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Original Research

Anti-Inflammatory Activity of Sanjie Zhentong Capsule Assessed By Network Pharmacology Analysis of Adenomyosis Treatment 

ORCID Icon, , , , &
Pages 697-713 | Published online: 20 Feb 2020

References

  • HinikerSM, DonaldsonSS. Recent advances in understanding and managing rhabdomyosarcoma. F1000Prime Rep. 2014;7:59.
  • García-SolaresJ, DonnezJ, DonnezO, DolmansMM. Pathogenesis of uterine adenomyosis: invagination or metaplasia? Fertil Steril. 2018;109(3):371–379. doi:10.1016/j.fertnstert.2017.12.03029566849
  • TLR. The important roles of steroid sulfatase and sulfotransferases in gynecological diseases. Front Pharmacol. 2016;7(5 Pt 1):30. doi:10.3389/fphar.2016.0032326924986
  • LeyendeckerG, WildtL. A new concept of endometriosis and adenomyosis: tissue injury and repair (TIAR). Horm Mol Biol Clin Investig. 2011;5(2):125–142. doi:10.1515/HMBCI.2011.002
  • VannucciniS, TostiC, CarmonaF, et al. Pathogenesis of adenomyosis: an update on molecular mechanisms. Reprod Biomed Online. 2017;35(5):S1472648317302961. doi:10.1016/j.rbmo.2017.06.016
  • ShenMH, LiuXS, ZhangHQ, GuoSW. Transforming growth factor β1 signaling coincides with epithelial-mesenchymal transition and fibroblast-to-myofibroblast transdifferentiation in the development of adenomyosis in mice. Hum Reprod. 2016;31(2):355–369. doi:10.1093/humrep/dev31426689216
  • ChenXF, HeXR, LiaoXP. Clinical observation on 30 cases of adenomyosis dysmenorrhea treated with Chailing Xiaozheng decoction. J Qiqihar Med Coll. 2016;37(22):2792–2794.
  • WangS, LuoMY, YuanY, et al. Effect of Xuanyu Tongjing Decoction in the treatment of dysmenorrhea of uterine adenomyosis. Contemp Chin Med. 2019;26(1):190–192.
  • DanLQ. The clinical effect of Jiawei Siwu decoction in the treatment of adenomyosis. Electron J Clin Med Lit. 2018;5(96):135–138.
  • WangHY, BaoXH, DaiJF. Treatment of ovarian cyst after ovulation-induction with Sanjie Zhentong capsule. Chin J Integr Trad West Med. 2008;28(28):1026–1028.
  • ZouJ, GuanZ, ZhangWY, XiaoW, LiYL. Beneficial effects of the Chinese herbal medicine Sanjie Zhentong capsule on experimental endometriosis in rats. Chin J Nat Med. 2013;11(6):666–672. doi:10.1016/S1875-5364(13)60077-124345508
  • ZouJ, GuanZ, ZhangWY. Comparison of the effects of Sanjie Zhentong capsule and danazol on the endometriosis rats. Chin J Integr Trad West Med. 2012;32(8):1112–1116.
  • ChaiHJ. Clinical observation of Sanjie Zhentong capsule in treating adenomyosis and infertility. North Pharm. 2017;14(9):68–69.
  • ShenXY, YuLG. Therapeutic effect of Sanjie Zhentong capsule on dysmenorrhea caused by adenomyosis. J Clin Ration Drug Use. 2013;6(12):74.
  • LiSY, LiHY. Effects of Sanjie Zhentong capsule combined with indometin suppository on serum CA125, TNF-ɑ, PGF2ɑ in patients with adenomyosis. J Integr Trad Chin Wes Med. 2015;24(35):3954-3955+3980.
  • ZhangR, ZhuX, BaiH, NingK. Network pharmacology databases for traditional Chinese medicine: review and assessment. Front Pharmacol. 2019;10:1–14. doi:10.3389/fphar.2019.0000130728774
  • ShiXQ, YueSJ, TangYP, et al. A network pharmacology approach to investigate the blood enriching mechanism of Danggui buxue Decoction. J Ethnopharmacol. 2019;235:227–242. doi:10.1016/j.jep.2019.01.02730703496
  • YangB, WangN, WangS, et al. Network-pharmacology-based identification of caveolin-1 as a key target of Oldenlandia diffusa to suppress breast cancer metastasis. Biomed Pharmacother. 2019;112:1–14. doi:10.1016/j.biopha.2019.108607
  • HsinK-Y, MatsuokaY, AsaiY, et al. systemsDock: a web server for network pharmacology-based prediction and analysis. Nucleic Acids Res. 2016;44:507–513. doi:10.1093/nar/gkw335
  • ClementeGP, GrassiR. Directed clustering in weighted networks: a new perspective. Chaos Solitons Fractals. 2017;107:26–38. doi:10.1016/j.chaos.2017.12.007
  • GuoSZ, LuZM, ZheC, HaoL. Strength-strength and strength-degree correlation measures for directed weighted complex network analysis. IEICE Trans Inf Syst. 2011;94-D(11):2284–2287. doi:10.1587/transinf.E94.D.2284
  • ZhangGR, YunWU, ShaWU, XiaoW. Simultaneous determination of five compounds in Sanjie Zhentong capsules by high-performance liquid chromatography coupled with ultraviolet and evaporative light scattering detectors. Chin J Exp Trad Med Formulae. 2015;21(5):65–68.
