160
Views
31
CrossRef citations to date
0
Altmetric
Original Research

Exosomes Derived from Mesenchymal Stem Cells Protect the Myocardium Against Ischemia/Reperfusion Injury Through Inhibiting Pyroptosis

ORCID Icon, , , , , , , ORCID Icon, , & show all
Pages 3765-3775 | Published online: 16 Sep 2020

References

  • CastedoE, SegoviaJ, EscuderoC, et al. [Ischemia-reperfusion injury during experimental heart transplantation. Evaluation of trimetazidine’s cytoprotective effect]. Rev Esp Cardiol. 2005;58(8):941–950. Spanish.16053828
  • KevinLG, CamaraAK, RiessML, et al. Ischemic preconditioning alters real-time measure of O2 radicals in intact hearts with ischemia and reperfusion. Am J Physiol Heart Circ Physiol. 2003;284(2):H566–574.12414448
  • ArslanF, de KleijnDP, TimmersL, et al. Bridging innate immunity and myocardial ischemia/reperfusion injury: the search for therapeutic targets. Curr Pharm Des. 2008;14(12):1205–1216.18473868
  • SongJQ, TengX, CaiY, et al. Activation of Akt/GSK-3beta signaling pathway is involved in intermedin(1-53) protection against myocardial apoptosis induced by ischemia/reperfusion. Apoptosis. 2009;14(11):1299–1307.19757065
  • ArmstrongPW, GrangerCB, BettN, BriegerD, et al. Pexelizumab for acute ST-elevation myocardial infarction in patients undergoing primary percutaneous coronary intervention: a randomized controlled trial. JAMA. 2007;297(1):43–51.17200474
  • GomezL, LiB, MewtonN, et al. Inhibition of mitochondrial permeability transition pore opening: translation to patients. Cardiovasc Res. 2009;83(2):226–233.19221132
  • Ruiz-MeanaM, InserteJ, Fernandez-SanzC, et al. The role of mitochondrial permeability transition in reperfusion-induced cardiomyocyte death depends on the duration of ischemia. Basic Res Cardiol. 2011;106(6):1259–1268.21959501
  • LemastersJJ, BondJM, ChaconE, et al. The pH paradox in ischemia-reperfusion injury to cardiac myocytes. EXS. 1996;76:99–114.8805791
  • LeeP, SataM, LeferDJ, et al. Fas pathway is a critical mediator of cardiac myocyte death and MI during ischemia-reperfusion in vivo. Am J Physiol Heart Circ Physiol. 2003;284(2):H456–463.12414449
  • ChenY, SmithMR, ThirumalaiK, et al. A bacterial invasin induces macrophage apoptosis by binding directly to ICE. EMBO J. 1996;15(15):3853–3860.8670890
  • ZhaoC, GuY, ZengX, et al. NLRP3 inflammasome regulates Th17 differentiation in rheumatoid arthritis. Clin Immunol. 2018;197:154–160.30236770
  • FrickerM, TolkovskyAM, BorutaiteV, et al. Neuronal Cell Death. Physiol Rev. 2018;98(2):813–880.29488822
  • ChenH, LuY, CaoZ, et al. Cadmium induces NLRP3 inflammasome-dependent pyroptosis in vascular endothelial cells. Toxicol Lett. 2016;246:7–16.26809137
  • DuewellP, KonoH, RaynerKJ, et al. NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals. Nature. 2010;464(7293):1357–1361.20428172
  • SchroderK, TschoppJ. The inflammasomes. Cell. 2010;140(6):821–832.20303873
  • LamkanfiM, DixitVM. Manipulation of host cell death pathways during microbial infections. Cell Host Microbe. 2010;8(1):44–54.20638641
  • ToldoS, AbbateA. The NLRP3 inflammasome in acute myocardial infarction. Nat Rev Cardiol. 2018;15(4):203–214.29143812
  • AudiaJP, YangXM, CrockettES, et al. Caspase-1 inhibition by VX-765 administered at reperfusion in P2Y12 receptor antagonist-treated rats provides long-term reduction in myocardial infarct size and preservation of ventricular function. Basic Res Cardiol. 2018;113(5):32.29992382
  • FrantzS, DucharmeA, SawyerD, et al. Targeted deletion of caspase-1 reduces early mortality and left ventricular dilatation following myocardial infarction. Mol Cell Cardiol. 2003;35(6):685–694.
  • JohnstoneRM, AdamM, HammondJR, et al. Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles (exosomes). J Biol Chem. 1987;262(19):9412–9420.3597417
