Oxymatrine Liposomes for Intervertebral Disc Treatment: Formulation, in vitro and vivo Assessments

References

• LinY, JiaoY, YuanY, et al. Propionibacterium acnes induces intervertebral disc degeneration by promoting nucleus pulposus cell apoptosis via the TLR2/JNK/mitochondrial-mediated pathway. Emerg Microbes Infect. 2018;7(1):1.29323102
   PubMed Web of Science ®Google Scholar
• BezM, ZhouZ, SheynD, et al. Molecular pain markers correlate with pH-sensitive MRI signal in a pig model of disc degeneration. Sci Rep. 2018;8(1):17363. doi:10.1038/s41598-018-34582-630478330
   PubMed Web of Science ®Google Scholar
• WangH, HeP, PanH, et al. Circular RNA circ-4099 is induced by TNF-α and regulates ECM synthesis by blocking miR-616-5p inhibition of Sox9 in intervertebral disc degeneration. Exp Mol Med. 2018;50(4):27. doi:10.1038/s12276-018-0056-729651107
   PubMed Web of Science ®Google Scholar
• KwonWK, MoonHJ, KwonTH, ParkYK, KimJH. The role of hypoxia in angiogenesis and extracellular matrix regulation of intervertebral disc cells during inflammatory reactions. Neurosurgery. 2017;81(5):867–875. doi:10.1093/neuros/nyx14928475716
   PubMed Web of Science ®Google Scholar
• Jabłońska-TrypućA, MatejczykM, RosochackiS. Matrix metalloproteinases (MMPs), the main extracellular matrix (ECM) enzymes in collagen degradation, as a target for anticancer drugs. J Enzyme Inhib Med Chem. 2016;31(sup1):177–183. doi:10.3109/14756366.2016.116162027028474
   PubMed Web of Science ®Google Scholar
• LiuQ, ZhaoG, ZhouC, et al. Oxaloacetate and adipose stromal cells-conditional medium synergistically protected potassium/serum deprivation-induced neuronal apoptosis. Brain Res Bull. 2017;128:7–12. doi:10.1016/j.brainresbull.2016.11.00227816553
   PubMed Web of Science ®Google Scholar
• Molina-HolgadoE, OrtizS, Molina-HolgadoF, GuazaC. Induction of COX-2 and PGE(2) biosynthesis by IL-1beta is mediated by PKC and mitogen-activated protein kinases in murine astrocytes. Br J Pharmacol. 2000;131(1):152–159. doi:10.1038/sj.bjp.070355710960082
   PubMed Web of Science ®Google Scholar
• TuJ, LiW, ZhangY, et al. Simvastatin inhibits IL-1β-Induced apoptosis and extracellular matrix degradation by suppressing the NF-kB and MAPK pathways in nucleus pulposus cells. Inflammation. 2017;40(3):725–734. doi:10.1007/s10753-017-0516-628188410
   PubMed Web of Science ®Google Scholar
• SangX, WangR, HanY, et al. T cell–associated immunoregulation and antiviral effect of oxymatrine in hydrodynamic injection HBV mouse model. Acta Pharm Sin B. 2017;7(3):311–318. doi:10.1016/j.apsb.2017.02.00528540167
   PubMed Web of Science ®Google Scholar
• LiY, WangG, LiuJ, OuyangL. Quinolizidine alkaloids derivatives from Sophora alopecuroides Linn: bioactivities, structure-activity relationships and preliminary molecular mechanisms. Eur J Med Chem. 2019;188:111972. doi:10.1016/j.ejmech.2019.11197231884408
   PubMed Web of Science ®Google Scholar
• LiangJ, ChangB, HuangM, et al. Oxymatrine prevents synovial inflammation and migration via blocking NF-κB activation in rheumatoid fibroblast-like synoviocytes. Int Immunopharmacol. 2018;55:105–111. doi:10.1016/j.intimp.2017.12.00629241159
   PubMed Web of Science ®Google Scholar
• DaiJP, WangQW, SuY, et al. Oxymatrine inhibits influenza A virus replication and inflammation via TLR4, p38 MAPK and NF-κB pathways. Int J Mol Sci. 2018;19(4):965. doi:10.3390/ijms19040965
   PubMed Web of Science ®Google Scholar
