwanaS. Exploring the potential of tocotrienol from Bixa orellana as a single agent targeting metabolic syndrome and bone loss. Bone. 2018;116:8–21. doi:10.1016/j.bone.2018.07.00329990585
   PubMed Web of Science ®Google Scholar
• WeivodaMM, HohlRJ. Effects of farnesyl pyrophosphate accumulation on calvarial osteoblast differentiation. Endocrinology. 2011;152(8):3113–3122. doi:10.1210/en.2011-001621586555
   PubMed Web of Science ®Google Scholar
• LimDA, TramontinAD, TrevejoJM, HerreraDG, Garcia-VerdugoJM, Alvarez-BuyllaA. Noggin antagonizes BMP signaling to create a niche for adult neurogenesis. Neuron. 2000;28(3):713–726. doi:10.1016/S0896-6273(00)00148-311163261
   PubMed Web of Science ®Google Scholar
• GajeraCR, EmichH, LioubinskiO, et al. LRP2 in ependymal cells regulates BMP signaling in the adult neurogenic niche. J Cell Sci. 2010;123(Pt 11):1922–1930. doi:10.1242/jcs.06591220460439
   PubMed Web of Science ®Google Scholar
• KempfT, SinningJM, QuintA, et al. Growth-differentiation factor-15 for risk stratification in patients with stable and unstable coronary heart disease: results from the AtheroGene study. Circul Cardiovas Genet. 2009;2(3):286–292. doi:10.1161/CIRCGENETICS.108.824870
   PubMedGoogle Scholar
• KempfT, WollertKC. Growth differentiation factor-15: a new biomarker in cardiovascular disease. Herz. 2009;34(8):594–599. doi:10.1007/s00059-009-3317-320024638
   PubMed Web of Science ®Google Scholar
• SiegelPM, MassagueJ. Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer. Nat Rev Cancer. 2003;3(11):807–821. doi:10.1038/nrc120814557817
   PubMed Web of Science ®Google Scholar
• ParkY, KimJW, KimDS, et al. The Bone Morphogenesis Protein-2 (BMP-2) is associated with progression to metastatic disease in gastric cancer. Cancer Res Treat. 2008;40(3):127–132. doi:10.4143/crt.2008.40.3.12719688119
   PubMedGoogle Scholar