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Original Research

Comparison of Pharmacokinetics of a Fixed-Dose Combination of Amlodipine/Losartan/Rosuvastatin with Concomitant Administration of Amlodipine/Losartan and Rosuvastatin in Healthy Volunteers

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Pages 661-668 | Published online: 19 Feb 2020

References

  • RothGA, JohnsonC, AbajobirA, et al. Global, Regional, and National Burden of Cardiovascular Diseases for 10 causes, 1990 to 2015. J Am Coll Cardiol. 2017;70(1):1–25. doi:10.1016/j.jacc.2017.04.05228527533
  • PiepoliMF, HoesAW, AgewallS, et al. 2016 European Guidelines on cardiovascular disease prevention in clinical practice: the sixth joint task force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of 10 societies and by invited experts) developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR). Eur Heart J. 2016;37(29):2315–2381. doi:10.1093/eurheartj/ehw10627222591
  • EatonCB, FeldmanHA, AssafAR, et al. Prevalence of hypertension, dyslipidemia, and dyslipidemic hypertension. J Fam Pract. 1994;38(1):17–23.8289046
  • JohnsonML, PietzK, BattlemanDS, BeythRJ. Prevalence of comorbid hypertension and dyslipidemia and associated cardiovascular disease. Am J Manag Care. 2004;10(12):926–932.15617368
  • DahlofB. Cardiovascular disease risk factors: epidemiology and risk assessment. Am J Cardiol. 2010;105(1 Suppl):3A–9A. doi:10.1016/j.amjcard.2009.10.007
  • WlodarczykJ, SullivanD, SmithM. Comparison of benefits and risks of rosuvastatin versus atorvastatin from a meta-analysis of head-to-head randomized controlled trials. Am J Cardiol. 2008;102(12):1654–1662. doi:10.1016/j.amjcard.2008.08.01419064019
  • JamesPA, OparilS, CarterBL, et al. 2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8). JAMA. 2014;311(5):507–520. doi:10.1001/jama.2013.28442724352797
  • ParkCG, YounHJ, ChaeSC, et al. Evaluation of the dose-response relationship of amlodipine and losartan combination in patients with essential hypertension: an 8-week, randomized, double-blind, factorial, Phase II, multicenter study. Am J Cardiovasc Drugs. 2012;12(1):35–47. doi:10.2165/11597170-000000000-0000022217192
  • WilliamsB, ManciaG, SpieringW, et al. 2018 ESC/ESH guidelines for the management of arterial hypertension. Eur Heart J. 2018;39(33):3021–3104.30165516
  • BangaloreS, KamalakkannanG, ParkarS, MesserliFH. Fixed-dose combinations improve medication compliance: a meta-analysis. Am J Med. 2007;120(8):713–719. doi:10.1016/j.amjmed.2006.08.03317679131
  • DevabhaktuniM, BangaloreS. Fixed combination of amlodipine and atorvastatin in cardiovascular risk management: patient perspectives. Vasc Health Risk Manag. 2009;5(1):377–387. doi:10.2147/vhrm.s333919475775
  • World Health Organization Guidelines for registration of fixed-dose combination medicinal products. Available from: http://www.gmp-compliance.org/guidemgr/files/WHO_TRS_929_ANNEX5.PDF. Accessed 89, 2019.
  • LeeHY, KimSY, ChoiKJ, et al. A randomized, multicenter, double-blind, placebo-controlled study to evaluate the efficacy and the tolerability of a triple combination of amlodipine/losartan/rosuvastatin in patients with comorbid essential hypertension and hyperlipidemia. Clin Ther. 2017;39(12):2366–2379. doi:10.1016/j.clinthera.2017.10.01329150250
  • ChoiY, LeeS, ChoSM, et al. Comparisons of the pharmacokinetics and tolerability of fixed-dose combinations of amlodipine besylate/losartan and amlodipine camsylate/losartan in healthy subjects: a randomized, open-label, single-dose, two-period, two-sequence crossover study. Drug Des Devel Ther. 2016;10:3021–3028. doi:10.2147/DDDT.S113891
  • OhM, GhimJL, ParkSE, KimEY, ShinJG. Pharmacokinetic comparison of a fixed-dose combination versus concomitant administration of fimasartan, amlodipine, and rosuvastatin using partial replicated design in healthy adult subjects. Drug Des Devel Ther. 2018;12:1157–1164. doi:10.2147/DDDT.S164215
  • OhM, ShinJG, AhnS, et al. Pharmacokinetic comparison of a fixed-dose combination versus concomitant administration of amlodipine, olmesartan, and rosuvastatin in healthy adult subjects. Drug Des Devel Ther. 2019;13:991–997. doi:10.2147/DDDT.S202730
  • SicaDA, GehrTW, GhoshS. Clinical pharmacokinetics of losartan. Clin Pharmacokinet. 2005;44(8):797–814. doi:10.2165/00003088-200544080-0000316029066
  • JiaJY, ZhangMQ, LiuYM, et al. Pharmacokinetics and bioequivalence evaluation of two losartan potassium 50-mg tablets: a single-dose, randomized-sequence, open-label, two-way crossover study in healthy Chinese male volunteers. Clin Ther. 2010;32(7):1387–1395. doi:10.1016/j.clinthera.2010.06.01820678685
  • RohatagiS, LeeJ, ShenoudaM, et al. Pharmacokinetics of amlodipine and olmesartan after administration of amlodipine besylate and olmesartan medoxomil in separate dosage forms and as a fixed-dose combination. J Clin Pharmacol. 2008;48(11):1309–1322. doi:10.1177/009127000832217618974285
  • McIntyreM, CaffeSE, MichalakRA, ReidJL. Losartan, an orally active angiotensin (AT1) receptor antagonist: a review of its efficacy and safety in essential hypertension. Pharmacol Ther. 1997;74(2):181–194. doi:10.1016/S0163-7258(97)82002-59336021
  • MartinPD, WarwickMJ, DaneAL, CantariniMV. A double-blind, randomized, incomplete crossover trial to assess the dose proportionality of rosuvastatin in healthy volunteers. Clin Ther. 2003;25(8):2215–2224. doi:10.1016/S0149-2918(03)80214-X14512129