112
Views
7
CrossRef citations to date
0
Altmetric
Original Research

Neuroprotective Effect of S-trans, Trans-farnesylthiosalicylic Acid via Inhibition of RAS/ERK Pathway for the Treatment of Alzheimer’s Disease

, ORCID Icon, ORCID Icon, ORCID Icon & ORCID Icon
Pages 4053-4063 | Published online: 29 Nov 2019

References

  • Lane CA, Hardy J, Schott JM. Alzheimer’s disease. Eur J Neurol. 2018;25(1):59–70. doi:10.1111/ene.2018.25.issue-128872215
  • Schmidt-Hieber C, Jonas P, Bischofberger J. Enhanced synaptic plasticity in newly generated granule cells of the adult hippocampus. Nature. 2004;429(6988):184–187. doi:10.1038/nature0255315107864
  • Winocur G, Wojtowicz JM, Sekeres M, Snyder JS, Wang S. Inhibition of neurogenesis interferes with hippocampus-dependent memory function. Hippocampus. 2006;16(3):296–304. doi:10.1002/(ISSN)1098-106316411241
  • Anacker C, Hen R. Adult hippocampal neurogenesis and cognitive flexibility – linking memory and mood. Nat Rev Neurosci. 2017;18(6):335–346. doi:10.1038/nrn.2017.4528469276
  • Hamilton LK, Aumont A, Julien C, Vadnais A, Calon F, Fernandes KJ. Widespread deficits in adult neurogenesis precede plaque and tangle formation in the 3xTg mouse model of Alzheimer’s disease. Eur J Neurosci. 2010;32(6):905–920. doi:10.1111/j.1460-9568.2010.07379.x20726889
  • Lazarov O, Hollands C. Hippocampal neurogenesis: learning to remember. Prog Neurobiol. 2016;138–140:1–18. doi:10.1016/j.pneurobio.2015.12.006
  • Selkoe DJ. Deciphering the genesis and fate of amyloid beta-protein yields novel therapies for Alzheimer disease. J Clin Invest. 2002;110(10):1375–1381. doi:10.1172/JCI021678312438432
  • Kirouac L, Rajic AJ, Cribbs DH, Padmanabhan J. Activation of Ras-ERK signaling and GSK-3 by amyloid precursor protein and amyloid beta facilitates neurodegeneration in Alzheimer’s disease. eNeuro. 2017;4:2. doi:10.1523/ENEURO.0149-16.2017
  • Murphy LO, Blenis J. MAPK signal specificity: the right place at the right time. Trends Biochem Sci. 2006;31(5):268–275. doi:10.1016/j.tibs.2006.03.00916603362
  • Lee MS, Kao SC, Lemere CA, et al. APP processing is regulated by cytoplasmic phosphorylation. J Cell Biol. 2003;163(1):83–95.14557249
  • Coleman ML, Marshall CJ, Olson MF. Ras promotes p21(Waf1/Cip1) protein stability via a cyclin D1-imposed block in proteasome-mediated degradation. EMBO J. 2003;22(9):2036–2046. doi:10.1093/emboj/cdg18912727871
  • Arendt T, Holzer M, Stöbe A, et al. Activated mitogenic signaling induces a process of dedifferentiation in Alzheimer’s disease that eventually results in cell death. Ann N Y Acad Sci. 2000;920:249–255. doi:10.1111/j.1749-6632.2000.tb06931.x11193159
  • Koseoglu MM, Ozdilek BA, Djakbarova U, Gulusur A. Targeting Ras activity prevented amyloid beta-induced aberrant neuronal cell cycle re-entry and death. Curr Alzheimer Res. 2016;13(11):1267–1276. doi:10.2174/156720501366616062507452027357648
  • Shields JM, Pruitt K, McFall A, Shaub A, Der CJ. Understanding Ras: ‘it ain’t over ‘til it’s over’. Trends Cell Biol. 2000;10(4):147–154. doi:10.1016/S0962-8924(00)01740-210740269
  • Dineley KT, Westerman M, Bui D, Bell K, Ashe KH, Sweatt JD. Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: in vitro and in vivo mechanisms related to Alzheimer’s disease. J Neurosci. 2001;21(12):4125–4133. doi:10.1523/JNEUROSCI.21-12-04125.200111404397