• WuXL, HangTJ, ShenJP, ZhangYD. Determination and pharmacokinetic study of oxymatrine and its metabolite matrine in human plasma by liquid chromatography tandem mass spectrometry. J Pharm Biomed Anal. 2006;41(3):918–924. doi:10.1016/j.jpba.2006.01.02916500065
   PubMed Web of Science ®Google Scholar
• AmelotA, MazelC. The intervertebral disc: physiology and pathology of a Brittle joint. World Neurosurg. 2018;120:265–273. doi:10.1016/j.wneu.2018.09.03230218798
   PubMed Web of Science ®Google Scholar
• MolinosM, AlmeidaCR, CaldeiraJ, CunhaC, GonçalvesRM, BarbosaMA. Inflammation in intervertebral disc degeneration and regeneration. J R Soc Interface. 2015;12(104):20141191. doi:10.1098/rsif.2014.119125673296
   PubMed Web of Science ®Google Scholar
• SercombeL, VeeratiT, MoheimaniF, WuSY, SoodAK, HuaS. Advances and challenges of liposome assisted drug delivery. Front Pharmacol. 2015;6:286. doi:10.3389/fphar.2015.0028626648870
   PubMed Web of Science ®Google Scholar
• MetselaarJM, StormG. Liposomes in the treatment of inflammatory disorders. Expert Opin Drug Deliv. 2005;2(3):465–476. doi:10.1517/17425247.2.3.46516296768
   PubMedGoogle Scholar
• HuaS, WuSY. The use of lipid-based nanocarriers for targeted pain therapies. Front Pharmacol. 2013;4:143. doi:10.3389/fphar.2013.0014324319430
   PubMed Web of Science ®Google Scholar
• PachisK, BlazakiS, TzatzarakisM, et al. Sustained release of intravitreal flurbiprofen from a novel drug-in-liposome-in-hydrogel formulation. Eur J Pharm Sci. 2017;109:324–333. doi:10.1016/j.ejps.2017.08.02828843864
   PubMed Web of Science ®Google Scholar
• TianZ, MaX, YasenM, et al. Intervertebral disc degeneration in a percutaneous mouse tail injury model. Am J Phys Med Rehabil. 2018;97(3):170–177. doi:10.1097/PHM.000000000000081828863006
   PubMed Web of Science ®Google Scholar
• WuX, LiuY, GuoX, et al. Prolactin inhibits the progression of intervertebral disc degeneration through inactivation of the NF-κB pathway in rats. Cell Death Dis. 2018;9(2):98. doi:10.1038/s41419-017-0151-z29367664
   PubMed Web of Science ®Google Scholar
• HenryN, ClouetJ, Le BideauJ, Le VisageC, GuicheuxJ. Innovative strategies for intervertebral disc regenerative medicine: from cell therapies to multiscale delivery systems. Biotechnol Adv. 2018;36(1):281–294. doi:10.1016/j.biotechadv.2017.11.00929199133
   PubMed Web of Science ®Google Scholar
• LiQ, CaiT, HuangY, XiaX, ColeSPC, CaiY. A review of the structure, preparation, and application of NLCs, PNPs, and PLNs. Nanomaterials (Basel, Switzerland). 2017;7(6). doi:10.3390/nano7120458
   Google Scholar
• DuS, DengY. Studies on the encapsulation of oxymatrine into liposomes by ethanol injection and pH gradient method. Drug Dev Ind Pharm. 2006;32(7):791–797. doi:10.1080/0363904060076055616908416
   PubMed Web of Science ®Google Scholar
• ZuckerD, MarcusD, BarenholzY, GoldblumA. Liposome drugs’ loading efficiency: a working model based on loading conditions and drug’s physicochemical properties. J Control Release. 2009;139(1):73–80. doi:10.1016/j.jconrel.2009.05.03619508880
   PubMed Web of Science ®Google Scholar
• ZhangS, WuJ, WangH, et al. Liposomal oxymatrine in hepatic fibrosis treatment: formulation, in vitro and in vivo assessment. AAPS PharmSciTech. 2014;15(3):620–629. doi:10.1208/s12249-014-0086-y24515270
   PubMed Web of Science ®Google Scholar
• MagarkarA, DhawanV, KallinteriP, et al. Cholesterol level affects surface charge of lipid membranes in saline solution. Sci Rep. 2014;4:5005. doi:10.1038/srep0500524845659
