Enzyme Inhibitory, Antioxidant And Antibacterial Potentials Of Synthetic Symmetrical And Unsymmetrical Thioureas

References

• Bhanja C, Jena S. Rational synthesis design of a potent anti-diabetic therapeutic’pioglitazone’using retrosynthetic analysis. J Chem Pharm Res. 2012;4(9):4323–4333.
   Google Scholar
• Kulshrestha AA. Physicochemical Studies of Some Compounds. Saurashtra University; 2009.
   Google Scholar
• Didwagh SS, Piste PB, Burungale AS, Nalawade AM. Synthesis and antimicrobial evaluation of novel 3-(4, 6-diphenyl-6H-1, 3-thiazin-2-yl)-2-(4-methoxyphenyl) thiazolidin-4-one derivatives. J Appl Pharm Sci. 2013;3(11):122–127.
   Google Scholar
• Alkherraz AM, Lusta ZI, Zubi AE. Synthesis and use of thiourea derivative (1-phenyl-3-benzoyl-2-thiourea) for extraction of cadmium ion. Int J Chem Nucl Metall Mater Eng. 2014;8:118–120.
   Google Scholar
• Shaik T, Chennamsetty S, Devineni S, et al. Catalyst-free green synthesis of urea and thiourea derivatives of tetramethylguanidine (TMG) and evaluation of biological activity. Published Bulgarian Chem Comm. 2014;46(4):724–730.
   Web of Science ®Google Scholar
• Wermuth C, Aldous D, Raboisson P, Rognan D. Medicinal chemistry: definitions and objectives, drug activity phases, drug classification systems In: The Practice of Medicinal Chemistry. Academic Press; 2015.
   Google Scholar
• Nagalakshmi G, Maity T, Maiti B. Synthesis, characterization and anti-HIV evaluation of some novel 2-[(substitutedphenyl/heteroaryl) imino]-3-phenyl-1, 3-thiazolidin-4-ones. Synthesis. 2013;5(5):2079–2089.
   Google Scholar
• Pattan S, Kedar M, Pattan J, et al. Synthesis and evaluation of some novel 2, 4-thiazolidinedione derivatives for antibacterial, antitubercular and antidiabetic activities. Indian J Chem 2012;51B:1421–1425. doi:10.1094/PDIS-11-11-0999-PDN.
   Google Scholar
• Bielenica A, Stefańska J, Stępień K, et al. Synthesis, cytotoxicity and antimicrobial activity of thiourea derivatives incorporating 3-(trifluoromethyl) phenyl moiety. Eur J Med Chem. 2015;101:111–125. doi:10.1016/j.ejmech.2015.06.02726119992
   PubMed Web of Science ®Google Scholar
• Kulakov I, Nurkenov O, Akhmetova S, Seidakhmetova R, Zhambekov Z. Synthesis and antibacterial and antifungal activities of thiourea derivatives of the alkaloid anabasine. Pharm Chem J. 2011;45(1):15–18.
   Web of Science ®Google Scholar
• Hosseinzadeh H, Nassiri‐Asl M. Avicenna’s (Ibn Sina) the canon of medicine and saffron (Crocus sativus): a review. Phytother Res. 2013;27(4):475–483. doi:10.1002/ptr.478422815242
   PubMed Web of Science ®Google Scholar
• Kumar V, Chimni SS. Recent developments on thiourea based anticancer chemotherapeutics. Anticancer Agents Med Chem. 2015;15(2):163–175.24712324
   PubMed Web of Science ®Google Scholar
• Bharate SB, Thompson CM. Antimicrobial, antimalarial, and antileishmanial activities of mono‐and bis‐quaternary pyridinium compounds. Chem Biol Drug Des. 2010;76(6):546–551.21040494
   PubMed Web of Science ®Google Scholar
• Choi J, Jee J-G. Repositioning of thiourea-containing drugs as tyrosinase inhibitors. Int J Mol Sci. 2015;16(12):28534–28548. doi:10.3390/ijms16122611426633377
   PubMed Web of Science ®Google Scholar
• Suyoga Vardhan D, Shantharam C, Suhas R, Sridhara M, Channe Gowda D. Synthesis and urease inhibition studies of ureas and thioureas derived from amino acids conjugated heterocycle. International Journal of Chemical and Pharmaceutical Sciences 2013;4(3):54–58.
