148
Views
17
CrossRef citations to date
0
Altmetric
Original Research

Dexmedetomidine Promotes Hippocampal Neurogenesis and Improves Spatial Learning and Memory in Neonatal Rats

, , , , &
Pages 4439-4449 | Published online: 03 Jan 2020

References

  • Bhana N, Goa KL, McClellan KJ Dexmedetomidine. Drugs.2000;59:263–268. doi:10.2165/00003495-200059020-0001210730549
  • Perez-Zoghbi JF, Zhu W, Grafe MR. Brambrink AM Dexmedetomidine-mediated neuroprotection against sevoflurane-induced neurotoxicity extends to several brain regions in neonatal rats. Br J Anaesth. 2017;119:506–516. doi:10.1093/bja/aex22228969317
  • Mason KP, Lerman J. Review article: dexmedetomidine in children: current knowledge and future applications. Anesth Analg. 2011;113:1129–1142. doi:10.1213/ANE.0b013e31822b862921821507
  • Pascual A, Hidalgo-Figueroa M, Piruat JI, Pintado CO, Gomez-Diaz R, Lopez-Barneo J. Absolute requirement of GDNF for adult catecholaminergic neuron survival. Nat Neurosci. 2008;11:755–761. doi:10.1038/nn.213618536709
  • Yan M, Dai H, Ding T, et al. Effects of dexmedetomidine on the release of glial cell line-derived neurotrophic factor from rat astrocyte cells. Neurochem Int. 2011;58:549–557. doi:10.1016/j.neuint.2011.01.01321241763
  • Sifringer M, von Haefen C, Krain M, et al. Neuroprotective effect of dexmedetomidine on hyperoxia-induced toxicity in the neonatal rat brain. Oxid Med Cell Longev. 2015;2015:530371. doi:10.1155/2015/53037125653737
  • Wang WX, Wu Q, Liang SS, et al. Dexmedetomidine promotes the recovery of neurogenesis in aged mouse with postoperative cognitive dysfunction. Neurosci Lett. 2018;677:110–116. doi:10.1016/j.neulet.2018.03.04329571823
  • Steiner B, Klempin F, Wang L, Kott M, Kettenmann H. Type-2 cells as link between glial and neuronal lineage in adult hippocampal neurogenesis. Glia. 2006;54:805–814. doi:10.1002/glia.2040716958090
  • Neurogenesis FJ. Gliogenesis in nervous system plasticity and repair. Annu Rev Cell Dev Biol. 2016;32:127–141. doi:10.1146/annurev-cellbio-111315-12495327298094
  • Akerud P, Canals JM, Snyder EY, Arenas E. Neuroprotection through delivery of glial cell line-derived neurotrophic factor by neural stem cells in a mouse model of Parkinson’s disease. J Neurosci. 2001;21:8108–8118. doi:10.1523/JNEUROSCI.21-20-08108.200111588183
  • Mizuno M, Yamada K, Maekawa N, Saito K, Seishima M, Nabeshima T. CREB phosphorylation as a molecular marker of memory processing in the hippocampus for spatial learning. Behav Brain Res. 2002;133:135–141. doi:10.1016/S0166-4328(01)00470-312110446
  • Paratcha G, Ledda F, Ibanez CF. The neural cell adhesion molecule NCAM is an alternative signaling receptor for GDNF family ligands. Cell. 2003;113:867–879. doi:10.1016/S0092-8674(03)00435-512837245
  • Xu Y, Tian Y, Tian Y, Li X, Zhao P. Autophagy activation involved in hypoxic-ischemic brain injury induces cognitive and memory impairment in neonatal rats. J Neurochem. 2016;139:795–805. doi:10.1111/jnc.1385127659442
  • Scobie KN, Hall BJ, Wilke SA, et al. Kruppel-like factor 9 is necessary for late-phase neuronal maturation in the developing dentate gyrus and during adult hippocampal neurogenesis. J Neurosci. 2009;29:9875–9887. doi:10.1523/JNEUROSCI.2260-09.200919657039
  • Kuniishi H, Ichisaka S, Yamamoto M, et al. Early deprivation increases high-leaning behavior, a novel anxiety-like behavior, in the open field test in rats. Neurosci Res. 2017;123:27–35. doi:10.1016/j.neures.2017.04.01228450152
  • Garthe A, Behr J, Kempermann G. Adult-generated hippocampal neurons allow the flexible use of spatially precise learning strategies. PLoS One. 2009;4:e5464. doi:10.1371/journal.pone.000546419421325
  • Pancaro C, Segal BS, Sikes RW, et al. Dexmedetomidine and ketamine show distinct patterns of cell degeneration and apoptosis in the developing rat neonatal brain. J Matern Fetal Neonatal Med. 2016;29:3827–3833. doi:10.3109/14767058.2016.114813226821538
  • Kutlu MG, Gould TJ. Nicotinic modulation of hippocampal cell signaling and associated effects on learning and memory. Physiol Behav. 2016;155:162–171. doi:10.1016/j.physbeh.2015.12.00826687895