  • Niv H, Gutman O, Kloog Y, Henis YI. Activated K-Ras and H-Ras display different interactions with saturable nonraft sites at the surface of live cells. J Cell Biol. 2002;157(5):865–872. doi:10.1083/jcb.20020200912021258
  • Kloog Y, Cox AD, Sinensky M. Concepts in Ras-directed therapy. Expert Opin Investig Drugs. 1999;8(12):2121–2140. doi:10.1517/13543784.8.12.2121
  • Wang Y, Chen T, Yuan Z, et al. Ras inhibitor S-trans, trans-farnesylthiosalicylic acid enhances spatial memory and hippocampal long-term potentiation via up-regulation of NMDA receptor. Neuropharmacology. 2018;139:257–267. doi:10.1016/j.neuropharm.2018.03.02629578035
  • Jin H, Chen T, Li G, et al. Dose-dependent neuroprotection and neurotoxicity of simvastatin through reduction of Farnesyl Pyrophosphate in mice treated with intracerebroventricular injection of Aβ 1-42. J Alzheimers Dis. 2016;50(2):501–516. doi:10.3233/JAD-15078226757191
  • Shohami E, Yatsiv I, Alexandrovich A, et al. The Ras inhibitor S-trans, trans-farnesylthiosalicylic acid exerts long-lasting neuroprotection in a mouse closed head injury model. J Cereb Blood Flow Metab. 2003;23(6):728–738. doi:10.1097/01.WCB.0000067704.86573.8312796721
  • Robert D, Mays W, Mays RW, et al. Development of an allogeneic adherent stem cell therapy for treatment of ischemic stroke. J Exp Stroke Transl Med. 2010;3:34–46. doi:10.6030/1939-067X-3.1.34
  • Wang C, Chen T, Li G, Zhou L, Sha S, Chen L. Simvastatin prevents β-amyloid(25–35)-impaired neurogenesis in hippocampal dentate gyrus through α7nAChR-dependent cascading PI3K-Akt and increasing BDNF via reduction of farnesyl pyrophosphate. Neuropharmacology. 2015;97:122–132. doi:10.1016/j.neuropharm.2015.05.02026051402
  • Li L, Xu B, Zhu Y, Chen L, Sokabe M, Chen L. DHEA prevents Aβ25-35-impaired survival of newborn neurons in the dentate gyrus through a modulation of PI3K-Akt-mTOR signaling. Neuropharmacology. 2010;59(4–5):323–333. doi:10.1016/j.neuropharm.2010.02.00920167228
  • Rao MS, Shetty AK. Efficacy of doublecortin as a marker to analyse the absolute number and dendritic growth of newly generated neurons in the adult dentate gyrus. Eur J Neurosci. 2004;19(2):234–246. doi:10.1111/j.0953-816X.2003.03123.x14725617
  • Yun HM, Kim HS, Park KR, et al. Placenta-derived mesenchymal stem cells improve memory dysfunction in an Aβ1-42-infused mouse model of Alzheimer’s disease. Cell Death Dis. 2013;4:e958. doi:10.1038/cddis.2013.49024336078
  • Verret L, Jankowsky JL, Xu GM, Borchelt DR, Rampon C. Alzheimer’s-type amyloidosis in transgenic mice impairs survival of newborn neurons derived from adult hippocampal neurogenesis. J Neurosci. 2007;27(25):6771–6780. doi:10.1523/JNEUROSCI.5564-06.200717581964
  • Kempermann G, Gast D, Kronenberg G, Yamaguchi M, Gage FH. Early determination and long-term persistence of adult-generated new neurons in the hippocampus of mice. Development. 2003;130(2):391–399. doi:10.1242/dev.0020312466205
  • Brown JP, Couillard-Després S, Cooper-Kuhn CM, Winkler J, Aigner L, Kuhn HG. Transient expression of doublecortin during adult neurogenesis. J Comp Neurol. 2003;467(1):1–10. doi:10.1002/cne.v467:114574675
  • Choi SH, Bylykbashi E, Chatila ZK, et al. Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer’s mouse model. Science. 2018;361:6406. doi:10.1126/science.aan8821