   Google Scholar
• Imran S, Taha M, Ismail NH, Fayyaz S, Khan KM, Choudhary MI. Synthesis, biological evaluation, and docking studies of novel thiourea derivatives of bisindolylmethane as carbonic anhydrase II inhibitor. Bioorg Chem. 2015;62:83–93. doi:10.1016/j.bioorg.2015.08.00126275866
   PubMed Web of Science ®Google Scholar
• Antunes S, Corre J-P, Mikaty G, Douat C, Goossens PL, Guichard G. Effect of replacing main-chain ureas with thiourea and guanidinium surrogates on the bactericidal activity of membrane active oligourea foldamers. Bioorg Med Chem. 2017;25(16):4245–4252.28687228
   PubMed Web of Science ®Google Scholar
• Bari WU, Zahoor M, Zeb A, et al. Anticholinesterase, antioxidant potentials, and molecular docking studies of isolated bioactive compounds from Grewia optiva. Int J Food Prop. 2019;22(1):1386–1396.
   Web of Science ®Google Scholar
• Zahoor M, Zafar R, Rahman NU. Isolation and identification of phenolic antioxidants from Pistacia integerrima gall and their anticholine esterase activities. Heliyon. 2018;4(12):e01007. doi:10.1016/j.heliyon.2018.e0100730623127
   PubMed Web of Science ®Google Scholar
• Nazir N, Zahoor M, Nisar M, et al. Phytochemical analysis and antidiabetic potential of Elaeagnus umbellata (Thunb.) in streptozotocin-induced diabetic rats: pharmacological and computational approach. BMC Complement Altern Med. 2018;18(1):332. doi:10.1186/s12906-018-2317-330545352
   PubMed Web of Science ®Google Scholar
• Zahoor M, Shafiq S, Ullah H, Sadiq A, Ullah F. Isolation of quercetin and mandelic acid from Aesculus indica fruit and their biological activities. BMC Biochem. 2018;19(1):5.29940844
   PubMed Web of Science ®Google Scholar
• Ovais M, Ayaz M, Khalil AT, et al. HPLC-DAD finger printing, antioxidant, cholinesterase, and α-glucosidase inhibitory potentials of a novel plant Olax nana. BMC Complement Altern Med. 2018;18(1):1. doi:10.1186/s12906-018-2317-329295712
   PubMed Web of Science ®Google Scholar
• Saeed A, Zaib S, Ashraf S, et al. Synthesis, cholinesterase inhibition and molecular modelling studies of coumarin linked thiourea derivatives. Bioorg Chem. 2015;63:58–63. doi:10.1016/j.bioorg.2015.09.00926440714
   PubMed Web of Science ®Google Scholar
• Zahoor M,Jan R, Naz S.  Investigation of repressive and enhancive effects of fruit extracts on the activity of glucose-6-phophatase. Pak J Phar Sci  2016;29(6):1985–1991.
   Google Scholar
• Gleason CA, Juul SE. Inborn Errors of Carbohydrate, Ammonia, Amino Acid, and Organic Acid Metabolism. In: J Lawrence Merritt II, Renata C Gallagher, editors. Avery’s Diseases of the Newborn (Tenth Edition). Elsevier; 2018:230–252.
   Google Scholar
• Lee M-W, Chanda D, Yang J, et al. Regulation of hepatic gluconeogenesis by an ER-bound transcription factor, CREBH. Cell Metab. 2010;11(4):331–339. doi:10.1016/j.cmet.2010.02.01620374965
   PubMed Web of Science ®Google Scholar
• Nugent TC, Umar MN, Bibi A. Picolylamine as an organocatalyst template for highly diastereo-and enantioselective aqueous aldol reactions. Org Biomol Chem. 2010;8(18):4085–4089.20623075
   PubMed Web of Science ®Google Scholar
• Peng L, Rong Z, Wang H, et al. A novel assay to determine acetylcholinesterase activity: the application potential for screening of drugs against Alzheimer’s disease. Biomed Chromatogr. 2017;31(10):e3971. doi:10.1002/bmc.3882
   Web of Science ®Google Scholar
• Fiske CH, Subbarow Y. The colorimetric determination of phosphorus. J Biol Chem. 1925;66(2):375–400.
   Google Scholar
• Re R, Pellegrini N, Proteggente A, Pannala A, Yang M, Rice-Evans C. Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radic Biol Med. 1999;26(9–10):1231–1237. doi:10.1016/s0891-5849(98)00315-310381194
   PubMed Web of Science ®Google Scholar
• Cheruiyot K, Olila D, Kateregga J. In-vitro antibacterial activity of selected medicinal plants from Longisa region of Bomet district, Kenya. Afr Health Sci. 2009;9(2):S42–S46.20589160
   PubMed Web of Science ®Google Scholar