  • ValadiH, EkströmK, BossiosA, et al. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol. 2007;9(6):654–659.17486113
  • BörgerV, BremerM, GörgensA, et al. Mesenchymal stem/stromal cell-derived extracellular vesicles as a new approach in stem cell therapy. ISBT Sci Ser. 2016;11(S1):228–234.
  • FengY, HuangW, WaniM, et al. Ischemic preconditioning potentiates the protective effect of stem cells through secretion of exosomes by targeting Mecp2 via miR-22. PLoS One. 2014;9(2):e88685.24558412
  • ZhaoY, SunX, CaoW, et al. Exosomes derived from human umbilical cord mesenchymal stem cells relieve acute myocardial ischemic injury. Stem Cell Int. 2015.
  • YuB, ZhangX, LiX. Exosomes derived from mesenchymal stem cells. Int J Mol Sci. 2014;15(3):4142–4157.24608926
  • LeeJK, ParkSR, JungBK, et al. Exosomes derived from mesenchymal stem cells suppress angiogenesis by down-regulating VEGF expression in breast cancer cells. PLoS One. 2013;8(12):e84256.24391924
  • Tavakoli DarganiZ, SinglaR, JohnsonT, et al. Exosomes derived from embryonic stem cells inhibit doxorubicin and inflammation-induced pyroptosis in muscle cells. Can J Physiol Pharmacol. 2018;96(3):304–307.28926719
  • BaiL, LennonDP, EatonV, et al. Human bone marrow-derived mesenchymal stem cells induce Th2-polarized immune response and promote endogenous repair in animal models of multiple sclerosis. Glia. 2009;57(11):1192–1203.19191336
  • SignoreM, ManganelliV, HodgeA. Antibody validation by western blotting. Methods Mol Biol. 2017;1606:51–70.28501993
  • XuB, ZhangY, DuXF, et al. Neurons secrete miR-132-containing exosomes to regulate brain vascular integrity. Cell Res. 2017;27(7):882–897.28429770
  • HuL, ZhouL, WuX, et al. Hypoxic preconditioning protects cardiomyocytes against hypoxia/reoxygenation injury through AMPK/eNOS/PGC-1α signaling pathway. Int J Clin Exp Pathol. 2014;7(11):7378–7388.25550773
  • LamkanfiM, DixitVM. Mechanisms and functions of inflammasomes. Cell. 2014;157(5):1013–1022.24855941
  • Henao-MejiaJ, ElinavE, ThaissCA, et al. Inflammasomes and metabolic disease. Annu Rev Physiol. 2014;76:57–78.24274736
  • TseHF, KwongYL, ChanJK, et al. Angiogenesis in ischemic myocardium by intramyocardial autologous bone marrow mononuclear cell implantation. Lancet. 2003;361(9351):47–49.12517468
  • da Silva MeirellesL, ChagastellesPC, NardiNB. Mesenchymal stem cells reside in virtually all post-natal organs and tissues. J Cell Sci. 2006;119(Pt 11):2204–2213.16684817
  • TakeharaY, YabuuchiA, EzoeK, et al. The restorative effects of adipose-derived mesenchymal stem cells on damaged ovarian function. Lab Invest. 2013;93(2):181–193.23212100
  • MurphyMB, MoncivaisK, CaplanAI. Mesenchymal stem cells: environmentally responsive therapeutics for regenerative medicine. Exp Mol Med. 2013;45:e54.24232253
  • LoozeC1, YuiD, LeungL, et al. Proteomic profiling of human plasma exosomes identifies PPARgamma as an exosome-associated protein. Biochem Biophys Res Commun. 2009;378(3):433–438.19028452
  • RobbinsPD, MorelliAE. Regulation of immune responses by extracellular vesicles. Nat Rev Immunol. 2014;14(3):195–208.24566916
  • JiT, XuC, SunL, et al. Aryl hydrocarbon receptor activation down-regulates IL-7 and reduces inflammation in a mouse model of DSS-induced colitis. Dig Dis Sci. 2015;60(7):1958–1966.25799939
  • ZhaoJ, LiX, HuJ, et al. Mesenchymal stromal cell-derived exosomes attenuate myocardial ischaemia-reperfusion injury through miR-182-regulated macrophage polarization. Cardiovasc Res. 2019;115(7):1205–1216.30753344
  • KellerA1, LudwigN, FehlmannT. Low miR-150-5p and miR-320b expression predicts reduced survival of COPD patients. Cells. 2019;8(10):pii: E1162.
  • ZhangS, ZhangX, SunQ, et al. LncRNA NR2F2-AS1 promotes tumourigenesis through modulating BMI1 expression by targeting miR-320b in non-small cell lung cancer. J Cell Mol Med. 2019;23(3):2001–2011.30592135