   PubMed Web of Science ®Google Scholar
• BriugliaML, RotellaC, McFarlaneA, LamprouDA. Influence of cholesterol on liposome stability and on in vitro drug release. Drug Deliv Transl Res. 2015;5(3):231–242. doi:10.1007/s13346-015-0220-825787731
   PubMed Web of Science ®Google Scholar
• RogT, Pasenkiewicz-GierulaM, VattulainenI, KarttunenM. Ordering effects of cholesterol and its analogues. Biochim Biophys Acta. 2009;1788(1):97–121. doi:10.1016/j.bbamem.2008.08.02218823938
   PubMed Web of Science ®Google Scholar
• LuRM, ChenMS, ChangDK, et al. Targeted drug delivery systems mediated by a novel Peptide in breast cancer therapy and imaging. PLoS One. 2013;8(6):e66128. doi:10.1371/journal.pone.006612823776619
   PubMed Web of Science ®Google Scholar
• NeogMK, RasoolM. Targeted delivery of p-coumaric acid encapsulated mannosylated liposomes to the synovial macrophages inhibits osteoclast formation and bone resorption in the rheumatoid arthritis animal model. Eur J Pharm Biopharm. 2018;133:162–175. doi:10.1016/j.ejpb.2018.10.01030339889
   PubMed Web of Science ®Google Scholar
• LiuM, JinS, YanH, DuS. Effect of oxymatrine HSPC liposomes on improving bioavailability, liver target distribution and hepatoprotective activity of oxymatrine. Eur J Pharm Sci. 2017;104:212–220. doi:10.1016/j.ejps.2017.03.04828389275
   PubMed Web of Science ®Google Scholar
• HamidzadehK, ChristensenSM, DalbyE, ChandrasekaranP, MosserDM. Macrophages and the recovery from acute and chronic inflammation. Annu Rev Physiol. 2017;79:567–592. doi:10.1146/annurev-physiol-022516-03434827959619
   PubMed Web of Science ®Google Scholar
• GhafariM, HaghiralsadatF, Khanamani Falahati-PourS, Zavar RezaJ. Development of a novel liposomal nanoparticle formulation of cisplatin to breast cancer therapy. J Cell Biochem. 2020. doi:10.1002/jcb.29651
   PubMed Web of Science ®Google Scholar
• JiaY, LongS, JiangN, et al. Oxymatrine ameliorates agomelatine-induced hepatocyte injury through promoting proteasome-mediated CHOP degradation. Biomed Pharmacother. 2019;114:108784. doi:10.1016/j.biopha.2019.10878430925456
   PubMed Web of Science ®Google Scholar
• JiangX, XieL, HuangC, et al. Oral oxymatrine for hepatitis B cirrhosis: a systematic review protocol. Medicine (Baltimore). 2018;97(49):e13482. doi:10.1097/MD.000000000001348230544440
   PubMed Web of Science ®Google Scholar
• ZhouH, ShiHJ, YangJ, et al. Efficacy of oxymatrine for treatment and relapse suppression of severe plaque psoriasis: results from a single-blinded randomized controlled clinical trial. Br J Dermatol. 2017;176(6):1446–1455. doi:10.1111/bjd.1531628112799
   PubMed Web of Science ®Google Scholar
• ZhangY, YanR, HuY. Oxymatrine inhibits lipopolysaccharide-induced inflammation by down-regulating Toll-like receptor 4/nuclear factor-kappa B in macrophages. Can J Physiol Pharmacol. 2015;93(4):253–260. doi:10.1139/cjpp-2014-036225668061
   PubMed Web of Science ®Google Scholar
• WeiK, DaiJ, WangZ, et al. Oxymatrine suppresses IL-1β-induced degradation of the nucleus pulposus cell and extracellular matrix through the TLR4/NF-κB signaling pathway. Exp Biol Med (Maywood). 2020;1535370219900773.31979980
   PubMed Web of Science ®Google Scholar
• ZhangZ, LiuQ, ZangH, ShaoQ, SunT. Oxymatrine protects against l-arginine-induced acute pancreatitis and intestine injury involving Th1/Th17 cytokines and MAPK/NF-κB signalling. Pharm Biol. 2019;57(1):595–603. doi:10.1080/13880209.2019.165790631496325
   PubMed Web of Science ®Google Scholar