  • LiJ, LiD, PanY, et al. Simultaneous determination of ten bioactive constituents of Sanjie Zhentong capsule in rat plasma by ultra-high-performance liquid chromatography tandem mass spectrometry and its application to a pharmacokinetic study. J Chromatogr B. 2017;1054:20–26. doi:10.1016/j.jchromb.2017.03.001
  • NakataH, KikuchiY, TodeT, et al. Inhibitory effects of ginsenoside Rh2 on tumor growth in nude mice bearing human ovarian cancer cells. Cancer Sci. 2010;89(7):733–740.
  • OhM, ChoiYH, ChoiS, et al. Anti-proliferating effects of ginsenoside Rh2 on MCF-7 human breast cancer cells. Int J Oncol. 1999;14(5):869–875. doi:10.3892/ijo.14.5.86910200336
  • HuangYQ, HuangHX, HanZD, et al. Ginsenoside Rh2 inhibits angiogenesis in prostate cancer by targeting CNNM1. J Nanosci Nanotechnol. 2019;19(4):1942–1950. doi:10.1166/jnn.2019.1640430486934
  • LiY, QianG, WenjinG, et al. Farrerol relieve lipopolysaccharide (LPS)-induced mastitis by inhibiting AKT/NF-κB p65, ERK1/2 and P38 signaling pathway. Int J Mol Sci. 2018;19(6):1770. doi:10.3390/ijms19061770
  • ZhengZ, XuL, ZhangS, et al. Peiminine inhibits colorectal cancer cell proliferation by inducing apoptosis and autophagy and modulating key metabolic pathways. Oncotarget. 2017;8(29):47619–47631. doi:10.18632/oncotarget.1741128496003
  • YoungCS, Tae YoulH, YunAJ, et al. Estrogenic activities of isoflavones and flavones and their structure-activity relationships. Planta Med. 2008;74(1):25–32. doi:10.1055/s-2007-99376018095219
  • NewillH, LoskeR, WagnerJ, et al. Oxidation products of stigmasterol interfere with the action of the female sex hormone 17beta-estradiol in cultured human breast and endometrium cell lines. Mol Nutr Food Res. 2007;51(7):888–898. doi:10.1002/mnfr.20070002517579897
  • LeeS, YounK, JunM. Major compounds of red ginseng oil attenuate Aβ25–35-induced neuronal apoptosis and inflammation by modulating MAPK/NF-κB pathway. Food Funct. 2018;9(8):4122–4134. doi:10.1039/C8FO00795K30014084
  • Lopez-GarciaG, CillaA, BarberaR, AlegriaA. Antiproliferative effect of plant sterols at colonic concentrations on Caco-2 cells. J Funct Foods. 2017;39:84–90. doi:10.1016/j.jff.2017.10.006
  • KangsamaksinT, ChaithongyotS, WootthichairangsanC, et al. Lupeol and stigmasterol suppress tumor angiogenesis and inhibit cholangiocarcinoma growth in mice via downregulation of tumor necrosis factor-α. PLoS One. 2017;12(12):e0189628. doi:10.1371/journal.pone.018962829232409
  • WangY, FanX, QuH, GaoX, ChengY. Strategies and techniques for multi-component drug design from medicinal herbs and traditional Chinese medicine. Curr Top Med Chem. 2012;12(12):1356–1362. doi:10.2174/15680261280131903422690682
  • LiB, ChenM, LiuX, GuoSW. Constitutive and tumor necrosis factor-α-induced activation of nuclear factor-κB in adenomyosis and its inhibition by andrographolide. Fertil Steril. 2013;100(2):568–577. doi:10.1016/j.fertnstert.2013.04.02823706331
  • WangY, QuY, SongW. Genetic variation in COX-2-1195 and the risk of endometriosis and adenomyosis. Clin Exp Obstetr Gynecol. 2015;42(2):168–172.
