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Original Research

Cinnamaldehyde Treatment of Prostate Cancer-Associated Fibroblasts Prevents Their Inhibitory Effect on T Cells Through Toll-Like Receptor 4

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Pages 3363-3372 | Published online: 18 Aug 2020

References

  • MarshT, PietrasK, McAllisterSS. Fibroblasts as architects of cancer pathogenesis. Biochim Biophys Acta. 2013;1832(7):1070–1078. doi:10.1016/j.bbadis.2012.10.01323123598
  • KalluriR. The biology and function of fibroblasts in cancer. Nat Rev Cancer. 2016;16(9):582–598. doi:10.1038/nrc.2016.7327550820
  • KalluriR, ZeisbergM. Fibroblasts in cancer. Nat Rev Cancer. 2006;6(5):392–401. doi:10.1038/nrc187716572188
  • ZianiL, ChouaibS, ThieryJ. Alteration of the antitumor immune response by cancer-associated fibroblasts. Front Immunol. 2018;9:414. doi:10.3389/fimmu.2018.0041429545811
  • LuY, YangW, QinC, et al. Responsiveness of stromal fibroblasts to IFN-gamma blocks tumor growth via angiostasis. J Immunol. 2009;183(10):6413–6421. doi:10.4049/jimmunol.090107319841170
  • SalinasCA, TsodikovA, Ishak-HowardM, CooneyKA. Prostate cancer in young men: an important clinical entity. Nat Rev Urol. 2014;11(6):317–323. doi:10.1038/nrurol.2014.9124818853
  • BrayF, FerlayJ, SoerjomataramI, SiegelRL, TorreLA, JemalA. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394–424. doi:10.3322/caac.2149230207593
  • WatsonPA, AroraVK, SawyersCL. Emerging mechanisms of resistance to androgen receptor inhibitors in prostate cancer. Nat Rev Cancer. 2015;15(12):701–711. doi:10.1038/nrc401626563462
  • CalcinottoA, SpataroC, ZagatoE, et al. IL-23 secreted by myeloid cells drives castration-resistant prostate cancer. Nature. 2018;559(7714):363–369. doi:10.1038/s41586-018-0266-029950727
  • AmmiranteM, LuoJL, GrivennikovS, NedospasovS, KarinM. B-cell-derived lymphotoxin promotes castration-resistant prostate cancer. Nature. 2010;464(7286):302–305. doi:10.1038/nature0878220220849
  • EiroN, Fernandez-GomezJ, SacristanR, et al. Stromal factors involved in human prostate cancer development, progression and castration resistance. J Cancer Res Clin Oncol. 2017;143(2):351–359. doi:10.1007/s00432-016-2284-327787597
  • GeorgeRC, LewJ, GravesDJ. Interaction of cinnamaldehyde and epicatechin with tau: implications of beneficial effects in modulating Alzheimer’s disease pathogenesis. J Alzheimers Dis. 2013;36(1):21–40. doi:10.3233/JAD-12211323531502
  • ShreazS, WaniWA, BehbehaniJM, et al. Cinnamaldehyde and its derivatives, a novel class of antifungal agents. Fitoterapia. 2016;112:116–131. doi:10.1016/j.fitote.2016.05.01627259370
  • JiangJ, EmontMP, JunH, et al. Cinnamaldehyde induces fat cell-autonomous thermogenesis and metabolic reprogramming. Metabolism. 2017;77:58–64. doi:10.1016/j.metabol.2017.08.00629046261
  • HagenlocherY, SatzingerS, CivelekM, et al. Cinnamon reduces inflammatory response in intestinal fibroblasts in vitro and in colitis in vivo leading to decreased fibrosis. Mol Nutr Food Res. 2017;61(9):1601085. doi:10.1002/mnfr.201601085
  • YuC, LiuSL, QiMH, ZouX. Cinnamaldehyde/chemotherapeutic agents interaction and drug-metabolizing genes in colorectal cancer. Mol Med Rep. 2014;9(2):669–676. doi:10.3892/mmr.2013.183024276478
  • MadarS, BroshR, BuganimY, et al. Modulated expression of WFDC1 during carcinogenesis and cellular senescence. Carcinogenesis. 2009;30(1):20–27. doi:10.1093/carcin/bgn23218842679
  • ChangWL, ChengFC, WangSP, ChouST, ShihY. Cinnamomum cassia essential oil and its major constituent cinnamaldehyde induced cell cycle arrest and apoptosis in human oral squamous cell carcinoma HSC-3 cells. Environ Toxicol. 2017;32(2):456–468. doi:10.1002/tox.2225026919256
  • ZhouL, LuY, YangG, WuJ. Research on tumorigenicity of cinnamaldehyde in melanoma cell lines and its mechanism. Tumor Biol. 2014;35(6):5717–5722. doi:10.1007/s13277-014-1757-8
  • MitamuraY, MuraiM, MitomaC, FurueM. NRF2 activation inhibits both TGF-beta1- and IL-13-mediated periostin expression in fibroblasts: benefit of cinnamaldehyde for antifibrotic treatment. Oxid Med Cell Longev. 2018;2018:2475047. doi:10.1155/2018/247504730186543
  • O’NeillLA, BowieAG. The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling. Nat Rev Immunol. 2007;7(5):353–364. doi:10.1038/nri207917457343
  • SekiE, De MinicisS, OsterreicherCH, et al. TLR4 enhances TGF-beta signaling and hepatic fibrosis. Nat Med. 2007;13(11):1324–1332. doi:10.1038/nm166317952090
  • ZhaoH, ZhangM, ZhouF, et al. Cinnamaldehyde ameliorates LPS-induced cardiac dysfunction via TLR4-NOX4 pathway: the regulation of autophagy and ROS production. J Mol Cell Cardiol. 2016;101:11–24. doi:10.1016/j.yjmcc.2016.10.01727838370
  • YounHS, LeeJK, ChoiYJ, et al. Cinnamaldehyde suppresses toll-like receptor 4 activation mediated through the inhibition of receptor oligomerization. Biochem Pharmacol. 2008;75(2):494–502. doi:10.1016/j.bcp.2007.08.03317920563
  • EferlR, WagnerEF. AP-1: a double-edged sword in tumorigenesis. Nat Rev Cancer. 2003;3(11):859–868. doi:10.1038/nrc120914668816
  • KimHJ, ChakravartiN, OridateN, ChoeC, ClaretFX, LotanR. N-(4-hydroxyphenyl)retinamide-induced apoptosis triggered by reactive oxygen species is mediated by activation of MAPKs in head and neck squamous carcinoma cells. Oncogene. 2006;25(19):2785–2794. doi:10.1038/sj.onc.120930316407847
  • HsiehMJ, ChienSY, LinJT, YangSF, ChenMK. Polyphyllin G induces apoptosis and autophagy cell death in human oral cancer cells. Phytomedicine. 2016;23(13):1545–1554. doi:10.1016/j.phymed.2016.09.00427823618
  • KawamotoT, IiM, KitazakiT, IizawaY, KimuraH. TAK-242 selectively suppresses Toll-like receptor 4-signaling mediated by the intracellular domain. Eur J Pharmacol. 2008;584(1):40–48. doi:10.1016/j.ejphar.2008.01.02618299127