  • McMorrow SP, Abramo TJ. Dexmedetomidine sedation: uses in pediatric procedural sedation outside the operating room. Pediatr Emerg Care. 2012;28:292–296. doi:10.1097/PEC.0b013e3182495e1b22391930
  • Sakurai Y, Obata T, Odaka A, Terui K, Tamura M, Miyao H. Buccal administration of dexmedetomidine as a preanesthetic in children. J Anesth. 2010;24:49–53. doi:10.1007/s00540-009-0863-z20175284
  • Zub D, Berkenbosch JW, Tobias JD. Preliminary experience with oral dexmedetomidine for procedural and anesthetic premedication. Paediatr Anaesth. 2005;15:932–938. doi:10.1111/j.1460-9592.2005.01623.x16238552
  • Hoffman WE, Kochs E, Werner C, Thomas C, Albrecht RF. Dexmedetomidine improves neurologic outcome from incomplete ischemia in the rat. Reversal by the alpha 2-adrenergic antagonist atipamezole. Anesthesiology. 1991;75:328–332.1677549
  • Alam A, Hana Z, Jin Z, Suen KC, Surgery MD. Neuroinflammation and cognitive impairment. EBioMedicine. 2018;37:547–556. doi:10.1016/j.ebiom.2018.10.02130348620
  • Degos V, Charpentier TL, Chhor V, et al. Neuroprotective effects of dexmedetomidine against glutamate agonist-induced neuronal cell death are related to increased astrocyte brain-derived neurotrophic factor expression. Anesthesiology. 2013;118:1123–1132. doi:10.1097/ALN.0b013e318286cf3623353792
  • Luo C, Ouyang MW, Fang YY, et al. Dexmedetomidine protects mouse brain from ischemia-reperfusion injury via inhibiting neuronal autophagy through up-regulating HIF-1alpha. Front Cell Neurosci. 2017;11:197. doi:10.3389/fncel.2017.0019728729825
  • Sanders RD, Xu J, Shu Y, et al. Dexmedetomidine attenuates isoflurane-induced neurocognitive impairment in neonatal rats. Anesthesiology. 2009;110:1077–1085. doi:10.1097/ALN.0b013e31819daedd19352168
  • Endesfelder S, Makki H, von Haefen C, Spies CD, Buhrer C, Sifringer M. Neuroprotective effects of dexmedetomidine against hyperoxia-induced injury in the developing rat brain. PLoS One. 2017;12:e0171498. doi:10.1371/journal.pone.017149828158247
  • Kronenberg G, Reuter K, Steiner B, et al. Subpopulations of proliferating cells of the adult hippocampus respond differently to physiologic neurogenic stimuli. J Comp Neurol. 2003;467:455–463. doi:10.1002/(ISSN)1096-986114624480
  • Leuner B, Kozorovitskiy Y, Gross CG, Gould E. Diminished adult neurogenesis in the marmoset brain precedes old age. Proc Natl Acad Sci U S A. 2007;104:17169–17173. doi:10.1073/pnas.070822810417940008
  • Trendelenburg G, Dirnagl U. Neuroprotective role of astrocytes in cerebral ischemia: focus on ischemic preconditioning. Glia. 2005;50:307–320. doi:10.1002/glia.2020415846804
  • Neves G, Cooke SF, Bliss TV. Synaptic plasticity, memory and the hippocampus: a neural network approach to causality. Nat Rev Neurosci. 2008;9:65–75. doi:10.1038/nrn230318094707
  • Aimone JB, Wiles J, Gage FH. Potential role for adult neurogenesis in the encoding of time in new memories. Nat Neurosci. 2006;9:723–727. doi:10.1038/nn170716732202
  • Groves JO, Leslie I, Huang GJ, et al. Ablating adult neurogenesis in the rat has no effect on spatial processing: evidence from a novel pharmacogenetic model. PLoS Genet. 2013;9(9):e100371824039591
  • Hsing CH, Lin CF, So E, et al. Alpha2-Adrenoceptor agonist dexmedetomidine protects septic acute kidney injury through increasing BMP-7 and inhibiting HDAC2 and HDAC5. Am J Physiol Renal Physiol. 2012;303:F1443–53. doi:10.1152/ajprenal.00143.201222933299
  • Shan Y, Yang F, Tang Z, et al. Dexmedetomidine ameliorates the neurotoxicity of sevoflurane on the immature brain through the BMP/SMAD signaling pathway. Front Neurosci. 2018;12:964. doi:10.3389/fnins.2018.0096430618586
  • Gajera CR, Emich H, Lioubinski O, et al. LRP2 in ependymal cells regulates BMP signaling in the adult neurogenic niche. J Cell Sci. 2010;123:1922–1930. doi:10.1242/jcs.06591220460439
  • Armenteros T, Andreu Z, Hortiguela R, Lie DC. Mira H BMP and WNT signalling cooperate through LEF1 in the neuronal specification of adult hippocampal neural stem and progenitor cells. Sci Rep. 2018;8:9241. doi:10.1038/s41598-018-27581-029915186
  • Lena B, Annabel C, Chandresh G, Annette HL, Thomas W. LRP2 in SHH-dependent adult neurogenesis. Mech Dev. 2017;145(Supplement):S116.