  • SamodelkinEI, MercuchevaNG, KosarevaPV, NesterovaLY. The role of prostaglandins and Cyclooxygenase in pathogenesis of chronic endometritis. Patol Fiziol Eksp Ter. 2017;61(2):98–100.29215850
  • LuoD, ChenH, LiX, et al. Activation of the ROCK1/MMP-9 pathway is associated with the invasion and poor prognosis in papillary thyroid carcinoma. Int J Oncol. 2017;51(4):1209–1218. doi:10.3892/ijo.2017.410028848996
  • JiangC, GongW, ChenR, et al. RhoA/ROCK/ARHGAP26 signaling in the eutopic and ectopic endometrium is involved in clinical characteristics of adenomyosis. J Int Med Res. 2018;46(12):5019–5029. doi:10.1177/030006051878903830387365
  • QiS, ZhaoX, LiM, et al. Aberrant expression of Notch1/numb/snail signaling, an epithelial mesenchymal transition related pathway, in adenomyosis. Reprod Biol Endocrinol. 2015;13(1):1–10. doi:10.1186/s12958-015-0084-225567742
  • ZhangD, XiaW, LiC, et al. Correlation between Cyr61 expression and clinicopathologic parameters in adenomyosis. J Reprod Immunol. 2016;118:42–49. doi:10.1016/j.jri.2016.08.00427644084
  • ZhengZZ, LiuZX. Activation of the phosphatidylinositol 3-kinase/protein kinase Akt pathway mediates CD151-induced endothelial cell proliferation and cell migration. Int J Biochem Cell Biol. 2007;39(2):340–348. doi:10.1016/j.biocel.2006.09.00117045834
  • CianciulliA, CalvelloR, PorroC, TrottaT, SalvatoreR, PanaroMA. PI3k/Akt signalling pathway plays a crucial role in the anti-inflammatory effects of curcumin in LPS-activated microglia. Int Immunopharmacol. 2016;36:282–290. doi:10.1016/j.intimp.2016.05.00727208432
  • PengalRA, GanesanLP, WeiG, FangH, OstrowskiMC, TridandapaniS. Lipopolysaccharide-induced production of interleukin-10 is promoted by the serine/threonine kinase Akt. Mol Immunol. 2006;43(10):1557–1564. doi:10.1016/j.molimm.2005.09.02216263172
  • QiuL, XuC, JiangH, LiW, TongS, XiaH. Cantharidin attenuates the proliferation and migration of vascular smooth muscle cells through suppressing inflammatory response. Biol Pharm Bull. 2018;42(1):34–42. doi:10.1248/bpb.b18-0046230393274
  • ErsahinT, TuncbagN, Cetin-AtalayR. The PI3K/AKT/mTOR interactive pathway. Mol Biosyst. 2015;11(7):1946–1954. doi:10.1039/C5MB00101C25924008
  • GuoJB, GaoJM, YuXH. Expression of DJ-1 and mTOR in eutopic and ectopic endometria of patients with endometriosis and adenomyosis. Gynecol Obstet Invest. 2015;79(3):195–200. doi:10.1159/00036556925721338
  • PerkinsND. Integrating cell-signalling pathways with NF-κB and IKK function. Nat Rev Mol Cell Biol. 2007;8(1):49–62. doi:10.1038/nrm208317183360
  • WongET, TergaonkarV. Roles of NF-κB in health and disease: mechanisms and therapeutic potential. Clin Sci. 2009;116(6):451. doi:10.1042/CS2008050219200055
  • LeeYH, JeonSJ, KimSH, et al. A new synthetic chalcone derivative, 2-hydroxy-3’,5,5’-trimethoxychalcone (DK-139), suppresses the Toll-like receptor 4-mediated inflammatory response through inhibition of the Akt/NF-κB pathway in BV2 microglial cells. Exp Mol Med. 2012;44(6):369–377. doi:10.3858/emm.2012.44.6.04222382990
  • KimJK, JungDH, KimSC, et al. Anti-inflammatory effect of Hemistepta lyrata Bunge (Bunge) on LPS- induced inflammation in RAW 264.7 cells. J Herbal Formula Sci. 2019;27(1):7–16.
  • DaiC, ZhengCQ, MengFJ, ZhouZ, JiangM. VSL#3 probiotics exerts the anti-inflammatory activity via PI3k/Akt and;NF-κ B pathway in rat model of DSS-induced colitis. Mol Cell Biochem. 2013;374(1–2):1–11. doi:10.1007/s11010-012-1488-323271629
  • NieJ, LuYX. Immunoreactivity of progesterone receptor isoform B, nuclear factor κB, and IκBalpha in adenomyosis. Fertil Steril. 2009;92(3):886–889. doi:10.1016/j.fertnstert.2009.01.08419296948
  • WangF, LiH, DuX, CuiM, WenZ. Expression of interleukin-10 in patients with adenomyosis. Fertil Steril. 2009;91(5):1681–1685. doi:10.1016/j.fertnstert.2008.02.16418439592
  • NataliaS, IouliaA, AnnaM. Cytokine network of eutopic and ectopic endometrium in women with adenomyosis. Am J Reprod Immunol. 2015;47(4):251–255.
