102
Views
11
CrossRef citations to date
0
Altmetric
Original Research

NMMHC IIA Inhibition Ameliorates Cerebral Ischemic/Reperfusion-Induced Neuronal Apoptosis Through Caspase-3/ROCK1/MLC Pathway

, , , , &
Pages 13-25 | Published online: 06 Jan 2020

References

  • ChenN, ZhouZ, LiJ, et al. 3-n-butylphthalide exerts neuroprotective effects by enhancing anti-oxidation and attenuating mitochondrial dysfunction in an in vitro model of ischemic stroke. Drug Des Devel Ther. 2018;12:4261–4271. doi:10.2147/DDDT.S189472
  • PandianJD, GallSL, KateMP, et al. Prevention of stroke: a global perspective. Lancet. 2018;392(10154):1269–1278. doi:10.1016/S0140-6736(18)31269-830319114
  • OzakiT, NakamuraH, KishimaH. Therapeutic strategy against ischemic stroke with the concept of neurovascular unit. Neurochem Int. 2019;126:246–251. doi:10.1016/j.neuint.2019.03.02230946849
  • SiniscalchiA, De SarroG, PacificiR, PisaniE, SanguigniS, GallelliL. Thrombolytic therapy in cocaine users with ischemic stroke: a review of current practice. Psychopharmacol Bull. 2019;49(1):70–79.30858640
  • PuyalJ, GinetV, ClarkePG. Multiple interacting cell death mechanisms in the mediation of excitotoxicity and ischemic brain damage: a challenge for neuroprotection. Prog Neurobiol. 2013;105:24–48. doi:10.1016/j.pneurobio.2013.03.00223567504
  • LiX, ZhengL, XiaQ, et al. A novel cell-penetrating peptide protects against neuron apoptosis after cerebral ischemia by inhibiting the nuclear translocation of annexin A1. Cell Death Differ. 2018;26(2):260–275. doi:10.1038/s41418-018-0116-529769639
  • ZhangYP, ZhangY, XiaoZB, et al. CFTR prevents neuronal apoptosis following cerebral ischemia reperfusion via regulating mitochondrial oxidative stress. J Mol Med (Berl). 2018;96(7):611–620. doi:10.1007/s00109-018-1649-229761302
  • LeeJC, WonMH. Neuroprotection of antioxidant enzymes against transient global cerebral ischemia in gerbils. Anat Cell Biol. 2014;47(3):149–156. doi:10.5115/acb.2014.47.3.14925276473
  • ColemanML, SahaiEA, YeoM, BoschM, DewarA, OlsonMF. Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I. Nat Cell Biol. 2001;3(4):339. doi:10.1038/3507000911283606
  • SebbaghM, RenvoizéC, HamelinJ, RichéN, BertoglioJ, BréardJ. Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbing. Nat Cell Biol. 2001;3(4):346. doi:10.1038/3507001911283607
  • ShenK, WangY, ZhangY, et al. Cocktail of four active components derived from Sheng Mai San inhibits hydrogen peroxide-induced PC12 cell apoptosis linked with the caspase-3/ROCK1/MLC pathway. Rejuvenation Res. 2015;18(6):517–527. doi:10.1089/rej.2015.169726058543
  • WangY, XuY, LiuQ, et al. Myosin IIA-related actomyosin contractility mediates oxidative stress-induced neuronal apoptosis. Front Mol Neurosci. 2017;10:75. doi:10.3389/fnmol.2017.0007528352215
  • TitusMA. Growing, splitting and stacking myosin II filaments. Nat Cell Biol. 2017;19(2):77. doi:10.1038/ncb346828139651
  • HuS, DasbiswasK, GuoZ, et al. Long-range self-organization of cytoskeletal myosin II filament stacks. Nat Cell Biol. 2017;19(2):133. doi:10.1038/ncb346628114270
  • MeddensMB, PandzicE, SlotmanJA, et al. Actomyosin-dependent dynamic spatial patterns of cytoskeletal components drive mesoscale podosome organization. Nat Commun. 2016;7:13127. doi:10.1038/ncomms1312727721497
  • LvY, FuL. The potential mechanism for Hydroxysafflor yellow A attenuating blood-brain barrier dysfunction via tight junction signaling pathways excavated by an integrated serial affinity chromatography and shotgun proteomics analysis approach. Neurochem Int. 2018;112:38–48. doi:10.1016/j.neuint.2017.10.01229107696
  • NasoMF, TomkowiczB, PerryWL, StrohlWR. Adeno-associated virus (AAV) as a vector for gene therapy. BioDrugs. 2017;31(4):317–334. doi:10.1007/s40259-017-0234-528669112
  • QuY, LiuY, NoorAF, TranJ, LiR. Characteristics and advantages of adeno-associated virus vector-mediated gene therapy for neurodegenerative diseases. Neural Regen Res. 2019;14(6):931. doi:10.4103/1673-5374.25057030761996
  • WangD, TaiPWL, GaoG. Adeno-associated virus vector as a platform for gene therapy delivery. Nat Rev Drug Discov. 2019;18(5):358–378. doi:10.1038/s41573-019-0012-930710128
  • WeinbergMS, SamulskiRJ, McCownTJ. Adeno-associated virus (AAV) gene therapy for neurological disease. Neuropharmacology. 2013;69:82–88. doi:10.1016/j.neuropharm.2012.03.00422465202