  • Bordet R, Ihl R, Korczyn AD, et al. Towards the concept of disease-modifier in post-stroke or vascular cognitive impairment: a consensus report. BMC Med. 2017;15(1):107. doi:10.1186/s12916-017-0869-628539119
  • Zhao C, Teng EM, Summers RG Jr, Ming GL, Gage FH. Distinct morphological stages of dentate granule neuron maturation in the adult mouse hippocampus. J Neurosci. 2006;26(1):3–11. doi:10.1523/JNEUROSCI.3648-05.200616399667
  • Haughey NJ, Liu D, Nath A, Borchard AC, Mattson MP. Disruption of neurogenesis in the subventricular zone of adult mice, and in human cortical neuronal precursor cells in culture, by amyloid beta-peptide: implications for the pathogenesis of Alzheimer’s disease. Neuromolecular Med. 2002;1(2):125–135. doi:10.1385/NMM:1:2:12512025858
  • Radak Z, Hart N, Sarga L, et al. Exercise plays a preventive role against Alzheimer’s disease. J Alzheimers Dis. 2010;20(3):777–783. doi:10.3233/JAD-2010-09153120182027
  • Lamb SE, Sheehan B, Atherton N; DAPA Trial Investigators, et al.. Dementia And Physical Activity (DAPA) trial of moderate to high intensity exercise training for people with dementia: randomised controlled trial. BMJ. 361:k1675.
  • Gärtner U, Holzer M, Arendt T. Elevated expression of p21ras is an early event in Alzheimer’s disease and precedes neurofibrillary degeneration. Neuroscience. 1999;91(1):1–5. doi:10.1016/S0306-4522(99)00059-710336054
  • Shaul YD, Seger R. The MEK/ERK cascade: from signaling specificity to diverse functions. Biochim Biophys Acta. 2007;1773(8):1213–1226. doi:10.1016/j.bbamcr.2006.10.00517112607
  • Lee HG, Casadesus G, Zhu X, et al. Cell cycle re-entry mediated neurodegeneration and its treatment role in the pathogenesis of Alzheimer’s disease. Neurochem Int. 2009;54(2):84–88. doi:10.1016/j.neuint.2008.10.01319114068
  • Ye X, Carew TJ. Small G protein signaling in neuronal plasticity and memory formation: the specific role of ras family proteins. Neuron. 2010;68(3):340–361. doi:10.1016/j.neuron.2010.09.01321040840
  • Li W, Cui Y, Kushner SA, et al. The HMG-CoA reductase inhibitor lovastatin reverses the learning and attention deficits in a mouse model of neurofibromatosis type 1. Curr Biol. 2005;15(21):1961–1967. doi:10.1016/j.cub.2005.09.04316271875
  • Pennisi G, Ferri R, Lanza G, et al. Transcranial magnetic stimulation in Alzheimer’s disease: a neurophysiological marker of cortical hyperexcitability. J Neural Transm (Vienna). 2011;118(4):587–598. doi:10.1007/s00702-010-0554-921207079
  • Cantone M, Bramanti A, Lanza G, et al. Cortical plasticity in depression. ASN Neuro. 2017;9(3):1759091417711512. doi:10.1177/175909141771151228629225
  • McTaggart SJ. Isoprenylated proteins. Cell Mol Life Sci. 2006;63(3):255–267. doi:10.1007/s00018-005-5298-616378247
  • Chambard JC, Lefloch R, Pouysségur J, Lenormand P. ERK implication in cell cycle regulation. Biochim Biophys Acta. 2007;1773(8):1299–1310. doi:10.1016/j.bbamcr.2006.11.01017188374
  • Tamemoto H, Kadowaki T, Tobe K, et al. Biphasic activation of two mitogen-activated protein kinases during the cell cycle in mammalian cells. J Biol Chem. 1992;267(28):20293–20297.1400347
  • Yan Y, Spieker RS, Kim M, Stoeger SM, Cowan KH. BRCA1-mediated G2/M cell cycle arrest requires ERK1/2 kinase activation. Oncogene. 2005;24(20):3285–3296. doi:10.1038/sj.onc.120849215735702