  • ZhengDX, DuanH, WangS, XuQ, GanL, DongQJ. FAK regulates epithelial‑mesenchymal transition in adenomyosis. Mol Med Rep. 2018;18(6):5461–5472. doi:10.3892/mmr.2018.960030365102
  • StreuliI, SantulliP, ChouzenouxS, ChapronC, BatteuxF. Serum osteopontin levels are decreased in focal adenomyosis. Reprod Sci. 2016;24(5):773–782. doi:10.1177/193371911666905427678100
  • XiaoY, LiTC, XiaEL, YangXL, SunX, ZhouYF. Expression of integrin β3 and osteopontin in the eutopic endometrium of adenomyosis during the implantation window. Eur J Obstet Gynecol Reprod Biol. 2013;170(2):419–422. doi:10.1016/j.ejogrb.2013.05.00724021319
  • Shira PelegH, TamiR, LarysaR, IdoW. Endocrine resistance in breast cancer: focus on the phosphatidylinositol 3-kinase/akt/mammalian target of rapamycin signaling pathway. Breast Care. 2013;8(4):248–255. doi:10.1159/00035475724415977
  • CrowderRJ, ChanphengP, YuT, et al. PIK3CA and PIK3CB inhibition produce synthetic lethality when combined with estrogen deprivation in estrogen receptor-positive breast cancer. Cancer Res. 2009;69(9):3955. doi:10.1158/0008-5472.CAN-08-445019366795
  • MajumderA, RayS, BanerjiA. Epidermal growth factor receptor-mediated regulation of matrix metalloproteinase-2 and matrix metalloproteinase-9 in MCF-7 breast cancer cells. Mol Cell Biochem. 2018;452:1–11.30051305
  • MillerTW. Endocrine resistance: what do we know?. Am Soc Clin Oncol Edu Book. 2013;2013:e37–e42.
  • PranweerapaiboonK, ApisawetakanS, NobsathianS, et al. An ethyl-acetate fraction of Holothuria scabra modulates inflammation in vitro through inhibiting the production of nitric oxide and pro-inflammatory cytokines via NF-κB and JNK pathways. Inflammopharmacology. 2019. doi:10.1007/s10787-019-00677-3
  • Chinetti-GbaguidiG, ColinS, StaelsB. Macrophage subsets in atherosclerosis. Nat Rev Cardiol. 2015;12:10–17. doi:10.1038/nrcardio.2014.17325367649
  • GeissmannF, GordonS, HumeDA, MowatAM, RandolphGJ. Unravelling mononuclear phagocyte heterogeneity. Nat Rev Immunol. 2010;10:453–460. doi:10.1038/nri278420467425
  • KimB, KimE, LeeE, et al. Panax notoginseng inhibits tumor growth through activating macrophage to M1 polarization. Am J Chin Med (Gard City N Y). 2018;46(06):1369–1385. doi:10.1142/S0192415X18500726
  • LiC, ChenR, JiangC, ChenL, ChengZ. Correlation of LOX-5 and COX-2 expression with inflammatory pathology and clinical features of adenomyosis. Mol Med Rep. 2019;19(1):727–733. doi:10.3892/mmr.2018.961830387822
  • ZhihongN, YunF, PingguiZ, et al. Cytokine profiling in the eutopic endometrium of adenomyosis during the implantation window after ovarian stimulation. Reprod Sci. 2016;23(1):124–133. doi:10.1177/193371911559776126239388
  • LiuJJ, DuanH, WangS. Expression of nitric oxide in uterine junctional zone of patients with adenomyosis. Zhonghua Fu Chan Ke Za Zhi. 2013;48(7):504.24284220
  • ZhiHZ, SuLZ, ZhangAJ. Cytokine profiling in the eutopic endometrium of adenomyosis during the implantation window after ovarian stimulation. Reprod Sci. 2016;23(1):124–133. doi:10.1177/193371911559776126239388
  • LiuD, CaoG, HanL, YeY, SimaY, GeW. Flavonoids from radix Tetrastigmae inhibit TLR4/MD-2 mediated JNK and NF-κB pathway with anti-inflammatory properties. Cytokine. 2016;84:29–36. doi:10.1016/j.cyto.2015.08.00327235587
  • LiJB, WangHY, YaoY, et al. Overexpression of microRNA-138 alleviates human coronary artery endothelial cell injury and inflammatory response by inhibiting the PI3K/Akt/eNOS pathway. J Cel Mol Med. 2017;21(8):1482–1491. doi:10.1111/jcmm.13074