  • ZengJ, WangY, LuoZ, et al. TRIM9-mediated resolution of neuroinflammation confers neuroprotection upon ischemic stroke in mice. Cell Rep. 2019;27(2):549–560. e6. doi:10.1016/j.celrep.2018.12.05530970257
  • SeharaY, InabaT, UrabeT, et al. Survivin overexpression via adeno-associated virus vector Rh10 ameliorates ischemic damage after middle cerebral artery occlusion in rats. Eur J Neurosci. 2018;48(12):3466–3476. doi:10.1111/ejn.2018.48.issue-1230251448
  • CaoG, JiangN, HuY, et al. Ruscogenin attenuates cerebral ischemia-induced blood-brain barrier dysfunction by suppressing TXNIP/NLRP3 inflammasome activation and the MAPK pathway. Int J Mol Sci. 2016;17(9):1418. doi:10.3390/ijms17091418
  • VélezAM, FishilevichE. The mysteries of insect RNAi: a focus on dsRNA uptake and transport. Pestic Biochem Physiol. 2018;151:25–31. doi:10.1016/j.pestbp.2018.08.00530704709
  • SchusterS, MiesenP, van RijRP. Antiviral RNAi in insects and mammals: parallels and differences. Viruses. 2019;11:(5)448. doi:10.3390/v11050448
  • WengY, XiaoH, ZhangJ, LiangXJ, HuangY. RNAi therapeutic and its innovative biotechnological evolution. Biotechnol Adv. 2019;37(5):801–825. doi:10.1016/j.biotechadv.2019.04.01231034960
  • FoustKD, NurreE, MontgomeryCL, HernandezA, ChanCM, KasparBK. Intravascular AAV9 preferentially targets neonatal neurons and adult astrocytes. Nat Biotechnol. 2009;27(1):59–65. doi:10.1038/nbt.151519098898
  • GuoYY, LuY, ZhengY, et al. Ubiquitin c-terminal hydrolase l1 (uch-l1) promotes hippocampus-dependent memory via its deubiquitinating effect on trkb. J Neurosci. 2017;37(25):5978–5995. doi:10.1523/JNEUROSCI.3148-16.201728500221
  • XiaoQ, HuX, WeiZ, TamKY. Cytoskeleton molecular motors: structures and their functions in neuron. Int J Biol Sci. 2016;12(9):1083–1092. doi:10.7150/ijbs.1563327570482
  • Newell-LitwaKA, HorwitzR, LamersML. Non-muscle myosin II in disease: mechanisms and therapeutic opportunities. Dis Model Mech. 2015;8(12):1495–1515. doi:10.1242/dmm.02210326542704
  • MaX, AdelsteinRS. The role of vertebrate nonmuscle Myosin II in development and human disease. Bioarchitecture. 2014;4(3):88–102. doi:10.4161/bioa.2976625098841
  • NishiyamaY, AkaishiJ, KatsumataT, KatsuraK, KatayamaY. Cerebral infarction in a patient with macrothrombocytopenia with leukocyte inclusions (MTCP, May-Hegglin anomaly/Sebastian syndrome). J Nippon Med Sch. 2008;75(4):228–232. doi:10.1272/jnms.75.22818781047
  • ZhaoY, WangJ, JiangH, YuZ, LiX, ShiJ. Following OGD/R, annexin 1 nuclear translocation and subsequent induction of apoptosis in neurons are assisted by myosin IIA in a TRPM7 kinase-dependent manner. Mol Neurobiol. 2015;51(2):729–742. doi:10.1007/s12035-014-8781-y24939696
  • SekerdagE, SolarogluI, Gursoy-OzdemirY. Cell death mechanisms in stroke and novel molecular and cellular treatment options. Curr Neuropharmacol. 2018;16(9):1396–1415. doi:10.2174/1570159X1666618030211554429512465
  • FrickerM, TolkovskyAM, BorutaiteV, ColemanM, BrownGC. Neuronal cell death. Physiol Rev. 2018;98(2):813–880. doi:10.1152/physrev.00011.201729488822
  • ZhangX, ZhangY, TangS, et al. Pien-Tze-Huang protects cerebral ischemic injury by inhibiting neuronal apoptosis in acute ischemic stroke rats. J Ethnopharmacol. 2018;219:117–125. doi:10.1016/j.jep.2018.03.01829550579
  • Ndozangue-TouriguineO, HamelinJ, BréardJ. Cytoskeleton and apoptosis. Biochem Pharmacol. 2008;76(1):11–18. doi:10.1016/j.bcp.2008.03.01618462707
  • YuP, SantiagoLY, KatagiriY, GellerHM. Myosin II activity regulates neurite outgrowth and guidance in response to chondroitin sulfate proteoglycans. J Neurochem. 2012;120(6):1117–1128. doi:10.1111/j.1471-4159.2011.07638.x22191382
  • MedeirosNA, BurnetteDT, ForscherFP. Myosin II functions in actin-bundle turnover in neuronal growth cones. Nat Cell Biol. 2006;8(3):216. doi:10.1038/ncb1367
  • ChangJ, XieM, ShahVR, et al. Activation of Rho-associated coiled-coil protein kinase 1 (ROCK-1) by caspase-3 cleavage plays an essential role in cardiac myocyte apoptosis. Proc Natl Acad Sci USA. 2006;103(39):14495–14500. doi:10.1073/pnas.060191110316983089
  • LiuL, LiG, LiQ, et al. Triptolide induces apoptosis in human leukemia cells through caspase-3-mediated ROCK1 activation and MLC phosphorylation. Cell Death Dis. 2013;4:e941. doi:10.1038/cddis.2013.46924309928
  • WangY, LiuQ, XuY, et al. Ginsenoside Rg1 protects against oxidative stress-induced neuronal apoptosis through myosin IIA-actin related cytoskeletal reorganization. Int J Biol Sci. 2016;12(11):1341. doi:10.7150/ijbs.1599227877086